<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Iranian Journal of Basic Medical Sciences</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ijbms.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2008-3866</journal_id_issn>
			<journal_id_issn_online>2008-3874</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>2026</year>
				<month>7</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2026</year>
				<month>7</month>
				<day>1</day>
			</pubdate>
			<volume>29</volume>
			<number>7</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Investigating the effects of taurine on Aβ-degradation proteins and neurogenesis-related genes in an LPS-induced neuroinflammatory SH-SY5Y cell model</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Taurine, a brain-abundant sulfonic acid, shows potential neuroprotective effects and may counter neurodegenerative processes. This study investigated the effects of taurine on neuroinflammation, focusing on Aβ-degrading proteins and gene expression related to neurogenesis in an LPS-stimulated SH-SY5Y cell model.Materials and Methods: The effects of taurine (0.5 and 1 mg/ml) and LPS (0.5 and 10 μg/ml) on SH-SY5Y cell viability were assessed using the MTT assay. IL-1β and IL-6 expression was measured by real-time PCR, while matrix metalloproteinases (MMPs) and angiotensin-converting enzyme (ACE) levels were quantified via ELISA. Neurogenesis-related gene expression was evaluated using the Neurogenesis Plus RT² Profiler PCR array.Results: The MTT assay results demonstrated that taurine treatment at concentrations of 0.5 and 1 mg/ml significantly attenuated the cytotoxicity induced by LPS stimulation in SH-SY5Y cells. Also, treatment with taurine significantly reduced the expression levels of the inflammatory genes IL-1β and IL-6 in LPS-stimulated SH-SY5Y cells (P&lt;0.05). ELISA results further revealed that taurine treatment significantly increased the secretion levels of ACE and MMP-9 enzymes in LPS-stimulated SH-SY5Y cells (P&lt;0.05). LPS exposure in SH-SY5Y cells significantly up-regulated genes related to apoptosis, cell migration, and synaptic function (P&lt;0.005). Conversely, taurine treatment significantly increased the expression of genes involved in cell adhesion, synaptic function, growth factors, cytokines, differentiation, cell cycle, signaling, transcription, and cofactor activity (P&lt;0.005).Conclusion: These results suggest that taurine may act as a potential neuroprotective agent by increasing the secretion of MMP-9 and ACE, regulating neurogenesis-related genes, and reducing LPS-induced neuroinflammation.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Lipopolysaccharides, Matrix metalloproteinase 9, Neurogenesis Neuroinflammatory - diseases, Neuroprotective agents Taurine</keyword>
				<start_page>1043</start_page>
				<end_page>1051</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_27828.html</web_url>
			<author_list><author>
				<first_name>Pirouz</first_name>
				<middle_name></middle_name>
				<last_name>Pourmohammad</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>pirouz.pourmohammad@iau.ac.ir</email>
				<code>122354</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Biochemistry, North Tehran Branch, Islamic Azad University, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Fereshteh</first_name>
				<middle_name></middle_name>
				<last_name>Rahmati</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>fereshtehrahmati20252525@gmail.com</email>
				<code>122355</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Biochemistry, North Tehran Branch, Islamic Azad University, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Fatemeh</first_name>
				<middle_name></middle_name>
				<last_name>Siadat</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>f.siadat@iau-tnb.ac.ir</email>
				<code>122356</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Biochemistry, North Tehran Branch, Islamic Azad University, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Sara</first_name>
				<middle_name></middle_name>
				<last_name>Simorgh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>srsimorgh@gmail.com</email>
				<code>122357</code>
				<coreauthor>No</coreauthor>
				<affiliation>Stem Cell and Regenerative Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran|Department of Tissue Engineering &amp; Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>