<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Iranian Journal of Basic Medical Sciences</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ijbms.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2008-3866</journal_id_issn>
			<journal_id_issn_online>2008-3874</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2014</year>
				<month>10</month>
				<day>1</day>
			</pubdate>
			<volume>17</volume>
			<number>10</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Gabapentin enhances anti-nociceptive effects of morphine on heat, cold, and mechanical hyperalgesia in a rat model of neuropathic pain</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s):Neuropathic pain is caused by lesions or diseases affecting the somatosensory system and often responds poorly to typical medications.  In this study, we evaluated anti-nociceptive effects of morphine, gabapentin and their combination on heat hyperalgesia, cold and mechanical allodynia in chronic constriction injury (CCI) model of neuropathic pain in rats. Materials and Methods: Morphine (2, 4 and 8 mg/kg) and gabapentin (5, 10 and 20 mg/kg) were administered either alone or in combination (morphine 2 mg/kg and gabapentin 5 mg/kg). Results:Our results showed that morphine and gabapentin alone produce anti-nociceptive effects at higher doses (morphine 4 and 8 mg/kg and gabapentin 10 and 20 mg/kg) whereas their combination resulted in better analgesia at lower doses as compared to other treatment groups (morphine 2 mg/kg or gabapentin 5 mg/kg). Conclusion: These findings suggest that gabapentin potentiates the analgesic effects of morphine in the chronic constriction injury (CCI) model of neuropathic pain and combination of these drugs may be considered as a beneficial treatment for neuropathic pain.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Gabapentin, Hyperalgesia, Neuropathic pain, Morphine</keyword>
				<start_page>753</start_page>
				<end_page>759</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_3449.html</web_url>
			<author_list><author>
				<first_name>Gholam Ali</first_name>
				<middle_name></middle_name>
				<last_name>Hamidi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email></email>
				<code>12846</code>
				<coreauthor>No</coreauthor>
				<affiliation>Physiology Research Center, Kashan University of Medical Sciences, Kashan. Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Majid</first_name>
				<middle_name></middle_name>
				<last_name>Jafari-Sabet</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>jafarisa@tums.ac.ir</email>
				<code>12847</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Alireza</first_name>
				<middle_name></middle_name>
				<last_name>Abed</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>alirezaabed@pharm.mui.ac.ir</email>
				<code>12848</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacology, School of Medicine, Kashan University of Medical Sciences, Kashan. Iran
5 Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Azam</first_name>
				<middle_name></middle_name>
				<last_name>Mesdaghinia</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mesdaghiniaazam@yahoo.com</email>
				<code>12849</code>
				<coreauthor>No</coreauthor>
				<affiliation>Physiology Research Center, Kashan University of Medical Sciences, Kashan. Iran .Department of Pharmacology, School of Medicine, Kashan University of Medical Sciences, Kashan. Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mohadeseh</first_name>
				<middle_name></middle_name>
				<last_name>Mahlooji</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>topoly20032002@yahoo.com</email>
				<code>12850</code>
				<coreauthor>No</coreauthor>
				<affiliation>Physiology Research Center, Kashan University of Medical Sciences, Kashan. Iran .Department of Pharmacology, School of Medicine, Kashan University of Medical Sciences, Kashan. Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hamid Reza</first_name>
				<middle_name></middle_name>
				<last_name>Banafshe</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email></email>
				<code>12851</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Addiction Studies, School of Medicine, Kashan University of Medical Sciences, Kashan. Iran
Physiology Research Center, Kashan University of Medical Sciences, Kashan. Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>