<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Iranian Journal of Basic Medical Sciences</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ijbms.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2008-3866</journal_id_issn>
			<journal_id_issn_online>2008-3874</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2015</year>
				<month>10</month>
				<day>1</day>
			</pubdate>
			<volume>18</volume>
			<number>10</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>MiR-493 suppresses the proliferation and invasion of gastric cancer cells by targeting RhoC</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s):MiRNAs have been proposed to be key regulators of tumorigenesis, progression and metastasis. However, their effect and prognostic value in gastric cancer is still poorly known.
Materials and Methods: Gastric cancer cell lines were cultured. Tissue samples obtained from 36 gastric cancer patients were used for quantitative real-time PCR (qRT-PCR) analysis. The tissue microarrays (TMAs) consisted of 126 cases of gastric carcinoma that were used for In situ hybridisation (ISH). Lentivirus plasmids were co-transfected into 293FT cells. Cell migration was examined using wound-healing assays. Statistical analyses were performed using SPSS16.0 software.
Results: In this study, we found that the expression levels of miR-493 were strongly down-regulated in gastric cancer and were associated with clinical stage and the presence of lymph node metastases. Moreover, miR-493 might independently predict OS and RFS in gastric cancer. We further found that up-regulation of miR-493 inhibited the proliferation and metastasis of gastric cancer cells, in vitro and in vivo. In addition, miR-493 directly targeted RhoC, which resulted in a marked reduction of the expression of mRNA and protein. This effect, in turn, led to a decreased ability of growth, invasion and metastasis in gastric cancer cells.
Conclusion: Taken together, our findings demonstrate that miR-493 is important for gastric cancer initiation and progression and holds promise as a prognostic biomarker to predict survival and relapse in gastric cancer. It is also a potential therapeutic tool to improve clinical outcomes in this disease.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Gastric cancer, miR-493, Proliferation, Invasion, Prognostic significance</keyword>
				<start_page>1027</start_page>
				<end_page>1033</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_5468.html</web_url>
			<author_list><author>
				<first_name>Wenhua</first_name>
				<middle_name></middle_name>
				<last_name>Zhou</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>jhnhdx@163.com</email>
				<code>21648</code>
				<coreauthor>No</coreauthor>
				<affiliation>Cancer Research Institute, University of South China, Key Laboratory of Cancer Cellular and Molecular Pathology of Hunan Provincial University, Hengyang, People&amp;#039;s Republic of China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Chi</first_name>
				<middle_name></middle_name>
				<last_name>Zhang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>zhangchi9966@163.com</email>
				<code>21649</code>
				<coreauthor>No</coreauthor>
				<affiliation>Function Laboratory Center, Medical School, University of South China, Hengyang, Hunan, People’s Republic of China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hao</first_name>
				<middle_name></middle_name>
				<last_name>Jiang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>nhdxtgh@163.com</email>
				<code>21650</code>
				<coreauthor>No</coreauthor>
				<affiliation>Center for Gastric Cancer Research of Human Province, The First Affiliated Hospital, University of South China, Hengyang, Hunan, People&amp;#039;s Republic of China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Zhiwei</first_name>
				<middle_name></middle_name>
				<last_name>Zhang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>nhdxzzw@qq.com</email>
				<code>21651</code>
				<coreauthor>No</coreauthor>
				<affiliation>Cancer Research Institute, University of South China, Key Laboratory of Cancer Cellular and Molecular Pathology of Hunan Provincial University, Hengyang, People&amp;#039;s Republic of China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Liming</first_name>
				<middle_name></middle_name>
				<last_name>Xie</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>1023322948@qq.com</email>
				<code>21652</code>
				<coreauthor>No</coreauthor>
				<affiliation>Center for Gastric Cancer Research of Human Province, The First Affiliated Hospital, University of South China, Hengyang, Hunan, People&amp;#039;s Republic of China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Xiusheng</first_name>
				<middle_name></middle_name>
				<last_name>He</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hexiusheng@hotmail.com</email>
				<code>21653</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Cancer Research Institute, University of South China, Key Laboratory of Cancer Cellular and Molecular Pathology of Hunan Provincial University, Hengyang, People&amp;#039;s Republic of China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>