<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Iranian Journal of Basic Medical Sciences</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ijbms.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2008-3866</journal_id_issn>
			<journal_id_issn_online>2008-3874</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2016</year>
				<month>2</month>
				<day>1</day>
			</pubdate>
			<volume>19</volume>
			<number>2</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Assessment of expressions of Bcl-XL, b-FGF, Bmp-2, Caspase-3, PDGFR-α, Smad1 and TGF-β1 genes in a rat model of lung ischemia/reperfusion</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s):Ischemia is described as organs and tissues are destitute of oxygen due to decreased arterial or venous blood flow. Many mechanisms play role in cell death happened as a consequence of a new blood flow is needed for both cell regeneration and to clean toxic metabolites during ischemia and later. Lung damage induced by ischemia/reperfusion (I/R) is a frequent problem in lung transplantation. Apoptosis (programmed cell death) is known as cell suicide, and plays a key role in embryonic developmental and in maintain adult tissue’s life.
Materials and Methods:It is investigated expressions of Smad1, Bmp-2, Bcl-XL, b-FGF, Caspase-3, TGF-β1, PDGFR-α genes for molecular changes in lung tissues, after I/R is formed, in this study. For this, we included 40 Wistar albino rats to this study and divided 4 groups (n=10). The Groups were determined as Control (C), Group 1= 1 hr ischemia (I), Group 2= 1 hr ischemia+2 hr reperfusion (I+2R), Group 3= 1 hr ischemia+4 hr reperfusion (I+4R). Besides, molecular analysis and histopathologic examinations of tissues were performed, and the results were evaluated by normalization and statistics analysis.
Results: We have found a significant increase in expression of Bcl-XL (P=0.046) and Caspase-3 (P=0.026) genes of group 1, and it was not monitored any significant difference in Group 2 and Group 3. In all groups, the changes in b-FGF (P=0.087), Bmp-2 (P=0.457), TGF-β1 (P=0.201) and PDGFR-α (P=0.116) were not significant compared to control group. We did not see any mRNA expression of Smad1 gene in all groups include control.
Conclusion: These findings suggest that I/R injury may trigger apoptotic mechanism in lung.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Apoptosis, Growth factors, Ischemia/Reperfusion, Lung</keyword>
				<start_page>209</start_page>
				<end_page>214</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_6547.html</web_url>
			<author_list><author>
				<first_name>Hasan</first_name>
				<middle_name></middle_name>
				<last_name>Şimşek</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hasansimsek47@hotmail.com</email>
				<code>25841</code>
				<coreauthor>No</coreauthor>
				<affiliation>Dumlupınar University, Department of Physiology, Faculty of Medicine, Kütahya, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Şeniz</first_name>
				<middle_name></middle_name>
				<last_name>Demiryürek</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sdemiryurek@gantep.edu.tr</email>
				<code>25842</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Gaziantep University, Department of Physiology, Faculty of Medicine, Gaziantep, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Tuncer</first_name>
				<middle_name></middle_name>
				<last_name>Demir</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>drtuncer2003@yahoo.com</email>
				<code>25844</code>
				<coreauthor>No</coreauthor>
				<affiliation>Gaziantep University, Department of Physiology, Faculty of Medicine, Gaziantep, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hüsne</first_name>
				<middle_name></middle_name>
				<last_name>Didem Atabay</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email></email>
				<code>25845</code>
				<coreauthor>No</coreauthor>
				<affiliation>Gaziantep University, Department of Physiology, Faculty of Medicine, Gaziantep, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ali Osman</first_name>
				<middle_name></middle_name>
				<last_name>Çeribasi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email></email>
				<code>25846</code>
				<coreauthor>No</coreauthor>
				<affiliation>Fırat University, Department of Pathology, Faculty of Veterinary Science, Elazığ, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Recep</first_name>
				<middle_name></middle_name>
				<last_name>Bayraktar</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>rbyrktr@gmail.com</email>
				<code>25847</code>
				<coreauthor>No</coreauthor>
				<affiliation>Gaziantep University, Department of Medical Biology, Faculty of Medicine, Gaziantep, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Davut</first_name>
				<middle_name></middle_name>
				<last_name>Sinan Kaplan</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email></email>
				<code>25848</code>
				<coreauthor>No</coreauthor>
				<affiliation>Gaziantep University, Department of Physiology, Faculty of Medicine, Gaziantep, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Serdar</first_name>
				<middle_name></middle_name>
				<last_name>Öztuzcu</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>oztuzcu@gantep.edu.tr</email>
				<code>25849</code>
				<coreauthor>No</coreauthor>
				<affiliation>Gaziantep University, Department of Medical Biology, Faculty of Medicine, Gaziantep, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Beyhan</first_name>
				<middle_name></middle_name>
				<last_name>Cengiz</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>beyhancengiz@hotmail.com</email>
				<code>25850</code>
				<coreauthor>No</coreauthor>
				<affiliation>Gazi University, Department of Medical Genetic, Faculty of Medicine, Ankara, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>