<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Iranian Journal of Basic Medical Sciences</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ijbms.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2008-3866</journal_id_issn>
			<journal_id_issn_online>2008-3874</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2016</year>
				<month>8</month>
				<day>1</day>
			</pubdate>
			<volume>19</volume>
			<number>8</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Hepatoprotective effects of licochalcone B on carbon tetrachloride-induced liver toxicity in mice</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): The objective of this study was to investigate the hepatoprotective effect of licochalcone B (LCB) in a mice model of carbon tetrachloride (CCl4)-induced liver toxicity. Materials and Methods: Hepatotoxicity was induced in mice by a single subcutaneous injection (SC) of CCl4. The LCB was administered orally once a day for seven days (PO) as pretreatment at three doses of 1, 5, and 25 mg/kg/day. The levels of superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH), glutathione disulfide (GSSG), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were analyzed by ELISA. The protein expression degrees of p38 mitogen activated protein kinases (p38) and nuclear factor-k-gene binding (NF-κB) were assayed by western blotting. Results: CCl4-induced hepatotoxicity was manifested by an increase in the levels of ALT, AST, MDA, IL-6, CRP, and TNF-ɑ, and a decrease in the SOD level and GSH/GSSG ratio in the serum. The histopathological examination of the liver sections revealed necrosis and inflammatory reactions. Pretreatment with LCB decreased the levels of ALT, AST, MDA, GSSG, IL-6, CRP, TNF-ɑ, and the protein expression of p38 and NF-κB, increased the level of SOD and GSH, and normalized the hepatic histo-architecture. Conclusion: LCB protected the liver from CCl4-induced injury. Protection may be due to inhibition of p38 and NFκB signaling, which subsequently reduced inflammation in the liver.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Antioxidant, Anti-inﬂammatory, Carbon tetrachloride, Hepatotoxicity, Licochalcone B, NF-κB, p38</keyword>
				<start_page>910</start_page>
				<end_page>915</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_7474.html</web_url>
			<author_list><author>
				<first_name>Haifeng</first_name>
				<middle_name></middle_name>
				<last_name>Teng</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>haifengt5@163.com</email>
				<code>30127</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Weihai Municipal Hospital, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Meng</first_name>
				<middle_name></middle_name>
				<last_name>Chen</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>labihai@163.com</email>
				<code>30128</code>
				<coreauthor>No</coreauthor>
				<affiliation>Yantai Yuhuangding Hospital of Laishan Branch, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ansheng</first_name>
				<middle_name></middle_name>
				<last_name>Chu</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>youxi111519@sohu.com</email>
				<code>30129</code>
				<coreauthor>No</coreauthor>
				<affiliation>Yantai City Hospital for Infectious Diseases, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Haili</first_name>
				<middle_name></middle_name>
				<last_name>Jiang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>1012045502@qq.com</email>
				<code>30130</code>
				<coreauthor>No</coreauthor>
				<affiliation>Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Jichun</first_name>
				<middle_name></middle_name>
				<last_name>Han</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>923023681@qq.com</email>
				<code>30131</code>
				<coreauthor>No</coreauthor>
				<affiliation>Shandong Provincial Qianfoshan Hospital, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Long</first_name>
				<middle_name></middle_name>
				<last_name>Sun</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sunlong@163.com</email>
				<code>30132</code>
				<coreauthor>No</coreauthor>
				<affiliation>Yishui Central Hospital, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Chao</first_name>
				<middle_name></middle_name>
				<last_name>Feng</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>y50040@163.com</email>
				<code>30133</code>
				<coreauthor>No</coreauthor>
				<affiliation>Yantaishan Hospital, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ju</first_name>
				<middle_name></middle_name>
				<last_name>Liu</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ju.liu@sdu.edu.cn</email>
				<code>30134</code>
				<coreauthor>No</coreauthor>
				<affiliation>Shandong Provincial Qianfoshan Hospital, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>