<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Iranian Journal of Basic Medical Sciences</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ijbms.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2008-3866</journal_id_issn>
			<journal_id_issn_online>2008-3874</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2017</year>
				<month>3</month>
				<day>1</day>
			</pubdate>
			<volume>20</volume>
			<number>3</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Protective effects of tanshinone IIA sodium sulfonate on ischemia-reperfusion-induced myocardial injury in rats</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): This study investigated the protective effect of tanshinone IIA sodium sulfonate (TSS) on ischemia-reperfusion (I/R) induced cardiac injury, and the underlying mechanism of action. Materials and Methods:Male Sprague-Dawley rats were subjected to a 30-min coronary arterial occlusion followed by 24 hours&#039; reperfusion. Half an hour before the left coronary artery ligation, rats were pretreated with TSS in three different dosages (15, 30, 70 mg/kg, IP). Twenty-four hours later, cardiac function was measured and the ratio of infarct size to area at risk (AAR) was calculated. Western blotting examined the expression of the inflammatory mediator high-mobility group box1 (HMGB-1), anti-apoptotic protein Bcl-2, pro-apoptotic mediators such as Bax and Caspase-3, markers of autophagy such as ratio of LC3B/LC3A and Beclin-1 expression. Results: Our results showed that TSS dose-dependently improves cardiac function, accompanied with decrease of HMGB1 level, increase of LC3B/LC3A ratio and increase of Beclin-1 expression. TSS treatment down-regulates Bax and Caspase-3 expression, while up-regulating Bcl-2 levels. Conclusion: TSS ameliorates I/R induced myocardial injury and improves cardiac function via reducing inflammation and apoptosis, while enhancing autophagy.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Apoptosis, Autophagy, Ischemia/reperfusion (I/R), Tanshinone IIA sodium-sulfonate (TSS)</keyword>
				<start_page>308</start_page>
				<end_page>315</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_8361.html</web_url>
			<author_list><author>
				<first_name>Yun</first_name>
				<middle_name></middle_name>
				<last_name>Pan</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>794291018@qq.com</email>
				<code>34110</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Emergency, The First Affiliated Hospital, Soochow University, 188 Shi-Zi Road, Suzhou 215006, PR China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Jin-Xian</first_name>
				<middle_name></middle_name>
				<last_name>Qian</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>szicu@sina.com</email>
				<code>34111</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Emergency, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, P.R. China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Shi-Qi</first_name>
				<middle_name></middle_name>
				<last_name>Lu</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>lushiqi2004@126.com</email>
				<code>34112</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Emergency, The First Affiliated Hospital, Soochow University, 188 Shi-Zi Road, Suzhou 215006, PR China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Jing-Wei</first_name>
				<middle_name></middle_name>
				<last_name>Chen</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>szszyxh@163.com</email>
				<code>34113</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Internal Medicine, The Affiliated Suzhou Chinese Traditional Medicine Hospital, Nanjing University of Chinese Medicine, Yang-Su Road, Suzhou 215003, P.R. China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Xiao-Dong</first_name>
				<middle_name></middle_name>
				<last_name>Zhao</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>xiaodong@medmail.com.cn</email>
				<code>34114</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Internal Medicine, The Affiliated Suzhou Chinese Traditional Medicine Hospital, Nanjing University of Chinese Medicine, Yang-Su Road, Suzhou 215003, P.R. China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Yan</first_name>
				<middle_name></middle_name>
				<last_name>Jiang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>yjiang@suda.edu.cn</email>
				<code>34115</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Physiology, Medical College of Soochow University, 199 Ren-Ai Road, Dushu Lake Campus, Suzhou Industrial Park, Suzhou   215123, P.R. China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Lin-Hui</first_name>
				<middle_name></middle_name>
				<last_name>Wang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>wanglinhui@suda.edu.cn</email>
				<code>34116</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Physiology, Medical College of Soochow University, 199 Ren-Ai Road, Dushu Lake Campus, Suzhou Industrial Park, Suzhou   215123, P.R. China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Guo-Xing</first_name>
				<middle_name></middle_name>
				<last_name>Zhang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>zhangguoxing@suda.edu.cn</email>
				<code>34117</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Physiology, Medical College of Soochow University, 199 Ren-Ai Road, Dushu Lake Campus, Suzhou Industrial Park, Suzhou   215123, P.R. China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>