Iranian Journal of Basic Medical Sciences

en Recent advances in the genetic engineering of the Leishmania parasite and anti-cancer properties Review Article Attenuated, Host-pathogen interactions, Immunotherapy, Neoplasms, Protozoan Infections, Reverse genetics, Vaccines 1447 1455 https://ijbms.mums.ac.ir/article_26544.html Saeid Rahim saeidrahim74@gmail.com 116522 No Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Hossein Yousofi Darani yousofidarani@gmail.com 116523 No Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Hossein Khanahmad hossein_khanahmad@yahoo.com 116524 No Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Nadia Pourmoshir pourmoshir.nadia@gmail.com 116525 No Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran Zahra Bakhshiyani z.bakhshiani2016@gmail.com 116526 No Department of Medical Biotechnology, Faculty of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran Sedigheh Saberi sedisaberi@med.mui.ac.ir 116527 Yes Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

en Syringic acid, a promising natural compound for the prevention and management of metabolic syndrome: A systematic review Review Article Diabetes, Dyslipidemia, Hypertension, metabolic syndrome, Obesity, Syringic acid 1456 1476 https://ijbms.mums.ac.ir/article_26319.html Habibeh Mashayekhi-Sardoo habibehmasha@gmail.com 115531 No Bio Environmental Health Hazards Research Center, Jiroft University of Medical Sciences, Jiroft, Iran|Student Research Committee Jiroft University of Medical Sciences, Jiroft, Iran Fatemeh Sadeghzadeh fsadeghzadeh7@gmail.com 115532 No Student Research Committee Jiroft University of Medical Sciences, Jiroft, Iran Maryam Rameshrad mrameshrad@gmail.com 115533 No Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran|Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran Hossein Hosseinzadeh hosseinzadehh@mums.ac.ir 115534 Yes Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran|Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

en Evaluating the effect of fucoidan-alginate combined dressing on wound healing in rats with full-thickness skin removed Original Article Alginate, Combined Dressing Fucoidan, Natural product, Wound healing 1477 1485 https://ijbms.mums.ac.ir/article_26341.html Guifa Wang wangguifa0323@163.com 115624 No Department of Biochemistry and Molecular Biology, School of Basic Medicine, Qingdao University, 308 Ningxia Road, Qingdao, 266071, China Nan Zhang zhangnan0784@163.com 115625 No 2Department of Nutrition and Food Hygiene, School of Public Health, Qingdao University, 308 Ningxia Road, Qingdao, 266071, China Xiaochen Zhang 13165007702@163.com 115626 No Adelaide 128 Waymouth St, Y Suites on Waymouth Adelaide SA 5000 Australia Zihan Guo qdgzh2020@163.com 115627 No Department of Clinical Nutrition, The Second People’s Hospital of Lianyungang, Lianyungang, 222000, China Man Liu lium_summer@126.com 115628 No Department of Nutrition and Food Hygiene, School of Public Health, Qingdao University, 308 Ningxia Road, Qingdao, 266071, China|School of Nursing, Qingdao University, 308 Ningxia Road, Qingdao, 266071, China Meilan Xue snowml@126.com 115629 Yes Department of Biochemistry and Molecular Biology, School of Basic Medicine, Qingdao University, 308 Ningxia Road, Qingdao, 266071, China Hui Liang qdlianghui@126.com 115630 Yes Department of Nutrition and Food Hygiene, School of Public Health, Qingdao University, 308 Ningxia Road, Qingdao, 266071, China

en Impact of trehalose and hydroxychloroquine on the function of BRAF (V600E)-siRNA in the A375 melanoma cells Original Article BRAF (V600E), Hydroxychloroquine, Melanoma, siRNA, Trehalose 1486 1494 https://ijbms.mums.ac.ir/article_26667.html Elmira Toobchi eli.tp995@gmail.com 117054 No Department of Genetics and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Rana Moradian Tehrani moradian@med.mui.ac.ir 117055 Yes Department of Genetics and Molecular Sciences, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Mohammadreza Sharifi mo_sharifi@med.mui.ac.ir 117056 No Department of Genetics and Molecular biology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Fatemeh Tabandeh fatemehtabandehfv.7593@gmail.com 117057 No Department of Genetics and Molecular biology, Faculty of Medicine, Isfahan university of Medical Sciences, Isfahan, Iran Negin Hadisadegh neginhadisadegh1998@gmail.com 117058 No Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran

en Linalool vs linalool-loaded chitosan nanoparticles in an Aβ-induced rat model of Alzheimer’s disease: A molecular, biochemical, histological, and behavioral study Original Article Alzheimer’s disease, Amyloid precursor protein - secretases, Hippocampus, Kynurenine, Linalool-loaded chitosan - nanoparticle, Oxidative stress, Spatial Memory 1495 1504 https://ijbms.mums.ac.ir/article_26445.html Mohammad Pakdel mohamadpakdel108@gmail.com 116068 No Department of Biology, SR.C., Islamic Azad University, Tehran, Iran Masoumeh Asle Rousta mrousta58@gmail.com 116069 Yes Department of Physiology, Za.C., Islamic Azad University, Zanjan, Iran Mehdi Sadegh m.sadegh@arakmu.ac.ir 116070 No Department of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran Akram Eidi akram_eidi@yahoo.com 116071 No Department of Biology, SR.C., Islamic Azad University, Tehran, Iran

en Effect of TGF-β1 transfected dental pulp derived mesenchymal stem cells on in vivo cartilage regeneration Original Article cartilage regeneration, Dental pulp, Mesenchymal stem cells, Osteochondral defects, TGF-β1 1505 1515 https://ijbms.mums.ac.ir/article_26550.html Betül Tekin Alpargu betus.t.87@gmail.com 116549 Yes Department of Histology and Embryology, Faculty of Medicine, Erciyes University, Kayseri, Türkiye Saim Ozdamar sozdamar@pau.edu.tr 116550 No Department of Histology and Embryology, Faculty of Medicine, Pamukkale University, Denizli, Türkiye Zeynep Burcin Gonen zeynepburcin@erciyes.edu.tr 116551 No Department of Oral and Maxillofacial Surgery, Genome and Stem Cell Center (GENKOK), Erciyes University, Kayseri, Türkiye Ayca Kara aycakara@erciyes.edu.tr 116552 No Genome and Stem Cell Center (GENKOK), Erciyes University, Kayseri, Türkiye Hasan Salkın hasansalkin@beykent.edu.tr 116553 No Department of Histology and Embryology, Faculty of Medicine, Istanbul Beykent University, Istanbul, Türkiye

en Pretreatment with a ketogenic diet inhibits mitochondrial damage in rat models of spinal cord injury via the PGC-1α/Sirt1/Nrf1 pathway Original Article Apoptosis, Ketogenic diet, Mitochondria, Sirtuin 1, Spinal cord injury 1516 1522 https://ijbms.mums.ac.ir/article_26416.html Xiaomeng Wang xiaomeng8934@163.com 115957 No Department of Spinal Surgery, Affiliated Longyan First Hospital of Fujian Medical University, Longyan, 364000, Fujian, China Weibin Lan jinjun478@163.com 115958 No Department of Spinal Surgery, Affiliated Longyan First Hospital of Fujian Medical University, Longyan, 364000, Fujian, China Yang Liao liqianmo23@163.com 115959 No Department of Radiology, Affiliated Longyan First Hospital of Fujian Medical University, Longyan, 364000, Fujian, China Haichuan Lu luhaichuan8934@163.com 115960 Yes Department of Spinal Surgery, Affiliated Longyan First Hospital of Fujian Medical University, Longyan, 364000, Fujian, China

en Silymarin exerts antipsoriatic effects against imiquimod-induced psoriasis in mice via NF-kB/TLR4 signaling pathway Original Article Imiquimod, Inflammation, male mice, Psoriasis, Silymarin 1523 1530 https://ijbms.mums.ac.ir/article_26543.html Behnaz Azimi behnazazimi00@gmail.com 116517 No Student Research Committee, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran Amir Kiani amir1kiani@yahoo.com 116518 No Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran|Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran Tayebeh Noori tayebehnoori94@gmail.com 116519 No Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran Antoni Sureda tosugo@hotmail.com 116520 No Research Group on Community Nutrition and Oxidative Stress (NUCOX) and Health Research Institute of Balearic Islands (IdISBa), University of Balearic Islands-IUNICS, Palma de Mallorca E-07122, Balearic Islands, Spain|CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain Samira Shirooie shirooie@gmail.com 116521 Yes Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

en Troxerutin attenuates LPS-induced inflammation in BV2 microglial cells involving Nrf2 activation and NF-κB pathway inhibition Original Article Anti-inflammatory agents, Lipopolysaccharides, Microglia, Neuroinflammation, NF-kappa B, NRF2 transcription factor 1531 1538 https://ijbms.mums.ac.ir/article_26444.html Shengnan Ma jane6386812@126.com 116062 Yes Department of Pharmacy, Tianjin Fourth Central Hospital, Tianjin 300140, China Hongguang Fan fan6hg@163.com 116063 No Department of Neurology, Tianjin Fourth Central Hospital, Tianjin 300140, China Jianhong Zhang zhang_jianhong66@sina.com 116064 No Department of Pharmacy, Tianjin Fourth Central Hospital, Tianjin 300140, China Lijun Wang wlj2004497@163.com 116065 No Department of Neurology, Tianjin Fourth Central Hospital, Tianjin 300140, China Haiwen Shi haiwenshitj@163.com 116066 No Department of Pharmacy, Tianjin Fourth Central Hospital, Tianjin 300140, China Changjun Li lchj0916@163.com 116067 No Department of Pharmacy, Tianjin Fourth Central Hospital, Tianjin 300140, China

en Anti-inflammatory and immunomodulatory effects of camel milk exosomes (CM-Exo) in rat models for burn wound healing Original Article Anti-Oxidants, Burn, Camel milk, Exosomes, Fibroblasts, Inflammatory, Wound healing 1539 1547 https://ijbms.mums.ac.ir/article_26665.html Ehsaneh Azaryan ehsaneh.azaryan@gmail.com 117040 No Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran Asghar Zarban azarban@bums.ac.ir 117041 No Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran|Clinical Biochemistry Department, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran Effat Alemzadeh effat.ealemzadeh@gmail.com 117042 No Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran Esmat Alemzadeh esmat.alemzadeh@gmail.com 117043 No Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran|Department of Biotechnology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran Mahdieh Rajabi-Moghaddam rajabimmh@gmail.com 117044 No Department of Pathology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran Alireza Zangooie zangooei65@gmail.com 117045 No Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran Samira Karbasi s.karbasi@bums.ac.ir 117039 Yes Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran

en Enhanced wound healing through hydrogel: Arthrospira platensis and Chlorella vulgaris in carboxymethyl cellulose/ carboxymethyl chitosan/gelatin matrix with decellularized amniotic membrane in male Wistar rats Original Article Tissue engineering, Wound healing, Skin regeneration, Scaffold, Arthrospira platensis, Chlorella vulgaris 1548 1562 https://ijbms.mums.ac.ir/article_26678.html Rasoul Kheradmandi rasoulkheradmandi@gmail.com 117111 No Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran Mohammad Kamalabadi Farahani mkfarahani64@yahoo.com 117112 No Regenerative Medicine Research Center, Shahroud University of Medical Sciences, Shahroud, Iran|Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran Morteza Alizadeh mor1361@gmail.com 117113 No Department of Tissue Engineering and Biomaterials, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran Nariman Rezaei nariman.rezaei67@gmail.com 117114 No Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran Sepehr Zamani zscalpel.2014@gmail.com 117115 No Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran Arian Ehterami arian.ehterami@irem.uzh.ch 117116 No Institute for Regenerative Medicine (IREM), University of Zurich, Zurich, Switzerland Majid Salehi msalehi.te1392@gmail.com 117117 Yes Regenerative Medicine Research Center, Shahroud University of Medical Sciences, Shahroud, Iran|Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran

en Dapagliflozin improves diabetic cardiomyopathy by suppressing the STAT3-YY1 signaling axis in cardiac fibroblasts Original Article Dapagliflozin, Diabetic cardiomyopathy, Fibroblast, Signal transducer and - activator of transcription 3 Yin Yang 1 1563 1574 https://ijbms.mums.ac.ir/article_26547.html Xing-Yi Shen xingyis8121@163.com 116539 No Department of Cardiology, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Nanjing Medical University, Suzhou, China Xi Ya Li l13092307770@163.com 116540 No Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China Zuo Ying Hu zuoying_hu@126.com 116537 Yes Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China Hao Xie xie_hao_08@163.com 116538 Yes Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China

en Exosomes from miR-149-3p-transfected menstrual blood-derived mesenchymal stem cells ameliorate inflammation and migration of endometriosis cells Original Article Endometriosis, Exosomes, Inflammation, Mesenchymal stem cells, MicroRNA 149, Migration 1575 1588 https://ijbms.mums.ac.ir/article_26577.html Hoda Fazaeli hodafazaely@yahoo.com 116683 No Department of Biology, Faculty of Sciences and Converging Technologies, Science and Research Branch, Islamic Azad University, Tehran, Iran Nasim Hayati Roodbari hayati@srbiau.ac.ir 116684 Yes Department of Biology, Faculty of Sciences and Converging Technologies, Science and Research Branch, Islamic Azad University, Tehran, Iran Ehsan Ehsani ee_ehsan@yahoo.com 116685 Yes Department of Biology, Faculty of Sciences, Islamic Azad University, Roudehen Branch, Roudehen, Iran Azar Sheikholeslami azareslami10@gmail.com 116686 No Department of Cell Biology and Regenerative Medicine, Academic Center for Education, Culture and Research (ACECR), Qom branch, Qom, Iran

en Elucidating the effect of deferoxamine, a hypoxia mimetic agent, on angiogenesis restoration in endothelial progenitor cells (EPCs) from diabetic mice Original Article Deferoxamine, Diabetes, Endothelial progenitor cell HIF-α, Tie2, VEGF 1589 1597 https://ijbms.mums.ac.ir/article_26664.html Vahid Siavashi vahid_siavashi@ut.ac.ir 117035 No Department of Pharmacology and Razi Drug Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran|Department of Clinical Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran Seyed Mahdi Nassiri 117036 No Department of Clinical Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran Mahdi Farhadi Mahalli mfarahani@ut.edu.my 117038 No Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran Tunku Kamarul tkzre@um.edu.my 117037 No Tissue Engineering Group (NOCERAL), Department of Orthopedic Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Ali Mohammad Sharifi sharifalim@gmail.com 117034 Yes Department of Pharmacology and Razi Drug Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran|Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran|Stem cell and Regenerative Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran|Tissue Engineering Group (NOCERAL), Department of Orthopedic Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

en Evaluation of myocardial classic and alternative pathways of the renin-angiotensin system in cholestasis-induced cardiac injury: A time-course experimental study in rats Original Article Angiotensin-converting - enzyme 2, Angiotensin receptors, Cholecardia syndrome, cholestasis, Renin-angiotensin system 1598 1606 https://ijbms.mums.ac.ir/article_26666.html Azadeh Khalili azadeh8058@yahoo.com 117046 No Department of Physiology-Pharmacology-Medical Physics, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran Parham Samimisedeh parhamsamimimd@gmail.com 117047 No Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran Mohammad Maleki khaliliaz8058@gmail.com 117048 No Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran Elmira Jafari Afshar elmirafshar72@gmail.com 117049 No Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran Mohammad Jadidian mohammadjadidian@yahoo.com 117051 No Department of Pathology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran Roham Mazloom rohammazloom@abzums.ac.ir 117050 No Department of Physiology-Pharmacology-Medical Physics, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran Gholamreza Bayat g.bayat@abzums.ac.ir 117052 Yes Department of Physiology-Pharmacology-Medical Physics, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran Hossein Karim h.karim@abzums.ac.ir 117053 Yes Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran|Department of Cardiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran