<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Iranian Journal of Basic Medical Sciences</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ijbms.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2008-3866</journal_id_issn>
			<journal_id_issn_online>2008-3874</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>2026</year>
				<month>6</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2026</year>
				<month>6</month>
				<day>1</day>
			</pubdate>
			<volume>29</volume>
			<number>6</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Emerging trends in nanomedicine: The role of RNAi-based therapies and onpattro’s clinical journey</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Review Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Nanomedicine has transformed therapeutic strategies by enabling precise delivery of nucleic acid-based drugs, including small interfering RNA (siRNA), messenger RNA (mRNA), and antisense oligonucleotides. A landmark achievement is Onpattro (patisiran), the first FDA-approved RNAi therapy, which employs lipid nanoparticles (LNPs) to silence transthyretin in hereditary amyloidosis. Its approval validates RNAi as a viable therapeutic modality and underscores the central role of nanocarriers in clinical translation. Despite this success, barriers such as nanoparticle stability, targeted delivery, immunogenicity, and manufacturing scalability remain. Recent advances in mRNA vaccines, CRISPR-based gene editing, and stimuli-responsive nanoparticles are addressing these challenges, supported by growing clinical case studies and real-world data. This review highlights Onpattro’s clinical development, compares delivery platforms, discusses translational challenges, and examines emerging technologies that will guide the next generation of RNAi nanomedicines in personalized therapy.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Amyloid neuropathies, familial, Drug delivery systems, Lipid nanoparticles, Nanomedicine, RNA interference, RNA, Small interfering</keyword>
				<start_page>812</start_page>
				<end_page>822</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_27663.html</web_url>
			<author_list><author>
				<first_name>Dilpreet</first_name>
				<middle_name></middle_name>
				<last_name>Singh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dilpreet.daman@gmail.com</email>
				<code>121499</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>School of Pharmaceutical Sciences, CT University, Ferozepur Rd, Sidhwan Khurd, Punjab 142024</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Satvir</first_name>
				<middle_name></middle_name>
				<last_name>Singh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>singhsatvir1994@gmail.com</email>
				<code>121501</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Applied Sciences, CT University, Ferozepur Rd, Sidhwan Khurd, Punjab 142024</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Nitin</first_name>
				<middle_name></middle_name>
				<last_name>Tandon</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>tandonnitin12004@gmail.com</email>
				<code>121500</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Applied Sciences, CT University, Ferozepur Rd, Sidhwan Khurd, Punjab 142024</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Akshay</first_name>
				<middle_name></middle_name>
				<last_name>Thakur</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>akshaythakurat09@gmail.com</email>
				<code>121502</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Pharmaceutical Sciences, CT University, Ferozepur Rd, Sidhwan Khurd, Punjab 142024</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Neena</first_name>
				<middle_name></middle_name>
				<last_name>Bedi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>neena.pharma@gndu.ac.in</email>
				<code>121503</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143001, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>AI-driven CRISPR strategies in breast cancer: Organoid modeling, adaptive editing, and precision delivery</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Review Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Triple-negative breast cancer (TNBC) is defined by profound heterogeneity, dormant metastatic reservoirs, and rapid therapy resistance. Building on our AI-Driven CRISPR Strategies in Breast Cancer framework, CRISPR–Cas9 is emerging as more than a gene-editing tool, capable of restoring circadian integrity, eliminating dormant clones, and re-programming immune surveillance. A structured PubMed, Scopus, and ClinicalTrials.gov review through 2025 integrated mechanistic, preclinical, and early clinical evidence. Beyond standard knockout, base, and prime editing, we highlight chrono-genomic repair of BMAL1/PER2, dormancy-focused synthetic-lethality screens, and genomic-collapse tactics for BRCA1-deficient tumors. Adaptive AI pipelines that iteratively refine guide RNAs and exosome-mimetic carriers, incorporating Boolean logic gates, were also evaluated for self-regulated, tumor-specific delivery. Proof-of-concept studies show that HER2 deletion, TP53 rescue, and ABCB1 silencing enhance chemosensitivity across luminal, HER2-positive, and TNBC models. Circadian restoration expands therapeutic windows and delays relapse in xenografts. Dormancy-directed CRISPR screens reveal unique vulnerabilities in disseminated tumor cells, whereas genomic collapse selectively destroys BRCA1-mutant clones. Integration with CAR-T cells and antibody–drug conjugates amplifies cytotoxicity, and transient nanoparticle or exosome systems improve solid-tumor penetration while minimizing off-target events. CRISPR–Cas9 is transitioning from a molecular scalpel to an adaptive, self-learning therapeutic ecosystem. By uniting AI-guided design, circadian reprogramming, dormancy eradication, and logic-gated delivery, the strategies detailed here define a next-generation precision-oncology paradigm capable of anticipating tumor evolution, overcoming resistance, and preventing metastatic relapse.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Artificial intelligence, Breast neoplasms, Circadian Rhythm, CRISPR-Cas systems, Gene editing, Gene knockout techniques, Neoplasm dormancy, Triple negative breast- neoplasms</keyword>
				<start_page>823</start_page>
				<end_page>843</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_27615.html</web_url>
			<author_list><author>
				<first_name>Anmar</first_name>
				<middle_name>Ghanim</middle_name>
				<last_name>Taki</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ammar.ghanim2000@gmail.com</email>
				<code>121289</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Radiology Techniques, Health and Medical Techniques College, Alnoor University, Nineveh, Iraq</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Abdulkareem</first_name>
				<middle_name></middle_name>
				<last_name>Shareef</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>abdulkareem.shareef@abu.edu.iq</email>
				<code>121290</code>
				<coreauthor>No</coreauthor>
				<affiliation>Ahl al bayt University, Kerbala, Iraq</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Vimal</first_name>
				<middle_name></middle_name>
				<last_name>Arora</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>drvimalarora1@outlook.com</email>
				<code>121291</code>
				<coreauthor>No</coreauthor>
				<affiliation>University institute of Pharma Sciences, Chandigarh University, Mohali, Punjab, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Rami</first_name>
				<middle_name></middle_name>
				<last_name>Oweis</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>rami.oweis@mcbs.edu.om</email>
				<code>121292</code>
				<coreauthor>No</coreauthor>
				<affiliation>Modern College of Business and Science, Muscat, Oman|On sabbatical leave, from Jordan University of Science and Technology, Irbid, Jordan</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>S. Renuka</first_name>
				<middle_name></middle_name>
				<last_name>Jyothi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>j.renuka@jainuniversity.ac.in</email>
				<code>121293</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Biotechnology and Genetics, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Udaybir</first_name>
				<middle_name></middle_name>
				<last_name>Singh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>udaybirsingh0202@outlook.com</email>
				<code>121294</code>
				<coreauthor>No</coreauthor>
				<affiliation>Center for Research Impact &amp; Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, 140401, Punjab, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Samir</first_name>
				<middle_name></middle_name>
				<last_name>Sahoo</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>samirsahu@soa.ac.in</email>
				<code>121295</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of General Medicine, IMS and SUM Hospital, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha-751003, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ashish</first_name>
				<middle_name>Singh</middle_name>
				<last_name>Chauhan</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ashishchauhan.pharmacy@gmail.com</email>
				<code>121296</code>
				<coreauthor>No</coreauthor>
				<affiliation>Uttaranchal Institute of Pharmaceutical Sciences, Division of Research and Innovation, Uttaranchal University, Dehradun, Uttarakhand, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Guzal</first_name>
				<middle_name></middle_name>
				<last_name>Klebleeva</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>laylo.djuraeva.88@bk.ru</email>
				<code>121297</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Skin and Venereal Diseases, Samarkand State Medical University, Samarkand, Uzbekistan</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hayder</first_name>
				<middle_name>Naji</middle_name>
				<last_name>Sameer</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hayder.sam@nust.edu.iq</email>
				<code>121298</code>
				<coreauthor>No</coreauthor>
				<affiliation>Collage of Pharmacy, National University of Science and Technology, Dhi Qar, 64001, Iraq</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ahmed</first_name>
				<middle_name></middle_name>
				<last_name>Yaseen</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ahmed.yaseen.alsharea@gau.edu.iq</email>
				<code>121299</code>
				<coreauthor>No</coreauthor>
				<affiliation>Gilgamesh Ahliya University, Baghdad, Iraq</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Zainab</first_name>
				<middle_name></middle_name>
				<last_name>H. Athab</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>zainb@g.alzahu.edu.iq</email>
				<code>121300</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mohaned</first_name>
				<middle_name></middle_name>
				<last_name>Adil</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mariamkh681@gmail.com</email>
				<code>121301</code>
				<coreauthor>No</coreauthor>
				<affiliation>Pharmacy college, Al-Farahidi University, Baghdad, Iraq</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Role of microRNAs in major brain diseases, focusing on neuroinflammation and neuronal apoptosis</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Review Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[MicroRNAs are non-coding small RNA molecules that play a significant role in regulating gene expression. Increasing lines of evidence have highlighted the microRNA dysregulation and neuroinflammation-associated apoptosis in common brain diseases, including Parkinson’s disease, Alzheimer’s disease, epilepsy, traumatic brain injury, depression, and migraine. In fact, microRNAs regulate multiple physiological and pathological processes, thus implicating them in both health and disease. Though studies have suggested that the alterations or modifications in microRNA-associated regulatory pathways might contribute to the disease pathogenesis, the underlying molecular mechanisms and the targeted genes remain exclusively unknown. We hope that the idea of using microRNAs as therapeutic targets for brain disorders is not far from reality, but important issues must be addressed before moving into clinical practice. The aim of this review is to enlighten the molecular mechanisms and targeted genes of microRNA implicated in the multifaceted brain disorders. Moreover, several microRNAs have been reported to be up-regulated following disease, but their targeted pathways have not been elucidated yet. This review also highlighted microRNAs that are expected to warrant further exploration of their mechanism of action. This comprehensive overview of the prediction of microRNAs’ functions might be helpful in providing more efficient insight for the development of microRNA-based therapeutic interventions for neuropsychiatric and neurodegenerative diseases.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Apoptosis, Brain diseases, Health and-disease, MicroRNA, Molecular Pathways, Neuroinflammation</keyword>
				<start_page>844</start_page>
				<end_page>869</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_27637.html</web_url>
			<author_list><author>
				<first_name>Nimra</first_name>
				<middle_name></middle_name>
				<last_name>Aziz</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>nimra.aziz@deaht.uol.edu.pk</email>
				<code>121388</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Emerging Allied Health Technologies, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ghulam</first_name>
				<middle_name></middle_name>
				<last_name>Hussain</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ghulamhussain@gcuf.edu.pk</email>
				<code>121389</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Physiology, Faculty of Life Sciences, Government College University Faisalabad, Faisalabad, Pakistan</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Qammar</first_name>
				<middle_name></middle_name>
				<last_name>Abbas</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>qammar.abbas@deaht.uol.edu.pk</email>
				<code>121390</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Emerging Allied Health Technologies, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Hyaluronic acid-coated niosomal sorafenib targets CD44 and suppresses NF‑κB signalling in oral squamous cell carcinoma</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Oral squamous cell carcinoma (OSCC) remains highly lethal and is driven, in part, by chronic NF-κB-mediated inflammation. Sorafenib, a multikinase inhibitor of RAF/VEGFR/PDGFR, can suppress these pathways, but its clinical utility is limited by hydrophobicity, toxicity, and poor tumor penetration. We engineered hyaluronic acid-coated niosomes encapsulating sorafenib (SOR@Nio/HA) to enable CD44-targeted delivery to OSCC cells.Materials and Methods: SOR@Nio/HA displayed a mean hydrodynamic diameter of 177±8 nm (PDI=0.23-0.26) and high encapsulation efficiency (86.34%), with pH-responsive release (45% at pH=5.5 and 30% at pH=7.4, in 24 hr).Results: In CAL27 cells, SOR@Nio/HA significantly enhanced cytotoxicity versus free sorafenib, lowering IC50 from 11.8±1.1 µM to 5.2±0.9 µM (P&lt;0.01), and increased Annexin V/PI-defined apoptosis relative to controls. qRT-PCR showed suppression of NF-κB targets, with COX-2 and MMP-9 reduced to 0.35-fold and 0.32-fold of the control, respectively, alongside a pro-apoptotic shift in the BAX/BCL-2 axis.Conclusion: Collectively, these data indicate that SOR@Nio/HA improves intracellular delivery and potentiates sorafenib’s antitumor activity by CD44-mediated uptake and inhibition of NF-κB-driven inflammatory and invasive programs. HA-guided niosomal sorafenib warrants in vivo validation as a selective nanotherapeutic strategy for OSCC.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Carcinoma, CD44, Drug delivery systems, Hyaluronic acid, Mouth neoplasms NF-kappa B, Sorafenib, Squamous Cell</keyword>
				<start_page>870</start_page>
				<end_page>882</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_27649.html</web_url>
			<author_list><author>
				<first_name>Ting</first_name>
				<middle_name></middle_name>
				<last_name>Wu</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ting12wu@outlook.com</email>
				<code>121437</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Stomatology, Shungeng Campus, Jinan Stomatological Hospital, No.73, Shungeng Road, Shizhong District, Jinan, Shandong, 250001, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Yongshu</first_name>
				<middle_name></middle_name>
				<last_name>Li</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>yongshuoli@outlook.com</email>
				<code>121438</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Stomatology, Central Hospital affiliated to Shandong First Medical University, No.105, Jiefang Road, Lixia District, Jinan, Shandong, 250013, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Zixian</first_name>
				<middle_name></middle_name>
				<last_name>Wang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>zixianwangg18@outlook.com</email>
				<code>121439</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Stomatology, Shandong Medical College, No 5460, Second Ring South Road, Jinan, Shandong, 250002, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Bin</first_name>
				<middle_name></middle_name>
				<last_name>Guo</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>likong071@gmail.com</email>
				<code>121440</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Stomatology, Central Hospital affiliated to Shandong First Medical University, No.105, Jiefang Road, Lixia District, Jinan, Shandong, 250013, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Mechanistic insights into the protective effects of vitamin E against olanzapine-induced testicular toxicity: The role of microRNAs in oxidative stress and apoptosis</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Research on the male gonadotoxic effects of olanzapine (OLZ) and the potential protective role of vitamin E (Vit E) remains limited. This investigation aimed to assess the toxic impact of OLZ on the testes integrity and the protective role of dietary Vit E. Materials and Methods: In this experimental study, twenty-eight rats were divided into four groups: a control group, a group administered 5 mg/kg of OLZ orally, a group receiving both OLZ and 100 mg/kg of Vit E, and a group treated with Vit E alone. We assessed testes dimensions, structural alterations, serum concentrations of testosterone and prolactin, sperm parameters, oxidative stress, and apoptosis. Additionally, the expression levels of microRNA (miR)-122 and miR-202-5p were quantified.Results: Administration of OLZ resulted in significant structural damages to the testes characterized by apoptosis, cellular stress, and disruption of miR-122 and miR-202-5p expression. Otherwise, Vit E restores the histological structure, apoptosis, and sperm quality affected by OLZ. Notably, hormonal profiles and indices of cellular stress showed significant improvement in rats receiving a combination of Vit E and OLZ. Furthermore, the expressions of miR-122 and miR-202-5p were normalized in the OLZ + Vit E treated group. Conclusion: This study highlights the protective role of dietary Vit E against OLZ-induced testicular toxicity by enhancing testicular histo-architecture, reducing stress markers, and modulating of microRNA expressions.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Histology, MicroRNA modulatory, Olanzapine, Rat, Vitamin E</keyword>
				<start_page>883</start_page>
				<end_page>892</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_27661.html</web_url>
			<author_list><author>
				<first_name>Afraa</first_name>
				<middle_name></middle_name>
				<last_name>Habeeb Qayssar</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>habibqhaysarafraa@gmail.com</email>
				<code>121491</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Histology, Faculty of Veterinary Sciences, Ilam University, Ilam, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ali</first_name>
				<middle_name></middle_name>
				<last_name>Louei Monfared</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>a.loueimonfared@ilam.ac.ir</email>
				<code>121492</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Histology, Faculty of Veterinary Sciences, Ilam University, Ilam, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Effects of glucocorticoid on cardiac chronotropic responsiveness in cirrhotic rats: A possible role for dopamine receptors</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Cirrhosis causes chronotropic dysfunction by weakening the β-adrenergic receptor (β-AR) signaling pathway in cirrhotic cardiomyopathy (CCM). Downstream signaling of glucocorticoids and dopamine receptors influences the β-AR pathway. Thus, the effects of glucocorticoids on chronotropic incompetence and the possible involved pathways were investigated in this experiment. Materials and Methods: Bile duct ligation (BDL) surgery was performed on Wistar rats to induce cirrhosis. Four weeks after BDL or sham surgery, the subjects were given an intramuscular injection of either saline (NS) or dexamethasone (dexa)  (2.2 mg/kg/day) for three consecutive days. In vivo, chronotropic responsiveness to isoproterenol and QTc interval were evaluated by electrocardiogram (ECG). Real-time polymerase chain reaction (RT-PCR) and immunohistochemistry (IHC) were performed to determine the effectiveness of dexa on dopamine D1, D2 receptors, and GNAL mRNA expression. Moreover, the tumor necrosis factor-alpha (TNF-α) and interleukin‐1beta (IL-1β) levels in rats’ hearts were assessed.Results: Dexa treatment reduced the prolonged QT intervals in cirrhosis. It also dedcreasd spleen weight, as well as TNF-α levels, which are increased in cirrhosis. Moreover, dexa increased D1 protein expression in IHC. Conclusion: Dexa effectively improved cirrotic heart by improving QT intervales and increasing spleen weight,  reducing a pro-inflammatory cytokine, and up-regulateing  D1 receptor protein expression. ]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Bile duct ligation, Cardiomyopathy, Cirrhosis, Dexamethasone, Dopamine receptors, GNAL mRNA</keyword>
				<start_page>893</start_page>
				<end_page>900</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_27662.html</web_url>
			<author_list><author>
				<first_name>Mohadese</first_name>
				<middle_name></middle_name>
				<last_name>Shokrian Zeini</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mhshokrian@yahoo.com</email>
				<code>121493</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran|Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Maryam</first_name>
				<middle_name></middle_name>
				<last_name>Shokrian Zeini</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>maryam.shokrian.z@gmail.com</email>
				<code>121494</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Qamar</first_name>
				<middle_name></middle_name>
				<last_name>Niaz</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>qamar.niazuvas@gmail.com</email>
				<code>121495</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore, Pakistan</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Seyed Soheil</first_name>
				<middle_name></middle_name>
				<last_name>Saeedi Saravi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>soheil.saeedi@uzh.ch</email>
				<code>121496</code>
				<coreauthor>No</coreauthor>
				<affiliation>Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, USA</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ahmad-Reza</first_name>
				<middle_name></middle_name>
				<last_name>Dehpour</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dehpour@yahoo.com</email>
				<code>121497</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran|Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Farahnaz</first_name>
				<middle_name></middle_name>
				<last_name>Jazaeri</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>f-jazaeri@sina.tums.ac.ir</email>
				<code>121498</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Hepatoprotective effect of hUC-MSC secretome in LPS-induced HepG2 cells</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): This study aimed to evaluate the cytotoxicity and hepatoprotective effects of human umbilical cord mesenchymal stem cell–derived secretome (hUCMSC-Sec) in lipopolysaccharide (LPS)-induced HepG2 cells as an in vitro model of liver inflammation.Materials and Methods: hUCMSC-Sec was obtained from conditioned media of hUCMSCs at passage four. Inflammation was induced in HepG2 cells using LPS. Cytotoxicity was assessed using the WST-8 assay. Hepatoprotective effects of hUCMSC-Sec at concentrations of 12.5%, 4.17%, and 1.39% were evaluated by measuring alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl transferase (GGT), and tumor necrosis factor-alpha (TNF-α). Gene expression levels of α-smooth muscle actin (α-SMA), SMAD-7, collagen type I alpha 1 (COL1A1), and matrix metalloproteinase-1 (MMP-1) were analyzed using quantitative real-time PCR.Results: hUCMSC-Sec concentrations ranging from 1.6% to 25% were non-toxic, maintaining cell viability above 90%. Treatment with hUCMSC-Sec significantly reduced ALT, AST, GGT, and TNF-α levels in LPS-induced HepG2 cells. In addition, hUCMSC-Sec down-regulated α-SMA, COL1A1, and MMP-1 expression, while up-regulating SMAD-7 expression. The concentration of 4.17% showed the most pronounced hepatoprotective effect.Conclusion: hUCMSC-derived secretome demonstrated hepatoprotective effects by attenuating inflammatory and fibrotic responses in LPS-induced HepG2 cells. However, as this study was limited to an in vitro model, further in vivo and clinical studies are required to confirm its therapeutic potential and translational applicability.  ]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Fibrosis, Inflammation, Protective agent, Secretome, Umbilical cord</keyword>
				<start_page>901</start_page>
				<end_page>908</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_27688.html</web_url>
			<author_list><author>
				<first_name>Wahyu</first_name>
				<middle_name></middle_name>
				<last_name>Widowati</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>wahyu_w60@yahoo.com</email>
				<code>121598</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Faculty of Medicine, Maranatha Christian University, Bandung 40164, West Java, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Philips</first_name>
				<middle_name></middle_name>
				<last_name>Onggowidjaja</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>philips.onggowidjaja@yahoo.com</email>
				<code>121599</code>
				<coreauthor>No</coreauthor>
				<affiliation>Faculty of Medicine, Maranatha Christian University, Bandung 40164, West Java, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Massoud</first_name>
				<middle_name></middle_name>
				<last_name>Vosough</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>masvos@yahoo.com</email>
				<code>121600</code>
				<coreauthor>No</coreauthor>
				<affiliation>Molecular Medicine Department, Biotechnology Research Center (BRC), Pasteur Institute of Iran, Tehran, Iran|Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran, Iran|Experimental Cancer Medicine, Institution for Laboratory Medicine, and Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Dwi Nur</first_name>
				<middle_name></middle_name>
				<last_name>Triharsiwi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dwinur@amubbrc.co.id</email>
				<code>121601</code>
				<coreauthor>No</coreauthor>
				<affiliation>Biomolecular and Biomedical Research Center, Aretha Medika Utama, Bandung 40163 West Java, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Anindita Putri</first_name>
				<middle_name></middle_name>
				<last_name>Distya</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>aninditaputri@amubbrc.co.id</email>
				<code>121602</code>
				<coreauthor>No</coreauthor>
				<affiliation>Biomolecular and Biomedical Research Center, Aretha Medika Utama, Bandung 40163 West Java, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Lisna Wahyu</first_name>
				<middle_name></middle_name>
				<last_name>Nurani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>lisnawahyunurani@upi.edu</email>
				<code>121604</code>
				<coreauthor>No</coreauthor>
				<affiliation>Departement of Biology, Faculty of Mathematics and Natural Science Universitas Pendidikan Indonesia, Bandung 40154, West Java, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ismia</first_name>
				<middle_name></middle_name>
				<last_name>Rahmawati</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>is.ismia.rahma27@gmail.com</email>
				<code>121605</code>
				<coreauthor>No</coreauthor>
				<affiliation>Departement of Biology, Faculty of Mathematics and Natural Science Universitas Pendidikan Indonesia, Bandung 40154, West Java, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Any</first_name>
				<middle_name></middle_name>
				<last_name>Aryani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>any_aryani@upi.edu</email>
				<code>121606</code>
				<coreauthor>No</coreauthor>
				<affiliation>Departement of Biology, Faculty of Mathematics and Natural Science Universitas Pendidikan Indonesia, Bandung 40154, West Java, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Didik</first_name>
				<middle_name></middle_name>
				<last_name>Priyandoko</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>didikpriyandoko@upi.edu</email>
				<code>121607</code>
				<coreauthor>No</coreauthor>
				<affiliation>Departement of Biology, Faculty of Mathematics and Natural Science Universitas Pendidikan Indonesia, Bandung 40154, West Java, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Rizal</first_name>
				<middle_name></middle_name>
				<last_name>Azis</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>rizal@eng.ui.ac.id</email>
				<code>121608</code>
				<coreauthor>No</coreauthor>
				<affiliation>Biomolecular and Biomedical Research Center, Aretha Medika Utama, Bandung 40163 West Java, Indonesia|Biomedical Engineering, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Depok 16425, West Java, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Dhanar Septyawan</first_name>
				<middle_name></middle_name>
				<last_name>Hadiprasetyo</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dhanar3095@gmail.com</email>
				<code>121609</code>
				<coreauthor>No</coreauthor>
				<affiliation>Biomolecular and Biomedical Research Center, Aretha Medika Utama, Bandung 40163 West Java, Indonesia|Faculty of Pharmacy, Universitas Jenderal Achmad Yani, Cimahi 40531, West Java, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Priyatharsini</first_name>
				<middle_name></middle_name>
				<last_name>Rajendran</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>priyatharsinirajendran@ldc.edu.in</email>
				<code>121610</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Zoology and Research Centre, Lady Doak College Madurai, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Kasim Sakran</first_name>
				<middle_name></middle_name>
				<last_name>Abass</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>kasim_abass@uokirkuk.edu.iq</email>
				<code>121611</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Physiology, Biochemistry, and Pharmacology; College of Veterinary Medicine, University of Kirkuk, Kirkuk 36001, Iraq</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Safira Dinda</first_name>
				<middle_name></middle_name>
				<last_name>Rifana</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>safiiradinda@gmail.com</email>
				<code>121603</code>
				<coreauthor>No</coreauthor>
				<affiliation>Biomolecular and Biomedical Research Center, Aretha Medika Utama, Bandung 40163 West Java, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Combined effects of EGCG and retinol on viability and apoptosis-related gene expression in Caco-2 and HCT-116 colon cancer cells</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Colorectal cancer remains a leading cause of cancer-related deaths worldwide, emphasizing the need for novel therapeutic strategies. Epigallocatechin-3-gallate (EGCG), a major green tea polyphenol, and retinol, a vitamin A derivative with antioxidant properties, have shown anti-cancer activity individually. This study investigates the combined effects of EGCG and retinol on human colorectal cancer cell lines, Caco-2 and HCT-116.Materials and Methods: Cytotoxic effects of EGCG and retinol, alone and in combination, were evaluated using resazurin-based cell viability assays. Intracellular reactive oxygen species (ROS) levels were measured by DCFDA assay to assess antioxidant activity. Changes in expression of apoptosis- and survival-related genes (p53, p21, AKT, and NF-κB) were analyzed using quantitative real-time PCR (RT-qPCR).Results: Combined treatment with EGCG and retinol reduced cell viability and intracellular ROS levels in both Caco-2 and HCT-116 cells. This treatment also modulated gene expression by increasing pro-apoptotic markers (p53 and p21) and decreasing anti-apoptotic markers (AKT and NF-κB), suggesting enhanced regulation of apoptosis-related pathways and inhibition of survival signaling.Conclusion: The combined effects of EGCG and retinol result in enhanced cytotoxicity, antioxidant activity, and modulation of apoptosis- and survival-related genes in colorectal cancer cells, supporting their potential as a combined therapeutic approach. Further studies are required to confirm these findings and explore clinical relevance.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Apoptosis, Colorectal cancer, Epigallocatechin gallate, Reactive Oxygen Species, Retinol</keyword>
				<start_page>909</start_page>
				<end_page>914</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_27671.html</web_url>
			<author_list><author>
				<first_name>Saeedeh</first_name>
				<middle_name></middle_name>
				<last_name>Ghorbani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>s.ghorbani9111@gmail.com</email>
				<code>121532</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Biochemistry, NT. C., Islamic Azad University, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Jamshidkhan</first_name>
				<middle_name></middle_name>
				<last_name>Chamani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>chamani.j@ut.ac.ir</email>
				<code>121531</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Monireh</first_name>
				<middle_name></middle_name>
				<last_name>Movahedi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mon_movahedi@yahoo.com</email>
				<code>121533</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Biochemistry, NT. C., Islamic Azad University, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Zahra</first_name>
				<middle_name></middle_name>
				<last_name>Kianmehr</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>z.kianmehr1@gmail.com</email>
				<code>121534</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Biochemistry, NT. C., Islamic Azad University, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>CRISPR/Cas9-mediated knockout of NEAT1 attenuates neurotoxicity in 6-hydroxydopamine model of Parkinson’s disease</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Parkinson’s disease (PD), a progressive neurodegenerative condition, involves the degeneration of dopaminergic neurons and the aggregation of α-synuclein (SNCA); however, the molecular mechanisms of this disorder remain incompletely understood.Materials and Methods: This study explores the role of the long non-coding RNA NEAT1 in PD by employing CRISPR/Cas9-mediated knockout in SH-SY5Y neuroblastoma cells treated with 6-hydroxydopamine (6-OHDA).Results: Deletion of NEAT1 was associated with increased cellular viability, attenuated both cytotoxicity and apoptosis, and elevated total antioxidant capacity (TAC), alongside a marked down-regulation of SNCA expression. Mechanistically, NEAT1 knockout was accompanied by increased hsa-let-7a-5p and decreased miR-506-3p expression, suggesting its function as a competing endogenous RNA (ceRNA) in miRNA-mediated stress pathways. Tyrosine hydroxylase (TH) levels remained unchanged, indicating that NEAT1 may influence neurotoxicity through post-transcriptional mechanisms.Conclusion: These results suggest NEAT1 is a crucial modulator of neurotoxicity in PD, with its inhibition offering therapeutic promise. Despite the in vitro nature of this study, our findings provide foundational insight into NEAT1’s dualistic roles in neurodegeneration and underscore its potential as a therapeutic target in PD.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Alpha-synuclein, Apoptosis, CRISPR/Cas9, Long non-coding RNA, microRNAs, NEAT1, Oxidative stress, Parkinson’s disease</keyword>
				<start_page>915</start_page>
				<end_page>926</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_27672.html</web_url>
			<author_list><author>
				<first_name>Ali</first_name>
				<middle_name></middle_name>
				<last_name>Samareh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>samarehali@yahoo.com</email>
				<code>121535</code>
				<coreauthor>No</coreauthor>
				<affiliation>Applied Cellular and Molecular Research Center, Kerman University of Medical Sciences, Kerman, Iran|Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran|Department of Clinical Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mohammad Hadi</first_name>
				<middle_name></middle_name>
				<last_name>Nematollahi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mh.nematollahi@yahoo.com</email>
				<code>121536</code>
				<coreauthor>No</coreauthor>
				<affiliation>Applied Cellular and Molecular Research Center, Kerman University of Medical Sciences, Kerman, Iran|Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran|Department of Clinical Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hossein</first_name>
				<middle_name></middle_name>
				<last_name>Pourghadamyari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>h.pourghadamyari@kmu.ac.ir</email>
				<code>121537</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Applied Cellular and Molecular Research Center, Kerman University of Medical Sciences, Kerman, Iran|Department of Clinical Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Sanaz</first_name>
				<middle_name></middle_name>
				<last_name>Rastegar</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sanazrastegarr@gmail.com</email>
				<code>121538</code>
				<coreauthor>No</coreauthor>
				<affiliation>Medical Mycology and Bacteriology Research Center, Kerman University of Medical Sciences, Kerman, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hosseinali</first_name>
				<middle_name></middle_name>
				<last_name>Ebrahimi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ebrahimi.ha@gmail.com</email>
				<code>121539</code>
				<coreauthor>No</coreauthor>
				<affiliation>Neurology Research Center, Kerman University of Medical Sciences, Kerman, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Morteza</first_name>
				<middle_name></middle_name>
				<last_name>Hadizadeh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>morteza.hadizade@gmail.com</email>
				<code>121540</code>
				<coreauthor>No</coreauthor>
				<affiliation>Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hongsheng</first_name>
				<middle_name></middle_name>
				<last_name>Wang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>whongsh@mail.sysu.edu.cn</email>
				<code>121541</code>
				<coreauthor>No</coreauthor>
				<affiliation>Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, The State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Lijun</first_name>
				<middle_name></middle_name>
				<last_name>Tao</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>cputaolijun@126.com</email>
				<code>121542</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hosseinali</first_name>
				<middle_name></middle_name>
				<last_name>Sasan</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hsasa@uk.ac.ir</email>
				<code>121543</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Gholamreza</first_name>
				<middle_name></middle_name>
				<last_name>Asadikaram</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>gh_asadi@kmu.ac.ir</email>
				<code>121544</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran|Department of Clinical Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran|Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Huanglian Jiedu decoction ameliorates Alzheimer’s disease by regulating calcium homeostasis via mitochondria-associated endoplasmic reticulum membranes</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Huanglian Jiedu decoction (HLJDD), a classic traditional Chinese medicine formula, is investigated for its protective effects against Alzheimer’s disease (AD). This study explored its mechanism in an AD cell model, focusing on calcium ion (Ca²⁺) homeostasis regulation via mitochondria-associated endoplasmic reticulum membranes (MAMs).Materials and Methods: Mouse hippocampal HT22 cells were induced with 10 μmol·L⁻¹ Aβ₁₋₄₂ to establish the AD model, then divided into blank, model, and 15% HLJDD-containing serum intervention groups. Fluorescent dyes, qRT-PCR, western blotting, laser scanning confocal microscopy, and Annexin V-FITC/PI staining were used to detect intracellular reactive oxygen species (ROS), mitochondrial membrane potential, VDAC1/GRP75/IP3R (mRNA/protein levels), MAMs formation, intracellular Ca²⁺, and cell apoptosis, respectively.Results: Aβ₁₋₄₂ reduced HT22 viability in a concentration-dependent manner, while HLJDD significantly improved viability. Compared to the model group, HLJDD evidently decreased ROS levels (P&lt;0.001), elevated mitochondrial membrane potential (P&lt;0.001), up-regulated GRP75  (mRNA/protein, P&lt;0.05), down-regulated VDAC1/IP3R (mRNA/protein, P&lt;0.05 or P&lt;0.001), reduced MAMs (via lower ER-mitochondria co-localization, P&lt;0.05), alleviated Ca²⁺ overload  (P&lt;0.001), and lowered apoptosis.Conclusion: HLJDD exerts protective anti-AD effects likely by reducing MAMs formation to alleviate intracellular Ca²⁺ overload, thereby lessening cell damage and apoptosis.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Alzheimer’s disease, Amyloid beta-peptides- (1-42), Calcium, Huanglian Jiedu decoction, Mitochondria-associated- membranes (MAMs)</keyword>
				<start_page>927</start_page>
				<end_page>934</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_27686.html</web_url>
			<author_list><author>
				<first_name>Yong</first_name>
				<middle_name></middle_name>
				<last_name>Yuan</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>yong2201@163.com</email>
				<code>121589</code>
				<coreauthor>No</coreauthor>
				<affiliation>Academy of Chinese Medical Sciences; Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan University of Chinese Medicine, Zhengzhou 450046, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Zhonghua</first_name>
				<middle_name></middle_name>
				<last_name>Li</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>lizh@hactcm.edu.cn</email>
				<code>121588</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Academy of Chinese Medical Sciences; Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan University of Chinese Medicine, Zhengzhou 450046, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ruifang</first_name>
				<middle_name></middle_name>
				<last_name>Wang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>2283934260@qq.com</email>
				<code>121590</code>
				<coreauthor>No</coreauthor>
				<affiliation>Academy of Chinese Medical Sciences; Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan University of Chinese Medicine, Zhengzhou 450046, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Huandong</first_name>
				<middle_name></middle_name>
				<last_name>Zhao</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>zhaohuandong.cn@163.com</email>
				<code>121591</code>
				<coreauthor>No</coreauthor>
				<affiliation>Academy of Chinese Medical Sciences; Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan University of Chinese Medicine, Zhengzhou 450046, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Junying</first_name>
				<middle_name></middle_name>
				<last_name>Song</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>junying1206@126.com</email>
				<code>121592</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Academy of Chinese Medical Sciences; Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan University of Chinese Medicine, Zhengzhou 450046, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>LKB1 dictates sensitivity to immunotherapy through Skp2-mediated ubiquitination of immune checkpoint proteins in HCC with python analysis</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Hepatocellular carcinoma (HCC) is a highly aggressive malignancy with limited treatment options, particularly in advanced stages. Immune checkpoint inhibitors (ICIs) targeting PD-1, PD-L1, and CTLA-4 have shown promise in cancer immunotherapy, but response rates in HCC remain variable. Materials and Methods: Hep3B and HepG2 HCC cells were cultured and genetically manipulated to overexpress or deplete LKB1. Western blotting, real-time PCR, and immunofluorescence were used to assess PD-L1 expression at the protein and mRNA levels. The role of Skp2 in PD-L1 regulation was evaluated through shRNA-mediated knockdown and overexpression. Additionally, kinase-dead LKB1 mutants were expressed to determine the importance of LKB1 kinase activity in PD-L1 stability. ImageJ software and Python-based computational tools were employed for quantitative analysis of immunofluorescence and Western blot data.Results: LKB1 overexpression up-regulated PD-L1 protein levels in HCC cells, while its depletion reduced PD-L1 expression, indicating a post-translational regulatory mechanism. Although Skp2 expression remained unchanged upon LKB1 modulation, Skp2 overexpression in LKB1-deficient cells increased PD-L1 levels, suggesting a context-dependent role for Skp2 in PD-L1 stability. Furthermore, wild-type LKB1, but not the kinase-dead mutant, restored PD-L1 expression, highlighting the essential role of LKB1 kinase activity in PD-L1 regulation.Conclusion: This study identifies LKB1 as a critical regulator of PD-L1 stability in HCC, with implications for tumor immune evasion and immunotherapy response. While Skp2 appears to influence PD-L1 stability in specific contexts, LKB1’s kinase activity is essential for PD-L1 regulation.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>HCC, Immune checkpoint - proteins, LKB1, Python analysis, Skp2</keyword>
				<start_page>935</start_page>
				<end_page>941</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_27717.html</web_url>
			<author_list><author>
				<first_name>Masoud</first_name>
				<middle_name></middle_name>
				<last_name>khodarahmi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>masoudkh@gmail.com</email>
				<code>121766</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Medicine,Tehran University of Medical Sciences,Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Danial</first_name>
				<middle_name></middle_name>
				<last_name>Amiri Manjili</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>danial.amiri@gmail.com</email>
				<code>121767</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Medicine,Tehran University of Medical Sciences,Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Foroozan</first_name>
				<middle_name></middle_name>
				<last_name>Yarahmadi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>foroozan@gmail.com</email>
				<code>121768</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Medicine,Tehran University of Medical Sciences,Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Tahere</first_name>
				<middle_name></middle_name>
				<last_name>Mokhtari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>taheremokhtari@gmail.com</email>
				<code>121769</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pathology, Division of Experimental Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Adib</first_name>
				<middle_name></middle_name>
				<last_name>Dashtizadeh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>adib.dashtizadeh@gmail.com</email>
				<code>121770</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Pharmacy ,Tehran University of Medical Sciences,Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Helia</first_name>
				<middle_name></middle_name>
				<last_name>Rajabi Dezfooli</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email></email>
				<code>121784</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Pharmacy ,Tehran University of Medical Sciences,Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Khaterehsadat</first_name>
				<middle_name></middle_name>
				<last_name>Monirvaghefi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>khaterehsadat.monirvaghefi@gmail.com</email>
				<code>121772</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Medicine,Tehran University of Medical Sciences,Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hossein</first_name>
				<middle_name></middle_name>
				<last_name>Gharedaghi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hossein.gharedaghi@gmail.com</email>
				<code>121773</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Medicine,Tehran University of Medical Sciences,Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Sina</first_name>
				<middle_name></middle_name>
				<last_name>Dolatshahi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sdolatshahi@gmail.com</email>
				<code>121781</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Medicine,Tehran University of Medical Sciences,Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Zahra</first_name>
				<middle_name></middle_name>
				<last_name>Hasanabadi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>zahra.hasanabadi@gmail.com</email>
				<code>121778</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Pharmacy ,Tehran University of Medical Sciences,Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Farzaneh</first_name>
				<middle_name></middle_name>
				<last_name>Moammer</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>farzaneh.moammer@gmail.com</email>
				<code>121782</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Medicine,Tehran University of Medical Sciences,Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mahya</first_name>
				<middle_name></middle_name>
				<last_name>Mobinikhaledi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mahyam@gmail.com</email>
				<code>121777</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Medicine,Tehran University of Medical Sciences,Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Aida</first_name>
				<middle_name></middle_name>
				<last_name>Yavari Kondori</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>aidayak@gmail.com</email>
				<code>121776</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Medicine,Tehran University of Medical Sciences,Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Zahra</first_name>
				<middle_name></middle_name>
				<last_name>Farajpour</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>zahraf@gmail.com</email>
				<code>121779</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Pharmacy ,Tehran University of Medical Sciences,Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Pardis</first_name>
				<middle_name></middle_name>
				<last_name>Kondori Varnosfaderani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>pardiskv@gmail.com</email>
				<code>121780</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Medicine,Tehran University of Medical Sciences,Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Zahra</first_name>
				<middle_name></middle_name>
				<last_name>Hashemi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>zahra.h@gmail.com</email>
				<code>121774</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Medicine,Tehran University of Medical Sciences,Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mohammad</first_name>
				<middle_name></middle_name>
				<last_name>Amin Mahdizadeh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mohammadam@gmail.com</email>
				<code>121775</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Medicine,Tehran University of Medical Sciences,Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Qumars</first_name>
				<middle_name></middle_name>
				<last_name>Behfar</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>submission1999@gmail.com</email>
				<code>121765</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Medicine,Tehran University of Medical Sciences,Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Siamak</first_name>
				<middle_name></middle_name>
				<last_name>Sandoghchian Shotorbani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>siamak1331@gmail.com</email>
				<code>121764</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Immunology Research Center,Tabriz University of Medical Sciences,Tabriz,Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Nasibeh</first_name>
				<middle_name></middle_name>
				<last_name>Sargazi Moghaddam</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>nasibeh.sargazi@gmail.com</email>
				<code>121783</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>School of Medicine,Tehran University of Medical Sciences,Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Hesperidin mitigates DEHP-induced nephrotoxicity through anti-oxidant, anti-apoptotic, and anti-inflammatory pathway modulation: Evidence from Nrf2/HO-1/Keap-1, Bax/Bcl-2/Caspase-3, and TLR4/NF-κB axis activatione</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): This study aimed to assess the protective role of hesperidin (HSP), a citrus flavonoid, against di-(2-ethylhexyl) phthalate (DEHP)-induced kidney toxicity in rats, focusing on oxidative stress, apoptosis, inflammation, and anti-oxidant defense pathways.Materials and Methods: Thirty-five male rats were randomly assigned into five groups (7 per group):  control group, DEHP-treated group (1 g/kg), DEHP + HSP (100 mg/kg) group, DEHP + HSP (200 mg/kg) group, and HSP-alone group, and treated orally for 10 consecutive days.  Kidney tissues were collected for biochemical assays, including malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Gene expression of Nrf2, Keap1, HO-1, Bax, Bcl-2, Caspase-3, TLR-4, and NF-κB was analyzed using real-time PCR, and protein levels were evaluated using Western blotting.Results: DEHP significantly increased oxidative damage and the expression of inflammatory and apoptotic markers, while decreasing anti-oxidant parameters. Co-treatment with HSP, particularly at 200 mg/kg, restored anti-oxidant balance, reduced lipid peroxidation, and down-regulated the expression of TLR-4, NF-κB, and Caspase-3. Moreover, HSP increased Bcl-2 levels and enhanced Nrf2/HO-1 signaling, as confirmed by both gene and protein expression data.Conclusion: HSP demonstrates dose-dependent renoprotective effects against DEHP-induced nephrotoxicity in rats. The protective mechanism involves anti-oxidant enhancement and inhibition of oxidative stress-induced inflammation and apoptosis, supporting the therapeutic potential of HSP in managing phthalate-related renal injury.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Apoptosis, Di-(2-ethylhexyl) phthalate, Hesperidin, Inflammation, Oxidative stress</keyword>
				<start_page>942</start_page>
				<end_page>951</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_27650.html</web_url>
			<author_list><author>
				<first_name>Tuba</first_name>
				<middle_name></middle_name>
				<last_name>Karaarslan</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>tuba.dogan@atauni.edu.tr</email>
				<code>121441</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Biochemistry, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Betul</first_name>
				<middle_name></middle_name>
				<last_name>Apaydin Yildirim</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>betulapaydin@atauni.edu.tr</email>
				<code>121442</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Biochemistry, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Fatih</first_name>
				<middle_name></middle_name>
				<last_name>Yildirim</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>fatihyildirim@atauni.edu.tr</email>
				<code>121443</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Animal Breeding and Husbandry, Faculty of Veterinary Medicine, Atatürk University, Erzurum,Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Omercan</first_name>
				<middle_name></middle_name>
				<last_name>Alat</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>omercanalat@atauni.edu.tr</email>
				<code>121444</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Biochemistry, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Involvement of SIRT3 downstream targets ANT1, VDAC, CYPD, and Drp1 in a rat model of hepatic encephalopathy: Therapeutic role of thymoquinone</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Hepatic encephalopathy (HE) is a brain disorder linked to hyperammonemia from liver injury. Elevated ammonia levels are known to impair mitochondrial function, the primary energy source for cells. Therefore, this study aimed to evaluate energy-related signaling pathways enhancing mitochondrial biogenesis using thymoquinone (TQ) in an HE model.Materials and Methods: Wistar rats were randomly divided into three groups: sham, HE (200 mg/kg thioacetamide (TAA) in 2ml saline, administered intraperitoneally (IP) once every 48 hr for 14 consecutive days), and HE + TQ (20 mg/kg, IP, in 2 ml DMSO 5% administered once daily for seven consecutive days). Mitochondrial biomarkers (membrane potential [MMP], oxidative stress), gene expression (AMPK, PGC-1α), and protein expression (AMPK, P-AMPK, SIRT3, ANT1, CYPD, DRP1, VDAC, and P53) were measured in brain tissue. Additionally, electroencephalogram (EEG) recordings were obtained from the dentate gyrus (DG).Results: Our findings indicate that TQ was associated with a significant increase in MMP and a concomitant decrease in mitochondrial oxidative stress. Furthermore, TQ appeared to augment the AMPK/PGC-1α/SIRT3 signaling pathway, and was associated with the reversal of HE-induced down-regulation of ANT1 and VDAC, as well as up-regulation of CYPD, DRP1, and P53. Besides, TQ treatment was also linked to increased power recorded in the EEG from the DG region of the rat hippocampus.Conclusion: The AMPK/PGC-1α/SIRT3 signaling pathway appears to function as a key energy sensor that may help revitalize the metabolic machinery in mitochondria, potentially facilitating metabolic exchanges and energy production, particularly in response to neurodegenerative diseases such as HE.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>ANT1, CYPD, DRP1, Hepatic encephalopathy, Local EEG, VDAC</keyword>
				<start_page>952</start_page>
				<end_page>960</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_27700.html</web_url>
			<author_list><author>
				<first_name>Somayeh</first_name>
				<middle_name></middle_name>
				<last_name>Hajipour</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hajipour.s1984@gmail.com</email>
				<code>121671</code>
				<coreauthor>No</coreauthor>
				<affiliation>Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mohammad Amin</first_name>
				<middle_name></middle_name>
				<last_name>Dehghani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mohammaddeh@yahoo.com</email>
				<code>121672</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Alireza</first_name>
				<middle_name></middle_name>
				<last_name>Sarkaki</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sarkaki.a@gmail.com</email>
				<code>121673</code>
				<coreauthor>No</coreauthor>
				<affiliation>Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Masoud</first_name>
				<middle_name></middle_name>
				<last_name>Mahdavinia</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mahdavinia.m@gmail.com</email>
				<code>121674</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Seyedeh Parisa</first_name>
				<middle_name></middle_name>
				<last_name>Navabi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>navabi.p@gmail.com</email>
				<code>121675</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>STAT3 ablation in keratinocytes ameliorates allergic contact dermatitis in DNCB-induced mice model</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Allergic contact dermatitis (ACD) is a T cell-mediated type IV hypersensitivity reaction to haptens. Its pathogenesis involves keratinocyte dysfunction and dysregulation of the Signal Transducer and Activator of Transcription 3 (STAT3)-signaling pathway. However, the specific role of keratinocyte produced STAT3 in ACD remains unclear. To investigate the effect of keratinocyte (KC)-specific STAT3 conditional knockout on 1-Chloro-2,4-dinitrobenzene (DNCB)-induced ACD in mice.Materials and Methods: We generated keratinocyte-specific STAT3 conditional knockout (cKO) mice (K14-Cre⁺; STAT3flox/flox) and subjected them to DNCB-induced ACD, with STAT3flox/flox littermates as controls. Epidermal barrier function (transepidermal water loss and electrolyte permeability), histopathological inflammation (H&amp;E and toluidine blue staining), and expression of inflammatory mediators (IL-1β, IL-6) were assessed. In vitro, STAT3 was knocked down by siRNA in HaCaT keratinocytes prior to stimulation with TNF-α/IFN-γ, followed by evaluation of inflammatory markers and STAT3 phosphorylation.Results: Keratinocyte-specific STAT3 deletion significantly ameliorated ACD severity, evidenced by reduced TEWL values, enhanced epidermal barrier function, decreased dermatitis scores, reduced clinical dermatitis scores, decreased dermal inflammatory infiltration, lower spleen index, and attenuated mast cell degranulation. Molecular analysis revealed down-regulation of inflammation-related factors (IL-1β, IL-6, TNF-α, JAK2) and significant inhibition of STAT3 phosphorylation. In vitro, STAT3 knockdown significantly suppressed IL-1β, IL-6, JAK2, Caspase-3, and MMP-3 expression in HaCaT cells and reduced STAT3 phosphorylation.Conclusion: Keratinocyte-specific STAT3 deletion alleviates epidermal barrier impairment and skin inflammation in ACD by inhibiting STAT3 phosphorylation and its downstream pro-inflammatory signaling.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Allergic contact dermatitis, Conditional knockout DNCB, JAK/STAT signaling pathway, Keratinocyte, Skin barrier function, STAT3</keyword>
				<start_page>961</start_page>
				<end_page>970</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_27701.html</web_url>
			<author_list><author>
				<first_name>Lu</first_name>
				<middle_name></middle_name>
				<last_name>Chen</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>674313762@qq.com</email>
				<code>121676</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Public Health, North China University of Science and Technology, Tangshan, 063210, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Cai</first_name>
				<middle_name></middle_name>
				<last_name>Zhang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>zhangcai990610@163.com</email>
				<code>121677</code>
				<coreauthor>No</coreauthor>
				<affiliation>North China University of Science and Technology Affiliated Hospital, Tangshan, 063000, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Limin</first_name>
				<middle_name></middle_name>
				<last_name>Li</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>707238273@qq.com</email>
				<code>121678</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Public Health, North China University of Science and Technology, Tangshan, 063210, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Huachun</first_name>
				<middle_name></middle_name>
				<last_name>Wang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>whc2569727527@163.com</email>
				<code>121679</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Public Health, North China University of Science and Technology, Tangshan, 063210, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Wenchao</first_name>
				<middle_name></middle_name>
				<last_name>Yao</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>18831297370@163.com</email>
				<code>121680</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Public Health, North China University of Science and Technology, Tangshan, 063210, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Lei</first_name>
				<middle_name></middle_name>
				<last_name>Xing</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>xlpangdun001@163.com</email>
				<code>121681</code>
				<coreauthor>No</coreauthor>
				<affiliation>North China University of Science and Technology Affiliated Hospital, Tangshan, 063000, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Jingyuan</first_name>
				<middle_name></middle_name>
				<last_name>Gao</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>gaojingyuan2009@126.com</email>
				<code>121682</code>
				<coreauthor>No</coreauthor>
				<affiliation>North China University of Science and Technology Affiliated Hospital, Tangshan, 063000, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Zhengxiao</first_name>
				<middle_name></middle_name>
				<last_name>Li</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>lizhengxiao1979@163.com</email>
				<code>121683</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Dermatology, the Second Affiliated Hospital of Xi ‘an Jiaotong University, Xi’an, 710004, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Faming</first_name>
				<middle_name></middle_name>
				<last_name>Tian</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>tfm9911316@163.com</email>
				<code>121684</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>School of Public Health, North China University of Science and Technology, Tangshan, 063210, China|North China University of Science and Technology Affiliated Hospital, Tangshan, 063000, China</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>In vivo assessment of imoxide and diluted vitamin C’s inhibitory effects on cervical cancer in mice</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective(s): Cervical cancer, the fourth most common malignancy among women, is strongly associated with high-risk human papillomavirus (HPV) infection. Emerging evidence suggests that hydrogen peroxide, alongside standard therapies, may enhance treatment. This study investigated the effects of Imoxide (0.5% hydrogen peroxide compound) and diluted vitamin C on tumor growth in the TC-1 papillomavirus mouse model. Materials and Methods: Cytotoxicity of 3% hydrogen peroxide and 100 mg/ml vitamin C was assessed using the MTT assay on TC-1 cells. Six-week-old female C57BL/6 mice were used to establish TC-1 tumor models in groups by grafting. Mice were divided into seven groups: intratumoral (IT) control, intraperitoneal (IP) control, IP Imoxide, IT Imoxide, cisplatin, IP vitamin C, and IT vitamin C. Tumor size was measured every other day. Histopathological analysis and real-time PCR were conducted to evaluate gene expression (P53, P21, BAX, BCL-2). Results: Dilutions of 10⁻³ and 10⁻⁴ of hydrogen peroxide resulted in cell survival rates of 53.7% and 58.8%, respectively. Imoxide markedly inhibited tumor growth in vivo, in some groups exceeding cisplatin. Histological findings showed limited apoptotic features. Gene-expression analysis revealed no statistically significant differences after multiple-testing correction.Conclusion: Imoxide substantially suppressed tumor growth in the murine model; however, modulation of apoptosis-related genes was minimal, suggesting that non-apoptotic pathways may contribute to its antitumor effects.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Cervical Cancer, H2O2, Hydrogen peroxide, Imoxide, Papillomavirus Vitamin C</keyword>
				<start_page>971</start_page>
				<end_page>978</end_page>
				<web_url>https://ijbms.mums.ac.ir/article_27719.html</web_url>
			<author_list><author>
				<first_name>Toktam</first_name>
				<middle_name></middle_name>
				<last_name>Dehghani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>toktamdehghaniii@gmail.com</email>
				<code>121789</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Seyed Mousalreza</first_name>
				<middle_name></middle_name>
				<last_name>Hosseini</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hoseinimr@mums.ac.ir</email>
				<code>121790</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Gastroenterology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Janbibi</first_name>
				<middle_name></middle_name>
				<last_name>Dorazehi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>jnbbdrz1992@gmail.com</email>
				<code>121791</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Seyedeh Elnaz</first_name>
				<middle_name></middle_name>
				<last_name>Nazari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>nazarie971@mums.ac.ir</email>
				<code>121792</code>
				<coreauthor>No</coreauthor>
				<affiliation>Metabolic Syndrome Research Center, Department of Physiology, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Bahram</first_name>
				<middle_name></middle_name>
				<last_name>Memar</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>memarb@mums.ac.ir</email>
				<code>121793</code>
				<coreauthor>No</coreauthor>
				<affiliation>Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mojtaba</first_name>
				<middle_name></middle_name>
				<last_name>Meshkat</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>m.meshkat@iau.ac.ir</email>
				<code>121794</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Community Medicine, MMS.C. Islamic Azad University, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hoorieh</first_name>
				<middle_name></middle_name>
				<last_name>Soleimanjahi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>soleim_h@modares.ac.ir</email>
				<code>121795</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Omid</first_name>
				<middle_name></middle_name>
				<last_name>Rajabi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>rajabio@mums.ac.ir</email>
				<code>121796</code>
				<coreauthor>No</coreauthor>
				<affiliation>Medical Chemistry Department, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Saeid</first_name>
				<middle_name></middle_name>
				<last_name>Zibaee</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>saeedzibaee@yahoo.co.uk</email>
				<code>121797</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Research and Development of Biological Products, Agricultural Research, Education and Extension Organization (AREEO), Razi Vaccine and Serum Research Institute, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Majid</first_name>
				<middle_name></middle_name>
				<last_name>Khazaei</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>khazaeim@mums.ac.ir</email>
				<code>121798</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Metabolic Syndrome Research Center, Department of Physiology, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Zahra</first_name>
				<middle_name></middle_name>
				<last_name>Meshkat</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>meshkatz@mums.ac.ir</email>
				<code>121799</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Antimicrobial Resistance Research Center, Basic Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>