Iranian Journal of Basic Medical Sciences

en Comparative evaluation of cell types for endothelialization in cardiovascular tissue engineering Review Article Cardiovascular tissue-engineering, Embryonic stem cells (escs), Endothelial progenitor cells- (epcs), Human umbilical vein-endothelial cells (huvecs), Induced pluripotent stem cells (ipscs), Mesenchymal stem cells- (mscs) 979 990 https://ijbms.mums.ac.ir/article_27790.html Mohamed Elkawafi mohamed.elkawafi@limu.edu.ly 122183 No Basic Medical Sciences Program, School of Health and Medical Sciences, Libyan International University, Benghazi, Libya Sufyan Elhashani sufyan.elhashani@manchester.ac.uk 122182 Yes Division of Medical Education, School of Medical Sciences, University of Manchester, Manchester, United Kingdom Atya Kushan atya_kushan@limu.edu.ly 122184 No Basic Medical Sciences Program, School of Health and Medical Sciences, Libyan International University, Benghazi, Libya Abdulla M. A Elmansoury abdulla.elmansoury@limu.edu.ly 122185 No Basic Medical Sciences Program, School of Health and Medical Sciences, Libyan International University, Benghazi, Libya Siraj Alabeedi siraj_3633@limu.edu.ly 122186 No Program of Medicine, School of Health and Medical Sciences, Libyan International University, Benghazi, Libya Mahmoud Aloriby mahmoud.aloriby@limu.edu.ly 122187 No Department of Pathology, Medical Center, Libyan International University, Benghazi, Libya

en Smart micro/nanoneedles for gene delivery Review Article Biomedicine, Carrier, Gene delivery, Microneedle, Nanoneedle 991 1011 https://ijbms.mums.ac.ir/article_27860.html Majid Farhadi farhadim991@mums.ac.ir 122484 No School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran|Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran Gelareh Karimi karimig991@mums.ac.ir 122485 No School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran|Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran Zahra Salmasi salmasiz@mums.ac.ir 122486 No Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran|Departments of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran Somayeh Marouzia marouzis4023@mums.ac.ir 122487 No Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran Fatemeh Mosaffa mosaffaf@mums.ac.ir 122488 No Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran|Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran Maryam Hashemi hashemim@mums.ac.ir 122489 Yes Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran|Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

en Time-dependent modulation of FXR and Nrf2 signaling in rat models of BDL-induced cholestasis Original Article Bile duct ligation (BDL), cholestasis, Cholestatic liver injury, Farnesoid X receptor, Nuclear factor erythroid 2-related factor 2 1012 1019 https://ijbms.mums.ac.ir/article_27720.html Seyed Ebrahim Daryabari ebrahimdaryabari@yahoo.com 121801 No Evidence-based Phytotherapy and Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj, Iran Elmira Jafari Afshar elmirafshar72@gmail.com 121800 No Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran Azadeh Khalili a.khalili@abzums.ac.ir 121802 No Evidence-based Phytotherapy and Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj, Iran|Department of Physiology-Pharmacology-Medical Physics, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran Seyed Ali Hashemi alihashemi@yahoo.com 121805 No Department of Pathology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran Parham Samimisedeh parhamsamimimd@gmail.com 121803 No Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran Gholamreza Bayat g.bayat@abzums.ac.ir 121804 Yes Department of Physiology-Pharmacology-Medical Physics, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran Hossein Karim h.karim@abzums.ac.ir 121806 Yes Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran|Department of Cardiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran

en Investigating the protective effect of zinc supplementation on streptozotocin-induced pancreatic beta-cell damage via the HMGB1/TLR2/MAPK pathway Original Article Apoptosis, Diabetes Mellitus, HMGB1 protein, Toll-like receptor 2, zinc 1020 1026 https://ijbms.mums.ac.ir/article_27721.html Sahin Yesildag sahin.yesildag@yahoo.com 121807 No Faculty of Health Sciences, Department of Nutrition and Dietetics, Demiroglu Bilim University, Istanbul, Türkiye Elvan Yılmaz Akyuz elvan.yilmazakyuz@sbu.edu.tr 121808 No Faculty of Hamidiye Health Sciences, Department of Nutrition and Dietetics, University of Health Sciences, Istanbul, Türkiye Eylem Taskin eylemtaskin@yahoo.com 121809 Yes Faculty of Medicine, Department of Physiology, Adiyaman University, Adiyaman, Türkiye|Health Science Institute, Translational Medicine, Cukurova University, Adana, Türkiye

en Synergistic myelin regenerative, immunomodulatory and anti-inflammatory effects of vanillin and adipose derived stem cells in cuprizone animal model of multiple sclerosis Original Article Adipose derived stem cells, Multiple Sclerosis, Myelin, Oligodendrocyte, Vanillin 1027 1034 https://ijbms.mums.ac.ir/article_27825.html Sara Gazmeh saragazmeh73@gmail.com 122339 No Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Mohammad Mardani mardani@med.mui.ac.ir 122338 Yes Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Nazem Ghasemi n-ghasemi@med.mui.ac.ir 122340 No Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

en Role of gallic acid in sarcopenia in D-galactose-treated mice Original Article Aging, Apoptosis, Autophagy, Gallic acid, Mitochondrion, sarcopenia 1035 1042 https://ijbms.mums.ac.ir/article_27759.html Xianchu Liu liuxc645@huas.edu.cn 122017 Yes Institute for Scientific Sports and Health Promotion, Hunan University of Arts and Science, Changde, Hunan, China Zile Zhu 1622852052@qq.com 122018 No Institute for Scientific Sports and Health Promotion, Hunan University of Arts and Science, Changde, Hunan, China Ming Liu liuming0206@huas.edu.cn 122019 No Faculty of Science, College of Furong, Hunan University of Arts and Science, Changde, Hunan, China Zhihe Mao maozhihe1729@huas.edu.cn 122020 Yes Institute for Scientific Sports and Health Promotion, Hunan University of Arts and Science, Changde, Hunan, China

en Investigating the effects of taurine on Aβ-degradation proteins and neurogenesis-related genes in an LPS-induced neuroinflammatory SH-SY5Y cell model Original Article Lipopolysaccharides, Matrix metalloproteinase 9, Neurogenesis Neuroinflammatory - diseases, Neuroprotective agents Taurine 1043 1051 https://ijbms.mums.ac.ir/article_27828.html Pirouz Pourmohammad pirouz.pourmohammad@iau.ac.ir 122354 No Department of Biochemistry, NT.C., Islamic Azad University, Tehran, Iran Fereshteh Rahmati fereshtehrahmati20252525@gmail.com 122355 Yes Department of Biochemistry, NT.C., Islamic Azad University, Tehran, Iran Fatemeh Siadat f.siadat@iau-tnb.ac.ir 122356 No Department of Cellular and Molecular Biology, NT.C., Islamic Azad University, Tehran, Iran Sara Simorgh srsimorgh@gmail.com 122357 No Stem Cell and Regenerative Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran|Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran

en Modulation of CCL5 and CXCR4 as EMT signaling biomarkers by cold atmospheric plasma and Anti-PD-1 combination therapy in melanoma: Insights from integrated bioinformatics and in vitro and in vivo validation Original Article Anti-PD-1, C-X-C chemokine receptor - type 4 (CXCR4), C-C motif chemokine ligand - 5 (CCL5), Cold atmospheric plasma - (CAP), Epithelial-mesenchymal - transition (EMT), Melanoma 1052 1065 https://ijbms.mums.ac.ir/article_27810.html Zeinab Rostami zeinabrostamy73@gmail.com 122258 No Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran|Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Fatemeh Akhundi akhoundi.fatemeh68@gmail.com 122259 No Department of Genetics, Faculty of Basic Sciences, Shahrekord University, Shahrekord, Iran Zahra Yazdani zahrayazdanikachooi1391@gmail.com 122260 No Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran|Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Mohammad Eslamijouybari drsinaeslami@gmail.com 122261 No Gastrointestinal Cancer Research Center, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran Mansooreh Mirzaei mansoorehmirzaei@yahoo.com 122262 No Department of Anatomy, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Foruzan Busaidi forouzanbousaeedi@gmail.com 122263 No Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran|Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Ghazaleh Rostami ghazale.rostami@gmail.com 122264 No Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Alireza Rafiei rafiei1710@gmail.com 122265 Yes Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

en Beyond bioactivity: Chitosan macromolecular coatings on titanium surfaces drive osseointegration and immune suppression through targeted epigenetic regulation Original Article Anti-inflammatory agents, Biological macromolecules, Chitosan coating, Epigenetic pharmaceuticals, Osteogenic processes, Titanium prosthetics 1066 1078 https://ijbms.mums.ac.ir/article_27824.html Rayshmi Balaji dr.rayshmi28@gmail.com 122333 No Department of Prosthodontics and Crown & Bridge, Government Dental College and Hospital, Cuddalore District, The Tamilnadu Dr. M.G.R. Medical University, Tamilnadu, India Nagarajan Mahendirakumar nmk.mds@gmail.com 122334 No Department of Prosthodontics and Crown & Bridge, Government Dental College and Hospital, Cuddalore District, The Tamilnadu Dr. M.G.R. Medical University, Tamilnadu Vijitha Dayasekaran vijitha95@gmail.com 122335 No Department of Prosthodontics and Crown & Bridge, Government Dental College and Hospital, Cuddalore District, The Tamilnadu Dr. M.G.R. Medical University Tamilnadu Sriram Kaliamoorthy ksrirammds@gmail.com 122332 Yes Department of Dentistry, Vinayaka Mission’s Medical College and Hospital, Vinayaka Mission’s Research Foundation (DU), Karaikal, Puducherry, India Kavitha Jayavel kavithajayavel@gmail.com 122336 No Department of Periodontology, Government Dental College and Hospital, Cuddalore District, TheTamilnadu Dr. M.G.R. Medical University, Tamilnadu, India

en Trigonelline protects against alcohol-induced brain damage by inhibition of oxidative stress, TLR4/NF-κB/proinflammatory cytokines pathway, and apoptosis Original Article Alcohol, Neuroinflammation, Neurotoxicity, TLR4/NF-κB, Trigonelline 1079 1088 https://ijbms.mums.ac.ir/article_27861.html Keyvan Amirshahrokhi k.amirshahrokhi@arums.ac.ir 122490 Yes Department of Pharmacology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran Ali Niapour niapour@gmail.com 122491 No Department of Anatomical Sciences, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran Mahsa Imani mimani@gmail.com 122492 No Department of Pharmacology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran

en Synthesis, radiolabeling, and biodistribution evaluation of novel hyperbranched polyglycerols-based radiotracers for targeting PSMA in prostate cancer Original Article Chelator, Hyperbranched - polyglycerol, Molecular imaging, PET Imaging, Prostate cancer, PSMA 1089 1099 https://ijbms.mums.ac.ir/article_27788.html Sara Roustaei roustaei.sara@gmail.com 122168 No Department of Nuclear Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Mehdi Akhlaghi m-akhlaghi@sina.tums.ac.ir 122169 Yes Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran Safura Jokar jokars@tums.ac.ir 122170 No Department of Nuclear Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Omid Bavi o.bavi@sutech.ac.ir 122171 No Department of Mechanical Engineering, Shiraz University of Technology, Shiraz, Iran Mehdi Shafiee Ardestani shafieeardestani@gmail.com 122172 No Department of Nuclear Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran|Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran Khosrou Abdi khmabdi@tums.ac.ir 122173 No Department of Nuclear Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Mona Mosayebnia m_mosayebnia@yahoo.com 122174 No Department of Pharmaceutical Chemistry and Radiopharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mahboobeh Asadi mahboobe.asadi1987@gmail.com 122175 No Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran Zahra Ghiamaty z.ghiamaty@gmail.com 122176 No Department of Nuclear Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Mahshid Kiani mahshidkiani@gmail.com 122177 No Department of Nuclear Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Davood Beiki beikidav@sina.tums.ac.ir 122178 Yes Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran

en Nerolidol attenuates cardiac hypertrophy and fibrosis in mice: Modulation of collagen type I, apoptotic and endothelial gene expression Original Article Cardiac hypertrophy, echocardiography, Endothelial nitric oxide - synthase, Isoproterenol, Nerolidol 1100 1106 https://ijbms.mums.ac.ir/article_27739.html Bushra Sadaf dr.bushra22@yahoo.com 121909 No Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan|Department of Experimental and Clinical Pharmacology, University of Minnesota, College of Pharmacy, 3-120 Weaver Densford Hall, 308 Harvard St SE, Minneapolis, MN 55455, United States Muhammad Naveed Mushtaq muhammad.mushtaq2@pharm.uol.edu.pk 121910 Yes Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan Waqas Younis waqas.younis@nyulangone.org 121911 No Division of Endocrinology, Diabetes and Metabolism, New York University, Grossmann School of Medicine, New York, USA Benu George benuaurth@gmail.com 121912 No Department of Experimental and Clinical Pharmacology, University of Minnesota, College of Pharmacy, 3-120 Weaver Densford Hall, 308 Harvard St SE, Minneapolis, MN 55455, United States Irfan Anjum irfan.scps@stmu.edu.pk 121913 No Department of Basic Medical Sciences, Shifa College of Pharmaceutical Sciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan Abdul Aleem abdul.aleem@pharm.uol.edu.pk 121914 No Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan

en Sacubitril/Valsartan: Breaking barriers in uterine adhesion and boosting pregnancy outcomes by suppressing inflammation and fibrosis Original Article Fibrosis, Infertility, Inflammation, pregnancy, Uterine 1107 1114 https://ijbms.mums.ac.ir/article_27811.html seyed alireza Parizadeh alireza.parizadeh@gmail.com 122268 No Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran Ahmad Asoodeh asoodeh@um.ac.ir 122269 Yes Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran Majid Khazaei khazaeim@mums.ac.ir 122270 Yes Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran|Department of Medical Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Seyed Mahdi Hassanian hasanianmehrm@mums.ac.ir 122271 No Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran|Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

en Protective efficacy of thymol in testicular ischemia/reperfusion injury in rats: A biochemical and histopathological evaluation Original Article Apoptosis, Endoplasmic reticulum-stress, Inflammation, Oxidative stress, Testicular torsion, Thymol 1115 1121 https://ijbms.mums.ac.ir/article_27722.html Ahmet Mentese amentese28@gmail.com 121811 No Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Türkiy Ilke Onur Kazaz drilke@gmail.com 121812 No Department of Urology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Türkiye Zeynep Sagnak Yilmaz zeynep.sagnak@hotmail.com 121813 No Department of Medical Pathology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Türkiye Nihal Turkmen Alemdar trkmn_nhl@hotmail.com 121814 No Department of Medical Services and Techniques, Vocational School of Health Services, Recep Tayyip Erdogan University, 53100 Rize, Türkiye Elif Ayazoglu Demir eliffayaz@gmail.com 121815 No Department of Chemistry and Chemical Processing Technologies, Macka Vocational School, Karadeniz Technical University, 61750 Trabzon, Türkiye Fatih Colak dr.fatihcolak@hotmail.com 121816 No Department of Urology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Türkiye Selim Demir selim-demir@hotmail.com 121810 Yes Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Türkiye

en Comparative analysis of second and third-generation nanobody-based CAR-NK cells targeting PSMA in prostate cancer immunotherapy: In silico and in vitro studies Original Article Chimeric antigen receptor, Natural killer cell, Single-domain antibodies (Nanobodies), Prostate-specific membrane antigen (PSMA), Prostatic Neoplasms, OX40 co-stimulatory domain, Molecular dynamics - Simulation 1122 1130 https://ijbms.mums.ac.ir/article_27812.html Masoud Gandomkar Ghalhar gandomkar.m67@gmail.com 122272 No Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Arezoo Karami Vandishi arezookarami1372@yahoo.com 122273 No Department of Tissue Engineering and Applied Cell Science, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Akram Ramazani ramezani1991@yahoo.com 122274 No Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Fatemeh Hajari Taheri f.h.taheri@gmail.com 122275 No Food and Drug Laboratory Research Center (FDLRC), Iran Food and Drug Administration (IFDA), MOH & ME, Tehran, Iran Zahra Sharifzadeh zsharifzadeh@gmail.com 122276 No Hybridoma Lab, Department of Immunology, Pasteur Institute of Iran, Tehran, Iran Mohsen Abolhassani mabolhassani@yahoo.com 122277 No Hybridoma Lab, Department of Immunology, Pasteur Institute of Iran, Tehran, Iran Masoud Soleimani soleimani.masoud@gmail.com 122278 No Department of Tissue Engineering and Applied Cell Science, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Niloofar Taghipour nilitaghipour@gmail.com 122279 No Department of Tissue Engineering and Applied Cell Science, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Wytske M van Weerden mahmoud.hassani66@gmail.com 122280 No Department of Urology, Erasmus Medical Center, Rotterdam, The Netherlands Mojgan Bandehpour bandehpourm@gmail.com 122281 No Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mahmoud Hassani mahmoud.hassani@yahoo.com 122282 Yes Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran|Department of Molecular Medicine, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Kowsar Bagherzadeh bagherzadeh.kw@gmail.com 122283 Yes Eye Research Center, Five Senses Health Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran