Iranian Journal of Basic Medical Sciences

en An in-depth examination of bone avascular necrosis and early-stage treatment modalities utilizing regenerative medicine Review Article femoral head, Injectable hydrogel, Osteonecrosis, Regenerative medicine, Stem cell therapy, Tissue engineering 1131 1153 https://ijbms.mums.ac.ir/article_28000.html Noshad Peyravian n.peyravian@gmail.com 123060 Yes Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran|Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran Zahra Pezeshkian zahrapezeshkian1992@gmail.com 123061 No Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran|Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran Raziyeh Najafloo raziyeh.najafloo@gmail.com 123062 No Department of Biomedical Engineering, TeMS.C., Islamic Azad University, Tehran, Iran Maziar Malekzadeh Kebria mazi.malekzadeh@gmail.com 123063 No Department of Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran|Cancer Research Center, Institute of Cancer, Avicenna Health Research Institute, Hamadan University of Medical Sciences, Hamadan, Iran Shayan Amiri amiri.shayan23@gmail.com 123064 No Bone and Joint Reconstruction Research Center, Department of Orthopedics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Hamzeh Mirshekari Jahangiri mirshekari07@yahoo.com 123065 No Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Mohamad Javad Hadi mohamadjavadhadi1@gmail.com 123066 No Department of Medical Nanotechnology, Faculty of Advanced Technology in Medicine, Iran University of Medical Sciences, Tehran, Iran Hamideh Valizadeh hamidehvalizadeh164@gmail.com 123067 No Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran|Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran Mehdi Moghtadaei mmoghtadaei@gmail.com 123068 No Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran|Orthopedic Department, Hazrat-Rasul Hospital, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran Peiman Brouki Milan peiman.brouki@gmail.com 123069 Yes Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran|Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran

en Musculoskeletal ultrasound-guided cellular therapy: Current applications and future directions in skeletal muscle regeneration Review Article Cellular therapy, Exosome, Fibrosis, Hydrogel, Muscle regeneration, Musculoskeletal ultrasound, Satellite cells, Sonoporation, Ultrasound-guided delivery, Volumetric muscle loss 1154 1173 https://ijbms.mums.ac.ir/article_27868.html Chunfeng Yu 15172955121@163.com 122510 No Department of Ultrasound Medicine, Minda Hospital of Hubei Minzu University, Enshi 445000, China|Hubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic Diseases, Minda Hospital of Hubei Minzu University, Enshi 445000, Hubei, China|Hubei Provincial Clinical Medical Research Center for Nephropathy, Minda Hospital of Hubei Minzu University, Enshi 445000, Hubei, China Xueqin Li shaquila2022@163.com 122511 No Department of Ultrasound Medicine, Minda Hospital of Hubei Minzu University, Enshi 445000, China|Hubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic Diseases, Minda Hospital of Hubei Minzu University, Enshi 445000, Hubei, China|Hubei Provincial Clinical Medical Research Center for Nephropathy, Minda Hospital of Hubei Minzu University, Enshi 445000, Hubei, China Wen Zhao m15327038318@163.com 122512 No Department of Ultrasound Medicine, Minda Hospital of Hubei Minzu University, Enshi 445000, China|Hubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic Diseases, Minda Hospital of Hubei Minzu University, Enshi 445000, Hubei, China|Hubei Provincial Clinical Medical Research Center for Nephropathy, Minda Hospital of Hubei Minzu University, Enshi 445000, Hubei, China Lingyan Zhou lingyan.zhou100@gmail.com 122509 Yes Department of Ultrasound Medicine, Minda Hospital of Hubei Minzu University, Enshi 445000, China|Hubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic Diseases, Minda Hospital of Hubei Minzu University, Enshi 445000, Hubei, China|Hubei Provincial Clinical Medical Research Center for Nephropathy, Minda Hospital of Hubei Minzu University, Enshi 445000, Hubei, China

en Non-coding RNAs related to PD1/PD-L1 signaling with potential diagnostic, prognostic, and therapeutic value in the tumorigenesis of brain cancers Review Article Brain neoplasms, PD-1/PD-L1, Immune evasion, Non-coding RNAs, microRNAs 1174 1183 https://ijbms.mums.ac.ir/article_28086.html Reihane Behnam-Rassouli behnamrasouli@um.ac.ir 123446 No Recombinant Proteins Research Group, The Research Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran|Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran Farzaneh Entezari dr.farzaneentezari@gmail.com 123447 No Department of Surgical and Diagnostic Integrated Sciences, University of Genova, Genova, Italy Majid Ghorbanzadeh farzadkums@gmail.com 123448 No School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran Ali Reyhani reihania4002@mums.ac.ir 123449 No Kashmar School of Medical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran Mohammadreza Nassiri nassiryr@um.ac.ir 123450 No Recombinant Proteins Research Group, The Research Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran Fereshteh Golab amirferns@yahoo.com 123451 No Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran Farzad Rahmani rahmanif@mums.ac.ir 123445 Yes Kashmar School of Medical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran|Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

en Development of a hybrid micelle–hydrogel system for topical delivery of doxorubicin to skin cancer cells Original Article Doxorubicin, Hyaluronic acid, Hydrogel, Polymeric micelle, skin cancer 1184 1194 https://ijbms.mums.ac.ir/article_27916.html Majid Zia-Behbahani aryogan@gmail.com 122738 No Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran|Students Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran Elahehnaz Parhizkar eparhizkar@sums.ac.ir 122739 No Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran Mahdokht Hossein Aghdaei mahdokht.aghdaei@gmail.com 122740 No Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Elaheh Esfandiari elahehesfandiari62@gmail.com 122741 No Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Shohreh Alipour alipour_sh@sums.ac.ir 122742 No Department of Quality Control, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran Fatemeh Ahmadi fahmadi1080@gmail.com 122743 Yes Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran

en Ponicidin alleviates atherosclerosis by inhibiting inflammation and oxidative stress through the SIRT1 and PI3K/Akt pathway Original Article Atherosclerosis, Inflammation, Oxidative stress, Ponicidin, SIRT1 1195 1201 https://ijbms.mums.ac.ir/article_27917.html Kang Ye 1329627285@qq.com 122744 No Department of Internal Medicine-Cardiovascular, Guangming Traditional Chinese Medicine Hospital of Pudong New Area, Shanghai 201399, China Jing Shi 20136135@qq.com 122745 No Department of Internal Medicine-Cardiovascular, Guangming Traditional Chinese Medicine Hospital of Pudong New Area, Shanghai 201321, China Ping Gong chengeziyu@163.com 122746 No Department of Internal Medicine-Cardiovascular, Guangming Traditional Chinese Medicine Hospital of Pudong New Area, Shanghai 201321, China Zhongsheng Zhu drzzs66@163.com 122747 Yes Department of Internal Medicine-Cardiovascular, Guangming Traditional Chinese Medicine Hospital of Pudong New Area, Shanghai 201399, China

en Promising therapeutic efficacy of kolaviron against prenatal valproate-induced autism spectrum disorder Original Article Autism spectrum disorder, Hippocampus, Kolaviron, Serotonin, Valproic acid 1202 1210 https://ijbms.mums.ac.ir/article_27936.html Vahid Khodashenas khodashenas.v@iums.ac.ir 122827 No Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Tourandokht Baluchnejadmojarad tmojarad@yahoo.com 122826 Yes Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Mitra Farbin mfarbin1374@gmail.com 122828 No Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Ali Khodabakhshi Korelaei alikhko95@yahoo.com 122829 No Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Soraya Mehrabi mehrabi.zhila@yahoo.com 122830 No Cellular and Molecular Research Center, Iran university of Medical Sciences, Tehran, Iran Mehrdad Roghani mehjour@yahoo.com 122831 No Neurophysiology Research Center, Shahed University, Tehran, Iran

en Radiotherapy-associated changes in the miR-124/SP1 axis in a rat glioma model Original Article Animal models, Gene expression regulation, Glioma, microRNAs, Radiotherapy, Rno-miR-124-3p, Sp1 transcription factor, Tumor cell line 1211 1217 https://ijbms.mums.ac.ir/article_28038.html Elham Ghasemi elhamqsm121@gmail.com 123243 No Department of Biotechnology and Molecular Medicine, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran Mehdi Sadegh m.sadegh@arakmu.ac.ir 123241 No Departments of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran Mahdieh Mondanizadeh m.mondanizadeh@arakmu.ac.ir 123239 Yes Department of Biotechnology and Molecular Medicine, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran|Molecular and Medicine Research Center, Arak University of Medical Sciences, Arak, Iran Behzad Khansarinejad b_khansarinejad@yahoo.com 123240 No Department of Microbiology, Arak University of Medical Sciences, Arak, Iran Fatemeh Seif fseif@arakmu.ac.ir 123242 No School of Allied Medical Sciences, Department of Radiotherapy, Arak University of Medical Sciences and Khansari Hospital, Arak, Iran

en Cordycepin ameliorates ischemia/reperfusion-induced acute kidney injury via inhibiting apoptosis and necroptosis Original Article Acute kidney injury, Apoptosis, Cordycepin, Necroptosis, Receptor-Interacting, Protein Serine-Threonine Kinase 1 (RIPK1) 1218 1228 https://ijbms.mums.ac.ir/article_27922.html Xiuzhao Fan fxz_bioinfo@163.com 122766 No Department of Nephrology, Fifth Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030012, China|Department of Nephrology, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi, 030012, China|Big Data Center of Kidney Disease, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi, 030012, China Xiutao Han 1625687797@qq.com 122767 No Department of Traditional Chinese Medicine, Yan’an Baota District People’s Hospital, Yan’an, Shaanxi, 716000, China Zhibo Zhao zhzbdoc@163.com 122768 No Department of Nephrology, Fifth Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030012, China|Department of Nephrology, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi, 030012, China|Big Data Center of Kidney Disease, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi, 030012, China Junhu Li 740671651@qq.com 122769 No Department of Nephrology, Fifth Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030012, China|Department of Nephrology, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi, 030012, China|Big Data Center of Kidney Disease, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi, 030012, China Shuangshuang Tian tss255@163.com 122770 No Department of Nephrology, Fifth Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030012, China|Department of Nephrology, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi, 030012, China|Big Data Center of Kidney Disease, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi, 030012, China Fang Zhang 756062570@qq.com 122771 No Department of Nephrology, Fifth Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030012, China|Department of Nephrology, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi, 030012, China|Big Data Center of Kidney Disease, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi, 030012, China Xiaoshuang Zhou xiaoshuangzhou69@163.com 122765 Yes Department of Nephrology, Fifth Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030012, China|Department of Nephrology, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi, 030012, China|Big Data Center of Kidney Disease, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi, 030012, China|Shanxi Provincial Key Laboratory of Kidney Disease, Taiyuan, Shanxi, 030012, China|Medicinal Basic Research Innovation Center of Chronic Kidney Disease, Ministry of Education, Shanxi Medical University, Taiyuan, Shanxi, 030012, China

en Fabrication of a five-layer wound dressing containing chitosan-LL37 peptide for the treatment of EB wounds and deep exudate patients Original Article Antibacterial peptide, Chitosan, Epidermolysis bullosa (EB), PDMS, Wound healing 1229 1240 https://ijbms.mums.ac.ir/article_28028.html Morteza Rabiei mrabiei6768@gmail.com 123189 No Nanobiotechnology Research Center, New Health Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran Mehrdad Mosazadeh Moghadam mm.genetics@gmail.com 123191 No Tissue Engineering and Regenerative Medicine Research Center, New Health Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran Hossein Derakhshankhah derakhshankhah.hossein@gmail.com 123190 No Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran Ramezan Ali Taheri r.a.taheri@gmail.com 123188 Yes Nanobiotechnology Research Center, New Health Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran

en Investigation of neuroprotective and antiapoptotic effects of rosmarinic acid in an in vitro Alzheimer’s disease model Original Article Alzheimer&rsquo, s Disease, Apoptosis, Neuroprotective agents, Rosmarinic acid, Cell line 1241 1248 https://ijbms.mums.ac.ir/article_27950.html Aysu Şen aysu.sen@erbakan.edu.tr 122899 Yes Necmettin Erbakan University, Faculty of Medicine, Department of Physiology, Konya, Turkey Canan Eroğlu Güneş ceroglu@erbakan.edu.tr 122900 No Necmettin Erbakan University, Faculty of Medicine, Department of Medical Biology, Konya, Turkey Ebru Nur Dursun endursun01@gmail.com 122901 No Necmettin Erbakan University, Faculty of Medicine, Department of Medical Biology, Konya, Turkey Ercan Kurar ekurar@erbakan.edu.tr 122902 No Necmettin Erbakan University, Faculty of Medicine, Department of Medical Biology, Konya, Turkey Selim Kutlu skutlu@erbakan.edu.tr 122903 No Necmettin Erbakan University, Faculty of Medicine, Department of Physiology, Konya, Turkey

en Resveratrol mitigates diazinon-induced neurotoxicity during fetal brain development Original Article Apoptosis, Diazinon, neurodevelopment, Neurogenesis, Neurotoxicity, Resveratrol, Transcription factors 1249 1258 https://ijbms.mums.ac.ir/article_28095.html Amir Delavar adelavar950@gmail.com 123496 No Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran Nasim Alipour nalipour971@gmail.com 123497 No Department of Basic Medical Sciences, MMS.C., Islamic Azad University, Mashhad, Iran|Innovative Medical Research Center, MMS.C., Islamic Azad University, Mashhad, Iran Javad Bagheri bagherijavadd@gmail.com 123498 No Department of Basic Medical Sciences, MMS.C., Islamic Azad University, Mashhad, Iran|Innovative Medical Research Center, MMS.C., Islamic Azad University, Mashhad, Iran Raheleh Baradaran baradaranraheleh@gmail.com 123499 No Department of Anatomical Sciences, Faculty of Medicine, Social Development and Health Promotion Research Center, Gonabad University of Medical Sciences, Gonabad, Iran Alireza Seddigh alirezaseddigh@nkums.ac.ir 123500 No Department of Advanced Technologies, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran Elham Feridouni elhamferidouni@gmail.com 123501 No Department of Biology, Gonbad Kavous University, Golestan, Iran Yousef Baghcheghi y.baghcheghi@gmail.com 123502 No Bio Environmental Health Hazards Research Center, Jiroft University of Medical Sciences, Jiroft, Iran Fatemeh Rahimi Anbarkeh rahimif2@nums.ac.ir 123503 Yes Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran

en Bioinformatic analysis and characterization of the Anti-CD20 scFv-Conjugated Fe₃O₄ nanoparticles for targeted therapy of CD20⁺ leukemia cells Original Article Chronic lymphocytic leukemia (CLL), Iron oxide nanoparticles, Molecular docking, ScFv antibody 1259 1268 https://ijbms.mums.ac.ir/article_28039.html Shabnam Tavangarroosta shabnamtavangar@sbmu.ac.ir 123244 No Department of Molecular Medicine, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mojgan Bandehpour m.bandehpour@sbmu.ac.ir 123245 Yes Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran|Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Masoumeh Rajabibazl rajabibazl_m@yahoo.com 123246 Yes Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Farhood Najafi fnajafi@icrc.ac.ir 123247 No Department of Environmental Research, Institute for Color Science and Technology, Tehran, Iran Sepideh Ghani s.ghani@sbmu.ac.ir 123248 No Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mahmoud Hassani mahmoud.hassani@yahoo.com 123249 No Department of Molecular Medicine, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Bahram Kazemi bahram_14@yahoo.com 123250 No Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

en Rosemary inhalation improves the behavior and cognition of vascular cognitive impairment rats by regulating SIRT1/mTOR pathway-mediated cell apoptosis and autophagy Original Article Rosemary oil, Cognitive impairment, SIRT1, Apoptosis, Autophagy 1269 1277 https://ijbms.mums.ac.ir/article_27918.html Fengfei Shi 429494126@qq.com 122748 No Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang 330006, China Ensi Hong 2224901965@qq.com 122749 No Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang 330006, China Jiewei Bao 403594318@qq.com 122750 No Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang 330006, China Wenguo Ye 648957967@qq.com 122751 No Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang 330006, China Hui Wang wanghuissy@hotmail.com 122752 No Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang 330006, China Liping Wang wlp_15797694300@126.com 122753 No Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang 330006, China Yanhui Zhang 13576037658@163.com 122754 Yes Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang 330006, China

en Allele-specific disruption of KRAS p.G12V in colorectal cancer cells using electroporated Cas9 RNPs Original Article Allele-specific, Colorectal cancer, CRISPR, Electroporation, KRAS, Ribonucleoprotein complex 1278 1285 https://ijbms.mums.ac.ir/article_28096.html Firouzeh Morshedzadeh f.morshedzadeh@ut.ac.ir 123504 No Department of Genetics, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran Samaneh Sharif samanehsharifsh@gmail.com 123505 No Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran|Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Maryam Peymani m.peymani@iau.ir 123506 Yes Department of Genetics, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran Malihe Lotfi lotfimalihe.genetic1395@gmail.com 123507 No Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Mohammad Reza Abbaszadegan m.r.abbaszadegan@gmail.com 123508 Yes Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran|Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

en Neuroprotective effects of ROCK inhibition on hippocampal energy metabolism in a rat model of metabolic syndrome Original Article Energy metabolism, Fasudil, Hippocampus metabolic syndrome, Neuroprotection, PI3K/Akt/mTOR, Rho-kinase (ROCK) 1286 1295 https://ijbms.mums.ac.ir/article_27937.html Nikoloz Zhgenti nikoloz.zhgenti@tsu.ge 122832 Yes Department of Biology, Faculty of Exact and Natural Sciences, Iv. Javakhishvili Tbilisi State University, Tbilisi, Georgia|Faculty of Medicine, Iv. Javakhishvili Tbilisi State University, Tbilisi, Georgian Otar Bibilashvili otar.bibilashvili@tsu.ge 122833 No Department of Biology, Faculty of Exact and Natural Sciences, Iv. Javakhishvili Tbilisi State University, Tbilisi, Georgia Irina Petriashvili irina.petriashvili@tsu.ge 122834 No Department of Pharmacology, Faculty of Medicine, Iv. Javakhishvili Tbilisi State University, Tbilisi, Georgia Nana Koshoridze nana.koshoridze@tsu.ge 122835 No Department of Biology, Faculty of Exact and Natural Sciences, Iv. Javakhishvili Tbilisi State University, Tbilisi, Georgia