Iranian Journal of Basic Medical Sciences

en Localized chemotherapy through nanofiber scaffolds: Progress, challenges, and future directions Review Article Cancer Treatment, Drug Delivery, Electrospun nanofibers, Localized chemotherapy, Nanomedicine 1296 1312 https://ijbms.mums.ac.ir/article_28090.html Akram Firouzi-Amandi akramfirouziamandi@gmail.com 123475 No Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran|Department of Pharmaceutical Engineering, University of Tehran, Tehran, Iran Seyed Abbas Shahrtash seyedabbassh@gmail.com 123476 No Department of Pharmaceutical Engineering, University of Tehran, Tehran, Iran Samaneh Moradi samanehmoradi@gmail.com 123477 No Departments of Internal Medical, Shiraz University of Medical Sciences, Shiraz, Iran Mehdi Dadashpour dadashpourmehdi1400@gmail.com 123474 Yes Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran|Cancer Research Center, Semnan University of Medical Sciences, Semnan, Iran|Department of Medical Biotechnology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran Tohid Kazemi tohdikazemi@gmail.com 123478 Yes Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran|Immunology Research Center, Tabriz University of Medical Sciences, Semnan, Iran

en Inflammasome-associated pyroptosis and tumor angiogenesis in prostate cancer Review Article Angiogenesis, Endothelium, Gasdermin D, Inflammasomes, Interleukin-1beta, Prostatic, Neoplasms Pyroptosis, Tumor Microenvironment 1313 1336 https://ijbms.mums.ac.ir/article_28116.html Hamzeh J. Alameer hamzehj.alameer3000@gmail.com 123603 Yes Faculty of Allied Medical Sciences, Hourani Center for Applied Scientific Research, Al-Ahliyya Amman University, Amman, Jordan Rafid Kamal Jameel rafid.kamal@alnoor.edu.iq 123604 No College of Pharmacy, Alnoor University, Mosul, Iraq Mahzuna Nasretdinova luna_1088@mail.ru 123605 No Department of Otorhinolaryngology, Samarkand State Medical University, Samarkand, Uzbekistan Ravshan Sultanov ravshansultanov.4846@gmail.com 123606 No Department of Medical Fundamental Sciences, Termez University of Economics and Service, Termez, Uzbekistan Djamila Polatova laylo.djuraeva.88@bk.ru 123607 No Scientific-Practical Medical Center for Pediatric Oncology, Hematology and Immunology, Tashkent, Uzbekistan Mohammed Abdul Alaal mohammed.abdul.alaal@iunajaf.edu.iq 123608 No Department of Pharmacy, College of Pharmacy, The Islamic University, Najaf, Iraq Navin Kumar Tailor navin_kumar_tailor@outlook.com 123609 No University Institute of Pharma Sciences, Chandigarh University, Mohali, Punjab, India Ritesh Singh drritesh7211@yahoo.com 123610 No Center for Research Impact & Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, 140401, Punjab, India

en Principles and regulatory pathways of exosome-based products in wound healing: Insights from the Iranian Food and Drug Organization Guideline Review Article Biological Products, Drug approval, Exosomes, Extracellular vesicles, Government regulation, Nanomedicine, Regenerative medicine, Wound healing 1337 1354 https://ijbms.mums.ac.ir/article_28145.html Delnavaz Nazari delnavaznazari@gmail.com 123731 No Department of Veterinary Basic Sciences, SR.C., Islamic Azad University, Tehran, Iran Banafsheh Heidari ban_heidari@yahoo.com 123732 Yes Department of Regenerative Medicine in Wound Healing, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran Nazanin Akbari nazaninakbarii000@gmail.com 123733 No Department of Biology, Shahid Beheshti University, Tehran, Iran Zahra Soleymani zahra.solymani@yahoo.com 123734 No Department of Veterinary Basic Sciences, SR.C., Islamic Azad University, Tehran, Iran

en Potential role of ferroptosis in sterile acute lung injury induced by a non-hypoxic ischemia-reperfusion insult Original Article Chemokine CXCL1, Inflammation, Interleukin-6, Lipid Peroxidation, Reperfusion injury 1355 1360 https://ijbms.mums.ac.ir/article_28089.html Farzaneh Kianian kianian.f1989@gmail.com 123470 Yes Department of Anesthesia and Perioperative Care, University of California, San Francisco, and San Francisco General Hospital, San Francisco, CA, USA|Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Xiaoli Tian xiaoli.tian@ucsf.edu 123471 No Department of Anesthesia and Perioperative Care, University of California, San Francisco, and San Francisco General Hospital, San Francisco, CA, USA Daisuke Maruyama daisuke.maruyama@ucsf.edu 123472 No Department of Anesthesia and Perioperative Care, University of California, San Francisco, and San Francisco General Hospital, San Francisco, CA, USA Arun Prakash arun.prakash@ucsf.edu 123473 No Department of Anesthesia and Perioperative Care, University of California, San Francisco, and San Francisco General Hospital, San Francisco, CA, USA

en Quercetin attenuates ferroptosis-associated myocardial injury in rats after coronary microembolization by activating the Nrf2/HO-1 signaling pathway Original Article Coronary-microembolization, Ferroptosis, Nrf2/HO-1, Oxidative stress, Quercetin 1361 1368 https://ijbms.mums.ac.ir/article_28126.html Junwen Huang 1763435278@qq.com 123654 No Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Cardiovascular Institute, Nanning 530021, Guangxi, China Zhiqi Tang 476003466@qq.com 123655 No Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Cardiovascular Institute, Nanning 530021, Guangxi, China Jiacong Nong njc_1996@163.com 123656 No Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Cardiovascular Institute, Nanning 530021, Guangxi, China Guangpeng Tu doctortgp@163.com 123657 No Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Cardiovascular Institute, Nanning 530021, Guangxi, China Xueyi Feng 770462414@qq.com 123658 No Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Cardiovascular Institute, Nanning 530021, Guangxi, China Lang Li drlilang@gxmu.edu.cn 123653 Yes Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Cardiovascular Institute, Nanning 530021, Guangxi, China

en Carvacrol attenuated acute renal injury induced by unilateral ureteral obstruction in male rats Original Article Apoptosis, Carvacrol, Inflammation, Oxidative stress, Unilateral ureteral obstruction 1369 1376 https://ijbms.mums.ac.ir/article_28127.html Ayat Kaeidi a.kayedi@gmail.com 123659 No Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran|Department of Physiology and Pharmacology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Elham Hakimizadeh hakimizadeh_elham@yahoo.com 123660 No 3 Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, afsanjan, Iran Seyed Hadi Jafari hadijafari669@gmail.com 123661 No 1 Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Jalal Hassanshahi hasanshahij@gmail.com 123662 Yes Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran|Department of Physiology and Pharmacology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

en Modular 3D culture platform combining methylcellulose, testicular ECM, and Sertoli cells for in vitro spermatogenesis Original Article Cell differentiation, Decellularized extracellular matrix, Hydrogels, Methylcellulose, Sertoli cells, Germline adult stem cells 1377 1389 https://ijbms.mums.ac.ir/article_28087.html Narjes Feizollahi n.feizollahi@yahoo.com 123455 No Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Ehsan Heidarian ehsan666hd@gmail.com 123456 No Urology and Nephrology Research Center, Research Institute for Urology and Nephrology, Shahid Beheshti University of Medical Sciences,Tehran, Iran Mehdi Forouzesh forouzeshiran@gmail.com 123457 No Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran Maryam Salem maryamsalem1111@gmail.com 123458 No Research Laboratory for Embryology and Stem Cells, Department of Anatomical Sciences, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran|Infertility Department, Alavi Hospital, Ardabil University of Medical Science, Ardabil, Iran Soheil Kianirad soheilkid@gmail.com 123459 No Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran Nasrin Ghanami Gashti nasrin.ghanamigashti@ul.ie 123460 No Bernal Institute and School of Engineering, University of Limerick, Limerick, Ireland Masoome Jabarpour masoomejabarpour@yahoo.com 123461 No Department of Infertility, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Rasool Setareyi rasoolstar.76@gmail.com 123462 No Department of Life Science Engineering, Faculty of New Science and Technology, University of Tehran, Tehran, Iran Ayob Jabari jabariayob@yahoo.com 123463 No Department of Obstetrics and Gynecology, Molud Infertility Treatment Center, Zahedan University of Medical Sciences, Zahedan, Iran|Clinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran Farnaz Khadivi farnazkhadivi031@gmail.com 123464 No Department of Anatomy, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran|Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran Morteza Koruji koruji1@gmail.com 123465 No Stem Cell and Regenerative Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran|Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Mohammad Naji naji_m_f@yahoo.com 123466 Yes Urology and Nephrology Research Center, Research Institute for Urology and Nephrology, Shahid Beheshti University of Medical Sciences,Tehran, Iran Mehdi Abbasi abbasima@tums.ac.ir 123467 Yes Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

en Down-regulation of AGXT2L1 promotes the development of nonalcoholic fatty liver disease Original Article Alanine-glyoxylate-aminotransferase 2-like1- (AGXT2L1), Apoptosis, ER stress, Inflammation, Nonalcoholic fatty liver disease (NAFLD), Phospholipid metabolism 1390 1397 https://ijbms.mums.ac.ir/article_28088.html Yue Yu 1479727708@qq.com 123469 No Department of Radiation Oncology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China Lu Wu melody80017@163.com 123468 Yes Department of Radiation Oncology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China

en Berberine protects against behavioral deficits, memory dysfunction, and callosal demyelination in cuprizone-intoxicated C57BL/6 mice Original Article Berberine, Cuprizone, Demyelination, Multiple Sclerosis, Oxidative stress 1398 1405 https://ijbms.mums.ac.ir/article_28117.html Mohaddeseh Sadat Alavi alavimhd@mums.ac.ir 123611 No Pharmacological Research Center of Medicinal Plants, Basic Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran|Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Seyede Faeze Hosseini hosseinifaeze@alumni.um.ac.ir 123612 No Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran Amir Afkhami-Goli amirgoli@cc.iut.ac.ir 123613 No Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran Mahsa Aminizade mah.aminizadeh@gmail.com 123614 No Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Emad Mokarramdust blackrider865@yahoo.com 123615 No Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Naghmeh Layegh Khavidaki naghmehlayegh@gmail.com 123616 No Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran Fatemeh Forouzanfar forouzanfarf@mums.ac.ir 123617 No Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Hamid Reza Sadeghnia sadeghniahr@mums.ac.ir 123618 Yes Pharmacological Research Center of Medicinal Plants, Basic Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran|Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

en Liquiritin ameliorates atherosclerosis in ApoE-/- mice by modulating SIRT1 and lipid metabolism Original Article Atherosclerosis, Dyslipidemia, Hepatic steatosis, Lipid metabolism, Liquiritin, SIRT1 1406 1412 https://ijbms.mums.ac.ir/article_28124.html Kang Ye 1329627285@qq.com 123637 No Department of Internal Medicine-Cardiovascular, Guangming Traditional Chinese Medicine Hospital of Pudong New Area, Shanghai 201321, China Jing Shi 20136135@qq.com 123638 No Department of Internal Medicine-Cardiovascular, Guangming Traditional Chinese Medicine Hospital of Pudong New Area, Shanghai 201321, China Ping Gong chengeziyu@163.com 123639 No Department of Internal Medicine-Cardiovascular, Guangming Traditional Chinese Medicine Hospital of Pudong New Area, Shanghai 201321, China Zhongsheng Zhu drzzs66@163.com 123640 Yes Department of Internal Medicine-Cardiovascular, Guangming Traditional Chinese Medicine Hospital of Pudong New Area, Shanghai 201321, China

en Intranasal administration of spike-specific mRNA-LNP confers more protection than the intramuscular route against SARS-CoV-2 Original Article COVID-19 vaccines, Intranasal Administration, Lipid nanoparticles, mRNA vaccines, Mucosal immunity, SARS-CoV-2 1413 1423 https://ijbms.mums.ac.ir/article_28148.html Mohsen Abdoli mohsen.abdoli20@gmail.com 123755 No Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Hoorieh Soleimanjahi soleimanjahihorie@gmail.com 123756 Yes Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Sara Soudi soudi@modares.ac.ir 123757 No Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Asghar Abdoli asghar.abdoli7@gmail.com 123758 No Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran

en Electroacupuncture ameliorates diabetic renal injury by regulating the AMPK-autophagy signaling pathway Original Article AMP-activated protein- kinase, Autophagy, Diabetic nephropathy, Electroacupuncture, ULK1 1424 1432 https://ijbms.mums.ac.ir/article_28150.html Zehao Zhang 3640753930@qq.com 123766 No Department of Nephrology, Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People’s Hospital, Lishui, Zhejiang 323000, China|The Nephrology Department of Xijing Hospital, The Fourth Military Medical University, Xi’an, Shaanxi 710032, China Meijuan Xiang 626297276@qq.com 123767 No Department of Nephrology, Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People’s Hospital, Lishui, Zhejiang 323000, China Lejian Lan 8753530@qq.com 123768 No Department of Nephrology, Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People’s Hospital, Lishui, Zhejiang 323000, China Duo Peng pengduo11@126.com 123769 No Department of Nephrology, Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People’s Hospital, Lishui, Zhejiang 323000, China Lixia You 1187801941@qq.com 123770 No The Nephrology Department of Xijing Hospital, The Fourth Military Medical University, Xi’an, Shaanxi 710032, China Mengmeng Jia 877983143@qq.com 123771 No Department of Nephrology, Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People’s Hospital, Lishui, Zhejiang 323000, China Jianyun Peng pengjianyun1@163.com 123765 Yes Department of Nephrology, Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People’s Hospital, Lishui, Zhejiang 323000, China

en High-intensity interval training attenuates neuroinflammation and seizure activity via miR-146a/NF-κB signaling in chronic mesial temporal lobe epilepsy Original Article Convulsion, Epilepsy, Exercise training, Hippocampus, Inflammation 1433 1439 https://ijbms.mums.ac.ir/article_28149.html Leila Saremi leila.saremi@ut.ac.ir 123759 No Department of Exercise Physiology, Faculty of Sport Sciences and Health, University of Tehran, Tehran, Iran Mohamadreza Kordi mrkordi@ut.ac.ir 123760 Yes Department of Exercise Physiology, Faculty of Sport Sciences and Health, University of Tehran, Tehran, Iran Amir Hossein Saffar Kohneh Quchan amirsaffar@ut.ac.ir 123761 No Department of Exercise Physiology, Faculty of Sport Sciences and Health, University of Tehran, Tehran, Iran Younes Sarkabood younessarkabood@ut.ac.ir 123763 No Department of Exercise Physiology, Faculty of Sport Sciences and Health, University of Tehran, Tehran, Iran Siroos Choobineh choobineh@ut.ac.ir 123762 No Department of Exercise Physiology, Faculty of Sport Sciences and Health, University of Tehran, Tehran, Iran Zahra Javaheri javaheri.z1256@ut.ac.ir 123764 No Department of Exercise Physiology, Faculty of Sport Sciences and Health, University of Tehran, Tehran, Iran

en Neuroprotective effect of selenium in rats subjected to chronic intermittent cold and immobilization stress: The role of phosphorylated tau Original Article Chronic stress, Cognitive impairment, Hippocampus, Neuroinflammation, Oxidative stress, p-tau, Rat, Selenium 1440 1447 https://ijbms.mums.ac.ir/article_28125.html Mohamed A. Abdallah mwmdy@yahoo.com 123646 No Medical Physiology Department, Faculty of Medicine, Menoufia University, Shebin-Elkom, Egypt|Medical Physiology Department, Faculty of Medicine, Menoufia National University, Menoufia, Egypt Hesahm A.D. Abdel-Razek h_abdelrazek@hotmail.com 123647 No Medical Physiology Department, Faculty of Medicine, Menoufia University, Shebin-Elkom, Egypt Sohair A. Saleh dr_sohairasaleh@hotmail.com 123648 No Medical Physiology Department, Faculty of Medicine, Menoufia University, Shebin-Elkom, Egypt Rasha S.A. Elseadawy dr.rashaneuro@yahoo.com 123649 No Neuropsychiatry Department, Faculty of Medicine, Menoufia University, Shebin-Elkom, Egypt Mona A. Kora monakora1987@gmail.com 123650 No Pathology Department, Faculty of Medicine, Menoufia University, Shebin-Elkom, Egypt Amal Gamal Younis amal.mousa@med.menofia.edu.eg 123651 No Medical Physiology Department, Faculty of Medicine, Menoufia University, Shebin-Elkom, Egypt|Medical Physiology Department, Faculty of Medicine, Menoufia National University, Menoufia, Egypt Heba Rady Salem heba.salem.12@med.menofia.edu.eg 123652 Yes Medical Physiology Department, Faculty of Medicine, Menoufia University, Shebin-Elkom, Egypt|Medical Physiology Department, Faculty of Medicine, Menoufia National University, Menoufia, Egypt

en MiR-124 alleviates cerebral ischemia-reperfusion injury by targeting SLC1A5 to inhibit neuronal ferroptosis Original Article Cerebral ischemia, Ferroptosis, MiR-124, Neuroprotection, Reperfusion injury, Solute carrier family 1 member 5 1448 1455 https://ijbms.mums.ac.ir/article_28146.html Zhu Yizhen yzzhu2005@126.com 123735 No Class 5, Grade 2023, Clinical Medicine, Guizhou Medical University, Gui’an New District, Guizhou 561113, People’s Republic of China Jiang Qian 1849697109@qq.com 123738 No Department of Anatomy and Neurobiology, Guizhou Medical University School of Basic Medicine, Gui’an New District, Guizhou 561113, People’s Republic of China Long Tingting 786664953@qq.com 123736 No Department of Anatomy and Neurobiology, Guizhou Medical University School of Basic Medicine, Gui’an New District, Guizhou 561113, People’s Republic of China Huang Tao 1742739402@qq.com 123739 No Department of Anatomy and Neurobiology, Guizhou Medical University School of Basic Medicine, Gui’an New District, Guizhou 561113, People’s Republic of China Zhu Junde jdzhu73@126.com 123737 Yes Department of Anatomy and Neurobiology, Guizhou Medical University School of Basic Medicine, Gui’an New District, Guizhou 561113, People’s Republic of China