Iranian Journal of Basic Medical Sciences

en Nose-to-brain drug delivery: A new frontier in targeted therapeutics Review Article Brain targeting, Central nervous system targeting, Intranasal, Nanoparticle, Nose-to-brain 1617 1630 https://ijbms.mums.ac.ir/article_28438.html SVVS Sai Sampath Karakavalasa saisampath2004@gmail.com 124940 No Department of Pharmaceutical Technology, Raghu College of Pharmacy, Visakhapatnam, Andhra Pradesh, India Rama Devi Korni ramakalyank@gmail.com 124939 Yes Department of Pharmaceutical Technology, Raghu College of Pharmacy, Visakhapatnam, Andhra Pradesh, India

en Resveratrol as an immune checkpoint inhibitor to enhance the efficacy of breast cancer immunotherapy Review Article Breast Cancer, Immune cells, Immunotherapy, Natural products, PD-1/PD-L1, Resveratrol, Tumor Microenvironment 1631 1647 https://ijbms.mums.ac.ir/article_28244.html Nafiseh Sadat Alamolhodaei alamolhodaein861@gmail.com 124186 No Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran Barry I. Hudson barry.hudson@georgetown.edu 124187 No Lombardi Compr ehensive Cancer Center, Department of Oncology, Georgetown University Medical Center, Georgetown University, Washington, DC, United States Fatemeh Mosaffa mosaffaf@mums.ac.ir 124188 No Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran Motahareh Boozari bouzarim@mums.ac.ir 124189 Yes Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

en Preparation, characterization, and comparison of the release of antibacterial peptide CM11 from PLGA nanoparticles and microparticles Original Article Antimicrobial peptide, Biofilms, Nanomedicine, Polylactic acid-polyglycolic-acid copolymer, Pseudomonas aeruginosa 1648 1658 https://ijbms.mums.ac.ir/article_28429.html Mohammadmahdi Eshaghi mohammadeshaghi3782@gmail.com 124896 No Nanobiotechnology Research Center, New Health Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran Mehrdad Moosazadeh Moghaddam mm.genetics@gmail.com 124897 No Tissue Engineering and Regenerative Medicine Research Center, New Health Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran Marzieh Dehghani marziyeh.dehghani@modares.ac.ir 124898 No Department of Biophysics, College of Biological Sciences, Tarbiat Modares University, Tehran, Iran Nematollah Jonaidi-Jafari jonaidi2000@gmail.com 124899 No Health Management Research Center, Lifestyle and Spiritual Health Research Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran Hamid Hesarikia h.hesarikia@gmail.com 124900 No Trauma Research Center, Clinical Sciences Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran Ramezan Ali Taheri taheri@bmsu.ac.ir 124901 Yes Nanobiotechnology Research Center, New Health Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran

en Imperatorin alleviates post-infarction cardiac fibrosis via the CD44/PI3K/AKT pathway in mice Original Article CD44, Imperatorin, myocardial fibrosis, Myocardial infarction, PI3K/Akt 1659 1669 https://ijbms.mums.ac.ir/article_28433.html Hui Yuan huiyuan1982@126.com 124914 No School of Basic Medical Sciences, Mudanjiang Medical University, Mudanjiang 157011, P.R. China|School of Stomatology, Mudanjiang Medical University, Mudanjiang 157011, P.R. China YanKun Hao 466129491@qq.com 124915 No School of Basic Medical Sciences, Mudanjiang Medical University, Mudanjiang 157011, P.R. China Mohammed Alaa Abdulzahra mohammed.sadran@uobabylon.edu.iq 124916 No DNA Research Center, University of Babylon, Hilla 51001, Iraq|Department of Pharmacy, AIAmal College for Specialized Medical Sciences, Karbala -56001, Iraq YueYing Yuan yuanyycircle@126.com 124917 No School of Basic Medical Sciences, Mudanjiang Medical University, Mudanjiang 157011, P.R. China Xuan Li 1260609327@qq.com 124918 No School of Basic Medical Sciences, Mudanjiang Medical University, Mudanjiang 157011, P.R. China Javeria Qadir javeriaqadir@hotmail.com 124919 No Department of Biological Sciences, International Islamic University Islamabad, Islamabad 04436, Pakistan ManYu Wang peekaboo8074@163.com 124920 No School of Basic Medical Sciences, Mudanjiang Medical University, Mudanjiang 157011, P.R. China YuanYuan Zhang 1693757090@qq.com 124921 No School of Basic Medical Sciences, Mudanjiang Medical University, Mudanjiang 157011, P.R. China TingTing Li 3062952695@qq.com 124922 No School of Basic Medical Sciences, Mudanjiang Medical University, Mudanjiang 157011, P.R. China Jian Sun mdjsunjian@126.com 124923 Yes Collaborative Innovation Center of Development and Application of North Medicine Resources in Mudanjiang City, Mudanjiang 157011, P.R. China|School of Basic Medical Sciences, Mudanjiang Medical University, Mudanjiang 157011, P.R. China

en Acute and chronic zolpidem administration changes hippocampal long-term potentiation (LTP) as a possible mechanism of memory impairment Original Article Acute, Chronic, Long-term potentiation, Spatial Memory, Zolpidem 1670 1676 https://ijbms.mums.ac.ir/article_28436.html Zahra Rezaeiasl rezaeiasl-z@kaums.ac.ir 124934 No Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran Mahmoud Salami salami-m@kaums.ac.ir 124935 No Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran Hamid Reza Banafshe banafshe57@hotmail.com 124936 Yes Department of Pharmacology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran|Department of Addiction Studies, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran

en Modulation of autophagy and PI3K/Akt/mTOR pathway by naringin in sepsis-induced acute kidney injury Original Article Acute kidney injury, Autophagy, Inflammation, Naringin, Sepsis 1677 1687 https://ijbms.mums.ac.ir/article_28428.html Ali Tuğrul Akin tugrul.akinn@gmail.com 124884 Yes Istinye University, Faculty of Medicine, Department of Medical Biology, Istanbul, Turkey|King’s College London, Cancer and Pharmaceutical Sciences, The Rayne Institute, London, UK Zeynep Yilmaz zeynep.yilmaz@gmail.com 124885 No Erciyes University, Genome and Stem Cell Center, Kayseri, Turkey Emin Kaymak e_kaymak@hotmail.com 124886 No Yozgat Bozok University, Faculty of Medicine, Histology-Embryology Department, Yozgat, Turkey Saban Varinli varinli79@gmail.com 124887 No Yozgat Bozok University, Graduate School of Health Sciences, Histology-Embryology Department, Yozgat, Turkey Esra Onal esra_onal@gmail.com 124888 No Erciyes University, Graduate School of Health Sciences, Histology-Embryology Department, Kayseri, Turkey Necla Deger necla_deger38@gmail.com 124890 No Erciyes University, Graduate School of Health Sciences, Histology-Embryology Department, Kayseri, Turkey Meryem Sayan sayan.meryem@gmail.com 124889 No Erciyes University, Graduate School of Health Sciences, Histology-Embryology Department, Kayseri, Turkey Derya Karabulut deryakkus@gmail.com 124891 No Erciyes University, Faculty of Medicine, Histology-Embryology Department, Kayseri, Turkey Zuleyha Doganyigit zuleyha_doganyigit@hotmail.com 124892 No Yozgat Bozok University, Faculty of Medicine, Histology-Embryology Department, Yozgat, Turkey Ayse Tuğrul Toluk atoluk@erciyes.edu.tr 124893 No Erciyes University, Faculty of Science, Department of Biology, Kayseri, Turkey

en Protective effects of vitamin B12 against LPS-induced cognitive impairment through modulation of neuroinflammation, oxidative stress, and cholinergic dysfunction Original Article Cholinergic system, Learning, Lipopolysaccharides, Memory, Oxidative stress, Vitamin B12 1688 1698 https://ijbms.mums.ac.ir/article_28354.html Zahra Khosravi zhrkhosravi76@gmail.com 124581 No Applied Biomedical Research Center, Basic Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran|Department of Clinical Psychology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Rasul Saberi rasulsaberii@gmail.com 124582 No Applied Biomedical Research Center, Basic Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran|Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Sajjad Mollaei sajjadmollaei98@gmail.com 124583 No Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Elham Taheri elhamtaheri85@gmail.com 124584 No Department of Clinical Psychology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Afsaneh Hokmabadi hokmabadia1@mums.ac.ir 124585 No Department of Anatomy and Cell Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Zahra Kioumarsi Darbandi z.kiumarsi.d@gmail.com 124586 No Applied Biomedical Research Center, Basic Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran|Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Hasan Hazimeh hazimehh981@mums.ac.ir 124587 No Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Arezoo Rajabian rajabianar@mums.ac.ir 124588 Yes Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran|Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Mahmoud Hosseini hosseinim@mums.ac.ir 124589 Yes Applied Biomedical Research Center, Basic Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran|Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

en Sappanone A suppresses CHOP expression and exerts neuroprotective effects in epilepsy Original Article Apoptosis, CHOP, Epilepsy, Inflammation, Oxidative stress, Sappanone A 1699 1707 https://ijbms.mums.ac.ir/article_28430.html Jie Fu fujessie@swmu.edu.cn 124902 Yes Department of Neurology, the Affiliated Hospital of Southwest Medical University. Taiping Street, Jiangyang District, Luzhou, 646000, China Jinglun Li jinglunli123@163.com 124903 No Department of Neurology, the Affiliated Hospital of Southwest Medical University. Taiping Street, Jiangyang District, Luzhou, 646000, China Xiu Chen xiu_chen1@126.com 124904 No Department of Neurology, the Affiliated Hospital of Southwest Medical University. Taiping Street, Jiangyang District, Luzhou, 646000, China

en Differential expression of the lncRNA MIR17HG and miR-18a/miR-20a as candidate ncRNA signatures in stage II/III breast cancer and bioinformatic analysis of ncRNA–mRNA regulatory axes Original Article Breast Cancer, Endocytosis, Hippo signaling pathway, Long non-coding RNA, MIR17HG, microRNAs, Noncoding RNA, RNA degradation 1708 1718 https://ijbms.mums.ac.ir/article_28353.html Reyhane Alidousti Shahraki reyhanealidousti@modares.ac.ir 124575 No Molecular Genetics Department, Biological Sciences Faculty, Tarbiat Modares University, Tehran, Iran Sara Tavallaei tavallaei.s@yahoo.com 124576 No Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran Afsaneh Malekzadeh Shafaroudi afsaneh.malekzadeh@um.ac.ir 124577 No Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran saba Abbassioun saba.abbassioun@modares.ac.ir 124578 No Molecular Genetics Department, Biological Sciences Faculty, Tarbiat Modares University, Tehran, Iran Nahid Nafissi nafissi.n@iums.ac.ir 124579 No Rasoul Akram Hospital Clinical Research and Development Center (RCRDC), Iran University of Medical Sciences, Tehran, Iran Seyed-Javad Mowla sjmowla@modares.ac.ir 124580 Yes Molecular Genetics Department, Biological Sciences Faculty, Tarbiat Modares University, Tehran, Iran

en Britanin alleviates myocardial damage in rats with acute myocardial infarction by inhibiting the JAK2/STAT3 signaling pathway Original Article Acute myocardial infarction, Britanin, JAK2/STAT3 signaling- pathway, NLRP3 inflammasome, Pyroptosis 1719 1727 https://ijbms.mums.ac.ir/article_28435.html Yiqing Zhang zhangyiqing94@outlook.com 124925 No Department of Cardiology, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University, Suzhou Dushu Lake Hospital, Suzhou City, Jiangsu Province, P. R. China|Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou City, Jiangsu Province, P. R. China Xian Li oliverqueen27@163.com 124926 No Department of Cardiology, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University, Suzhou Dushu Lake Hospital, Suzhou City, Jiangsu Province, P. R. China Hezi Jiang heezjiang@163.com 124927 No Department of Cardiology, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University, Suzhou Dushu Lake Hospital, Suzhou City, Jiangsu Province, P. R. China Guo-Xing Zhang zhangguoxing@suda.edu.cn 124924 Yes Department of Physiology and Neurosciences, Medical College of Soochow University, Suzhou City, Jiangsu Province, P. R. China Yafeng Zhou dryafengzhou@163.com 124928 Yes Department of Cardiology, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University, Suzhou Dushu Lake Hospital, Suzhou City, Jiangsu Province, P. R. China

en Topical buspirone accelerates wound healing in rats through modulation of inflammation, angiogenesis, and collagen formation Original Article 5HT1A, Buspirone, Serotonin receptors, Skin, Wound healing 1728 1735 https://ijbms.mums.ac.ir/article_28291.html Mehdi Zahmatkesh mahdizahmatkesh1379@gmail.com 124362 No Medicinal Plants and Natural Products Research Center, Institute of Cancer, Hamadan University of Medical Sciences, Hamadan, Iran|Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran Pari Tamri ptamri@gmail.com 124363 Yes Medicinal Plants and Natural Products Research Center, Institute of Cancer, Hamadan University of Medical Sciences, Hamadan, Iran|Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran Mojdeh Mohammadi m.mohammadi@umsha.ac.ir 124364 No Medicinal Plants and Natural Products Research Center, Institute of Cancer, Hamadan University of Medical Sciences, Hamadan, Iran|Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran Fatemeh Mirzaei fatemehmirzaei1990@gmail.com 124365 No Department of Anatomical Sciences, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

en Harmaline improves diabetes-associated renal alterations in nicotinamide/streptozotocin-induced diabetic mice: Possible involvement of oxidative stress, inflammation, and renin–angiotensin system signaling Original Article Diabetic nephropathy, Harmaline, Inflammation, microRNAs, NF-kappa B, Nuclear factor E2-related factor 2, Oxidative stress 1736 1746 https://ijbms.mums.ac.ir/article_28450.html Farima Malekinia farimamalekiania74074@gmail.com 124991 No Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Akram Ahangarpour ahangarpur@ajums.ac.ir 124992 Yes Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Khojasteh Hoseinynejad khoseinynejad@yahoo.com 124993 No Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Seyyed Ali Mard alimard77@gmail.com 124994 No Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Maryam Radan radan.maryam@yahoo.com 124995 No Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Fereshteh Nejaddehbashi fereshte_negad@yahoo.com 124996 No Cellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

en Enhanced effects of Wharton’s jelly–derived MSC secretome and microbial exopolysaccharide on cellular responses and tissue repair in diabetic wound healing Original Article Diabetes Mellitus, Wound healing, Mesenchymal stem cells, Secretome, Fibroblasts, Endothelial cells, Exopolysaccharide 1747 1758 https://ijbms.mums.ac.ir/article_28293.html Hossein Rostami h_rostami@razi.tums.ac.ir 124377 No Department of Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran Seyed Mohamad Amin Haramshahi sma.haramshahi@gmail.com 124378 No Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran|Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran Nasim Vousooghi dr.n.vosoughi@gmail.com 124379 No Department of Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran Somayeh Shamlou somayeh.shamlou@gmail.com 124380 No Department of Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran Zeinab Shahmahmoudi z.shahmahmoodi@gmail.com 124381 No Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran|Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran Peiman Brouki Milan peiman.brouki@gmail.com 124382 No Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran|Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran Javad Verdi j-verdi@sina.tums.ac.ir 124383 Yes Department of Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

en Rutin attenuates cuprizone-induced demyelination in C57BL/6 mice through activation of Nrf2 signaling and inhibition of NF-κB Original Article Cuprizone, Demyelination, Mice, NF-kB, Nrf2, Rutin 1759 1768 https://ijbms.mums.ac.ir/article_28452.html Seyede Darya Alavi alavi_darya@yahoo.com 125000 No Student Research Committee, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran Samira Shirooie shirooie@gmail.com 125001 Yes Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran Antoni Sureda tosugo@hotmail.com 125002 No Research Group on Community Nutrition and Oxidative Stress (NUCOX) and Health Research Institute of Balearic Islands (IdISBa), University of Balearic Islands-IUNICS, Palma de MallorcaE-07122, Balearic Islands, Spain|CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain Mohammad Hosein Farzaei mh.farzaei@gmail.com 125003 No Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran Sajad Fakhri pharmacy.sajad@yahoo.com 125004 No Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran Sedigheh Asgary mahtabkeshvari87@gmail.com 125030 No Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

en Linalool restores post-morphine hippocampal-striatal PI3K/Akt and CREB/ΔFosB mRNA expression and LFP power in adult male rats Original Article &Delta, FosB, Hippocampus, LFP, Linalool, Morphine, PI3K, Ventral striatum 1769 1778 https://ijbms.mums.ac.ir/article_28197.html Mohsen Khanlari Piraliloo khanlari.m@gmail.com 123972 No Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Yaghoob Farbood farbood.y@gmail.com 123973 No Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Alireza Sarkaki sarkaki.a@gmail.com 123974 No Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Neda Yazdanfar yazdanfar.n@gmail.com 123975 No Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Seyedeh Parisa Navabi navabi.p@gmail.com 123976 Yes Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran