Iranian Journal of Basic Medical Sciences

Iranian Journal of Basic Medical Sciences

Nephroprotective effects of Feijoa Sellowiana leaves extract on renal injury induced by acute dose of ecstasy (MDMA) in mice

Authors
Mohammad Karami 1
Faezeh Karimian Nokabadi 1
Mohammad Ali Ebrahimzadeh 2
Farshad Naghshvar 3
1 Department of Toxicopharmacology, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
2 Department of Chemistry, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
3 Department of Pathology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
10.22038/ijbms.2014.2159
Abstract
 




Objective(s): Because of the high total phenolic contents of Feijoa sellowiana
, its nephroprotective effect was determined in 3,4-methylene dioxymethamphetamine (MDMA) treated mice.
 
Materials and Methods:
Animals received 10, 20 and 40 mg/kg doses of aqueous or methanol extract of F. sellowiana
leaves, intra-peritoneally. After one hour, an acute administration of MDMA (20 mg/kg, IP) was injected. Nephroprotective effect was assayed by determination of serum creatinine, serum urea and kidney glutathione level. Histopathological study was also used.
 
Results
 
: Both extracts at 40 mg/kg resulted in a significant reversal in the raised serum creatinine levels (P <0.05). Not statistically significant was observed in effect of two extracts (P>0.05). A decrease in urea/ creatinine ratio was observed following aqueous extract treatment. Methanolic extract showed higher activity in increasing kidney glutathione (P

Conclusion:
 
F. sellowiana extract resulted in a markedly decrease in the nephrotoxicity of MDMA in mice.
Keywords
Feijoa sellowiana
Kidney glutathione
MDMA
Nephrotoxicity
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