The role of calcium channel blockers in wound healing

Document Type: Editorial

Author

Department of Pharmacology, Abadan School of Medical Sciences, Abadan, Iran

Abstract

Wound healing is a natural response to restore the injured tissue to normal. Wound healing is also complicated process involving different cellular, molecular and biochemical mechanisms and various types of cytokines and growth factors. Calcium channel blockers belong to cardiovascular medicine and administrated to treatment of hypertension, angina and cardiac arrhythmia because of vasodilatory effect. Calcium channel blockers is divided to dihydropyridine and non-dihydropyrine. The potential of both dihydropyridine and non-dihydropyrine calcium channel blockers in wound healing have been reported in different animal models and in vitro previously. Amlodipine, verapamil, diltiazem, nifedipine, and azelnidipine are calcium channel blockers that indicated wound healing property. The various mechanisms that involve in wound healing effect of calcium channel blockers are discussed in this article.

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1. Akkol EK, Koca U, Peşin I, Yılmazer D, Toker G, Yeşilada E. Exploring the wound healing activity of Arnebia densiflora (Nordm.) Ledeb. by in vivo models. J Ethnopharmacol. 2009;124:137-141.
2. Gilman AG. Goodman and Gilman’s the Pharmacological Basis of Therapeutics. 2017.
3. Bagheri M, Jahromi BM, Mirkhani H, Solhjou Z, Noorafshan A, Zamani A, et al. Azelnidipine, a new calcium channel blocker, promotes skin wound healing in diabetic rats. J Surg Res. 2011;169:e101-e107.
4. Bhasker H, Udupa SL, Udupa AL. Effect of nifedipine and amlodipine on wound healing in rats. Indian J Physiol Pharmacol. 2004;48:111-114.
5. Ashkani-Esfahani S, Hosseinabadi OK, Moezzi P, Moafpourian Y, Kardeh S, Rafiee S, et al. Verapamil, a calcium-channel clocker, improves the wound healing process in rats with excisional full-thickness skin wounds based on stereological parameters. Adv Skin Wound Care. 2016;29:371-374.
6. Hemmati AA, Forushani HM, Asgari HM. Wound healing potential of topical amlodipine in full thickness wound of rabbit. Jundishapur J Nat Pharm Prod. 2014;9. e15638.
7. Ma J, Kishida S, Wang GQ, Meguro K, Imuta H, Oonuma H, et al. Comparative effects of azelnidipine and other Ca2+-channel blockers on the induction of inducible nitric oxide synthase in vascular smooth muscle cells. J Cardiovasc Pharmacol. 2006;47:314-321.
8. Frank S, Stallmeyer B, KÄmpfer H, Kolb N, Pfeilschifter J. Nitric oxide triggers enhanced induction of vascular endothelial growth factor expression in cultured keratinocytes (HaCaT) and during cutaneous wound repair. The FASEB J. 1999;13:2002-2014.
9. Nomura S, Inami N, Kimura Y, Omoto S, Shouzu A, Nishikawa M, et al. Effect of nifedipine on adiponectin in hypertensive patients with type 2 diabetes mellitus. J Hum Hypertens 2007;21:38.
10. Triveni M, Rudrakshi C, Mehta D. Amlodipine-induced gingival overgrowth. J Indian Soci Periodontol 2009;13:160-163.