The Role of Target and Bystander Cells in Dose-Response Relationship of Radiation-Induced Bystander Effects in Two Cell Lines

Authors

1 Medical Physics Resaerch Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran 2 Department of Medical Physics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2 Medical Physics Resaerch Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Medical Physics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

3 Medical Physics Resaerch Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Keywords


Matsumoto H, Takahashi A, Ohnishi T. Radiation–induced adap

tive responses and bystander effects. Biol Sci Space 2004; 18: 247- 254.

2. Shao C, Aoki M,Furusawa Y. Bystander effect on cell growth stimulation in neoplastic HSGc cells induced by heavy-ion irradiation. Radiat Environ Biophys 2003; 42:183-187.

 

3. Belyakov OV, Folkard M, Mothersill C, Prise KM, Michael BD. Bystander-induced apoptosis and premature differentiation in primary urothelial explants after charged particle microbeam irradiation. Radiat Prot Dosimetry 2002; 99:249-251.

 

4. Shao C, Folkard M, Michael BD, Prise KM. Bystander signaling between glioma cells and fibroblasts targeted with counted particles. Int J Cancer 2005; 116:45–51.

 

5. Yang H, Assad N, Held KD. Medium-mediated intercellular communication is involved in bystander responses of X-ray-irradiated normal human fibroblasts. Oncogene 2005; 24:2096–2103.

 

6. Wang R, Coderre JA. A bystander effect in alpha-particle irradiations of human prostate tumor cells. Radiat Res 2005; 164:711– 722.

 

7. Konopacka M, Rzeszowska-Wolny J. The bystander effect-induced formation of micronucleated cells is inhibited by antioxidants, but parallel induction of apoptosis and loss of viability are not affected. Mutat Res 2006; 593:32-38.

 

8. Hu B, WU L, Han W, Zhang L, Chen S, Xu A,

 

 

et al.

The time and spatial effects of bystander response in mammalian cells induced by low dose radiation. Carcinogenesis 2006; 27:245-251.

9. Shao C, Folkard M, Prise KM. Role of TGF-β1 and nitric oxide in the bystander response of irradiated glioma cells. Oncogene 2008; 27:434-440.

 

10. Shao C, Aoki M, Furusawa Y. Bystander effect in lymphoma cells vicinial to irradiated neoplastic epithelial cells: nitric oxide is involved. J Radiat Res 2004; 45:97-103.

 

11. Baskar R, Balajee AS, Geard CR. Effects of low and high LET radiations on bystander human lung fibroblast cell survival. Int J Radiat Biol 2007; 83:551-559.

 

12. Hamada N, Matsumoto H, Hara T, Kobayashi, Y. Intercellular and intracellular signaling pathways mediating ionizing radiation-induced bystander effects. J Radiat Res 2007; 48:87-95.

 

13. Mothersill C, Seymour C. Radiation-induced bystander effects: past history and future directions. Radiat Res 2001; 155:759-767.

 

14. Trott KR. Non-targeted radiation effects in radiotherapy. Acta Oncol 2001; 40:976-980.

 

15. Mothersill CE, Moriarty MJ, Seymour CB. Radiotherapy and the potential exploitation of bystander effects. Int J Radiat Oncol Biol Phys 2004; 58:575-579.

 

16. Azzam EI, Little JB. The radiation-induced bystander effect: evidence and significance. Hum Exp Toxicol 2004; 23:61-65.

 

17. Mothersill C, Seymour C. Radiation-induced bystander effects: are they good or bad or both. Med Confl Surviv 2005; 21:101-110.

 

18. Mothersill C, Seymour C. Radiation-induced bystander and other non-targeted effects: novel intervention points in cancer therapy? Curr Cancer Drug Targets 2006; 6:447-454.

 

19. Prise KM, O’Sullivan JM. Radiation-induced Bystander Signaling in Cancer Therapy. Nat Rev Cancer 2009; 9:351-360.

 

20. Groesser T, Cooper B, Rydberg B. Lack of bystander effects from high-LET radiation for early cytogenetic end points. Radiat Res 2008; 170:794-802.

 

21. Tome WA, Fenwick JD, Bentzen SM. Dose a local bystander effect necessitate a revision of TCP models that are based on observed clinical data? Acta Oncol 2006; 45:406-411.

 

22. Boyd M, Ross SC, Dorrens J, Fullerton NE, Tan KW, Zalutsky MR,

 

 

et al. Radiation-induced biologic bystander effect elicited in vitro

by targeted radiopharmaceuticals labeled with -, β, γ and auger electron emitting radionuclides. J Nucl Med 2006; 47:1007-1015.

23. Widel M, Szurko A, Przybyszewski W, Lanuszewska J. Non-irradiated bystander fibroblasts attenuate damage to irradiated cancer cells. 36th annual meeting of the European Radiation Research Society. Radioprotection 2008; 43, N ° 5.

 

24. Butterworth KT, McGarry CK, Trainor C, O’Sulivan JM, Honsell AR, Prise KM. Out-of-field cell survival following exposure to intensity-modulated radiation fields. Int J Radiat Oncol Biol Phys 2011; 79:1516-1522.

 

25. Ponnaiy B, Jenkins-Baskar G, Brenner DJ, Hall EJ, Randers-pehrson G, Geard CR. Biological responses in known bystander cells relative to known microbeam-irradiated cells. Radiat Res 2004; 162: 426-432.

 

26. Tartier L, Gilchrist S, Burdak-Rothkamm S, Folkard M, Prise KM. Cytoplasmic irradiation induces mitochondrial-dependent 53BP1 protein relicalization in irradiated and bystander cells. Cancer Res 2007; 67:5872-5879.

 

27. Belloni P, Latini P, Palitti F. Radiation-induced bystander effect in healthy G0 human lymphocytes: Biological and clinical significance. Mutat Res 2011; 713:32-38.

 

28. Mitchell SA, Randers-Pehrson G, Brenner DJ, Hall EJ. The Bystander Response in C3H 10T½ Cells: The Influence of Cell-to-Cell Contact. Radiat Res 2004; 161:397–401.

 

29. Maguire P, Mothersill C, Seymour C, Lyng FM. Medium from irradiated cells induces dose-dependent mitochondrial changes and BCL2 responses in unirradiated human keratinocytes. Radiat Res 2005; 163:384-390.

 

30. Persaud R, Zhou H, Hei TK, Hall EJ. Demonstration of a radiation-induced bystander effect for low dose low LET β-particles. Radiat Environ Biophys 2007; 46:395-400.

 

31. Shao C, Furusawa Y, Aoki M, Ando K. Mechanism of irradiation bystander effect on lymphoma cells. Nati Ins Radiol Sci ?? 2003; 166:101-102.

 

32. Soleymanifard Sh, Bahreyni Toossi MT. Comparing the level of bystander effect in a couple of tumor and normal cell lines. J Med Phys 2012; 37:102- 106.

 

33. Cole SP, Campling BG, Dexter DF, Holden JJ, Roder JC. Establishment of a human large cell lung tumor line (QU-DB) with metastatic properties in athymic mice. Cancer 1986; 58:917-923.

 

34. Jacobs JP, Jones CM, Baille JP. Characteristics of a human diploid cell designated MRC-5. Nature 1970; 227:168-170.

 

35. Neshasteriz A, Shafaee Gh, Mozdarani H. Comprative evaluation of cytogenetic aberrations induced by cobalt 60 in glioma cells in presence or absence of IUdr. Iran J Med Physics?? 2006; 3:73-84 [in Persian].

 

36. Shereef MM, Cui N, Burikhanov R, Gupta S, Satishkumar S, Shajahan S,

 

 

et al

Role of tumor necrosis factor-α and trail in high-dose radiation-induced bystander signaling in lung adenocarcinoma. Cancer Res 2007; 67:11811-11820.

37. Chen S, Zhao Y, Han W, Zhao G, Zhu L, Wang J,

 

 

et al

Mitochondria-dependent signaling pathway is involved in the early process of radiation-induced bystander effects. Br J Cancer 2008; 98:1839 – 1844.

38. Ryan LA, Smith RW, Seymour CB, Mothersill CE. Dilution of irradiated cell conditioned medium and bystander effect. Radiat Res 2008; 169:188-196.

 

39. Mackonis EC, Suchoweska N, Zhang M, Ebert M. Cellular response to modulated radiation fields. Phys Med Biol 2007; 52:5469-5482.

 

40. Gow MD, Seymour CB, Byun S, Mothersill CE. Effect of dose rate on the radiation-induced bystander response. Phys Med Biol 2008; 53:119-132