Antidiabetic and hypolipidemic effects of Dorema aucheri hydroalcoholic leave extract in streptozotocin-nicotinamide induced type 2 diabetes in male rats

Authors

1 Health Research institute, Diabetes Research Center, Dept of Physiology, Faculty of Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

2 Faculty of Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

3 Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran

4 Department of sport physiology, Faculty of physical education and sport science, Shahid Chamran University of Ahvaz, Ahvaz, Iran

5 Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences. Ahvaz, Iran and Department of Physiology, Faculty of Medical Sciences, Qom University of Medical Sciences, Qom, Iran

Abstract

Objective(s):The present study investigated the antidiabetic and hypolipidemic properties of Dorema aucheri leave hydroalcoholic extract in nicotinamide-streptozotocin induced type 2 diabetic rats.
Materials and Methods: nicotinamide/streptozotocin-induced diabetic rats were supplemented orally with three different doses of D.  aucheri (100, 200 and 400 mg/kg BW) or glibenclamide (0.25 mg/kg) for 4 weeks. Ultimately, blood of animals has taken and glucose, insulin, lipid profiles, SGPT, alkaline phosphatase, SGOT, leptin levels were assayed.
Results: D. aucheri has highly significant blood glucose lowering effect. Administration of the extract to diabetic rats resulted in a remarkable change in serum lipid profiles, insulin and leptin levels relative to diabetic group. Also the extract reversed back the serum levels of SGPT, alkaline phosphatase and SGOT to near normal in treated diabetic rats.
Conclusion: D. aucheri could be useful in treatment of diabetes. Moderate dose of D. aucheri (200 mg/kg) was more effective than the others.

Keywords


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