1.Hatsukari I, Hitosugi N, Ohno R, Hashimoto K, Nakamura S, Satoh K, et al. Induction of apoptosis by morphine in human tumor cell lines in vitro. Anticancer Res 2007; 27: 857-864.
2.Elvenes J, Andjelkov N, Figenschau Y, Seternes T, Bjorkoy G, Johansen O. Expression of functional [mu]- opioid receptors in human osteoarthritic cartilage and chondrocytes. Biochem Biophys Res Commun 2003; 311:202-207.
3.Tachdjian Mihrano. Physeal plate anatomy and physiology. In tachdian pediatric Orthopedics. 2th ed. Saunder's company; 1998. p. 3016-30203.
4.Wilsman NJ, Farnum CE, Leiferman EM, Fry M, Barreto C. Differential growth by growth plates as a function of multiple parameters of chondrocytic kinetics. J Orthop Res 1996; 14: 927-936.
5.Hunziker EB, Schenk RK. Physiological mechanisms adopted by chondrocytes in regulating longitudinal bone growth in rats. J Physiol 1989; 414:55-71.
6.Kember NF. Aspects of the maturation process in growth cartilage in the rat tibia. Clin Orthop Relat Res 1973; 288-294.
7.Siebler T, Robson H, Shalet SM, Williams GR. Glucocorticoids, thyroid hormone and growth hormone interactions: implications for the growth plate. Horm Res 2001; 1:7-12.
8.Yilmaz B, Konar V, Kutlu S, Sandal S, Canpolat S, Gezen MR, et al. Influence of chronic morphine exposure on serum LH, FSH, testosterone levels, and body and testicular weights in the developing male rat. Arch Androl 1999; 43:189-196.
9.Karimi-Mobarakah M. Effect of morphine dependency on bone healing in rat. J Kerman Univ Med Sci 2004; 11:1-6.
10.Leung CM, Dai S, Ogle CW. Rapid induction of dependence to morphine in rats. Neuropharm 1986; 25:305-307.
11.Sahraei H, Kaka G, Ghoshooni H, Shams Lahijani M, Ramezani M. Effect of oral morphine administration on fertility of Balb/c mice. J Rep and Infer 2002. 3(3); 11: 4-10
12.Sarkaki A, Assaei R, Motamedi F, Badavi M, Pajouhi N. Effect of parental morphine addiction on hippocampal long-term potentiation in rats offspring. Behav Brain Res 2008; 186:72-77.
13.Ho AKS, Chen R, Kreek MJ. Morphine withdrawal in the rat: assessment by quantitation of diarrhea and modification by ethanol. Pharmacology 1979; 18:9-17.
14.Silverman, J. and W.W. Muir 3rd, A review of laboratory animal anesthesia with chloral hydrate and chloralose. Laboratory animal science, 1993. 43(3): p. 210.
15.Tegeder I, Grosch S, Schmidtko A, Haussler A, Schmidt H, Niederberger E, et al. G protein-independent G1 cell cycle block and apoptosis with morphine in adenocarcinoma cells: involvement of p53 phosphorylation. Cancer Res 2003; 63:1846-1852.
16.Yin D, Woodruff M, Zhang Y, Whaley S, Miao J, Ferslew K, et al. Morphine promotes Jurkat cell apoptosis through pro-apoptotic FADD/P53 and anti-apoptotic PI3K/Akt/NF-kappaB pathways. J Neuroimmunol 2006; 174:101-107.
17.Singhal PC, Sharma P, Sanwal V, Prasad A, Kapasi A, Ranjan R, et al. Morphine modulates proliferation of kidney fibroblasts. Kidney Int 1998; 53:350-357.
18.Agarwal D, Glasel JA. Differential effects of opioid and adrenergic agonists on proliferation in a cultured cell line. Cell Prolif 1999; 32: 215-229.
19.Glasel JA. The effects of morphine on cell proliferation. Prog Drug Res 2000; 55:33-80.
20.Kauser S, Thody AJ, Schallreuter KU, Gummer CL, Tobin DJ. beta-Endorphin as a regulator of human hair follicle melanocyte biology. J Invest Dermatoln 2004; 123:184-95.
21.Castano MT, Freire-Garabal M, Giraldez M, Nunez MJ, Belmonte A, Couceiro J, et al. Autoradiographic evidence of 125I-[beta]-endorphin binding sites in the articular cartilage of the rat. Life Sci 1991; 49: PL103-105.
22.Sharma SK, Nirenberg M, Klee WA. Morphine receptors as regulators of adenylate cyclase activity. Proc Natl Acad Sci USA 1975; 72: 590.
23.Lambert DG, Atcheson R, Hirst RA, Rowbotham DJ. Effects of morphine and its metabolites on opiate receptor binding, cAMP formation and [3H] noradrenaline release from SH-SY5Y cells. Biochem Pharmacol 1993; 46:1145-1150.
24.Wang JF, Ren MF, Xue JC, Han JS. Cyclic AMP mediates mu and delta, but not kappa opioid analgesia in the spinal cord of the rat.. Life Sci 1993; 52:1955-1960.
25.Cicero TJ, Meyer ER, Bell RD, Koch GA. Effects of morphine and methadone on serum testosterone and luteinizing hormone levels and on the secondary sex organs of the male rat. Endocrinology 1976; 98:367-372.
26.Olney RC, Prickett TC, Yandle TG, Espiner EA, Han JC, Mauras N. Amino-terminal propeptide of C-type natriuretic peptide and linear growth in children: effects of puberty, testosterone, and growth hormone. J Clin Endocrinol Metab 2007; 92:4294-4298.
27.Carrascosa A, , Audi L, Ferrandez MA, Ballabriga A. Biological effects of androgens and identification of specific dihydrotestosterone-binding sites in cultured human fetal epiphyseal chondrocytes. J Clin Endocrinol Metab 1990; 70:134-140.
28.Muraki T, Nakadate T, Tokunaga Y, Kato R. Effect of morphine on the release of thyroid-stimulating hormone stimulated by exposure to cold, thyroidectomy and the administration of thyrotrophin releasing hormone in male rats. J Endocrinol 1980; 86:357-362.
29.Robson H, Siebler T, Stevens DA, Shalet SM, Williams GR. Thyroid hormone acts directly on growth plate chondrocytes to promote hypertrophic differentiation and inhibit clonal expansion and cell proliferation. Endocrinology 2000; 141:3887.
30.Lewinson D, Harel Z, Shenzer P, Silbermann M, Hochberg Z. Effect of thyroid hormone and growth hormone on recovery from hypothyroidism of epiphyseal growth plate cartilage and its adjacent bone. Endocrinology 1989; 124:937-945.