ioactivity of Malva Sylvestris L., a Medicinal Plant from Iran


1 Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, Iran

2 Department of Animal Sciences, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran

3 Department of Statistics, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran


Malva sylvestris L. (Malvaceae), an annual plant, has been already commonly used as a medicinal plant in Iran. In the present work, we evaluate some bioactivities of the plant extracts.
Materials and Methods
The aired-dried plant flowers and leaves were extracted by soxhlet apparatus with n-hexane, dichloromethane and methanol. The antimicrobial, cytotoxic, and phytotoxic of the plant extracts were evaluated using disk diffusion method, MTT, and Lettuce assays, respectively.
Both flowers and leaves of M. sylvestris methanol extracts exhibited strong antibacterial effects against Erwinia carotovora, a plant pathogen, with MIC value of 128 and 256 pg/ml, respectively. The flowers extract also showed high antibacterial effects against some human pathogen bacteria strains such as Staphylococcus aureus, Streptococcus agalactiae, Entrococcus faecalis, with MIC value of 192, 200 and 256 pg/ml, respectively. The plant methanol extracts had relatively high cytotoxic activity against MacCoy cell line.
We concluded that Malva sylvestris can be candidated as an antiseptic, a chemopreventive or a chemotherapeutic agent.


1.Davis PH. Flora of Turkey and East Aegean Islands. Vol2. Edinburgh: Edinburgh University Press; 1966.

2.Pirbalouti AG, Yousefi M, Heshmetollah N, Karimi I, Koohpayeh A. Evaluation of burn healing properties of Arnehia euchroma and Malva sylvestris. Electron J Biol 2009; 5:62-66.

3.Gurbuz I, Ozkan AM, Yesiada E, Kutselm O. Anti-ulcerogenic activity of some plants used in folk medicine of pinnarbasi. J Ethnopharmacol 2005; 101:313-318.

4.Veshkorova O, Golubenko Z, Pshenichnov E, Avzanov I, Uzbekov V, Sultanova S, et al. Malvone A, a phytoalexin found in Malva sylvestris (Family Malvaceae). Phytochemistry 2010; 67:2376-2379.

5.Cutillo F, D’Abrosca B, Dellagreca M, Fiorentino A, Zarrelli A. Terpenoides and phenol derivatives from Malva sylvestris. Phytochemistry 2006; 67:481-485.

6.Razavi SM, Zarrini G. Bioactivity of aviprin and aviprin-3"-O-glucoside, two linear furanocoumarins from Apiaceae. Bioorg Khim 2010; 36:359-362.

7.Razavi SM, Nejad-Ebrahimi S.Chemical composition, allelopatic and cytotoxic effects of essential oils of flowering tops and leaves of Crambe orientalis. Nat Prod Res 2009; 23:1492-1498. 

8. Razavi SM, Zarrini G, Zahri S, Mohammadi S. Biological activity of Prangos uloptera, a medicinal plants from Iran. Nat Prod Res 2010; 24:797-803.

9.Razavi SM, Ghasemiyan A, Salehi S, Zahri F. Screening of biological activity of Zosima absinthifolia fruits extracts. Eur Asia J Bio Sci 2009; 4:25-28.

10.Razavi SM, Zahri S, Motamed Z, Ghasemi G. Bioscreening of oxypeucedanin, a known furanocoumarin. Iran J Basic Med Sci 2010; 13:133-138.

11.Guarrera PM. Traditional phytotherapy in central italy (Marche, Abruzzo and Latium). Fitotrapia 2005; 76:1-25.

12.Camejo- Rodrigues J, Ascensao L, Bonet MA, Valles J. An ethnobotanical study of medicinal and aromatic plants in the natural park of Serra de Sao Maeda (Portugal). J Ethnopharmacol 2003; 89:199-209.

13.Wang ZY. Impact of anthocyanin from Malva sylvestris on plasma lipids and free radical. J For Res 2005; 16:228-232.

14.Dogan Y, Baslar S,Ay G, Mert HH. The use of wild edible plants in Western and Central Anatolia (Turkey). Econ Bot 2004; 58:684-690.