Bioscreening of Oxypeucedanin, a Known Furanocoumarin

Document Type: Original Article

Authors

1 Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, Iran

2 Department of Statistics, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, Iran

Abstract

Objective(s)
As an important class of natural products, coumarins exhibit many biological activities and the diversity of their bioactivity is so huge that the pharmacological promiscuity has been applied on their case. Oxypeucedanine also named as prangolarin is a linear furanocoumarin with an oxygenated prenylated substitution at C-5 of the nucleus. To our knowledge, there are few reports on pharmacological and biological activities of this compound. In the present work, we focused on some bioactive aspects of it.
Materials and Methods
In the present work, the compound was purified from Prangos uloptera using TLC and its phytotoxic, antibacterial, antifungal, antioxidant and cytotoxic effects were evaluated by Lettuce assay, disc diffusion method, mycelia radial growth, DPPH and MTT assays, respectively.
Results
Our results revealed that oxypeucedanin exhibit considerable phytotoxic activity and might play an allelopathic role for plants. The compound indicated high cytotoxic activity with IC50 value of 3'4 pg/ml. No antipathogenic and antioxidant activity were found for oxypeucedanin in this study.
Conclusion
We conclude that oxypeucedanin (found in some vegetables) can be considered as an antiproliferative agent.

Keywords


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