Review of the Pharmacological and Toxicological Effects of Salvia leriifolia

Document Type: Review Article

Authors

1 Department of Pharmacodynamy and Toxicology, Pharmaceutical Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

2 Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

3 Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

4 Department of Pharmaceutical Microbiology, Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Salvia leriifolia Benth. (vernacular names such as Nuruozak and Jobleh) is a perennial herbaceous plant that grows exclusively in south and tropical regions of Khorasan and Semnan provinces, I. R. Iran. Unlike other species of Salvia genus, the chemical constituents of S. leriifolia are not well recognized. The stem oil of the plant consisted mainly both monoterpenes and sesquiterpenes, while in leaf and flower oils monoterpenes predominated over sesquiterpenes. In recent years, the different properties of this plant such as the attenuation of morphine dependence, hypoglycemic, antinociceptive and antiinflammatory, antioxidant, anti‌ischemia, anticonvulsant, antiulcer effects, antibacterial activities and antimutagenic effects were evaluated. These effects introduce this plant for more toxicological and clinical trials evaluations as a herbal medicine.

Keywords

References

1.Rechinger KH. Flora Iranica, No. 150 Labiatae. Tab 582 (Tabulate). Graz-Austeria: Akademische Druk-U. Verlangsantlat; 1982.

2.Guan-hua D, Jun-tian Z. The general situation and progress of the modern research of red sage root (Radix Salviae miltiorrhizae). Yiyao Daobao 2004; 23:435-440.

3.Lu Y, Foo Y. Polyphenolics of Salvia-a review. Phytochemistry 2002; 59:117-140.

4.Rustaiyan A, Shafeghat A, Masoudi S, Akhlaghy H, Tabatabaei-Anaraki M. Chemical composition of the essential oils from stems, leaves and flowers of Salvia leriifolia Benth. Iran J Essen Oil-Bearing Plants 2007; 10:121-126.

5.Rustaiyan A, Masoudi S, Yari M, Rabbani M, Motiefar HR. Larijani K. Essential oil of Salvia lereifolia Benth. J Essent Oil Res 2000; 2:601-602.

6.Habibi Z, Eftekhar F, Samiee K, Rustaiyan A. Structure and antibacterial activity of a new labdane diterpenoid from Salvia leriifolia. J Nat Prod 2000; 63: 270-271.

7.Khooei AR, Hosseinzadeh H, Imanshahidi M. Pathologic evaluation of anti-ischemic effect of Salvia leriifolia Benth. seed and leaf extracts in rats after global cerebral ischemia. Iran J Basic Med Sci 2003; 5:200-205.

8.Hosseinzadeh H, Khooei AR, Jaafari MR, Ghasami Pour J. Antihypoxic, anti-ischemic and acute toxicity effect of Salvia leriifolia Benth. root in mice and rats. J Herbs Spices Med Plants 2002; 1:1-10.

9.Hosseinzadeh H, Imanshahidi M. Effect of Salvia leriifolia Benth. aqueous and ethanolic leaf and seed extracts on surviving time of hypoxic mice. Iran J Basic Med Sci 1999; 2:75-81.

10.Imanshahidi M, Hosseinzadeh H. The pharmacological effects of Salvia species on the central nervous system. Phytother Res 2006; 20: 427-437.

11.Hosseinzadeh H, Hosseini A, Nassiri-Asl M, Sadeghnia HR. Effect of Salvia leriifolia Benth. root extracts on ischemia-reperfusion in rat skeletal muscle. BMC Complement Altern Med 2007; 7: 23.

12.Hosseinzadeh H, Hassanzadeh AR. Muscle relaxant and hypnotic effects of Salvia leriifolia Benth. leaves extract in mice. Iran J Basic Med Sci 2001; 4:130-138.

13.Lee CM, Wong HN, Chui KY, Choang TF, Hon PM, Chang HM. Miltiron a central benzodiazepine receptor partial agonist from a Chinese medicinal herb Salvia miltiorrhizae. Neurosci Lett 1991; 127:237-241.

14.Sadeghnia HR, Nassiri Asl M, Haddad Khodaparast MH, Hosseinzadeh H. Effect of Salvia leriifolia Benth. root extracts on lipid peroxidation level during global ischemic-reperfusion in rat hippocampus. J Med Plants 2003; 7:19-28.

15.Hosseinzadeh H, Arabsanavi J. Anticonvulsant effect of Salvia leriifolia Benth. seed and leaf extracts in mice. Iran J Basic Med Sci 2001; 3:163-170.

16.Hosseinzadeh H, Lari P. Effect of Salvia leriifolia extract on morphine dependence in mice. Phytother Res 2000, 14: 384-387.

17.Hosseinzadeh H, Yavary M. Anti-inflammatory effect of Salvia leriifolia Benth. leaf extract in mice and rats. Pharm Pharmacol Lett 1999; 2:60-61.

18.Hosseinzadeh H, Haddadkhodaparast MH, Arash A. Antinociceptive, anti-inflammatory and acute toxicity effects of Salvia leriifolia Benth. seed extract in mice and rats. Phytother Res 2003; 17: 422-425.

19.Farhoosh R, Purazrang H, Khodaparast MHH, Rahimizadeh M, Seyedi SM. Extraction and separation of antioxidative compounds from Salvia leriifolia leaves. J Agric Sci Technol 2004; 6: 57-62.

20.Farhoosh R, Khodaparast MHH, Poorazarang H, Rahimizadeh M, Sayedi M. Invistigation of heat stability of major antioxidant fraction of Salvia leriifolia leaves. J Agricul Sci Technol 2003; 17: 53-9.

21.Fazly-Bazzaz BS, Izadyar AR. Antimutagemic activity of different fractions of Salvia leriifolia extract. Iran J Basic Med Sci 2002; 4:241-50.

22.Pishghadam A. Mutagenicity of the extracts of Salvia leriifolia and Chelidoniuum majus. Thesis (Pharm D), School of Pharmacy, Mashhad University of Medical Sciences, 1998.

23.Vujosevic M, Blagojevic J. Antimutagenic effects of extracts from sage (Salvia officinalis) in mammalian system in vivo. Acta Vet Hung 2004; 52:439-43.

24.Habibi Z, Eftekhar F, Samiee K, Rustaiyan A. Structure and antibacterial activity of a new labdane diterpenoid from Salvia leriifolia. J Nat Prod 2000; 63: 270-1.

25.Ulubelen A. Cardioactive and antibacterial terpenoids from some Salvia species. Phytochemistry 2003; 64:395¬399.

26.Jabbarzadeh M. Antimicrobial effect of seed and root extracts of Salvia leriifolia, Thesis (Pharm D), School of Pharmacy, Mashhad University of Medical Sciences, 1999.

27.Hosseinzadeh H, Haddad Khodaparast MH, Shokoohizadeh H. Antihyperglycemic activity of Salvia leriifolia Benth. leaf and seed extracts in mice. Iran J Basic Med Sci 1998; 4:94-8.

28.Hosseinzadeh H, Khazaei MH, Montazami Sh. Clinical trial of antidiabetic effect of Salvia leriifolia leaves extracts. Iran J Basic Med Sci 2001; 2:71-83.

29.Hosseinzadeh H, Eghbal A. Effect of Salvia leriifolia leaves extract on liver transaminases in mice. Iran J Basic Med Sci 2002; 4: 207-214. 

30.Lee TY, Mai LM, Wang GJ, Chiu JH, Lin YL, Lin HC. Protective mechanism of salvia miltiorrhiza on carbon tetrachloride-induced acute hepatotoxicity in rats. J Pharmacol Sci 2003; 91: 202-210.

31.Hosseinzadeh H, Haddad Khodaparast MH, Hosseini E. Anti-ulcer effect of Salvia leriifolia Benth. leaf extracts in mice . Pharm Pharmacol Lett 2000; 2: 63-4.

32. Hosseinzadeh H, Danaee A, Ziaee T. Anti-anxiety effect of aqueous and ethanolic extracts of Salvia leriifolia Benth. leaves in mice using elevated plus maze. J Med Plants 2008; 7:25-36.

33.Moallem SA, Hosseinzadeh H, Izadi Z, Ziai ST, Kermani T. Evaluation of teratogenicity of Salvia leriifolia Benth. in mice. J Med Plants 2008; 7:1-9.

Iranian Journal of Basic Medical Sciences

Volume 12, Issue 1
January 2009
Pages 1-8

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