Effect of Portulaca oleraceae L. extracts on the Morphine Dependence in Mice

Document Type: Original Article

Authors

1 Department of Pharmacodynamy and Toxicology, School of Pharmacy and Medical Research Toxicology Center, Mashhad University of Medical Sciences, Mashhad, Iran

2 School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

3 Pharmacist

Abstract

Objective
This study was initiated to investigate the effect of Portulaca oleraceae on morphine dependence in mice.
Materials and Methods
Dependence was induced using the subcutaneous injections of morphine for 3 days. On the day 4, morphine
injected 2 h prior to intraperitoneal injection of naloxone. The plant extracts ethanolic or aqueous
administered 0.5 h before the final dose of morphine. The number of jumping during the 30 min period after naloxone injection was considered as a measure of withdrawal syndrome.
Results
Both extracts reduced the jumping episodes dose-dependently. The maximum effect was observed at doses
of 0.28 g/kg and 1.4 g/kg for the aqueous and ethanolic extracts, respectively. Clonidine and extracts
decreased the total activity in locomotion test.
Conclusion
These findings indicated that Portulacea oleraceae extracts can decrease morphine dependence in mice.

Keywords


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