Therapeutic effects of saffron (Crocus sativus L.) in digestive disorders: a review

Document Type: Review Article


Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


Saffron, the dried red-orange stigmas of Crocus sativus L, has been known as a flavoring agent, food coloring and traditional herbal medicine. Pharmacological effects of saffron are mainly attributed to crocin, crocetin, picrocrocin and safranal. These components especially crocin, have significant effects including antidepressant and anticonvulsant, analgesic, anti-cancer and other therapeutic effects on different parts of our body namely cardiovascular, immune, respiratory, genital-urinary and central nervous system. According to the reports and findings, saffron plays a key role to cure different digestive system disorders via chemopreventive, inhibition of cell proliferation, induction of apoptosis, antioxidant effects and radical scavenging, genoprotective property, prevention of lipid peroxidation and anti-inflammatory processes. The outcome of the above mentioned mechanisms shows potential therapeutic properties of saffron against liver cancer, hepatotoxicity, fatty liver, hyperlipidemia, stomach cancer, peptic ulcer, colon cancer, ulcerative colitis, diabetes and pancreas cancer and ileum contractions. According to global statistics, the susceptibility to intestinal diseases is considered as a significant matter and can be important in health planning in any community. Several strategies for treatment and prevention of the digestive system diseases have provided that the use of herbal remedies seems effective and useful. Considering the available findings, the present study aims to introduce saffron as a prophylactic and therapeutic agent against gastrointestinal tract disorders. However, further clinical studies seem necessary in various aspects of saffron effects in different parts of body to verify these findings.


1. Jalali-Heravi M, Parastar H, Ebrahimi-Najafabadi H. Characterization of volatile components of Iranian saffron using factorial-based response surface modeling of ultrasonic extraction combined with gas chromatography–mass spectrometry analysis. J Chromatogr A 2009; 1216:6088-6097.

2. Caballero-Ortega H, Pereda-Miranda R, Abdullaev FI. HPLC quantification of major active components from 11 different saffron (Crocus sativus L.) sources. Food Chem 2007; 100:1126-1131.

3. Bathaie SZ, Mousavi SZ. New applications and mechanisms of action of saffron and its important ingredients. Crit Rev Food Sci 2010; 50:761-786.

4. Hosseinzadeh H, Ziaee T, Sadeghi A. The effect of saffron, Crocus sativus stigma, extract and its constituents, safranal and crocin on sexual behaviors in normal male rats. Phytomedicine 2008; 15:491-495.

5. Rios J, Recio M, Giner R, Manez S. An update review of saffron and its active constituents. Phytother Res 1996; 10:189-193.

6. Hariri AT, Moallem SA, Mahmoudi M, Memar B, Hosseinzadeh H. Sub-acute effects of diazinon on biochemical indices and specific biomarkers in rats: protective effects of crocin and safranal. Food Chem Toxicol 2010; 48:2803-2808.

7. Moghaddasi MS. Saffron chemicals and medicine usage. J Med Plants Res 2010; 4:427-430.

8. Kianbakht S. A systematic review on pharmacology of saffron and its active constituents. J Med Plants Res 2008; 7:1-2.

9. Gresta F, Lombardo G, Siracusa L, Ruberto G. Saffron, an alternative crop for sustainable agricultural systems: a review. Agron Sustain Dev 2008; 28:95-112.

10. Hosseinzadeh H. Saffron: herbal medicine of third millennium. Jundishapur J Nat Pharm Prod 2014; 9:1-2.

11. Hosseinzadeh H, Behravan J, Ramezani M, Ajgan Kh. Anti-tumor and cytotoxic evaluation of Crocus sativus L. stigma and petal extracts using brine shrimp and potato disc assays. J Med Plants Res 2005; 4:59-65.

12. Amin B, Hosseinzadeh H. Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats. Fitoterapia 2012; 83:888-895.

13. Srivastava R, Ahmed H, Dixit R. Crocus sativus L.: a comprehensive review. Pharmacogn Rev 2010; 4:200.

14. Hosseinzadeh H, Sadeghnia HR, Ziaee T, Danaee A. Protective effect of aqueous saffron extract (Crocus sativus L.) and crocin, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats. J Pharm Pharm Sci 2005; 8:387-393.

15. Jagadeeswaran R, Thirunavukkarasu C, Gunasekaran P, Ramamurty N, Sakthisekaran D. In vitro studies on the selective cytotoxic effect of crocetin and quercetin. Fitoterapia 2000; 71:395-399.

16. Moshiri M, Vahabzadeh M, Hosseinzadeh H. Clinical applications of saffron (Crocus sativus) and its constituents: a review. Drug Res 2014; 64:1-9.

17. Hosseinzadeh H, Ghenaati J. Evaluation of the antitussive effect of stigma and petals of saffron (Crocus sativus) and its components, safranal and crocin in guinea pigs. Fitoterapia 2006; 77:446-448.

18. Nilakshi N, Gadiya RV, Abhyankar M, Champalal KD. Detailed profile of Crocus sativus. Int J Pharmacogn 2011; 2:530-540.

19. Tabatabai SM, Dashti S, Doosti F, Hosseinzadeh H. Phytotherapy of opioid dependence and withdrawal syndrome: a Review. Phytother Res 2014; 28:811-830.

20. Boskabady Ma, Aslani M. Relaxant effect of Crocus sativus (saffron) on guinea‐pig tracheal chains and its possible mechanisms. J Pharm Pharmacol 2006; 58:1385-1390.

21. Zamani Taghizadeh Rabe S, Sahebari M, Mahmoudi Z, Hosseinzade H, Haghmorad D, Tabasi N, et al. Inhibitory effect of Crocus sativus L. ethanol extract on adjuvant-induced arthritis. Food Agr Immunol 2015; 26:170-180.

22. Bolhassani A, Khavari A, Bathaie SZ. Saffron and natural carotenoids: biochemical activities and anti-tumor effects. BBA-Rev Cancer 2014; 1845:20-30.

23. Hosseinzadeh H, Modaghegh MH, Saffari Z. Crocus sativus L. (saffron) extract and its active constituents (crocin and safranal) on ischemia-reperfusion in rat skeletal muscle. Evid-Based Compl Alt 2009; 6:343-350.

24. Hosseinzadeh H, Talebzadeh F. Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice. Fitoterapia 2005; 76:722-724.

25. Hosseinzadeh H, Sadeghnia HR. Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: Involvement of GABAergic and opioids systems. Phytomedicine 2007; 14:256-262.

26. Hosseinzadeh H, Khosravan V. Anticonvulsant effects of aqueous and ethanolic extracts of Crocus sativus L. stigmas in mice. Arch Iran Med 2002; 5:44-47.

27. Rezaee R, Hosseinzadeh H. Safranal: from an aromatic natural product to a rewarding pharmacological agent. Iran J Basic Med Sci 2013; 16:12-26.

28. Hosseinzadeh H, Motamedshariaty V, Hadizadeh F. Antidepressant effect of kaempferol, a constituent of saffron (Crocus sativus) petal, in mice and rats. Pharmacologyonline 2007; 2:367-370.

29. Ghasemi T, Abnous K, Vahdati F, Mehri S, Razavi BM, Hosseinzadeh H. Antidepressant effect of Crocus sativus aqueous extract and its effect on CREB, BDNF, and VGF transcript and protein levels in rat hippocampus. Drug Res 2015; 65:337-343.

30. Vahdati Hassani F, Naseri V, Razavi BM, Mehri S, Abnous K, Hosseinzadeh H. Antidepressant effects of crocin and its effects on transcript and protein levels of CREB, BDNF, and VGF in rat hippocampus. J Pharm Sci 2014; 22:16.

31. Hosseinzadeh H, Karimi G, Niapoor M. Antidepressant effect of Crocus sativus L. stigma extracts and their constituents, crocin and safranal, in mice. Acta Hortic 2004; 650:435-445.

32. Mehri S, Abnous K, Mousavi SH, Shariaty VM, Hosseinzadeh H. Neuroprotective effect of crocin on acrylamide-induced cytotoxicity in PC12 cells. Cell Mol Neurobiol 2012; 32:227-235.

33. Tashakori-Sabzevar F, Hosseinzadeh H, Motamedshariaty VS, Movassaghi AR, Mohajeri SA. Crocetin attenuates spatial learning dysfunction and hippocampal injury in a model of vascular dementia. Curr Neurovasc Res 2013; 10:325-334.

34. Hosseinzadeh H, Noraei NB. Anxiolytic and hypnotic effect of Crocus sativus aqueous extract and its constituents, crocin and safranal, in mice. Phytother Res 2009; 23:768-774.

35. Hosseinzadeh H, Sadeghnia HR, Ghaeni FA, Motamedshariaty VS, Mohajeri SA. Effects of saffron (Crocus sativus L.) and its active constituent, crocin, on recognition and spatial memory after chronic cerebral hypoperfusion in rats. Phytother Res 2012; 26:381-386.

36. Hosseinzadeh H, Jahanian Z. Effect of Crocus sativus L. (saffron) stigma and its constituents, crocin and safranal, on morphine withdrawal syndrome in mice. Phytother Res 2010; 24:726-730.

37. Mehdizadeh R, Parizadeh MR, Khooei AR, Mehri S, Hosseinzadeh H. Cardioprotective effect of saffron extract and safranal in isoproterenol-induced myocardial infarction in wistar rats. Iran J Basic Med Sci 2013; 16:56-63.

38. Razavi BM, Hosseinzadeh H, Movassaghi AR, Imenshahidi M, Abnous K. Protective effect of crocin on diazinon induced cardiotoxicity in rats in subchronic exposure. Chem-Biol Interact 2013; 203:547-555.

39. He SY, Qian ZY, Tang FT, Wen N, Xu GL, Sheng L. Effect of crocin on experimental atherosclerosis in quails and its mechanisms. Life Sci 2005; 77:907-921.

40. Razavi M, Hosseinzadeh H, Abnous K, Motamedshariaty VS, Imenshahidi M. Crocin restores hypotensive effect of subchronic administration of diazinon in rats. Iran J Basic Med Sci 2013; 16:64-72.

41. Sheng L, Qian Z, Zheng S, Xi L. Mechanism of hypolipidemic effect of crocin in rats: crocin inhibits pancreatic lipase. Eur J Pharmacol 2006; 543:116-122.

42. Hariri AT, Moallem SA, Mahmoudi M, Hosseinzadeh H. The effect of crocin and safranal, constituents of saffron, against subacute effect of diazinon on hematological and genotoxicity indices in rats. Phytomedicine 2011; 18:499-504.

43. Ayatollahi H, Javan AO, Khajedaluee M, Shahroodian M, Hosseinzadeh H. Effect of Crocus sativus L. (saffron) on coagulation and anticoagulation systems in healthy volunteers. Phytother Res 2014; 28:539-543.

44. Modaghegh MH, Shahabian M, Esmaeili HA, Rajbai O, Hosseinzadeh H. Safety evaluation of saffron (Crocus sativus) tablets in healthy volunteers. Phytomedicine 2008; 15:1032-1037.

45. Hosseinzadeh H, Younesi HM. Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice. BMC Pharmacol 2002; 2:7.

46. Hosseinzadeh H, Shariaty VM. Anti-nociceptive effect of safranal, a constituent of Crocus sativus (saffron), in mice. Pharmacologyonline 2007; 2:498-503.

47. Schmidt M, Betti G, Hensel A. Saffron in phytotherapy: pharmacology and clinical uses. Wien Med Wochenschr 2007; 157:315-319.

48. Shamsa A, Hosseinzadeh H, Molaei M, Shakeri MT, Rajabi O. Evaluation of Crocus sativus L. (saffron) on male erectile dysfunction: a pilot study. Phytomedicine 2009; 16:690-693.

49. Alavizadeh SH, Hosseinzadeh H. Bioactivity assessment and toxicity of crocin: a comprehensive review. Food Chem Toxicol 2014; 64:65-80.

50. Golmohammadzadeh S, Imani F, Hosseinzadeh H, Jaafari MR. Preparation, characterization and evaluation of sun protective and moisturizing effects of nanoliposomes containing safranal. Iran J Basic Med Sci 2011; 14:521-533.

51. Golmohammadzadeh S, Jaafari MR, Hosseinzadeh H. Does saffron have antisolar and moisturizing effects? Iran J Pharm Res 2010; 9:133-140.

52. Mashmoul M, Azlan A, Yusof BNM, Khaza'ai H, Mohtarrudin N, Boroushaki MT. Effects of saffron extract and crocin on anthropometrical, nutritional and lipid profile parameters of rats fed a high fat diet. J Funct Foods 2014; 8:180-187.

53. Liu TZ, Qian ZY. Pharmacokinetics of crocetin in rats. Acta Pharm Sin B 2002; 37:367-369.

54. Chryssanthi DG, Lamari FN, Georgakopoulos CD, Cordopatis P. A new validated SPE-HPLC method for monitoring crocetin in human plasma-application after saffron tea consumption. J Pharm Biomed Anal 2011; 55:563-568.

55. Mohammadpour AH, Ramezani M, Tavakoli Anaraki N, Malaekeh-Nikouei B, Amel Farzad S, Hosseinzadeh H. Development and validation of HPLC method for determination of crocetin, a constituent of saffron, in human serum samples. Iran J Basic Med Sci 2013; 16:47-56.

56. Jin YY, Zhang JS, Zhang Y, Zhang YH. Studies on the intestinal absorption of crocin in rats and determination of the partition coefficient. J China Pharmac Univ 2004; 35:283-284.

57. Hirota S, Takahama U. Starch can inhibit nitrite-dependent oxidation of crocin in gastric lumen increasing bioavailability of carotenoids. Food Sci Technol Res 2013; 19:1121-1126.

58. Xi L, Qian Z, Du P, Fu J. Pharmacokinetic properties of crocin (crocetin digentiobiose ester) following oral administration in rats. Phytomedicine 2007; 14:633-636.

59. Zhang Y, Liu JX, Lin L, Li LQ. Pharmacokinetics of crocin-1 after oral administration in rats. Chin. Pharm. J 2012; 47:136-140.

60. Li XY, Feng WL, Zhu JB, Nima CR, Ge RL. Effect of Tibetan medicine Zuotai on in vivo pharmacokinetics of crocin-1 in rats. Zhong Cao Yao 2009; 40:1425-1428.

61. Asai A, Nakano T, Takahashi M, Nagao A. Orally administered crocetin and crocins are absorbed into blood plasma as crocetin and its glucuronide conjugates in mice. J Agr Food Chem 2005; 53:7302-7306.

62. Hosseinzadeh H, Nassiri‐Asl M. Avicenna's (Ibn Sina) the Canon of Medicine and saffron (Crocus sativus): a review. Phytother Res 2013; 27:475-483.

63. Inoue E, Shimizu Y, Shoji M, Tsuchida H, Sano Y, Ito C. Pharmacological properties of N-095, a drug containing red ginseng, polygala root, saffron, antelope horn and aloe wood. Am J Chinese Med 2005; 33:49-60.

64. Nabavizadeh F, Salimi E, Sadroleslami Z, Karimian SM, Vahedian J. Saffron (Crocus sativus) increases gastric acid and pepsin secretions in rats: role of nitric oxide (NO). Afr J Pharm Pharmaco 2009; 3:181-184.

65. Al-Mofleh IA, Alhaider AA, Mossa JS, Al-Sohaibani, MO, Qureshi S, Rafatullah S. Antigastric ulcer studies on 'saffron' Crocus sativus L. in rats. Pak J Biol Sci 2006; 9:1009-1013.

66. He K, Si P, Wang H, Tahir U, Chen K, Xiao J, et al. Crocetin induces apoptosis of BGC-823 human gastric cancer cells. Mol Med Rep 2014; 9:521-526.

67. Bathaie SZ, Hoshyar R, Miri H, Sadeghizadeh M. Anticancer effects of crocetin in both human adenocarcinoma gastric cancer cells and rat model of gastric cancer. Biochem Cell Biol 2013; 91:397-403.

68. Hoshyar R, Bathaie SZ, Sadeghizadeh M. Crocin triggers the apoptosis through increasing the Bax/Bcl-2 ratio and caspase activation in human gastric adenocarcinoma, AGS, cells. DNA Cell Biol 2013; 32:50-57.

69. Anthea M, Hopkins J, William McLaughlin C, Johnson S, Quon Warner M, LaHart D, D. Wright J. Human biology and health. 1993; ISBN 0-13-981176-1.

70. Shamsi Bh, Sharifian A, Esmaeili S, Minaei B. Paper: hepatoprotective herbs, Avicenna viewpoint. Iran Red Crescent Med J 2014; 16: e12313.

71. Modaresi M, Messripour M, Marghmaleki MA. Effect of saffron extract on proteins biochemical parameter of serum. Asian J Chem 2010; 22:1939-1943.

72. Rahbani M, Mohajeri D, Rezaie A, Nazeri M. Protective effect of ethanolic extract of saffron (dried stigmas of Crocus sativus L.) on hepatic tissue injury in streptozotocin-induced diabetic rats. J Anim Vet Adv 2012; 11:1985-1994.

73. Farahmand SK, Samini F, Samini M, Samarghandian S. Safranal ameliorates antioxidant enzymes and suppresses lipid peroxidation and nitric oxide formation in aged male rat liver. Biogerontology 2013; 14:63-71.

74. Ramadan A, Soliman G, Mahmoud SS, Nofal SM, Abdel-Rahman RF. Evaluation of the safety and antioxidant activities of Crocus sativus and Propolis ethanolic extracts. J. Saudi Chem. Soc 2012; 16:13-21.

75. Chen Y, Yang T, Huang J, Tian X, Zhao C, Cai L, et al. Comparative evaluation of the antioxidant capacity of crocetin and crocin in vivo. Chin Pharm Bull 2010; 26:248-251.

76. Bandegi AR, Vafaei Abbas A, Ghaderdoost B, Rashidy-Pour A. Protective effects of Crocus sativus L. extract and crocin against chronic-stress induced oxidative damage of brain, liver and kidneys in rats. Adv Pharm Bull 2014; 4:493-499.

77. Lari P, Rashedinia M, Abnous K, Hosseinzadeh H. Crocin improves lipid dysregulation in subacute diazinon exposure through ERK1/2 pathway in rat liver. Drug Res 2014; 64:301-305.

78. Lari P, Abnous K, Imenshahidi M, Rashedinia M, Razavi M, Hosseinzadeh H. Evaluation of diazinon-induced hepatotoxicity and protective effects of crocin. Toxicol Ind Health 2015; 31:367-376.

79. Pan TL, Wu TH, Wang PW, Leu YL, Sintupisut N, Huang CH, et al. Functional proteomics reveals the protective effects of saffron ethanolic extract on hepatic ischemia‐reperfusion injury. Proteomics 2013; 13:2297-2311.

80. Noureini SK, Wink M. Antiproliferative effects of crocin in HepG2 cells by telomerase inhibition and hTERT down-regulation. Asian Pac J Cancer Prev 2012; 13:2305-2309.

81. Yang R, Vernon K, Thomas A, Morrison D, Qureshi N, Van Way CW. Crocetin reduces activation of hepatic apoptotic pathways and improves survival in experimental hemorrhagic shock. Jpen-Parenter Enter 2011; 35:107-113.

82. Amin A, Hamza AA, Bajbouj K, Ashraf SS, Daoud S. Saffron: a potential candidate for a novel anticancer drug against hepatocellular carcinoma. Hepatology 2011; 54:857-867.

83. Sun Y, Yang J, Wang L, Sun L, Dong Q. Crocin attenuates cisplatin-induced liver injury in the mice. Hum Exp Toxicol 2013; 33:855-862.

84. Jnaneshwari S, Hemshekhar M, Santhosh MS, Sunitha K, Thushara R, Thirunavukkarasu C, et al. Crocin, a dietary colorant mitigates cyclophosphamide‐induced organ toxicity by modulating antioxidant status and inflammatory cytokines. J Pharm Pharmacol 2013; 65:604-614.

85. Tavakkol-Afshari J, Brook A, Mousavi SH. Study of cytotoxic and apoptogenic properties of saffron extract in human cancer cell lines. Food Chem Toxicol 2008; 46:3443-3447.

86. Parizadeh MR, Ghafoori Gharib F, Abbaspour AR, Tavakol Afshar J, Ghayour-Mobarhan M. Effects of aqueous saffron extract on nitric oxide production by two human carcinoma cell lines: hepatocellular carcinoma (HepG2) and laryngeal carcinoma (Hep2). Phytomedicine 2011; 1:43-50.

87. Rongjie Yang, Vernon K, Thomas A, Morrison D, Qureshi N, Van Way CW. Crocetin reduces activation of hepatic apoptotic pathways and improves survival in experimental hemorrhagic shock. Jpen-Parenter Enter 2011; 35:107-113.

88. Iranshahi M, Khoshangosht M, Mohammadkhani Z, Karimi G. Protective effects of aqueous and ethanolic extracts of saffron stigma and petal on liver toxicity induced by carbon tetrachloride in mice. Pharmacologyonline 2011; 1:203-212.

89. Wang CJ, Shiow SJ, Lin JK. Effects of crocetin on the hepatotoxicity and hepatic DNA binding of aflatoxin B1 in rats. Carcinogenesis 1991; 12:459-462.

90. Shati AA, Alamri SA. Role of saffron (Crocus sativus L.) and honey syrup on aluminum-induced hepatotoxicity. Saudi Med J 2010; 31:1106-1113.

91. Hosseinzadeh H, Abootorabi A, Sadeghnia HR. Protective effect of Crocus sativus stigma extract and crocin (trans-crocin 4) on methyl methanesulfonate–induced DNA damage in mice organs. DNA Cell Biol 2008; 27:657-664.

92. Hosseinzadeh H, Sadeghnia HR. Effect of safranal, a constituent of Crocus sativus (saffron), on methyl methanesulfonate (MMS)-induced DNA damage in mouse organs: an alkaline single-cell gel electrophoresis (comet) assay. DNA Cell Biol 2007; 26:841-846.

93. Shi Y, Sheng L, Qian ZY, Chen Z. Beneficial effects of crocetin on alcoholic fatty liver in rats and the mechanism. Chin J New Drugs 2008; 17:2115-2118.

94. Asdaq SMB, Inamdar MN. Potential of Crocus sativus (saffron) and its constituent, crocin, as hypolipidemic and antioxidant in rats. Appl Biochem Biotech 2010; 162:358-372.

95. Bajbouj K, Schulze-Luehrmann J, Diermeier S, Amin A, Schneider-Stock R. The anticancer effect of saffron in two p53 isogenic colorectal cancer cell lines. BMC Complem Altern M 2012; 12:69-78.

96. Li CY, Huang WF, Wang QL, Wang F, Cai E, Hu B, et al. Crocetin induces cytotoxicity in colon cancer cells via p53-independent mechanisms. Asian Pac J Cancer P 2012; 13:3757-3761.

97. Garc-Olmo DC, Riese HH, Escribano J, Ontan J, Fernandez JA, Atiénzar M, et al. Effects of long-term treatment of colon adenocarcinoma with crocin, a carotenoid from saffron (Crocus sativus L.): an experimental study in the rat. Adv Exp Med Biol 1999; 35:120-126.

98. Rastgoo M, Hosseinzadeh H, Alavizadeh H, Abbasi A, Ayati Z, Jaafari MR. Antitumor activity of PEGylated nanoliposomes containing crocin in mice bearing C26 colon carcinoma. Planta Med 2013; 79:447-451.

99. Aung H, Wang C, Ni M, Fishbein A, Mehendale S, Xie J, et al. Crocin from Crocus sativus possesses significant anti-proliferation effects on human colorectal cancer cells. Exp Oncol 2007; 29:175-180.

100. Kazi HA, Qian Z. Crocetin reduces TNBS-induced experimental colitis in mice by downregulation of NFkB. Saudi J Gastroenterol 2009; 15:181-187.

101. Kawabata K, Tung NH, Shoyama Y, Sugie S, Mori T, Tanaka T. Dietary crocin inhibits colitis and colitis-associated colorectal carcinogenesis in male ICR mice. Evid-Based Compl Alt 2012; 2012: 820415.

102. Sheng L, Qian Z, Shi Y, Yang L, Xi L, Zhao B, et al. Crocetin improves the insulin resistance induced by high‐fat diet in rats. Brit J Pharmacol 2008; 154:1016-1024.

103. Xi L, Qian Z, Shen X, Wen N, Zhang Y. Crocetin prevents dexamethasone-induced insulin resistance in rats. Planta Med 2005; 71:917-922.

104. Xi L, Qian Z, Xu G, Zheng S, Sun S, Wen N, et al. Beneficial impact of crocetin, a carotenoid from saffron, on insulin sensitivity in fructose-fed rats. J Nutr Biochem 2007; 18:64-72.

105. Mohajeri D, Mousavi G, Doustar Y. Antihyperglycemic and pancreas-protective effects of Crocus sativus L. (saffron) stigma-ethanolic extract on rats with alloxan-induced diabetes. J Biol Sci 2009; 9:302-310.

106. Rajaei Z, Hadjzadeh MAR, Nemati H, Hosseini M, Ahmadi M, Shafiee S. Antihyperglycemic and antioxidant


activity of crocin in streptozotocin-induced diabetic rats. J Med Food 2013; 16:206-210.

107. Bajerska J, Mildner-Szkudlarz S, Podgórski T, Oszmatek-Pruszyńska E. Saffron (Crocus sativus L.) powder as an ingredient of rye bread: an anti-diabetic evaluation. J Med Food 2013; 16:847-856.

108. Bakshi H, Sam S, Rozati R, Sultan P, Islam T, Rathore B, et al. DNA fragmentation and cell cycle arrest: a hallmark of apoptosis induced by crocin from kashmiri saffron in a human pancreatic cancer cell line. Asian Pac J Cancer P 2010; 11:675-679.

109. Dhar A, Mehta S, Dhar G, Dhar K, Banerjee S, Van Veldhuizen P, et al. Crocetin inhibits pancreatic cancer cell proliferation and tumor progression in a xenograft mouse model. Mol Cancer Ther 2009; 8:315-323.

110. Fatehi M, Rashidabady T, Fatehi-Hassanabad Z. Effects of Crocus sativus petals' extract on rat blood pressure and on responses induced by electrical field stimulation in the rat isolated vas deferens and guinea-pig ileum. J Ethnopharmacol 2003; 84:199-203.