Apoptosis Induced by 13-S-hydroxyoctadecadienoic acid in the Breast Cancer Cell Lines, MCF-7 and MDA-MB-231

Document Type: Original Article


Department of Clinical Biochemistry, Cancer Research Laboratory, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran


1. Lambrechts S, Decloedt J, Neven P. Breast cancer prevention: Lifestyle

changes and chemoprevention. Acta Clin Belg 2011; 66:283-


2. Kasibhatla S, Tseng B. Why target apoptosis in cancer treatment?

Mol Cancer Ther 2003; 2:573-580.

3. Brash AR. Lipoxygenases: Occurrence, functions, catalysis, and acquisition

of substrate. J Biol Chem 1999; 274:23679-23682.

4. Brash AR, Jisaka M, Boeglin WE, Chang MS, Keeney DS, Nanney LB,







Investigation of a second 15s-lipoxygenase in humans and its

expression in epithelial tissues. Adv Exp Med Biol 1999; 469:83-




5. Shureiqi I, Wojno KJ, Poore JA, Reddy RG, Moussalli MJ, Spindler





et al

. Decreased 13-s-hydroxyoctadecadienoic acid levels and

15-lipoxygenase-1 expression in human colon cancers. Carcinogenesis


1999; 20:1985-1995.


6. Yuan H, Li MY, Ma LT, Hsin MK, Mok TS, Underwood MJ, Chen GG.


15-lipoxygenases and its metabolites 15(s)-hete and 13(s)-hode


in the development of non-small cell lung cancer. Thorax 2010;




7. Nixon JB, Kim KS, Lamb PW, Bottone FG, Eling TE. 15-lipoxygenase-1


has anti-tumorigenic effects in colorectal cancer. Prostaglandins


Leukot Essent Fatty Acids 2004; 70:7-15.


8. Xu XC, Shappell SB, Liang Z, Song S, Menter D, Subbarayan V,




et al.


. Reduced 15s-lipoxygenase-2 expression in esophageal cancer

specimens and cells and upregulation

in vitro

by the cyclooxygenase-

2 inhibitor, ns398. Neoplasia 2003; 5:121-127.


9. Hennig R, Kehl T, Noor S, Ding XZ, Rao SM, Bergmann F,



et al.


15-lipoxygenase-1 production is lost in pancreatic cancer and


overexpression of the gene inhibits tumor cell growth. Neoplasia


2007; 9:917-926.


10. Jiang WG, Watkins G, Douglas-Jones A, Mansel RE. Reduction of isoforms


of 15-lipoxygenase (15-lox)-1 and 15-lox-2 in human breast


cancer. Prostaglandins Leukot Essent Fatty Acids 2006; 74:235-




11. Shureiqi I, Chen D, Lee JJ, Yang P, Newman RA, Brenner DE,



et al


15-lox-1: A novel molecular target of nonsteroidal anti-inflammatory


drug-induced apoptosis in colorectal cancer cells. J Natl


Cancer Inst 2000; 92:1136-1142.


12. Hsi LC, Xi X, Lotan R, Shureiqi I, Lippman SM. The histone deacetylase


inhibitor suberoylanilide hydroxamic acid induces apoptosis


via induction of 15-lipoxygenase-1 in colorectal cancer cells.


Cancer Res 2004; 64:8778-8781.


13. Kumar KA, Arunasree KM, Roy KR, Reddy NP, Aparna A, Reddy GV,


Reddanna P. Effects of (15s)-hydroperoxyeicosatetraenoic acid


and (15s)-hydroxyeicosatetraenoic acid on the acute- lymphoblastic-


leukaemia cell line jurkat: Activation of the fas-mediated


death pathway. Biotechnol Appl Biochem 2009; 52:121-133.


14. Shureiqi I, Chen D, Lotan R, Yang P, Newman RA, Fischer SM,









15-lipoxygenase-1 mediates nonsteroidal anti-inflammatory

drug-induced apoptosis independently of cyclooxygenase-2 in


colon cancer cells. Cancer Res 2000; 60:6846-6850.


15. Shureiqi I, Wu Y, Chen D, Yang XL, Guan B, Morris JS,



et al

. The critical

role of 15-lipoxygenase-1 in colorectal epithelial cell terminal


differentiation and tumorigenesis. Cancer Res 2005; 65:11486-




16. Pasqualini ME, Heyd VL, Manzo P, Eynard AR. Association between


e-cadherin expression by human colon, bladder and breast cancer


cells and the 13-hode:15-hete ratio. A possible role of their


metastatic potential. Prostaglandins Leukot Essent Fatty Acids


2003; 68:9-16.


17. Cimen I, Tuncay S, Banerjee S. 15-lipoxygenase-1 expression suppresses


the invasive properties of colorectal carcinoma cell lines


hct-116 and ht-29. Cancer Sci 2009; 100:2283-2291.


18. Youssef J, Badr M. Peroxisome proliferator-activated receptors


and cancer: Challenges and opportunities. Br J Pharmacol




19. Chawla A, Repa JJ, Evans RM, Mangelsdorf DJ. Nuclear receptors


and lipid physiology: Opening the x-files. Science 2001; 294:1866-




20. Foreman JE, Sharma AK, Amin S, Gonzalez FJ, Peters JM. Ligand


activation of peroxisome proliferator-activated receptor-beta/


delta (pparbeta/delta) inhibits cell growth in a mouse mammary


gland cancer cell line. Cancer Lett 2010; 288:219-225.


21. Zuo X, Wu Y, Morris JS, Stimmel JB, Leesnitzer LM, Fischer SM,









. Oxidative metabolism of linoleic acid modulates ppar-beta/

delta suppression of ppar-gamma activity. Oncogene 2006;




22. Sigal E, Grunberger D, Highland E, Gross C, Dixon RA, Craik CS.


Expression of cloned human reticulocyte 15-lipoxygenase and


immunological evidence that 15-lipoxygenases of different cell




13(S)-HODE Tavakoli-Yaraki M et al

Iran J Basic Med Sci; Vol. 16, No. 4, Apr 2013

types are related. J Biol Chem 1990; 265:5113-5120.

23. Mahipal SV, Subhashini J, Reddy MC, Reddy MM, Anilkumar K, Roy


et al

. Effect of 15-lipoxygenase metabolites, 15-(s)-hpete and

15-(s)-hete on chronic myelogenous leukemia cell line k-562: Reactive


oxygen species (ros) mediate caspase-dependent apoptosis.


Biochem Pharmacol 2007; 74:202-214.


24. Kim JH, Chang JH, Yoon JH, Lee JG, Bae JH, Kim KS. 15-lipoxygenase-1


induced by interleukin-4 mediates apoptosis in oral cavity cancer


cells. Oral Oncol 2006; 42:825-830.


25. Viita H, Pacholska A, Ahmad F, Tietavainen J, Naarala J, Hyvarinen





et al.

15-lipoxygenase-1 induces lipid peroxidation and apoptosis,

and improves survival in rat malignant glioma.



In Vivo




26. Glinghammar B, Skogsberg J, Hamsten A, Ehrenborg E. Ppardelta


activation induces cox-2 gene expression and cell proliferation


in human hepatocellular carcinoma cells. Biochem Biophys Res


Commun 2003; 308:361-368.


27. Stephen RL, Gustafsson MC, Jarvis M, Tatoud R, Marshall BR, Knight





et al

. Activation of peroxisome proliferator-activated receptor

delta stimulates the proliferation of human breast and prostate


cancer cell lines. Cancer Res 2004; 64:3162-3170.


28. Yin Y, Russell RG, Dettin LE, Bai R, Wei ZL, Kozikowski AP,



et al

. Peroxisome

proliferator-activated receptor delta and gamma agonists


differentially alter tumor differentiation and progression during


mammary carcinogenesis. Cancer Res 2005; 65:3950-3957.


29. Ghosh M, Ai Y, Narko K, Wang Z, Peters JM, Hla T. Ppardelta is protumorigenic


in a mouse model of cox-2-induced mammary cancer.


Prostaglandins Other Lipid Mediat 2009; 88:97-100.


30. Glasgow WC, Hui R, Everhart AL, Jayawickreme SP, Angerman-


Stewart J, Han BB,



et al.

The linoleic acid metabolite, (13s)-hydroperoxyoctadecadienoic

acid, augments the epidermal growth


factor receptor signaling pathway by attenuation of receptor


dephosphorylation. Differential response in syrian hamster embryo


tumor suppressor phenotypes. J Biol Chem 1997; 272:19269-




31. Sauer LA, Dauchy RT, Blask DE, Armstrong BJ, Scalici S. 13-hydroxyoctadecadienoic


acid is the mitogenic signal for linoleic


acid-dependent growth in rat hepatoma 7288ctc



in vivo

. Cancer

Res 1999; 59:4688-4692.


32. Kelavkar UP, Cohen C, Kamitani H, Eling TE, Badr KF. Concordant


induction of 15-lipoxygenase-1 and mutant p53 expression in human


prostate adenocarcinoma: Correlation with gleason staging.


Carcinogenesis 2000; 21:1777-1787.


33. Kelavkar UP, Nixon JB, Cohen C, Dillehay D, Eling TE, Badr KF. Overexpression


of 15-lipoxygenase-1 in pc-3 human prostate cancer


cells increases tumorigenesis. Carcinogenesis 2001; 22:1765-1773.