Evaluation of HTLV-I and HCV Prevalence in Non-Hodgkin’s Lymphoma

Document Type: Original Article


1 Immunology Research Centre, BuAli Research Institute, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2 Department of Pathology, Imam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


Jeang KT, Widen SG, Semmes OJ , Wilson SH .HTLV-I trans-acting

protein tax is a trans-repressor of the human Beta-polymerase

gene. Science 1990; 247:1082-1084.

2. Manns A, Cleghorn FR, Falk RT, Hanchard B, Jaffe ES, Bartholomew


et al.

Role of HTLV-I in development of non-Hodgkin lymphoma

in Jamaica and Trinidad and Tobago. Lancet 1993; 342:1447-




3. Chindamo MC, Spector N, Segadas JA, Pimenta G, Vanderborght


B, Morais JC,



et al.

Prevalence of hepatitis C infection in patients

with non-Hodgkin lymphomas. Oncol Rep 2002; 9:657-659.


4. Rafatpanah H, Hedayati-Moghaddam MR, Fathimoghadam F,


Bidkhori HR, Shamsian SK, Ahmadi S,



et al

. High prevalence of

HTLV-I infection in Mashhad, Northeast Iran: a population-based


seroepidemiology survey. J Clin Virol 2011; 52:172-176.


5. Uchiyama T .Human T cell leukemia Virus type 1 (HTLV-I) and human


diseases. Annu Rev Immunol 1997; 15:15-37.


6. Jeang KT, Giam CZ, Majone M .Life,death and tax: role of HTLV-I


oncoprotein in genetic instability and cellular transformation. J


Biol Chem 2004; 27:31991-31994.


7. Yenice N, Gulluk F, Arican N, Turlman S .HCV prevalence in Hodgkin


and non-Hodgkin lymphoma cases. Turk J Gasteroenterol


2003; 14:173-176.



Table 1.


Histological characteristics of NHL lymphoma samples in this study

Place of resentment

Histological forms of NHL Number GI Tract Cervical lymphatic


Inguinal lymphatic


Other sites HTLV-I positive


HCV positive


Disseminated 32 9 10 3 10 8 3

Nodular 6 unidentified unidentified unidentified unidentified - -

Great cell lymphomas 5 - 4 - 1 - -

Low grade lymphomas 2 - - 1 1 - 1

Burkitt’s like lymphoma 1 - 1 - - 1 -

Atypical NHL 2 - - - 2 - -

NHL with mixed cellularity 5 - 3 - 2 1 -

Total 54 9 18 4 16 10 4


Rastin M et al HTLV-I and HCV Prevalence in NHL

Iran J Basic Med Sci; Vol. 16, No. 3, Mar 2013

8. El-Seraq HB, Hampel H, Yeh C, Rabeneck L .Extrahepatic manifestation

of hepatitis C amoung United states male veterans. Hepathol

2002; 36:1439-1445.

9. Flint M, Quinn ER, Levy S .In search of hepatitis C virus receptor(s).

Clin Liver Dis 2001; 5: 873-893.

10. Delaporte E, Klotz F, Peeters M, Martin-Prevel Y, Bedjabaga L,

Larouze B

, et al

. Non-Hodgkin lymphoma in Gabon and its relation

to HTLV-I. Int J Cancer 1993; 53:48-50.


11. Adedayo OA, Shehu SM .Human T-cell lymphotropic virus type 1


(HTLV-I) and lymphoid malignancies in Dominica: a seroprevalence


study. Am J Hematol 2004; 77:336- 339.


12. Laskus T, Radkowski M, Wang LF, Vargas H, Rakela J .Search for


hepatitis C virus extrahepatic replication sites in patients with


acquired immunodeficiency syndrome: specific detection of


negative-strand viral RNA in various tissues. Hepatology 1998;




13. Gisbert JP, Garcia-Buey L, Arranz R, Blas C, Pinilla I, Khorrami S,









The prevalence of hepatitis C virus infection in patients with

non-Hodgkin’s lymphoma. Eur J Gastroenterol Hepatol 2004;




14. Rabkin CS, Tess BH, Christianson RE, Wright WE, Waters DJ, Alter





et al.

Prospective study of hepatitis C viral infection as a risk

factor for subsequent B-cell neoplasia. Blood 2002; 99:4240-