Association between HLA Class I Alleles and Proviral Load in HTLV-I Associated Myelopathy/Tropical Spastic Paraperesis (HAM/TSP) Patients in Iranian Population

Document Type : Original Article

Authors

1 HTLV-I Foundation, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

2 Immunology Research Centre, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

3 Inflammation and inflammatory Disease Research Centre, Faculty of Medicine ,Mashhad University of Medical Sciences, Mashhad, Iran

4 Allergy Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

5 Immunology Research Centre, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran 3 Inflammation and inflammatory Disease Research Centre, Faculty of Medicine ,Mashhad University of Medical Sciences, Mashhad, Iran

Keywords

References

Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci 1980; 77:7415-7419.
2. Gessain A, Vernant J, Maurs L, Barin F, Gout O, Calender A. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet 1985; 326:407-410.
3. Osame M. HTLV-I-associated myelopathy; A new clinical entity. Lancet 1986; 1031-2.
4. Cartier LM, Cea JG, Vergara C, Araya F, Born P. Clinical and neuropathological study of six patients with spastic paraparesis associated with HTLV-I: an axomyelinic degeneration of the central nervous system. J Neuropathol ExpNeurol 1997; 56:403-413.
5. Kaplan JE, Osame M, Kubota H, Igata A, Nishitani H, Maeda Y,
et al.
The risk of development of HTLV-I-associated myelopathy/tropical spastic paraparesis among persons infected with HTLV-I. J. Acquir Immune Defic syndr 1990; 3:1096.
6. Vine AM, Heaps AG, Kaftantzi L, Mosley A, Asquith B, Witkover A,
 
 
et al
. The role of CTLs in persistent viral infection: cytolytic gene expression in CD8+ lymphocytes distinguishes between individuals with a high or low proviral load of human T cell lymphotropic virus type 1. J Immunol 2004; 173:5121-5129.
7. Azarpazhooh MR, Hasanpour K, Ghanbari M, Rezaee SAR, Mashkani B, Hedayati-Moghaddam MR,
 
 
et al
. Human T-lymphotropic virus type 1 prevalence in Northeastern Iran, Sabzevar: an epidemiologic-based study and phylogenetic analysis. AIDS Res Hum Rretroviruses 2012.
8. Bangham CRM, Osame M. Cellular immune response to HTLV-I. Oncogene 2005; 24:6035-6046.
 
9. Rafatpanah H, Pravica V, Farid Hosseini R, Tabatabaei A, Ollier W, Poulton K,
 
 
et al.
Association between HLA-DRB1* 01 and HLA-Cw* 08 and outcome following HTLV-I infection. Iran J Immunol 2007; 4:94-100.
10. Jeffery KJM, Siddiqui AA, Bunce M, Lloyd AL, Vine AM, Witkover AD,
 
 
et al.
The influence of HLA class I alleles and heterozygosity on the outcome of human T cell lymphotropic virus type I infection. J Immunol 2000; 165:7278-7284.
11. Kubota R, Hanada K, Furukawa Y, Arimura K, Osame M, Gojobori T,
 
 
et al. Genetic stability of human T lymphotropic virus type I despite antiviral pressures by CTLs. J Immunol
2007; 178:5966-5972.
12. Jeffery KJM, Usuku K, Hall SE, Matsumoto W, Taylor GP, Procter J,
 
 
et al.
HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy. Proc Natl Acad Sci 1999; 96:3848-3853.
13. Kubota R, Takenouchi N, Matsuzaki T, Takashima H, Izumo S. HLA-A24-restricted HTLV-I-specific CTL response reduces the HTLV-I proviral load but the HLA increases the risk of HAM/TSP. Retrovirol 2011; 8:A113.
 
14. Osame M, Blattner WA, editors. Review of WHO Kagoshima meeting and diagnostic guidelines for HAM/TSP1990: Retrovirol.
 
15. Rafatpanah H, Rezaee A, Etemadi MM, Hosseini RF, Khorram B, Afsahr L,
 
 
et al.
The impact of interferon-alpha treatment on clinical and immunovirological aspects of HTLV-I-associated myelopathy in northeast of Iran. J Neuroimmunol 2012.
16. Zetterquist H, Olerup O. Identification of the< i> HLA-DRB1
 
 
∗ 04,- DRB1∗ 07, and< i>-DRB1∗
09 Alleles by PCR Amplification with sequence-specific primers (PCR-SSP) in 2 hr. Hum Immunol 1992; 34:64-74.
17. Allison A, editor. Polymorphism and natural selection in human populations. Cold Spring Harbor symposia on quantitative biology. Cold Spring Harb Lab Press; 1964.
 
18. Middleton D, Menchaca L, Rood H, Komerofsky R. New allele frequency database. Tissue antigens [serial online] 2003; 61:403- 407.Available at: http://www. allelefrequencies. net.
 
19. Gastaldello R, Iñiguez AM, Otsuki K, Lamas G, Balangero M, Barbas MG
 
 
, et al.
HTLV type 1 genetic types among native descendants in Argentina. AIDS Rres Hum Retrov 2008; 24:1139-1146.
20. Furukawa Y, Yamashita M, Usuku K, Izumo S, Nakagawa M, Osame M. Phylogenetic Subgroups of Human T Cell Lymphotropic Virus (HTLV) Type I in the tax Gene and Their Association with Different Risks for HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis. J Infect Dis 2000; 182:1343-1349.
 
 

Files

Share

How to cite

Statistics