Role of microRNAs in major brain diseases, focusing on neuroinflammation and neuronal apoptosis

Document Type : Review Article

Authors

1 Department of Emerging Allied Health Technologies, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan

2 Department of Physiology, Faculty of Life Sciences, Government College University Faisalabad, Faisalabad, Pakistan

10.22038/ijbms.2026.88184.19047

Abstract

MicroRNAs are non-coding small RNA molecules that play a significant role in regulating gene expression. Increasing lines of evidence have highlighted the microRNA dysregulation and neuroinflammation-associated apoptosis in common brain diseases, including Parkinson’s disease, Alzheimer’s disease, epilepsy, traumatic brain injury, depression, and migraine. In fact, microRNAs regulate multiple physiological and pathological processes, thus implicating them in both health and disease. Though studies have suggested that the alterations or modifications in microRNA-associated regulatory pathways might contribute to the disease pathogenesis, the underlying molecular mechanisms and the targeted genes remain exclusively unknown. We hope that the idea of using microRNAs as therapeutic targets for brain disorders is not far from reality, but important issues must be addressed before moving into clinical practice. The aim of this review is to enlighten the molecular mechanisms and targeted genes of microRNA implicated in the multifaceted brain disorders. Moreover, several microRNAs have been reported to be up-regulated following disease, but their targeted pathways have not been elucidated yet. This review also highlighted microRNAs that are expected to warrant further exploration of their mechanism of action. This comprehensive overview of the prediction of microRNAs’ functions might be helpful in providing more efficient insight for the development of microRNA-based therapeutic interventions for neuropsychiatric and neurodegenerative diseases.

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Main Subjects


1. Dwivedi S, Purohit P, Sharma P. MicroRNAs and diseases: Promising biomarkers for diagnosis and therapeutics. Indian J Clin Biochem 2019; 34: 243-245. 
2. Zhou H, Huang X, Cui H, Luo X, Tang Y, Chen S, et al. MiR-155 and its star-form partner miR-155* cooperatively regulate type I interferon production by human plasmacytoid dendritic cells. Blood 2010; 116: 5885-5994. 
3. O’Brien J, Hayder H, Zayed Y, Peng C. Overview of microRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol 2018; 9: 402.
4. Aziz N, Ruzza C, Falcicchia C, Guarino A, Soukupova M, Asth L, et al. Lack of direct effects of neurotrophic factors in an in vitro model of neuroinflammation. Int J Mol Sci 2024; 25: 4160. 
5. Yang Q qiao, Zhou J wei. Neuroinflammation in the central nervous system: Symphony of glial cells. Glia 2019; 67: 1017–1035. 
6. Gorji A. Neuroinflammation: The pathogenic mechanism of neurological disorders. Int J Mol Sci 2022; 23: 1-5. 
7. Hata A. Functions of microRNAs in cardiovascular biology and disease. Annu Rev Physiol 2013; 75: 69-93. 
8. Sakamoto K, Crowley JJ. A comprehensive review of the genetic and biological evidence supports a role for MicroRNA-137 in the etiology of schizophrenia. Am J Med Genet Part B Neuropsychiatr Genet 2018; 177: 242–256. 
9. Hussain G, Anwar H, Rasul A, Imran A, Qasim M, Zafar S, et al. Lipids as biomarkers of brain disorders. Crit Rev Food Sci Nut 2020; 60: 351-374. 
10. Zhang QS, Liu W, Lu GX. miR-200a-3p promotes β-Amyloid-induced neuronal apoptosis through down-regulation of SIRT1 in Alzheimer’s disease. J Biosci 2017; 42: 397-404. 
11. Kim SH, Choi KY, Park Y, McLean C, Park J, Lee JH, et al. Enhanced expression of microrna-1273g-3p contributes to alzheimer’s disease pathogenesis by regulating the expression of mitochondrial genes. Cells 2021; 10: 2697. 
12. Cheng Z, Zou X, Jin Y, Gao S, Lv J, Li B, et al. The role of KLF4 in Alzheimer’s disease. Fron Cell Neurosci 2018; 12: 325. 
13. Zhao K, Liu J, Sun T, Zeng L, Cai Z, Li Z, et al. The miR-25802/KLF4/NF-κB signaling axis regulates microglia-mediated neuroinflammation in Alzheimer’s disease. Brain Behav Immun 2024; 118: 31-48.
14. Badr A, Daily KP, Eltobgy M, Estfanous S, Tan MH, Chun-Tien Kuo J, et al. Microglia-targeted inhibition of miR-17 via mannose-coated lipid nanoparticles improves pathology and behavior in a mouse model of Alzheimer’s disease. Brain Behav Immun 2024; 119: 919-944.
15. Cong L, Cong Y, Feng N, Liang W, Wu Y. Up-regulated microRNA-132 reduces the cognition-damaging effect of sevoflurane on Alzheimer’s disease rats by inhibiting FOXA1. Genomics 2021; 113: 3644–3652. 
16. Du W, Lei C, Dong Y. Microrna-149 is down-regulated in alzheimer’s disease and inhibits β-amyloid accumulation and ameliorates neuronal viability through targeting bace1. Genet Mol Biol 2021; 44: 1–8. 
17. Pan K, Chen S, Wang Y, Yao W, Gao X. MicroRNA-23b attenuates tau pathology and inhibits oxidative stress by targeting GnT-III in Alzheimer’s disease. Neuropharmacology 2021; 196: 108671. 
18. Jiang Y, Xu B, Chen J, Sui Y, Ren L, Li J, et al. Micro-RNA-137 inhibits tau hyperphosphorylation in alzheimer’s disease and targets the CACNA1C gene in transgenic mice and human neuroblastoma SH-SY5Y cells. Med Sci Monit 2018; 24: 5635-5644. 
19. Liu Y, Zhang Y, Liu P, Bai H, Li X, Xiao J, et al. MicroRNA-128 knockout inhibits the development of Alzheimer’s disease by targeting PPARγ in mouse models. Eur J Pharmacol 2019; 843: 134-144. 
20. Higaki S, Muramatsu M, Matsuda A, Matsumoto K, Satoh J ichi, Michikawa M, et al. Defensive effect of microRNA-200b/c against amyloid-beta peptide-induced toxicity in Alzheimer’s disease models. PLoS One 2018; 13: 1-18. 
21. Lin Y, Liang X, Yao Y, Xiao H, Shi Y, Yang J. Osthole attenuates APP-induced Alzheimer’s disease through up-regulating miRNA-101a-3p. Life Sci 2019; 225: 117–131. 
22. Swingler TE, Niu L, Pontifex MG, Vauzour D, Clark IM. The microRNA-455 null mouse has memory deficit and increased anxiety, targeting key genes involved in Alzheimer’s disease. Int J Mol Sci 2022; 23: 554 
23. Kumar S, Hemachandra Reddy P. A new discovery of MicroRNA-455-3p in Alzheimer’s disease. J Alzheimer’s Dis 2019; 72: S117-130. 
24. Liang C, Zou T, Zhang M, Fan W, Zhang T, Jiang Y, et al. MicroRNA-146a switches microglial phenotypes to resist the pathological processes and cognitive degradation of Alzheimer’s disease. Theranostics 2021; 11: 4103–4121. 
25. Aquino R, de Concini V, Dhenain M, Lam S, Gosset D, Baquedano L, et al. Intrahippocampal inoculation of Aβ1–42 peptide in rat as a model of Alzheimer’s disease identified MicroRNA-146a-5p as blood marker with anti-inflammatory function in astrocyte cells. Cells 2023; 12: 694. 
26. Dey RK, Kumari R, Patra R, Soni DK, Biswas R, Patnaik S, Ghosh D. MicroRNA-129-5p-mediated translational repression of microglial ROCK1 leads to enhanced phagocytosis. J Biol Chem 2025; 301: 110293. 
27. Anwar S, Rivest S. Alzheimer’s disease: Microglia targets and their modulation to promote amyloid phagocytosis and mitigate neuroinflammation. Expert Opin Ther Targets 2020; 24: 331-344. 
28. Li R, Yao S, Wei F, Chen M, Zhong Y, Zou C, et al. Down-regulation of miR‑181c‑5p in Alzheimer’s disease weakens the response of microglia to Aβ phagocytosis. Sci Rep 2024; 14: 11487. 
29. Sun X, Deng Y, Ge P, Peng Q, Soufiany I, Zhu L, et al. Diminazene ameliorates neuroinflammation by suppression of astrocytic miRNA-224-5p/NLRP3 axis in Alzheimer’s disease model. J Inflamm Res 2023; 16: 1639-1652. 
30. Zhou L, Huang X, Li H, Wang J, Lu Z. Triptolide improves Alzheimer’s disease by regulating the NF‑κB signaling pathway through the lncRNA NEAT1/microRNA 361‑3p/TRAF2 axis. Exp Ther Med 2023; 26: 1-11. 
31. Yang LX, Luo M, Li SY.  Tanshinone IIA improves Alzheimer’s disease via RNA nuclear-enriched abundant transcript 1/microRNA-291a-3p/member RAS oncogene family Rab22a axis. World J Psychiatry 2024; 14: 563–581. 
32. Ren H, Qiu W, Zhu B, Li Q, Peng C, Chen X. The long non-coding RNA BDNF-AS induces neuronal cell apoptosis by targeting miR-125b-5p in Alzheimer’s disease models. Adv Clin Exp Med 2024; 33: 233-345. 
33. Lian X, Zhang X, Chen W, Xue F, Wang G. Dexmedetomidine mitigates neuroinflammation in an Alzheimer’s disease mouse model via the miR-204-3p/FBXL7 signaling axis. Brain Res 2024; 1822: 148612.
34. Cao J, Huang M, Guo L, Zhu L, Hou J, Zhang L, et al. MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer’s disease pathogenesis. Mol Psychiatry 2021; 26: 4687–4701. 
35. Nagaraj S, Want A, Laskowska-Kaszub K, Fesiuk A, Vaz S, Logarinho E, et al. Candidate Alzheimer’s disease biomarker mir-483-5p lowers tau phosphorylation by direct erk1/2 repression. Int J Mol Sci 2021; 22: 3653. 
36. Zhang YY, Dong LX, Bao HL, Liu Y, An FM, Zhang GW. Inhibition of interleukin-1β plays a protective role in Alzheimer’s disease by promoting microRNA-9-5p and down-regulating targeting protein for xenopus kinesin-like protein 2. Int Immunopharmacol 2021; 97: 107578. 
37. Xie Y, Xie D, Chen C. Hsa_circ_0049472 contributed to amyloid-beta peptide-induced neurotoxicity, apoptosis and inflammation via regulating PI3K-AKT signaling pathway by interacting with miR-22–3p/ZNF217 axis. Brain Res Bull 2024; 215: 111004. 
38. Su D, Chen Z, An X, Yang J, Yang J, Wang X, et al. MicroRNA-195 liposomes for therapy of Alzheimer’s disease. J Control Release 2024; 365: 583–601. 
39. Milanese C, Gabriels S, Barnhoorn S, Cerri S, Ulusoy A, Gornati SV, et al. Gender biased neuroprotective effect of Transferrin Receptor 2 deletion in multiple models of Parkinson’s disease. Cell Death Differ 2021; 28: 1720-1732
40. Gong X, Huang M, Chen L. Mechanism of miR-132-3p promoting neuroinflammation and dopaminergic neurodegeneration in Parkinson’s disease. eNeuro 2022; 9: 1-17. 
41. Zhang HQ, Wang JY, Li ZF, Cui L, Huang SS, Zhu LB, et al. DNA methyltransferase 1 is dysregulated in Parkinson’s disease via mediation of miR-17. Mol Neurobiol 2021; 58: 2620–2633. 
42. Lin X, Wang R, Li R, Tao T, Zhang D, Qi Y. Diagnostic performance of miR-485-3p in patients with Parkinson’s disease and its relationship with neuroinflammation. NeuroMolecular Med 2022; 24: 195-201.
43. Zhu J, Xu X, Liang Y, Zhu R. Down-regulation of microRNA-15b-5p targeting the Akt3-mediated GSK-3 β/β -catenin signaling pathway inhibits cell apoptosis in Parkinson’s disease. Biomed Res Int 2021; 2021: 8814862. 
44. Zhao J, Yang M, Li Q, Pei X, Zhu X. MiR-132-5p regulates apoptosis and autophagy in MPTP model of Parkinson’s disease by targeting ULK1. Neuroreport 2020; 31: 959-965. 
45. Sun L, Wang F, Han J, Bai L, DU J. Repetitive transcranial magnetic stimulation reduces neuronal loss and  neuroinflammation in parkinson’s disease through the miR-195a-5p/CREB axis. Turk Neurosurg 2023; 33: 229-237. 
46. Zhang L, Chen X, Chang M, Jiao B. MiR-30c-5p/ATG5 axis regulates the progression of Parkinson’s disease. Front Cell Neurosci 2021; 15: 644507.
47. Ammal Kaidery N, Ahuja M, Thomas B. Crosstalk between Nrf2 signaling and mitochondrial function in Parkinson’s disease. Mol Cell Neurosci 2019; 101: 103413
48. Lang Y, Zhang H, Yu H, Li Y, Liu X, Li M. Long non-coding RNA myocardial infarction-associated transcript promotes 1-Methyl-4-phenylpyridinium ion-induced neuronal inflammation and oxidative stress in Parkinson’s disease through regulating microRNA-221-3p/ transforming growth factor /nuclear fact. Bioengineered 2022; 13: 930–940. 
49. Zhang F, Yao Y, Miao N, Wang N, Xu X, Yang C. Neuroprotective effects of microRNA 124 in Parkinson’s disease mice. Arch Gerontol Geriatr 2022; 99: 104588. 
50. Wang D, Gao H, Qin Q, Li J, Zhao J, Qu Y, et al. MicroRNA-218-5p-Ddx41 axis restrains microglia-mediated neuroinflammation through down-regulating type I interferon response in a mouse model of Parkinson’s disease. J Transl Med 2024; 22: 1-14. 
51. Li T, Tan X, Tian L, Jia C, Cheng C, Chen X, et al. The role of Nurr1-miR-30e-5p-NLRP3 axis in inflammation-mediated neurodegeneration: insights from mouse models and patients’ studies in Parkinson’s disease. J Neuroinflammation 2023; 20: 1-19. 
52. Caggiu E, Paulus K, Mameli G, Arru G, Sechi G Pietro, Sechi LA. Differential expression of miRNA 155 and miRNA 146a in Parkinson’s disease patients. eNeurologicalSci 2018; 13: 1–4. 
53. Yao L, Ye Y, Mao H, Lu F, He X, Lu G, et al. MicroRNA-124 regulates the expression of MEKK3 in the inflammatory pathogenesis of Parkinson’s disease. J Neuroinflammation 2018; 15: 1-19. 
54. Xing RX, Li LG, Liu XW, Tian BX, Cheng Y. Down regulation of miR-218, miR-124, and miR-144 relates to Parkinson’s disease via activating NF-κB signaling. Kaohsiung J Med Sci 2020; 36: 786-792. 
55. Chen MY, Fan K, Zhao LJ, Wei JM, Gao JX, Li ZF. Long non-coding RNA nuclear enriched abundant transcript 1 (NEAT1) sponges microRNA-124-3p to up-regulate phosphodiesterase 4B (PDE4B) to accelerate the progression of Parkinson’s disease. Bioengineered 2021; 12: 708-719.
56. Watanabe R, Buschauer R, Böhning J, Audagnotto M, Lasker K, Lu TW, et al. The in situ structure of Parkinson’s disease-linked LRRK2. Cell 2020; 182: 1508-1518. 
57. Oliveira SR, Dionísio PA, Gaspar MM, Correia Guedes L, Coelho M, Rosa MM, et al. miR-335 targets LRRK2 and mitigates inflammation in Parkinson’s disease. Front Cell Dev Biol 2021; 9: 661461. 
58. Bai X, Dong Q, Zhao L, Yao Y, Wang B. microRNA-106b-containing extracellular vesicles affect autophagy of neurons by regulating CDKN2B in Parkinson’s disease. Neurosci Lett 2021; 760: 136094.
59. Sherbaf FG, Mohajer B, Ashraf-Ganjouei A, Zadeh MM, Javinani A, Moghaddam HS, et al. Serum insulin-like growth factor-1 in Parkinson’s disease; study of cerebrospinal fluid biomarkers and white matter microstructure. Front Endocrinol 2018; 9: 608. 
60. Qin X, Zhang X, Li P, Wang M, Yan L, Pan P, et al. MicroRNA-185 activates PI3K/AKT signalling pathway to alleviate dopaminergic neuron damage via targeting IGF1 in Parkinson’s disease. J Drug Target 2021; 29: 875–883. 
61. Yang X, Zhang M, Wei M, Wang A, Deng Y, Cao H. MicroRNA-216a inhibits neuronal apoptosis in a cellular Parkinson’s disease model by targeting Bax. Metab Brain Dis 2020; 35: 627-635. 
62. Li H, Yu L, Li M, Chen X, Tian Q, Jiang Y, et al. MicroRNA-150 serves as a diagnostic biomarker and is involved in the inflammatory pathogenesis of Parkinson’s disease. Mol Genet Genomic Med 2020; 8: e1189. 
63. Baghi M, Rostamian Delavar M, Yadegari E, Peymani M, Pozo D, Hossein Nasr-Esfahani M, et al. Modified level of miR-376a is associated with Parkinson’s disease. J Cell Mol Med 2020; 24: 2622–2634. 
64. Zhou J, Zhao Y, Li Z, Zhu M, Wang Z, Li Y, et al. miR-103a-3p regulates mitophagy in Parkinson’s disease through Parkin/Ambra1 signaling. Pharmacol Res 2020; 160: 105197. 
65. Ma X, Zhang H, Yin H, Geng S, Liu Y, Liu C, et al. Up-regulated microRNA-218-5p ameliorates the damage of dopaminergic neurons in rats with Parkinson’s disease via suppression of LASP1. Brain Res Bull 2021; 166: 92–101. 
66. Guo S, Gao Y, Zhao Y. Neuroprotective microRNA-381 binds to repressed early growth response 1 (EGR1) and alleviates oxidative stress injury in Parkinson’s disease. ACS Chem Neurosci 2023; 14: 1981–1991. 
67. Wang X, Liu Z, Wang F. MicroRNA-93 blocks signal transducers and activator of transcription 3 to reduce neuronal damage in Parkinson’s disease. Neurochem Res 2021; 46: 1859–1868. 
68. Gao Y, Sheng D, Chen W. Regulatory mechanism of miR-20a-5p in neuronal damage and inflammation in lipopolysaccharide-induced BV2 cells and MPTP-HCl-induced Parkinson’s disease mice. Psychogeriatrics 2024; 24: 752-764. 
69. Zhang YJ, Zhu WK, Qi FY, Che FY. CircHIPK3 promotes neuroinflammation through regulation of the  miR-124-3p/STAT3/NLRP3 signaling pathway in Parkinson’s disease. Adv Clin Exp Med 2023; 32: 315-329. 
70. Liao Y, Gu Y, Wang J, Tian Y, Ni X, Zhou L, et al. HSF1 inhibits microglia activation to attenuate neuroinflammation via regulating  miR-214-3p and NFATc2 in Parkinson’s disease. Folia Neuropathol 2023; 61: 53-67. 
71. Yao Y, Zhao Z, Zhang F, Miao N, Wang N, Xu X, et al. microRNA-221 rescues the loss of dopaminergic neurons in a mouse model of  Parkinson’s disease. Brain Behav 2023; 13: e2921. 
72. Han YP, Liu ZJ, Bao HH, Wang Q, Su LL. MiR-126-5p targets SP1 to inhibit the progression of Parkinson’s disease. Eur Neurol 2022; 85: 235-244. 
73. Kong H, Wang H, Zhuo Z, Li Z, Tian P, Wu J, et al. Inhibition of miR-181a-5p reduces astrocyte and microglia activation and oxidative stress by activating SIRT1 in immature rats with epilepsy. Lab Investig 2020; 100: 1223-1237. 
74. Zhu X, Zhang A, Dong J, Yao Y, Zhu M, Xu K, et al. MicroRNA-23a contributes to hippocampal neuronal injuries and spatial memory impairment in an experimental model of temporal lobe epilepsy. Brain Res Bull 2019; 152: 175-183. 
75. Li TR, Jia YJ, Ma C, Qiu WY, Wang Q, Shao XQ, et al. The role of the microRNA-146a/complement factor H/interleukin-1?-mediated inflammatory loop circuit in the perpetuate inflammation of chronic temporal lobe epilepsy. DMM Dis Model Mech 2018; 11: 1-11. 
76. Wu X, Wang Y, Sun Z, Ren S, Yang W, Deng Y, et al. Molecular expression and functional analysis of genes in children with temporal lobe epilepsy. J Integr Neurosci 2019; 18: 71–77. 
77. Vangoor VR, Reschke CR, Senthilkumar K, Van De Haar LL, De Wit M, Giuliani G, et al. Antagonizing increased miR-135a levels at the chronic stage of experimental TLE reduces spontaneous recurrent seizures. J Neurosci 2019; 39: 5064–5079. 
78. Li TR, Jia YJ, Wang Q, Shao XQ, Zhang P, Lv RJ. Correlation between tumor necrosis factor alpha mRNA and microRNA-155 expression in rat models and patients with temporal lobe epilepsy. Brain Res 2018; 1700: 56–65. 
79. Duan W, Chen Y, Wang XR. MicroRNA-155 contributes to the occurrence of epilepsy through the PI3K/Akt/mTOR signaling pathway. Int J Mol Med 2018; 42: 1577–1584. 
80. Korotkov A, Broekaart DWM, van Scheppingen J, Anink JJ, Baayen JC, Idema S, et al. Increased expression of matrix metalloproteinase 3 can be attenuated by inhibition of microRNA-155 in cultured human astrocytes. J Neuroinflammation 2018; 15: 211. 
81. Tang C, Gu Y, Wang H, Wu H, Wang Y, Meng Y, et al. Targeting of microRNA-21-5p protects against seizure damage in a kainic acid-induced status epilepticus model via PTEN-mTOR. Epilepsy Res 2018; 144: 34–42. 
82. Chen DZ, Wang WW, Chen YL, Yang XF, Zhao M, Yang YY. MiR-128 is up-regulated in epilepsy and promotes apoptosis through the SIRT1 cascade. Int J Mol Med 2019; 44: 694–704. 
83. Kong H, Wang H, Zhuo Z, Li Z, Tian P, Wu J, et al. Inhibition of miR-181a-5p reduces astrocyte and microglia activation and  oxidative stress by activating SIRT1 in immature rats with epilepsy. Lab Invest 2020; 100: 1223–1237. 
84. Geng J feng, Liu X, Zhao H biao, Fan W fei, Geng J jie, Liu X zhi. LncRNA UCA1 inhibits epilepsy and seizure-induced brain injury by regulating miR-495/Nrf2-ARE signal pathway. Int J Biochem Cell Biol 2018; 99: 133–139. 
85. Feng X, Xiong W, Yuan M, Zhan J, Zhu X, Wei Z, et al. Down-regulated microRNA-183 mediates the Jak/Stat signaling pathway to attenuate hippocampal neuron injury in epilepsy rats by targeting Foxp1. Cell Cycle 2019; 18: 3206–3222. 
86. Chen Y, Chen J, Chen Y, Li Y. miR-146a/KLF4 axis in epileptic mice: A novel regulator of synaptic plasticity involving STAT3 signaling. Brain Res 2022; 1790: 147988. 
87. Xiao D, Lv J, Zheng Z, Liu Y, Zhang Y, Luo C, et al. Mechanisms of microRNA-142 in mitochondrial autophagy and hippocampal damage in a rat model of epilepsy. Int J Mol Med 2021; 47: 98. 
88. He Z, Chen H, Zhong Y, Yang Q, Wang X, Chen R, et al. MicroRNA 223 Targeting ATG16L1 Affects Microglial Autophagy in the Kainic Acid Model of Temporal Lobe Epilepsy. Front Neurol 2021; 12: 1–13. 
89. Hamamoto O, Tirapelli DP da C, Lizarte Neto FS, Freitas-Lima P, Saggioro FP, Cirino ML de A, et al. Modulation of NMDA receptor by miR-219 in the amygdala and hippocampus of patients with mesial temporal lobe epilepsy. J Clin Neurosci 2020; 74: 180-186. 
90. Huang Y, Liu X, Liao Y, Liao Y, Zou D, Wei X, et al. Role of miR-34c in the cognitive function of epileptic rats induced by pentylenetetrazol. Mol Med Rep 2018; 17: 4173–4180. 
91. Xiang L, Ren Y, Cai H, Zhao W, Song Y. MicroRNA-132 aggravates epileptiform discharges via suppression of BDNF/TrkB signaling in cultured hippocampal neurons. Brain Res 2015; 1622: 484–495.
92. Zhu X, Zhang A, Dong J, Yao Y, Zhu M, Xu K, et al. MicroRNA-23a contributes to hippocampal neuronal injuries and spatial memory  impairment in an experimental model of temporal lobe epilepsy. Brain Res Bull 2019; 152: 175–183. 
93. Du Y, Chi X, An W. Down-regulation of microRNA-200c-3p reduces damage of hippocampal neurons in epileptic rats by up-regulating expression of RECK and inactivating the AKT signaling pathway. Chem Biol Interact 2019; 307: 223–233. 
94. Rosciszewski G, Cadena V, Auzmendi J, Cieri MB, Lukin J, Rossi AR, et al. Detrimental effects of HMGB-1 require microglial-astroglial interaction: Implications for the status epilepticus -induced neuroinflammation. Front Cell Neurosci 2019; 13: 1-19. 
95. Wu Y, Zhang Y, Zhu S, Tian C, Zhang Y. MiRNA‐29a serves as a promising diagnostic biomarker in children with temporal lobe.Epileptic Disord 2022; 23: 8230832. 
96. Liu T, Liu H, Xue S, Xiao L, Xu J, Tong S, et al. MiR129-5p-loaded exosomes suppress seizure-associated neurodegeneration in status  epilepticus model mice by inhibiting HMGB1/TLR4-mediated neuroinflammation. Mol Biol Rep 2024; 51: 292. 
97. Alves VS, da Silva JP, Rodrigues FC, Araújo SMB, Gouvêa AL, Leite-Aguiar R, et al. P2X7 receptor contributes to long-term neuroinflammation and cognitive impairment  in sepsis-surviving mice. Front Pharmacol 2023; 14: 1179723. 
98. Li X, Quan P, Si Y, Liu F, Fan Y, Ding F, et al. The microRNA-211-5p/P2RX7/ERK/GPX4 axis regulates epilepsy-associated neuronal ferroptosis and oxidative stress. J Neuroinflammation 2024; 1: 13. 
99. Xiang J, Wen F, Zhang L, Zhou Y. FOXD3 inhibits SCN2A gene transcription in intractable epilepsy cell models. Exp Neurol 2018; 302: 14-21. 
100. Wen F, Tan Z, Huang D, Jiang Y, Xiang J. LncRNA PVT1 promotes neuronal cell apoptosis and neuroinflammation by regulating miR-488-3p/FOXD3/SCN2A axis in epilepsy. Neurochem Res 2023; 48: 895-908. 
101. Cui H, Zhang W, Khalaf OI. The neuroprotective effect of miR-136 on pilocarpine-induced temporal lobe epilepsy rats by inhibiting Wnt/β-catenin signaling pathway. Comput Math Methods Med 2022; 2022: 1938205
102. Fu P, Yuan Q, Sun Y, Wu X, Du Z, Li Z, et al. Baicalein ameliorates epilepsy symptoms in a pilocarpine-induced rat model by regulation of IGF1R. Neurochem Res 2020; 45: 3021-3033. 
103. Niu X, Zhu HL, Liu Q, Yan JF, Li ML. MiR-194-5p serves as a potential biomarker and regulates the proliferation and apoptosis of hippocampus neuron in children with temporal lobe epilepsy. J Chinese Med Assoc 2021; 84: 510-516. 
104. Li N, Pan J, Liu W, Li Y, Li F, Liu M. MicroRNA-15a-5p serves as a potential biomarker and regulates the viability and apoptosis of hippocampus neuron in children with temporal lobe epilepsy. Diagn Pathol 2020; 15: 46.
105. Li X, Giri  vikash, Cui Y, Yin M, Xian Z, Li J. LncRNA FTX inhibits hippocampal neuron apoptosis by regulating miR-21-5p/SOX7 axis in a rat model of temporal lobe epilepsy. Biochem Biophys Res Commun 2019; 512: 79-86. 
106. Zhu Z, Wang S, Cao Q, Li G. CircUBQLN1 promotes proliferation but inhibits apoptosis and oxidative stress of hippocampal neurons in epilepsy via the miR-155-mediated SOX7 up-regulation. J Mol Neurosci 2021; 71: 1933–1943. 
107. Zhou Q, Wang Q, He B, Kong H, Luo H, Wang X, et al. MicroRNA 322-5p reduced neuronal inflammation via the TLR4/TRAF6/NF-κB axis in a rat epilepsy model. Open Med (Wars) 2022; 17: 907-914. 
108. Zhou Q, Wang Q, He B, Kong H, Luo H, Wang X, et al. MicroRNA 322-5p reduced neuronal inflammation via the TLR4/TRAF6/NF-κB axis in a rat epilepsy model. Open Med 2022; 17: 907–914. 
109. Ou S, Liu X, Xu T, Yu X, Wang T, Chen Y, et al. miRNA-let-7i modulates status epilepticus via the TLR4 pathway. Acta Epileptol 2022; 4: 1–11. 
110. Hu L, Zeng Z, Xia Q, Liu Z, Feng X, Chen J, et al. Metformin attenuates hepatoma cell proliferation by decreasing glycolytic flux through the HIF-1α/PFKFB3/PFK1 pathway. Life Sci 2019; 239: 116966.
111. Li R, Hu J, Cao S. The clinical significance of miR-135b-5p and its role in the proliferation and apoptosis of hippocampus neurons in children with temporal lobe epilepsy. Dev Neurosci 2021; 42: 187–194. 
112. Dewan MC, Rattani A, Gupta S, Baticulon RE, Hung YC, Punchak M, et al. Estimating the global incidence of traumatic brain injury J Neurosurg 2019; 130: 1080-97. 
113. Qi R, Wang X. Inhibition of miR-429 improves neurological recovery of traumatic brain injury mice and attenuates microglial neuroinflammation. Int Immunopharmacol 2020; 79: 106091. 
114. Henry RJ, Doran SJ, Barrett JP, Meadows VE, Sabirzhanov B, Stoica BA, et al. Inhibition of miR-155 limits neuroinflammation and improves functional recovery after experimental traumatic brain injury in mice. Neurotherapeutics 2019; 16: 216-230. 
115. Yu J, Chen J, Yang H, Chen S, Wang Z. Overexpression of MIR‑200a‑3p promoted inflammation in sepsis‑induced brain injury through ROS‑induced NLRP3. Int J Mol Med 2019; 44: 1811–1823. 
116. Ge X, Li W, Huang S, Yin Z, Yang M, Han Z, et al. Increased miR-21-3p in injured brain microvascular endothelial cells after traumatic brain injury aggravates blood-brain barrier damage by promoting cellular apoptosis and inflammation through targeting MAT2B. J Neurotrauma 2019; 36: 1291–1305. 
117. Schindler CR, Woschek M, Vollrath JT, Kontradowitz K, Lustenberger T, Störmann P, et al. MiR-142-3p expression is predictive for severe traumatic brain injury (TBI) in trauma patients. Int J Mol Sci 2020; 21: 1–16. 
118. Zhao L, Zhang L, Zhu W, Chen H, Ding Y, Cui G. Inhibition of microRNA-203 protects against traumatic brain injury induced neural damages via suppressing neuronal apoptosis and dementia-related molecues. Physiol Behav 2021; 228: 113190. 
119. Gupta S Das, Ciszek R, Heiskanen M, Lapinlampi N, Kukkonen J, Leinonen V, et al. Plasma miR-9-3p and miR-136-3p as potential novel diagnostic biomarkers for experimental and human mild traumatic brain injury. Int J Mol Sci 2021; 22: 1–27. 
120. Tang W, Guo ZD, Chai WN, Du DL, Yang XM, Cao L, et al. Down-regulation of miR-491-5p promotes neovascularization after traumatic brain injury. Neural Regen Res 2022; 17: 577-586. 
121. Wu J, Li H, He J, Tian X, Luo S, Li J, et al. Down-regulation of microRNA-9-5p promotes synaptic remodeling in the chronic phase after traumatic brain injury. Cell Death Dis 2021; 12: 9. 
122. Sun Y, Xiong Y, Yan C, Chen L, Chen D, Mi B, et al. Down-regulation of microRNA-16-5p accelerates fracture healing by promoting proliferation and inhibiting apoptosis of osteoblasts in patients with traumatic brain injury. Am J Transl Res 2019; 11: 4746-4760. 
123. Kowiański P, Lietzau G, Czuba E, Waśkow M, Steliga A, Moryś J. BDNF: A key factor with multipotent impact on brain signaling and synaptic plasticity. Cell Mol Neurobiol 2018; 38: 579-593.
124. Kang EM, Jia Y Bin, Wang JY, Wang GY, Chen HJ, Chen XY, et al. Down-regulation of microRNA-124-3p promotes subventricular zone neural stem cell activation by enhancing the function of BDNF downstream pathways after traumatic brain injury in adult rats. CNS Neurosci Ther 2022; 28: 1081–1092. 
125. Yang X, Tang X, Sun P, Shi Y, Liu K, Hassan SH, et al. MicroRNA-15a/16-1 antagomir ameliorates ischemic brain injury in experimental stroke. Stroke 2017; 48: 1941-1947. 
126. Zhou C, Li S, Qiu N, Sun P, Hamblin MH, Dixon CE, et al. Loss of microRNA-15a/16-1 function promotes neuropathological and functional recovery in experimental traumatic brain injury. JCI Insight 2024; 9: e178650. 
127. Lv J, Zeng Y, Qian Y, Dong J, Zhang Z, Zhang J. MicroRNA let-7c-5p improves neurological outcomes in a murine model of traumatic brain injury by suppressing neuroinflammation and regulating microglial activation. Brain Res 2018; 1685: 91-104. 
128. Huang S, Ge X, Yu J, Han Z, Yin Z, Li Y, et al. Increased miR-124-3p in microglial exosomes following traumatic brain injury inhibits neuronal inflammation and contributes to neurite outgrowth via their transfer into neurons. FASEB J 2018; 32: 512-528. 
129. Shi M, Chai Y, Zhang J, Chen X. Endoplasmic reticulum stress-associated neuronal death and innate immune response in neurological diseases. Front Immunol 2022; 12: 1-26. 
130. Wang Y, Li D, Zhang L, Yin Z, Han Z, Ge X, et al. Exosomes derived from microglia overexpressing miR-124-3p alleviate neuronal endoplasmic reticulum stress damage after repetitive mild traumatic brain injury. Neural Regen Res 2024; 19: 2010-2018. 
131. Zhao C, Deng Y, He Y, Huang X, Wang C, Li W. Decreased level of exosomal miR-5121 released from microglia suppresses neurite outgrowth and synapse recovery of neurons following traumatic brain injury. Neurotherapeutics 2021; 18: 1273–1294. 
132. Long X, Yao X, Jiang Q, Yang Y, He X, Tian W, et al. Astrocyte-derived exosomes enriched with miR-873a-5p inhibit neuroinflammation via microglia phenotype modulation after traumatic brain injury. J Neuroinflammation 2020; 17: 1-15. 
133. Yang Y, Ye Y, Fan K, Luo J, Yang Y, Ma Y. MiR-124 reduced neuroinflammation after traumatic brain injury by inhibiting TRAF6. Neuroimmunomodulation 2023; 30: 55–68. 
134. Nong A, Li Q, Huang Z, Xu Y, He K, Jia Y, et al. MicroRNA miR-126 attenuates brain injury in septic rats via NF-κB signaling pathway. Bioengineered 2021; 12: 2639–2648. 
135. Zhang L, Zhao L, Zhu W, Ding Y, Chen H, Chi N. miR-146a mimics ameliorates traumatic brain injury involving JNK and NF-κB signaling pathway. NeuroMolecular Med 2020; 22: 484-492. 
136. Li Z, Xu R, Zhu X, Li Y, Wang Y, Xu W. MicroRNA-23a-3p improves traumatic brain injury through modulating the neurological apoptosis and inflammation response in mice. Cell Cycle 2020; 19: 24-38. 
137. Meissner L, Gallozzi M, Balbi M, Schwarzmaier S, Tiedt S, Terpolilli NA, et al. Temporal profile of microRNA expression in contused cortex after traumatic brain injury in mice. J Neurotrauma 2015; 33: 713–720. 
138. Wang JX, Xiao X, He XC, He BD, Liu CM, Teng ZQ. Agomir-331 suppresses reactive gliosis and neuroinflammation after traumatic brain injury. Cells 2023; 12: 1–17. 
139. Xiong Y, Cao F, Hu L, Yan C, Chen L, Panayi AC, et al. miRNA-26a-5p accelerates healing via down-regulation of PTEN in fracture patients with traumatic brain injury. Mol Ther Nucleic Acids 2019; 17: 223–234. 
140. Chen W, Feng J, Tong W. Phosphorylation of astrocytic connexin43 by ERK1/2 impairs blood-brain barrier in acute cerebral ischemia. Cell Biosci 2017; 7: 43. 
141. Chen W, Zhao L, Zhang J, Wang B, Xu G, Lin C, et al. Elevated expression of miR-302 cluster improves traumatic brain injury by inhibiting phosphorylation of connexin43 via ERK signaling. J Chem Neuroanat 2019; 99: 1–8. 
142. Chin AC. Neuroinflammation and the cGAS-STING pathway. J Neurophysiol 2019; 121: 1087-1091.
143. He XC, Wang J, Du HZ, Liu CM, Teng ZQ. Intranasal administration of agomir-let-7i improves cognitive function in mice with traumatic brain injury. Cells 2022; 11: 1348. 
144. Wang D, Jacobs SA, Tsien JZ. Targeting the NMDA receptor subunit NR2B for treating or preventing age-related memory decline. Expert Opinion on Therapeutic Targets 2014; 18: 1121-1130. 
145. Schumann J, Alexandrovich GA, Biegon A, Yaka R. Inhibition of NR2B phosphorylation restores alterations in NMDA receptor expression and improves functional recovery following traumatic brain injury in mice. J Neurotrauma 2008; 25: 945-957. 
146. Shi Y, Cui W, Wang Q, Zhou J, Wu X, Wang J, et al. MicroRNA-124/death-associated protein kinase 1 signaling regulates neuronal apoptosis in traumatic brain injury via phosphorylating NR2B. Front Cell Neurosci 2022; 16: 1-13. 
147. Feng C, Tian Q, Tang X, Yu J, Li H, Geng C, et al. microRNA-9a-5p disrupts the ELAVL1/VEGF axis to alleviate traumatic brain injury. Exp Neurol 2024; 375: 114721. 
148. Zhang H, Xing Z, Zheng J, Shi J, Cui C. Ursolic acid ameliorates traumatic brain injury in mice by regulating microRNA-141-mediated PDCD4/PI3K/AKT signaling pathway. Int Immunopharmacol 2023; 120: 110258. 
149. Malki K, Pain O, Tosto MG, Du Rietz E, Carboni L, Schalkwyk LC. Identification of genes and gene pathways associated with major depressive disorder by integrative brain analysis of rat and human prefrontal cortex transcriptomes. Transl Psychiatry 2015; 5: e519. 
150. Roy B, Dunbar M, Shelton RC, Dwivedi Y. Identification of microRNA-124-3p as a putative epigenetic signature of major depressive disorder. Neuropsychopharmacology 2017; 42: 864-875. 
151. Wang SS, Mu RH, Li CF, Dong SQ, Geng D, Liu Q, et al. microRNA-124 targets glucocorticoid receptor and is involved in depression-like behaviors. Prog Neuro-Psychopharmacology Biol Psychiatry 2017; 79: 417–425. 
152. Khandelwal N, Dey SK, Chakravarty S, Kumar A. miR-30 family miRNAs mediate the effect of chronic social defeat stress on hippocampal neurogenesis in mouse depression model. Front Mol Neurosci 2019; 12: 1–19. 
153. Yuan N, Li X, Tang K, Gan H, Da X, Hao W, et al. Xiaoyaosan inhibits neuronal apoptosis by regulating the miR-200/NR3C1 signaling in the prefrontal cortex of chronically stressed rats. Phytomedicine 2022; 103: 154239.
154. Li S, Ma H, Yuan X, Zhou X, Wan Y, Chen S. Microrna-382-5p targets nuclear receptor subfamily 3 group c member 1 to regulate depressive-like behaviors induced by chronic unpredictable mild stress in rats. Neuropsychiatr Dis Treat 2020; 16: 2053–2061. 
155. Su B, Cheng S, Wang L, Wang B. MicroRNA-139-5p acts as a suppressor gene for depression by targeting nuclear receptor subfamily 3, group C, member 1. Bioengineered 2022; 13: 11856-11866. 
156. Zhang Z, Xia D jian, Xu A ding. Therapeutic effect of fastigial nucleus stimulation is mediated by the microRNA-182 & microRNA-382/BDNF signaling pathways in the treatment of post-stroke depression. Biochem Biophys Res Commun 2022; 627: 137–145. 
157. Xin C, Xia J, Liu Y, Zhang Y. MicroRNA-202-3p targets brain-derived neurotrophic factor and is involved in depression-like behaviors. Neuropsychiatr Dis Treat 2020; 16: 1073–1083. 
158. Yu CF, Peng WM, Schlee M, Barchet W, Eis-Hübinger AM, Kolanus W, et al. SOCS1 and SOCS3 target IRF7 degradation to suppress TLR7-mediated type I IFN production of human plasmacytoid dendritic cells. J Immunol 2018; 200: 4024-4035. 
159. Liu Y, Yu J, Wang X, Dong J. MicroRNA-345-5p regulates depression by targeting suppressor of cytokine signaling 1. Brain Behav 2020; 10: 1–10. 
160. Guo L, Zhu Z, Wang G, Cui S, Shen M, Song Z, et al. MicroRNA-15b contributes to depression-like behavior in mice by affecting synaptic protein levels and function in the nucleus accumbens. J Biol Chem 2020; 295: 6831–6848. 
161. Zhai X, Liu J, Ni A, Ye J. MiR-497 promotes microglia activation and proinflammatory cytokines production in  chronic unpredictable stress-induced depression via targeting FGF2. J Chem Neuroanat 2020; 110: 101872. 
162. Tang Y, Zhou M, Huang R, Shen L, Yang L, Zhou Z, et al. Involvement of HECTD1 in LPS-induced astrocyte activation via σ-1R-JNK/p38-FOXJ2 axis. Cell Biosci 2021; 11: 62. 
163. Zhang Y, Du L, Bai Y, Han B, He C, Gong L, et al. CircDYM ameliorates depressive-like behavior by targeting miR-9 to regulate microglial activation via HSP90 ubiquitination. Mol Psychiatry 2020; 25: 1175–1190. 
164. Chen Y, Cao P. Circ-Bnc2 alleviates neuroinflammation in LPS-stimulated microglial cells to  inhibit neuron cell apoptosis through regulating miR-497a-5p/HECTD1 axis. Brain Behav 2023; 13: e2935. 
165. Magill ST, Cambronne XA, Luikart BW, Lioy DT, Leighton BH, Westbrook GL, et al. MicroRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus. Proc Natl Acad Sci U S A 2010; 107: 20382–20387. 
166. Im HI, Kenny PJ. MicroRNAs in neuronal function and dysfunction. Trends Neurosci 2012; 35: 325-334. 
167. Su M, Hong J, Zhao Y, Liu S, Xue X. MeCP2 controls hippocampal brain-derived neurotrophic factor expression via homeostatic interactions with microRNA-132 in rats with depression. Mol Med Rep 2015; 12: 5399–5406. 
168. Qi S, Yang X, Zhao L, Calhoun VD, Perrone-Bizzozero N, Liu S, et al. MicroRNA132 associated multimodal neuroimaging patterns in unmedicated major depressive disorder. Brain 2018; 141: 916–926. 
169. Pei G, Xu L, Huang W, Yin J. The protective role of microRNA-133b in restricting hippocampal neurons apoptosis and inflammatory injury in rats with depression by suppressing CTGF. Int Immunopharmacol 2020; 78: 106076. 
170. Shen J, Zhang P, Li Y, Fan C, Lan T, Wang W, et al. Neuroprotective effects of microRNA-211-5p on chronic stress-induced neuronal apoptosis and depression-like behaviours. J Cell Mol Med 2021; 25: 7028–7038. 
171. Lan T, Li Y, Fan C, Wang L, Wang W, Chen S, et al. MicroRNA-204-5p reduction in rat hippocampus contributes to stress-induced pathology via targeting RGS12 signaling pathway. J Neuroinflammation 2021; 18: 1–20. 
172. Li Y, Fan C, Wang L, Lan T, Gao R, Wang W, et al. MicroRNA-26a-3p rescues depression-like behaviors in male rats via preventing hippocampal neuronal anomalies. J Clin Invest 2021; 131: e148853. 
173. Rossetti AC, Paladini MS, Brüning CA, Spero V, Cattaneo MG, Racagni G, et al. Involvement of the IL-6 signaling pathway in the anti-anhedonic effect of the  antidepressant agomelatine in the chronic mild stress model of depression. Int J Mol Sci 2022; 23: 12453. 
174. Yang JC, Zhao J, Chen YH, Wang R, Rong Z, Wang SY, et al. miR-29a-5p rescues depressive-like behaviors in a CUMS-induced mouse model by  facilitating microglia M2-polarization in the prefrontal cortex via TMEM33 suppression. J Affect Disord 2024; 360: 188–197. 
175. Wang W, Qin X, Wang R, Xu J, Wu H, Khalid A, et al. EZH2 is involved in vulnerability to neuroinflammation and depression-like  behaviors induced by chronic stress in different aged mice. J Affect Disord 2020; 272: 452–464. 
176. Fanelli G, Benedetti F, Wang SM, Lee SJ, Jun TY, Masand PS, et al. Reduced CXCL1/GRO chemokine plasma levels are a possible biomarker of elderly  depression. J Affect Disord 2019; 249: 410–417. 
177. Liu XF, Wang RQ, Hu B, Luo MC, Zeng QM, Zhou H, et al. MiR-15a contributes abnormal immune response in myasthenia gravis by targeting  CXCL10. Clin Immunol 2016; 164: 106–113. 
178. Huang X, Yang C, Huang M. Protective mechanism of the EZH2/microRNA-15a-5p/CXCL10 axis in rats with  depressive-like behaviors. J Chem Neuroanat 2023; 132: 102283. 
179. Min XL, Liu HJ, Dou XK, Chen FX, Zhao Q, Zhao XH, et al. Extracellular vesicles from neural stem cells carry microRNA-16-5p to reduce  corticosterone-induced neuronal injury in depression rats. Neuroscience 2024; 538: 95–109. 
180. Guo H, Huang B, Wang Y, Zhang Y, Ma Q, Ren Y. Bone marrow mesenchymal stem cells-derived exosomes improve injury of hippocampal neurons in rats with depression by up-regulating microRNA-26a expression. Int Immunopharmacol 2020; 82: 106285. 
181. Huang Y, Jin Y, Yao S, Nan G, Mao Y. LncRNA NEAT1 inhibits neuronal apoptosis and induces neuronal viability of depressed rats via microRNA-320-3p/CRHR1 axis. Neurochem Res 2024; 49: 2352-2363. 
182. Zhai Y, Zhu YY. MiR-30a relieves migraine by degrading CALCA. Eur Rev Med Pharmacol Sci 2018; 22: 2022–2028. 
183. Giamberardino MA, Martelletti P. Emerging drugs for migraine treatment. Expert Opin Emerg Drugs 2015; 20: 137-147. 
184. Cheng CY, Chen SP, Liao YC, Fuh JL, Wang YF, Wang SJ. Elevated circulating endothelial-specific microRNAs in migraine patients: A pilot study. Cephalalgia 2018; 38: 1585–1591. 
185. Jiang L, Zhang Y, Jing F, Long T, Qin G, Zhang D, et al. P2X7R-mediated autophagic impairment contributes to central sensitization in a chronic migraine model with recurrent nitroglycerin stimulation in mice. J Neuroinflammation 2021; 18: 5. 
186. Long T, He W, Pan Q, Zhang S, Zhang D, Qin G, et al. Microglia P2X4R-BDNF signalling contributes to central sensitization in a recurrent nitroglycerin-induced chronic migraine model. J Headache Pain 2020; 21: 4. 
187. Wen Q, Wang Y, Pan Q, Tian R, Zhang D, Qin G, et al. MicroRNA-155-5p promotes neuroinflammation and central sensitization via inhibiting SIRT1 in a nitroglycerin-induced chronic migraine mouse model. J Neuroinflammation 2021; 18: 287. 
188. Gallelli L, Cione E, Peltrone F, Siviglia S, Verano A, Chirchiglia D, et al. Hsa-miR-34a-5p and hsa-miR-375 as biomarkers for monitoring the effects of drug treatment for migraine pain in children and adolescents: A pilot study. J Clin Med 2019; 8: 928. 
189. Gazerani P. Current evidence on potential uses of microRNA biomarkers for migraine: From diagnosis to treatment. Mol Diagnosis Ther 2019; 23: 681–694.
190. Tana C, Giamberardino MA, Cipollone F. microRNA profiling in atherosclerosis, diabetes, and migraine. Ann Med 2017; 49: 93-105. 
191. Ahmad L, Demartini C, Corrado M, Vaghi G, Piella EM, Allena M, et al. Expression of selected microRNAs in migraine: A new class of possible biomarkers of disease? Processes 202; 19: 2199.
192. Ye S, Li S, Ma Y, Wei L, Zeng Y, Hu D, et al. Ambient NO(2) exposure induces migraine in rats: Evidence, mechanisms and  interventions. Sci Total Environ 2022; 844: 157102. 
193. Ye S, Wei L, Jiang Y, Yuan Y, Zeng Y, Zhu L, et al. Mechanism of NO(2)-induced migraine in rats: The exploration of the role of  miR-653-3p/IGF1 axis. J Hazard Mater 2024; 465: 133362. 
194. Cannataro R, Perri M, Caroleo MC, Gallelli L, Sarro G De, Cione E. Modulation of microRNAs linked to pain-migraine by ketogenic diet (P14-007-19). Curr Dev Nutr 2019; 3: nzz052-P14. 
195. Zhai Y, Zhu YY. MiR-30a relieves migraine by degrading CALCA. Eur Rev Med Pharmacol Sci 2018; 22: 2022–2028. 
196. Liu W, Lv Y, Ren F. PI3K/Akt pathway is required for spinal central sensitization in neuropathic pain. Cell Mol Neurobiol 2018; 38: 747-755. 
197. Guo JR, Wang H, Jin XJ, Jia DL, Zhou X, Tao Q. Effect and mechanism of inhibition of PI3K/Akt/mTOR signal pathway on chronic neuropathic pain and spinal microglia in a rat model of chronic constriction injury. Oncotarget 2017; 8: 52923.