Dose Ramadan Fasting Affects Inflammatory Responses: Evidences for Modulatory Roles of This Unique Nutritional Status via Chemokine Network

Document Type : Original Article


1 Pistachio Safety Research Center, Rafsanjan University of Medical Science, Rafsanjan, Iran

2 Occupational Environment Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran 3 Molecular Medicine Research Center, Rafsanjan University of Medical Science, Rafsanjan, Iran

3 Molecular Medicine Research Center, Rafsanjan University of Medical Science, Rafsanjan, Iran

4 Department of Medicine, Kerman University of Medical Sciences, Kerman, Iran

5 Geriatric Care Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

6 Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran



The impact of fasting in Ramadan as a unique type of nutritional regimen on biochemical and hematological parameters is still an issue of debate. Almost very little is known regarding the regulatory role(s) of this nutritional status on immune responses or inflammation.
Materials and Methods:
The levels of biochemical parameters were determined using commercial diagnostic kits. Hematological parameters were also examined. We also employed ELISA for detection of CXCL1, CXCL10 and CXCL12 chemokines. The Student-T test was used to compare the values of different parameters obtained in the first and last day of Ramadan fasting by employing SPSS (version 18) software.
As our findings demonstrated, there was a markedly difference between before and after Ramadan BMI of the individuals who fast. Our results also revealed that there was a remarkable difference between the levels of total cholesterol, FBS, Triglycerides and LDL before and after Ramadan fasting. Results revealed that among studied hematological parameters only the numbers of platelets were markedly different before and after Ramadan fasting program in individuals who practice fasting. Our results also showed decreased levels of pro-inflammatory CXC chemokines but unaltered levels of homoeostatic ones.
The results of this study may reveal that Ramadan fasting is quite safe for normal healthy adults and so very useful in reduction of cholesterol and triglycerides in relation with dyslipidemia. It is also possible to conclude that fasting is important in controlling of inflammation via chemokines.


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