Anti-diabetic effects of Sargassum oligocystum on Streptozotocin- induced diabetic rat

Document Type : Short Communication

Authors

1 Departments of Biochemistry, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran

2 The Student’s Committee Research, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran

3 Departments of Anatomy, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran

4 The Persian Gulf Marine Biotechnology Research Center, Bushehr University of Medical Sciences, Bushehr, Iran

5 Departments of Environmental Health Engineering, Faculty of Health, Bushehr University of Medical Sciences, Bushehr, Iran

6 Departments of Hematology, Faculty of Allied Medicine, Bushehr University of Medical Sciences, Bushehr, Iran

7 Departments of Pharmacology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran

Abstract

Objective(s): Diabetes is a metabolic syndrome which is associated with the worldwide major public health problems. There are many natural compounds from the sea-market, as a valuable aquatic source, along with the variety of health and therapeutic benefits. In the present research, with respect to the traditional and ethnic uses of Sargassum oligocystum algae for healing of some diseases which have similar metabolic mechanism to the diabetes, its anti-diabetic effects in animal model was proposed.
Materials and Methods: The animals (rat) were divided into the normal control, diabetic control, positive control and, the test groups. The test groups were gavaged with oral doses of 150 and 300 mg/kg of algae hydroalcoholic extracts. After 30 days of intervention the serum glucose, cholesterol, triglyceride, HDLC, LDLC, insulin, insulin resistance, β-cells function and, the histopathology of pancreatic tissue were evaluated.
Results: In animals that were fed with algae extracts a significant decrease in the fasting blood glucose, triglyceride and HOMA-IR and an increase in the HOMA-B with no significant impacts on the insulin, cholesterol and HDL were observed. Also, the histopathology evaluations in the groups which were treated with algae extract revealed the regeneration and reconstitution of damaged pancreatic β-cells.
Conclusion: The results give evidence that, the S. oligocystum algae extract has a healing effect on diabetes which can be considered as a new research prospect for the natural therapy of diabetes.

Keywords

Main Subjects

References

1. Olokoba AB, Obateru OA, Olokoba LB. Type 2 diabetes mellitus: a review of current trends. Oman Med J 2012; 27:269-273.
2. King H, Aubert RE, Herman WH. Global burden of diabetes, 1995–2025: prevalence, numerical estimates, and projections. Diabetes care 1998;21:1414-1431.
3. Desco M-C, Asensi M, Márquez R, Martínez-Valls J, Vento M, Pallardó FV, et al. Xanthine oxidase is involved in free radical production in type 1 diabetes. Diabetes 2002;51:1118-1124.
4. Tabatabaie T, Vasquez-Weldon A, Moore DR, Kotake Y. Free Radicals and the Pathogenesis of Type 1 Diabetes. Diabetes 2003;52:1994-1999.
5. Tiwari P, Rahuja N, Kumar R, Lakshmi V, Srivastava MN, Agarwal SC, et al. Search for antihyperglycemic activity in few marine flora and fauna. Indian. J Sci Technol 2008;1:1-5.
6. Lee S-H, Min K-H, Han J-S, Lee D-H, Park D-B, Jung W-K, et al. Effects of brown alga, Ecklonia cava on glucose and lipid metabolism in C57BL/KsJ-db/db mice, a model of type 2 diabetes mellitus. Food Chem Toxicol 2012;50:575-582.
7. Montagne C. Plantes cellulaires. In ‘Voyage au Pôle Sud et dans l’Océanie surles corvettes l’Astrolabe et la Zelée... pendant les années 1837–1838–1839–1840, sous le commandement de MJ Dumont d’Urville. Botanique. 1845;1:20.
8. Yende SR, Harle UN, Chaugule BB. Therapeutic potential and health benefits of Sargassum species. Pharmacogn Rev 2014;8:1-7.
9. Zandi K, Ahmadzadeh S, Tajbakhsh S, Rastian Z, Yousefi F, Farshadpour F, et al. Anticancer activity of Sargassum oligocystum water extract against human cancer cell lines. Eur Rev Med Pharmacol Sci 2010;14:669-673.
10. Patel S. Therapeutic importance of sulfated polysaccharides from seaweeds: updating the recent findings. 3 Biotech 2012;2:171-185.
11. Sarvestani FS, Esmaeili H, Ramavandi B. Modification of Sargassum angustifolium by molybdate during a facile cultivation for high-rate phosphate removal from wastewater: structural characterization and adsorptive behavior. 3 Biotech 2016;6:251.
12. Vasconcelos C, Maranhão H, Batista T, Carneiro E, Ferreira F, Costa J, et al. Hypoglycaemic activity and molecular mechanisms of Caesalpinia ferrea Martius bark extract on streptozotocin-induced diabetes in Wistar rats. J Ethnopharmacol 2011;137:1533-1541.
13. Kawai S, Takagi Y, Kaneko S, Kurosawa T. Effect of three types of mixed anesthetic agents alternate to ketamine in mice. Exp Anim 2011;60:481-487.
14. Trinder P. Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen. J Clin Pathol 1969;22:158-161.
15. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502.
16. Song Y, Manson JE, Tinker L, Howard BV, Kuller LH, Nathan L, et al. Insulin sensitivity and insulin secretion determined by homeostasis model assessment and risk of diabetes in a multiethnic cohort of women the Women's Health Initiative Observational Study. Diabetes care 2007;30:1747-1752.
17. Franz MJ. Medical nutrition therapy for diabetes mellitus and hypoglycemia of nondiabetic origin. Krause’s food 2008.
18. Choi JS, Yokozawa T, Oura H. Improvement of hyperglycemia and hyperlipemia in streptozotocin-diabetic rats by a methanolic extract of Prunus davidiana stems and its main component, prunin. Planta Med 1991;57:208-211.
19. Han YR, Ali M, Woo MH, Jung HA, Choi JS. Anti‐Diabetic and Anti‐Inflammatory Potential of the Edible Brown Alga Hizikia Fusiformis. J Food Biochem 2015;39:417-428.
20. Kang M-C, Wijesinghe W, Lee S-H, Kang S-M, Ko S-C, Yang X, et al. Dieckol isolated from brown seaweed Ecklonia cava attenuates type ІІ diabetes in db/db mouse model. Food Chem Toxicol 2013;53:294-298.
21. Kim K-J, Lee O-H, Lee B-Y. Fucoidan, a sulfated polysaccharide, inhibits adipogenesis through the mitogen-activated protein kinase pathway in 3T3-L1 preadipocytes. Life Sci 2010;86:791-797.
22. Kim K-J, Yoon K-Y, Lee B-Y. Fucoidan regulate blood glucose homeostasis in C57BL/KSJ m+/+ db and C57BL/KSJ db/db mice. Fitoterapia 2012;83:1105-1109.
23. Thomes P, Rajendran M, Pasanban B, Rengasamy R. Cardioprotective activity of Cladosiphon okamuranus fucoidan against isoproterenol induced myocardial infarction in rats. Phytomedicine 2010;18:52-57.
24. Shan X, Liu X, Hao J, Cai C, Fan F, Dun Y, et al. In vitro and in vivo hypoglycemic effects of brown algal fucoidans. Int J Biol Macromol 2016;82:249-255.
25. Kang S-I, Kim M-H, Shin H-S, Kim H-M, Hong Y-S, Park J-G, et al. A water-soluble extract of Petalonia binghamiae inhibits the expression of adipogenic regulators in 3T3-L1 preadipocytes and reduces adiposity and weight gain in rats fed a high-fat diet. J Nutr Biochem 2010;21:1251-1257.
26. Oh J-H, Kim J, Lee Y. Anti-inflammatory and anti-diabetic effects of brown seaweeds in high-fat diet-induced obese mice. Nutr Res Pract 2016;10:42-48.
27. Sharma B, Salunke R, Balomajumder C, Daniel S, Roy P. Anti-diabetic potential of alkaloid rich fraction from Capparis decidua on diabetic mice. J Ethnopharmacol 2010;127:457-462.
28. Duan X-J, Zhang W-W, Li X-M, Wang B-G. Evaluation of antioxidant property of extract and fractions obtained from a red algae, Polysiphonia urceolata. Food Chem 2006;95:37-43.
29. MacArtain P, Gill CI, Brooks M, Campbell R, Rowland IR. Nutritional value of edible seaweeds. Nutr Rev 2007;65: 535-543.
Iranian Journal of Basic Medical Sciences
Volume 21, Issue 3
March 2018
Pages 342-346

Files

Share

How to cite

Statistics