1. Mecacci F, Biagioni S, Ottanelli S, Mello G. Nutrition in pregnancy and lactation: how a healthy infant is born. J Pediatr Neonat Individual Med 2015; 4:e040236.
2. Barker DJ. Fetal nutrition and cardiovascular disease in later life. Br Med Bull 1997; 53:96-108.
3. Sullivan EL, Nousen EK, Chamlou KA. Maternal high fat diet consumption during the perinatal period programs offspring behavior. Physiol Behav 2014; 123:236-242.
4. Tozuka Y, Kumon M, Wada E, Onodera M, Mochizuki H, Wada K. Maternal obesity impairs hippocampal BDNF production and spatial learning performance in young mouse offspring. Neurochem Int 2010; 57:235-247.
5. Arnold SE, Lucki I, Brookshire BR, Carlson GC, Browne CA, Kazi H, et al. High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice. Neurobiol Dis 2014; 67:79-87.
6. Boitard C, Cavaroc A, Sauvant J, Aubert A, Castanon N, Layé S, et al. Impairment of hippocampal-dependent memory induced by juvenile high-fat diet intake is associated with enhanced hippocampal inflammation in rats. Brain Behav Immun 2014; 40:9-17.
7. Lu J, Wu D-m, Zheng Y-l, Hu B, Cheng W, Zhang Z-f, et al. Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IκB kinase β/nuclear factor-κB-mediated inflammatory pathways in mice. Brain Behav Immun 2011; 25:1658-1667.
8. Miller AH, Haroon E, Raison CL, Felger JC. Cytokine Targets in the Brain: Impact on Neurotransmitters and Neurocircuits. Depress Anxiety 2013; 30:297-306.
9. Das U. Is obesity an inflammatory condition? Nutrition 2001; 17:953-966.
10. Freeman LR, Haley-Zitlin V, Rosenberger DS, Granholm A-C. Damaging effects of a high-fat diet to the brain and cognition: A review of proposed mechanisms. Nutr Neurosci 2014; 17:241-251.
11. Tatemoto K, Hosoya M, Habata Y, Fujii R, Kakegawa T, Zou M-X, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun 1998; 251:471-476.
12. Lee DK, Cheng R, Nguyen T, Fan T, Kariyawasam AP, Liu Y, et al. Characterization of apelin, the ligand for the APJ receptor. J Neurochem 2000; 74:34-41.
13. Medhurst AD, Jennings CA, Robbins MJ, Davis RP, Ellis C, Winborn KY, et al. Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J Neurochem 2003; 84:1162-1172.
14. Boucher J, Masri B, Daviaud D, Gesta S, Guigné C, Mazzucotelli A, et al. Apelin, a newly identified adipokine up-regulated by insulin and obesity. Endocrinol 2005; 146:1764-1771.
15. Bertrand C, Valet P, Castan-Laurell I. Apelin and energy metabolism. Front Physiol 2015; 6:115.
16. Castan-Laurell I, Dray C, Knauf C, Kunduzova O, Valet P. Apelin, a promising target for type 2 diabetes treatment? Trends Endocrinol Metab 2012; 23:234-241.
17. Falcão-Pires I, Leite-Moreira AF. Apelin: a novel neurohumoral modulator of the cardiovascular system. Pathophysiologic importance and potential use as a therapeutic target. Revista Portuguesa de Cardiologia 2005; 24:1263-1276.
18. Galanth C, Hus-Citharel A, Li B, Llorens-Cortes C. Apelin in the control of body fluid homeostasis and cardiovascular functions. Curr Pharm Des 2012; 18:789-798.
19. Han L, Luo H, Huang F, Tian S, Qin X. Apelin-13 Impaires Acquisition but Not Consolidation or Expression of Contextual Fear in Rats. Neurochem Res 2016; 41:2345-2351.
20. Han R-w, Xu H-j, Zhang R-s, Wang R. The role of apelin-13 in novel object recognition memory. Peptides 2014; 62:155-158.
21. Cheng B, Chen J, Bai B, Xin Q. Neuroprotection of apelin and its signaling pathway. Peptides 2012; 37:171-173.
22. Fan S-h, Zhang Z-f, Zheng Y-l, Lu J, Wu D-m, Shan Q, et al. Troxerutin protects the mouse kidney from d-galactose-caused injury through anti-inflammation and anti-oxidation. Int Immunopharmacol 2009; 9:91-96.
23. Thomas NS, George K, Arivalagan S, Mani V, Siddique AI, Namasivayam N. The in vivo antineoplastic and therapeutic efficacy of troxerutin on rat preneoplastic liver: biochemical, histological and cellular aspects. Eur J Nutr 2016.
24. Badalzadeh R, Layeghzadeh N, Alihemmati A, Mohammadi M. Beneficial effect of troxerutin on diabetes-induced vascular damages in rat aorta: histopathological alterations and antioxidation mechanism. Int J Endocrinol Metab Disord 2015; 13:e25969.
25. Liu C-M, Ma J-Q, Lou Y. Chronic administration of troxerutin protects mouse kidney against D-galactose-induced oxidative DNA damage. Food Chem Toxicol 2010; 48:2809-2817.
26. Babri S, Amani M, Mohaddes G, Alihemmati A, Ebrahimi H. Protective effects of troxerutin on β-Amyloid (1-42)-induced impairments of spatial learning and memory in rats. Neurophysiol 2012; 44:387-393.
27. Babri S, Mohaddes G, Feizi I, Mohammadnia A, Niapour A, Alihemmati A, et al. Effect of troxerutin on synaptic plasticity of hippocampal dentate gyrus neurons in a β-amyloid model of Alzheimer,s disease: An electrophysiological study. Eur J Pharmacol 2014; 732:19-25.
28. Farajdokht F, Amani M, Bavil FM, Alihemmati A, Mohaddes G, Babri S. Troxerutin protects hippocampal neurons against amyloid beta-induced oxidative stress and apoptosis. EXCLI J 2017; 16:1081-1089.
29. Lu J, Wu D-m, Hu B, Cheng W, Zheng Y-l, Zhang Z-f, et al. Chronic administration of troxerutin protects mouse brain against d-galactose-induced impairment of cholinergic system. Neurobiol Learn Mem 2010; 93:157-164.
30. Tabari S-sS, Babri S, Mirzaie F, Farajdokht F, Mohaddes G. Enduring amnesia induced by ICV scopolamine is reversed by sesame oil in male rats. Acta Cirurgica Brasileira 2016; 31:520-526.
31. Tozuka Y, Wada E, Wada K. Diet-induced obesity in female mice leads to peroxidized lipid accumulations and impairment of hippocampal neurogenesis during the early life of their offspring. FASEB J 2009; 23:1920-1934.
32. White CL, Pistell PJ, Purpera MN, Gupta S, Fernandez-Kim S-O, Hise TL, et al. Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: contributions of maternal diet. Neurobiol Dis 2009; 35:3-13.
33. Niculescu MD, Lupu DS. High fat diet-induced maternal obesity alters fetal hippocampal development. Int J Dev Neurosci 2009; 27:627-633.
34. Greenwood CE, Winocur G. High-fat diets, insulin resistance and declining cognitive function. Neurobiol Aging 2005; 26:42-45.
35. Page KC, Jones EK, Anday EK. Maternal and postweaning high-fat diets disturb hippocampal gene expression, learning, and memory function. Am J Physiol Regul Integr Comp Physiol 2014; 306:R527-R537.
36. Lépinay AL, Larrieu T, Joffre C, Acar N, Gárate I, Castanon N, et al. Perinatal high-fat diet increases hippocampal vulnerability to the adverse effects of subsequent high-fat feeding. Psychoneuroendocrinol 2015; 53:82-93.
37. Graf AE, Lallier SW, Waidyaratne G, Thompson MD, Tipple TE, Hester ME, et al. Maternal high fat diet exposure is associated with increased hepcidin levels, decreased myelination, and neurobehavioral changes in male offspring. Brain Behav Immun 2016; 58:369-378.
38. Bilbo SD, Tsang V. Enduring consequences of maternal obesity for brain inflammation and behavior of offspring. FASEB J 2010; 24:2104-2115.
39. Lu J, Wu D-m, Zheng Y-l, Hu B, Cheng W, Zhang Z-f, et al. Troxerutin counteracts domoic acid–induced memory deficits in mice by inhibiting CCAAT/enhancer binding protein β–mediated inflammatory response and oxidative stress. J Immunol 2013; 190:3466-3479.
40. Zhang S, Li H, Zhang L, Li J, Wang R, Wang M. Effects of troxerutin on cognitive deficits and glutamate cysteine ligase subunits in the hippocampus of streptozotocin-induced type 1 diabetes mellitus rats. Brain Res 2017; 1657:355-360.
41. Kabaran S, Besler HT. Do fatty acids affect fetal programming? Health Popul Nutr 2015; 33:14-23.
42. Zhang Z, Wang X, Zheng G, Shan Q, Lu J, Fan S, et al. Troxerutin attenuates enhancement of hepatic gluconeogenesis by inhibiting NOD activation-mediated inflammation in high-fat diet-treated mice. Int J Mol Sci 2017; 18:31.
43. Zhang Z-F, Fan S-H, Zheng Y-L, Lu J, Wu D-M, Shan Q, et al. Troxerutin improves hepatic lipid homeostasis by restoring NAD+-depletion-mediated dysfunction of lipin 1 signaling in high-fat diet-treated mice. Biochem Pharmacol 2014; 91:74-86.
44. Vinothkumar R, Kumar RV, Sudha M, Viswanathan P, Balasubramanian T, Nalini N. Modulatory effect of troxerutin on biotransforming enzymes and preneoplasic lesions induced by 1, 2-dimethylhydrazine in rat colon carcinogenesis. Exp Mol Pathol 2014; 96:15-26.
45. Masuyama H, Mitsui T, Eguchi T, Tamada S, Hiramatsu Y. The effects of paternal high-fat diet exposure on offspring metabolism with epigenetic changes in the mouse adiponectin and leptin gene promoters. Am J Physiol Endocrinol Metab 2016; 311:E236-E245.
46. D’Asti E, Long H, Tremblay-Mercier J, Grajzer M, Cunnane SC, Di Marzo V, et al. Maternal dietary fat determines metabolic profile and the magnitude of endocannabinoid inhibition of the stress response in neonatal rat offspring. Endocrinol 2010; 151:1685-1694.
47. Wei L, Hou X, Tatemoto K. Regulation of apelin mRNA expression by insulin and glucocorticoids in mouse 3T3-L1 adipocytes. Regul Pept 2005; 132:27-32.
48. Henley DE, Buchanan F, Gibson R, Douthwaite JA, Wood SA, Woltersdorf WW, et al. Plasma apelin levels in obstructive sleep apnea and the effect of continuous positive airway pressure therapy. J Endocrinol 2009; 203:181-188.
49. Hosoya M, Kawamata Y, Fukusumi S, Fujii R, Habata Y, Hinuma S, et al. Molecular and functional characteristics of APJ tissue distribution of mRNA and interaction with the endogenous ligand apelin. J Biol Chem 2000; 275:21061-21067.
50. Telegdy G, Adamik A, Jászberényi M. Involvement of neurotransmitters in the action of apelin-13 on passive avoidance learning in mice. Peptides 2013; 39:171-174.
51. Li E, Deng H, Wang B, Fu W, You Y, Tian S. Apelin-13 exerts antidepressant-like and recognition memory improving activities in stressed rats. Eur Neuropsychopharmacol 2016; 26:420-430.