ADAM33 gene polymorphisms in Southwestern Iranian patients with asthma

Document Type : Original Article

Authors

1 Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran

2 Allergy Clinic of Ali-Asghar Hospital, Shiraz University of Medical Sciences, Shiraz, Iran

Abstract

Objective(s): Asthma, the most frequent chronic respiratory disease, results from a complex interaction between multiple genes and environmental factors. To date, more than 100 candidate genes and single nucleotide polymorphisms (SNPs) have been reported to be associated with asthma. One of the discovered genes related to asthma is ADAM33. However, the relationship between ADAM33 gene polymorphisms and asthma is controversial. The aim of this study was to investigate the association between four ADAM33 gene SNPs and susceptibility to asthma in patients from southwestern Iran.
Materials and Methods: ADAM33 gene polymorphisms at positions T+1 (rs2280091), T1 (rs3918396), S1 (rs2280089), and F+1 (rs511898) were examined in 150 patients with asthma and 149 age- and sex-matched healthy controls with a PCR-RFLP method.
Results: There were no differences between patients and controls in allelic or genotype frequencies of ADAM33 SNPs. We found no associations between allelic or genotype distribution of the SNPs and spirometry indices, concomitant involvement of other allergic diseases, or exposure to cigarette smoke. In contrast to H4 haplotype, which appeared to be protective against asthma, inheritance of H2 and H3 haplotypes increased the risk of asthma up to 2–3 folds.
Conclusion: ADAM33 gene polymorphisms appear to play a partial role in asthma susceptibility, investigation of expression changes in this gene in response to environmental factors or the local formation of a soluble form of the molecule in the lung can be helpful to elucidate the impact of this molecule in the induction of asthma.

Keywords

Main Subjects

References

1. Backman H, Räisänen P, Hedman L, Stridsman C, Andersson M, Lindberg A, et al. Increased prevalence of allergic asthma from 1996 to 2006 and further to 2016 - results from three population surveys. Clin Exp Allergy 2017;47:1426-1435.
2. Peters SP. Asthma phenotypes: nonallergic (intrinsic) asthma. J Allergy Clin Immunol Pract 2014;2:650-652.
3. Meyers DA. Genetics of Asthma and Allergy: What have we learned? J Allergy Clin Immunol 2010;126:439-446.
4. Bijanzadeh M, Mahesh PA, Ramachandra NB. An understanding of the genetic basis of asthma. Indian J Med Res 2011;134:149-161.
5.Van Eerdewegh P, Little RD, Dupuis J, Del Mastro RG, Falls K, Simon J, et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature 2002;418:426-430.
6. Yoshinaka T, Nishii K, Yamada K, Sawada H, Nishiwaki E, Smith K, et al. Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity. Gene 2002;282:227-236.
7. Powell RM, Wicks J, Holloway JW, Holgate ST, Davies DE. The splicing and fate of ADAM33 transcripts in primary human airways fibroblasts. Am J Respir Cell Mol Biol 2004;31:13-21.
8. Reijmerink NE, Kerkhof M, Koppelman GH, Gerritsen J, de Jongste JC, Smit HA, et al. Smoke exposure interacts with ADAM33 polymorphisms in the development of lung function and hyperresponsiveness. Allergy 2009;64:898-904.
9. Figarska SM, Vonk JM, van Diemen CC, Postma DS, Boezen HM. ADAM33 gene polymorphisms and mortality. A prospective cohort study. PLoS One 2013;8:e67768.
10. Holgate ST, Davies DE, Rorke S, Cakebread J, Murphy G, Powell RM, Holloway JW. ADAM 33 and its association with airway remodeling and hyperresponsiveness in asthma. Clin Rev Allergy Immunol 2004;27:23-34.
11. National Asthma Education and Prevention Program. Expert Panel Report 3 (EPR-3): guidelines for the Diagnosis and Management of Asthma-Summary Report 2007. J Allergy Clin Immunol 2007;120:S94-S138.
12. Pulmonary function testing. Clin Privil White Pap 2012; 38:1-15.
13. Liang S, Wei X, Gong C, Wei J, Chen Z, Deng J. A disintegrin and metalloprotease 33 (ADAM33) gene polymorphisms and the risk of asthma: a meta-analysis. Hum Immunol 2013;74:648-657.
14. Nair AK, Sugunan D, Kumar H, Anilkumar G. Case-control analysis of SNPs in GLUT4, RBP4 and STRA6: association of SNPs in STRA6 with type 2 diabetes in a South Indian population. PLoS One 2010;5:e11444.
15. Sharma N, Tripathi P, Awasthi S. Role of ADAM33 gene and associated single nucleotide polymorphisms in asthma. Allergy Rhinol (Providence) 2011;2: e63-e70.
16. Howard TD, Postma DS, Jongepier H, Moore WC, Koppelman GH, Zheng SL, et al. Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations. J Allergy Clin Immunol 2003;112:717-722.
17. Blakey J, Halapi E, Bjornsdottir US, Wheatley A, Kristinsson S, Upmanyu R, et al. Contribution of ADAM33 polymorphisms to the population risk of asthma. Thorax 2005;60:274-276.
18. Hirota T, Hasegawa K, Obara K, Matsuda A, Akahoshi M, Nakashima K, et al. Association between ADAM33 polymorphisms and adult asthma in the Japanese population. Clin Exp Allergy 2006;36:884-891.
19. Kedda MA, Duffy DL, Bradley B, O’Hehir RE, Thompson PJ. ADAM33 haplotypes are associated with asthma in a large Australian population. Eur J Hum Genet 2006;14:1027-1036.
20. Shen B, Lin R, Wang CC, Rei J, Sun Y, Yang YL, Lin YY. ADAM33 gene polymorphisms identified to be associated with asthma in a Chinese Li population. Biomed Rep 2017;6:323-328.
21. Lee JH, Park HS, Park SW, Jang AS, Uh ST, Rhim T, et al. ADAM33 polymorphism: association with bronchial hyper-responsiveness in Korean asthmatics. Clin Exp Allergy 2004;34:860-865.
22. Bijanzadeh M, Ramachandra NB, Mahesh PA, Mysore RS, Kumar P, Manjunath BS, Jayaraj BS. Association of IL-4 and ADAM33 gene polymorphisms with asthma in an Indian population. Lung 2010;188:415-422.
23. Bora E, Arikan-Ayyildiz Z, Firinci F, Çankaya T, Giray-Bozkaya Ö, Uzuner N, Ülgenalp A. ADAM33 Gene polymorphisms are not associated with asthma in Turkish children. Pediatr Allergy Immunol Pulmonol 2012;25:97-100.
24. Karimi MR, Faridhosseini R, Abbaszadegan MR, Azad FJ, Shirkani A, Riyahi A, Montazar M, Gholamin M. Association of ADAM33 gene polymorphisms with allergic asthma. Iran J Basic Med Sci 2014;17:716-721.
25. Davies ER, Kelly JF, Howarth PH, Wilson DI, Holgate ST, Davies DE, et al. Soluble ADAM33 initiates airway remodeling to promote susceptibilityfor allergic asthma in earlylife. JCI Insight 2016;1: e87632.
26. Reijmerink NE, Kerkhof M, Koppelman GH, Gerritsen J, de Jongste JC, Smit HA, et al. Smoke exposure interacts with ADAM33 polymorphisms in the development of lung function and hyperresponsiveness. Allergy 2009;64:898-904.
27. Jongepier H, Boezen HM, Dijkstra A, Howard TD, Vonk JM, Koppelman GH, et al. Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma. Clin Exp Allergy 2004;34:757-760.
28. El-Falaki MM, Wilson MM, Ezzat GM, Mokhtar DA, El Baz MS, Hamed DH. A disintegrin and metalloproteinase 33 (ADAM33) gene polymorphism association with asthma in Egyptian children. Egypt J Med Human Genet 2013,14:55-62.
29. Lee JY, Park SW, Chang HK, Kim HY, Rhim T, Lee JH, et al. A disintegrin and metalloproteinase 33 protein in patients with asthma: Relevance to air flow limitation. Am J Respir Crit Care Med 2006;173:729-735.
30. Zhang X, Su D, Zhang X, Sui H, Jin L, Lü F, Zhang J. Association of ADAM33 gene polymorphisms with adult concomitant allergic rhinitis and asthma in Chinese Han population. Mol Biol Rep 2009;36:1505-1509.
31. Matsusue A, Kiyohara C, Tanaka K, Sasaki S, Miyake Y. ADAM33 genetic polymorphisms and risk of atopic dermatitis among Japanese children. Clin Biochem. 2009;42:477-483.
32. Raby BA, Silverman EK, Kwiatkowski DJ, Lange C, Lazarus R, Weiss ST. ADAM33 polymorphisms and phenotype associations in childhood asthma. J Allergy Clin Immunol 2004;113:1071-1078.
33. de Bakker PI, Yelensky R, Pe’er I, Gabriel SB, Daly MJ, Altshuler D. Efficiency and power in genetic association studies. Nat Genet 2005;37:1217-1223.

Iranian Journal of Basic Medical Sciences
Volume 21, Issue 8
August 2018
Pages 813-817

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