1. Tang A, Hallouch O, Chernyak V, Kamaya A, Sirlin CB. Epidemiology of hepatocellular carcinoma: target population for surveillance and diagnosis. Abdom Radiol 2018; 43:13-25.
2. Burak KW. Prognosis in the early stages of hepatocellular carcinoma: Predicting outcomes and properly selecting patients for curative options. Can J Gastroenterol Hepatol 2011; 25:482-484.
3. Aggarwal M, Arain A, Jin Z. Systemic treatment for hepatocellular carcinoma. Chronic Dis Transl Med 2018; 4:148-155.
4. Janevska, D, Chaloska-Ivanova V, Janevski V. Hepatocellular carcinoma: risk factors, diagnosis and treatment. Open Access Maced J Med Sci 2015; 3:732.
5. Klein J, Dawson LA, Tran TH, Adeyi O, Purdie T, Sherman M, et al. Metabolic syndrome–related hepatocellular carcinoma treated by volumetric modulated arc therapy. Curr Oncol 2014; 21.e340. 6. Siegel AB, Zhu AX. Metabolic syndrome and hepatocellular carcinoma: two growing epidemics with a potential link. Cancer-Am Cancer Soc 2009; 115:5651-5661.
7. Yu P, Ma D, Xu M. Nested genes in the human genome. Genomics 2005; 86:414-422.
8. Tseng YH, Yeh YH, Chen WJ, Lin KH. Emerging regulation and function of betatrophin. Int J Mol Sci 2014; 15:23640-23657.
9. Zhang R, Abou-Samra AB. Emerging roles of Lipasin as a critical lipid regulator. Biochem Biophys Res Commun 2013; 432:401-405.
10. Dijk W, Kersten S. Regulation of lipid metabolism by angiopoietin-like proteins. Curr Opin Lipidol 2016; 27:249-256.
11. Luo M, Peng D. ANGPTL8: an important regulator in metabolic disorders. Front Endocrinol 2018; 9:169.
12. Saito S, Ojima H, Ichikawa H, Hirohashi S, Kondo T. Molecular background of α‐fetoprotein in liver cancer cells as revealed by global RNA expression analysis. Cancer Sci 2008; 99:2402-2409.
13. Ammerpohl O, Pratschke J, Schafmayer C, Haake, A, Faber W, von Kampen O, et al. Distinct DNA methylation patterns in cirrhotic liver and hepatocellular carcinoma. Int J Cancer 2012; 130:1319-1328.
14. Dong XY, Pang XW, Yu ST, Su Y R, Wang HC, Yin YH, et al. Identification of genes differentially expressed in human hepatocellular carcinoma by a modified suppression subtractive hybridization method. Int J Cancer 2004; 112:239-248.
15. Vilchez V, Turcios L, Marti F, Gedaly R. Targeting Wnt/β-catenin pathway in hepatocellular carcinoma treatment. World J Gastroenterol 2016; 22:823-832.
16. Liu LJ, Xie SX, Chen YT, Xue JL, Zhang CJ, Zhu F. Aberrant regulation of Wnt signaling in hepatocellular carcinoma. World J Gastroenterol 2016; 22:7486.
17. Fatima S, Lee NP, Tsang FH, Kolligs FT, Ng IOL, Poon RTP, et al. Dickkopf 4 (DKK4) acts on Wnt/β-catenin pathway by influencing β-catenin in hepatocellular carcinoma. Oncogene 2012; 31:4233-4244.
18. Song G, Cao HX, Yao SX, Li CT. Abnormal expression of WIF1 in hepatocellular carcinoma cells and its regulating effect on invasion and metastasis factors of TIMP-3 and caveolin-1 of hepatocellular carcinoma. Asian Pacific Tropical Medicine 2015; 8:958-963.
19. Yao Y, Sun S, Wang J, Fei F, Dong Z, Ke A, et al. Canonical Wnt signaling remodels lipid metabolism in zebrafish hepatocytes following Ras oncogenic insult. Cancer Res 2018; 78:5548-5560.
20. Popov VB. Role of beta-catenin in regulating hepatic lipid metabolism in NAFLD. Yale University 2014.
21. Gholami S, Gheibi N, Falak R, Chegini KG. Cloning, expression, purification and CD analysis of recombinant human betatrophin. Rep Biochem Mol Biol 2018; 6:158-163.
22. Aravalli RN, Steer CJ, Cressman EN. Molecular mechanisms of hepatocellular carcinoma. Hepatology 2008; 48:2047-2063.
23. Rasool M, Rashid S, Arooj M, Ansari SA, Khan KM, Malik A, et al. New possibilities in hepatocellular carcinoma treatment. Anticancer Res 2014; 34:1563-1571.
24. Khemlina G, Ikeda S, Kurzrock R. The biology of Hepatocellular carcinoma: implications for genomic and immune therapies. Mol Cancer 2017; 16:149.
25. Kumari R, Sahu MK, Tripathy A, Uthansingh K, Behera M. Hepatocellular carcinoma treatment: hurdles, advances and prospects. Hepat Oncol 2018; 5:HEP08.
26. Alhasan SF. Biotechnology studies of Sulfatase 2 as a novel target for the treatment of hepatocellular carcinoma. 2014.
27. Wang W, Xu L, Liu P, Jairam K, Yin Y, Chen K, et al. Blocking wnt secretion reduces growth of hepatocellular carcinoma cell lines mostly independent of β-catenin signaling. Neoplasia 2016; 18:711-723.
28. Bengochea A, De Souza MM, Lefrancois L, Le Roux E, Galy O, Chemin I, et al. Common dysregulation of Wnt/Frizzled receptor elements in human hepatocellular carcinoma. Br J Cancer 2008; 99: 143-150.
29. Yang W, Yan HX, Chen L, Liu Q, He YQ, Yu LX, et al. Wnt/β-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cells. Cancer Res 2008; 68:4287-4295.
30. Wang CJ, Guo DK, You TG, Shen DW, Wang C, Tang L, et al. Inhibition of hepatocellular carcinoma by fulvestrant involves the estrogen receptor α and Wnt pathways in vitro and in patients. Mol Med Rep 2014; 10:3125-3131.
31. Lui KY, Zhao H, Qiu C, Li C, Zhang Z, Peng H, et al. Integrator complex subunit 6 (INTS6) inhibits hepatocellular carcinoma growth by Wnt pathway and serve as a prognostic marker. BMC cancer 2017; 17:644-656.
32. Ding Z, Qian YB, Zhu LX, Xiong QR. Promoter methylation and mRNA expression of DKK-3 and WIF-1 in hepatocellular carcinoma. World J Gastroenterol 2009; 15:2595-2601.
33. Chen J, Rajasekaran M, Hui KM. Atypical regulators of Wnt/β-catenin signaling as potential therapeutic targets in Hepatocellular Carcinoma. Exp Biol Med 2017; 242:1142-1149.
34. Van Nhieu JT, Renard CA, Wei Y, Cherqui D, Zafrani ES, & Buendia MA. Nuclear accumulation of mutated β-catenin in hepatocellular carcinoma is associated with increased cell proliferation. Am J Pathol 1999; 155:703-710.
35.Wong CM, Fan ST, Ng IO. β‐Catenin mutation and overexpression in hepatocellular carcinoma: clinicopathologic and prognostic significance. Cancer 2001; 92:136-145.
36. Zhang Y, Guo X, Yan W, Chen Y, Ke M, Cheng C, et al. ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ. Nat Commun 2017; 8:2164-2158.
37. Willert K, Brown JD, Danenberg E, Duncan AW, Weissman, IL, Reya T, et al. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 2003; 423:448.
38. Takada R, Satomi Y, Kurata T, Ueno N, Norioka S, Kondoh H, et al. Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion. Dev Cell 2006; 11:791-801.
39. Gao C, Xiao G, Hu J. Regulation of Wnt/β-catenin signaling by posttranslational modifications. Cell Biosci 2014; 4:13-32.
40.de La Coste A, Romagnolo B, Billuart P, Renard CA, Buendia MA, Soubrane O, et al. Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas. Proc Natl Acad Sci U S A 1998; 95:8847-8851.