Flavonoid-rich foods (FRF): A promising nutraceutical approach against lifespan-shortening diseases

Document Type : Review Article


1 State Key Laboratory of Natural Medicines, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, Jiangsu Province, PR China

2 Department of Veterinary Microbiology, Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University Tandojam 70060, Pakistan

3 Faculty of Animal Production and Technology, Cholistan University of Veterinary and Animal Sciences, Bahawalpur 6300, Pakistan

4 Department of Physical Education, Shaanxi Normal University, Xian, Shaanxi Province, P.R China

5 School of Public Health, Nanjing Medical University, Jiangsu Province, 211166, P.R China

6 School of Pharmacy, Nanjing Medical University, Jiangsu Province, 211166, P.R China

7 Faculty of Health Sciences, University of Macau, Avenida de UniversidadeTaipa, Macau

8 Department of Veterinary Medicine, Faculty of Animal Husbandry and Veterinary Science, Sindh Agriculture University, Tandojam 70060, Pakistan

9 Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan

10 Departmentof Poultry, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt


It is well documented that life expectancy in developed countries at birth is going to increase from the 20th century. However, regrettably, a potential decline in life expectancy has been proposed for these nations in the 21st century due to a rapid upsurge in the prevalence of fatal degenerative diseases like cardiovascular diseases (CVD), cancer and diabetes. Collectively, these three diseases accounted for 65% of all deaths in urbanized societies and considered as a dynamic issue for shortening the genetically determined lifespan through increased mortalities, morbidities, disabilities, immense sufferings, and premature aging. These fatal degenerative diseases and premature aging are closely associated with oxidative stress produced by the free radicals in the body. In epidemiologic studies, flavonoid-rich foods (FRF) like fruits, vegetables, and beverages have been associated as protective agents against these diseases. These also have been observed for their geroprotective effects and help in preventing the premature aging and the deterioration of brain function, which is related to Alzheimer’s disease and dementia. In this review, we presented a comprehensive overview of the FRF for their potential role against lifespan-shortening complications, i.e., CVD, cancer, and diabetes. We also had drawn the future perspective and dietary guidelines to reduce the fatal diseases burden in urban populations.


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