Dopaminergic D1 receptors in nucleus basalis modulate recovery from propofol anesthesia in rats

Document Type : Original Article


1 Department of Anesthesiology, Hospital of Stamatology, Zunyi Medical University, Dalian road, Zunyi 563000, Guizhou, China

2 Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, Dalian road 149, Zunyi 563000, Guizhou, China

3 Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Dalian road 149, Zunyi 563000, Guizhou, China


Objective(s): Melatonin, an important hormone secreted by the epiphysis, is a powerful anti-oxidant with a high potential to neutralize medical toxins. The goal of this study was to demonstrate the beneficial effect of melatonin on epididymal sperm and reproductive parameters in mice treated with acetylsalicylic acid (ASA).
Materials and Methods: Thirty-nine SD rats were randomly split into D1 receptor agonist (chloro-APB), D1 receptor antagonist (SCH23390), and saline groups after preparing NB microinjection model. We observed the effect of NB microinjection of SCH23390, chloro-APB, or saline on the period of induction and recovery time of propofol anesthesia and recorded the changes of electroencephalogram (EEG) simultaneously.
Results: NB microinjection of chloro-APB accelerated the recovery from propofol anesthesia (P<0.05), without affecting the induction of anesthesia (P>0.05); NB microinjection of SCH23390 produced the opposite effects. NB microinjection of saline did not influence the induction or recovery of propofol anesthesia (P>0.05). NB injection of chloro-APB decreased the ratio of δ power and increasedαand β ratios in prefrontal cortex EEG (P<0.05); NB microinjection of SCH23390 increased δ ratio and decreased β ratio (P<0.05); NB microinjection of saline had no significant effect on EEG (P>0.05).
Conclusion: D1 dopamine receptors in NB are involved in modulating the emergence from propofol anesthesia, but not affecting the induction of propofol anesthesia.


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