1. Haroon E, Miller AH, Sanacora G. Inflammation, glutamate, and glia: a trio of trouble in mood disorders. Neuropsychopharmacol 2017; 42:193-215.
2. Obrenovitch T, Urenjak J, Zilkha E, Jay T. Excitotoxicity in neurological disorders-the glutamate paradox. Int J Dev Neurosci 2000; 18:281-287.
3. Buckingham SC, Campbell SL, Haas BR, Montana V, Robel S, Ogunrinu T, et al. Glutamate release by primary brain tumors induces epileptic activity. Nat Med 2011; 17:1269-1274
4. Lai TW, Zhang S, Wang YT. Excitotoxicity and stroke: identifying novel targets for neuroprotection. Prog Neurobiol 2014; 115:157-188.
5. Sontheimer H. A role for glutamate in growth and invasion of primary brain tumors. J Neurochem 2008; 105:287-295.
6. Al-Snafi AE. Therapeutic properties of medicinal plants: a review of medicinal plants with central nervous effects (part 1). Int J of Pharmacology & Toxicol 2015; 5:177-192.
7. Afshari AR, Sadeghnia HR, Mollazadeh H. A review on potential mechanisms of Terminalia chebula in Alzheimer’s disease. Adv Pharmacol Sci 2016; 2016:8964849.
8. Boroushaki MT, Mollazadeh H, Afshari AR. Pomegranate seed oil: A comprehensive review on its therapeutic effects. Int J Pharm Sci Rev Res 2016; 7:430-442.
9. Sadeghnia HR, Jamshidi R, Afshari AR, Mollazadeh H, Forouzanfar F, Rakhshandeh H. Terminalia chebula attenuates quinolinate-induced oxidative PC12 and OLN-93 cell death. Mult Scler Relat Disord 2017; 14:60-67.
10. Mollazadeh H, Afshari AR, Hosseinzadeh H. Review on the potential therapeutic roles of Nigella sativa in the treatment of patients with Cancer: involvement of apoptosis:-Black cumin and cancer. J Pharmacopuncture 2017; 20:158-172.
11. Afshari AR, Roshan MK, Soukhtanloo M, Ghorbani A, Rahmani F, Jalili-Nik M, et al. Cytotoxic effects of auraptene against a human malignant glioblastoma cell line. Avicenna J Phytomed 2019; 9:334-346.
12. Crupi R, Impellizzeri D, Cuzzocrea S. Role of Metabotropic Glutamate Receptors in Neurological Disorders. Front Mol Neurosci 2019; 12.
13. Carvalho TG, Alves-Silva J, de Souza JM, Real AL, Doria JG, Vieira EL, et al. Metabotropic glutamate receptor 5 ablation accelerates age-related neurodegeneration and neuroinflammation. Neurochem Int 2019; 126:218-228.
14. Palazzo E, Neugebauer V, Maione S. Metabotropic Glutamate Receptors and Neurological/Psychiatric Disorders. Front Mol Neurosci 2019; 12:67.
15. Lewerenz J, Maher P. Chronic glutamate toxicity in neurodegenerative diseases—what is the evidence? Front Neurosci 2015; 9:469.
16. Wang R, Reddy PH. Role of glutamate and NMDA receptors in Alzheimer’s disease. J Alzheimers Dis 2017; 57:1041-1048.
17. Zhang Y, Li P, Feng J, Wu M. Dysfunction of NMDA receptors in Alzheimer’s disease. Neurol Sci 2016; 37:1039-1047.
18. Nicholls DG, Budd SL. Mitochondria and neuronal survival. Physiol Rev 2000; 80:315-360.
19. Ward MW, Rego AC, Frenguelli BG, Nicholls DG. Mitochondrial membrane potential and glutamate excitotoxicity in cultured cerebellar granule cells. J Neurosci 2000; 20:7208-7219.
20. Rehman MU, Wali AF, Ahmad A, Shakeel S, Rasool S, Ali R, et al. Neuroprotective Strategies for Neurological Disorders by Natural Products: An update. Curr Neuropharmacol 2019; 17:247-267.
21. Hügel HM, Lingham AR, Jackson N, Rook T. Dietary Directions Against Dementia Disorders. Pathology, Prevention and Therapeutics of Neurodegenerative Disease: Springer; 2019. p. 265-278.
22. Wang Z, He C, Shi J. Natural Products for the Treatment of Neurodegenerative Diseases. Curr Med Chem 2019.
23. Ansari N, Khodagholi F. Natural products as promising drug candidates for the treatment of Alzheimer’s disease: molecular mechanism aspect. Curr Neuropharmacol 2013; 11:414-429.
24. Mattson MP. Apoptosis in neurodegenerative disorders. Nat Rev Mol Cell Biol 2000;1(2):120-129.
25. Mattson MP. Glutamate and neurotrophic factors in neuronal plasticity and disease. Ann N Y Acad Sci 2008; 1144:97.
26. Hussein G, Sankawa U, Goto H, Matsumoto K, Watanabe H. Astaxanthin, a carotenoid with potential in human health and nutrition. J Nat Prod 2006; 69:443-449.
27. Wu Q, Zhang X-S, Wang H-D, Zhang X, Yu Q, Li W, et al. Astaxanthin activates nuclear factor erythroid-related factor 2 and the antioxidant responsive element (Nrf2-ARE) pathway in the brain after subarachnoid hemorrhage in rats and attenuates early brain injury. Mar Drugs 2014; 12:6125-6141.
28. Barros MP, Poppe SC, Bondan EF. Neuroprotective properties of the marine carotenoid astaxanthin and omega-3 fatty acids, and perspectives for the natural combination of both in krill oil. Nutrients 2014; 6:1293-1317.
29. Niwano T, Terazawa S, Nakajima H, Wakabayashi Y, Imokawa G. Astaxanthin and withaferin A block paracrine cytokine interactions between UVB-exposed human keratinocytes and human melanocytes via the attenuation of endothelin-1 secretion and its downstream intracellular signaling. Cytokine 2015; 73:184-197.
30. Wang H-Q, Sun X-B, Xu Y-X, Zhao H, Zhu Q-Y, Zhu C-Q. Astaxanthin upregulates heme oxygenase-1 expression through ERK1/2 pathway and its protective effect against beta-amyloid-induced cytotoxicity in SH-SY5Y cells. Brain Res 2010; 1360:159-167.
31. Paw I, Carpenter RC, Watabe K, Debinski W, Lo HW. Mechanisms regulating glioma invasion. Cancer letters 2015; 362:1-7.
32. Prasansuklab A, Tencomnao T. Acanthus ebracteatus leaf extract provides neuronal cell protection against oxidative stress injury induced by glutamate. BMC Complement Altern Med 2018; 18:278.
33. Yu X, Ceballos YW, Zhao H, Xu Z. Neuroprotective effect of Alpinia oxyphylla extract against glutamate‐induced apoptosis in cultured mouse cortical neurons. Neurosci Res Commun 2003; 33:105-103.
34. Pereira EP, Braga-de-Souza S, Santos CC, Santos LO, Cerqueira MD, Ribeiro PR, et al. Amburana cearensis seed extracts protect PC-12 cells against toxicity induced by glutamate. Rev Bras Farmacogn 2017; 27:199-205.
35. Lee HY, Weon JB, Ryu G, Yang WS, Kim NY, Kim MK, et al. Neuroprotective effect of Aronia melanocarpa extract against glutamate-induced oxidative stress in HT22 cells. BMC Complement Altern Med 2017; 17:207.
36. Rajabian A, Boroushaki MT, Hayatdavoudi P, Sadeghnia HR. Boswellia serrata protects against glutamate-induced oxidative stress and apoptosis in PC12 and N2a cells. DNA Cell Biol 2016; 35:666-679.
37. Shivasharan B, Nagakannan P, Thippeswamy B, Veerapur V. Protective effect of Calendula officinalis L. flowers against monosodium glutamate induced oxidative stress and excitotoxic brain damage in rats. Indian J Clin Biochem 2013; 28:292-298.
38. Hosseini A, Rajabian A. Protective effect of Rheum turkestanikum root against doxorubicin-induced toxicity in H9c2 cells. Revist Brasi Farmacogn 2016; 26:347-351.
39. Tayeboon GS, Tavakoli F, Hassani S, Khanavi M, Sabzevari O, Ostad SN. Effects of Cymbopogon citratus and Ferula assa-foetida extracts on glutamate-induced neurotoxicity. In Vitro Cell Dev Biol Anim 2013; 49:706-715.
40. Sadeghnia HR, Rajabian A, Ghorbani A, Moradzadeh M, Hosseini A. Effects of standardized extract of Ferula gummosa root on glutamate-induced neurotoxicity. Folia Neuropathol 2017; 55:340-346.
41. Li Z, Hu H, Lin R, Mao J, Zhu X, Hong Z, et al. Neuroprotective effects of Gua Lou Gui Zhi decoction against glutamate-induced apoptosis in BV-2 cells. Int J Mol Med 2014; 33:597-604.
42. Moon H-I, Lee J-H. Neuroprotective effects of triterpene glycosides from glycine max against glutamate induced toxicity in primary cultured rat cortical cells. Int J Mol Sci 2012; 13:9642-9648.
43. Kim HN, Kim YR, Jang JY, Choi YW, Baek JU, Hong JW, et al. Neuroprotective effects of Polygonum multiflorum extract against glutamate-induced oxidative toxicity in HT22 hippocampal cells. J Ethnopharmacol 2013; 150:108-115.
44. Kim SS, Seo JY, Lim SS, Suh HJ, Kim L, Kim J-S. Neuroprotective effect of Reseda luteola L. extract in a mouse neuronal cell model. Food Sci Biotechnol 2015; 24:333-339.
45. Rajabian A, Sadeghnia H-R, Moradzadeh M, Hosseini A. Rheum turkestanicum reduces glutamate toxicity in PC12 and N2a cell lines. Folia Neuropathol 2018; 56:354-361.
46. Brimson JM, Brimson SJ, Brimson CA, Rakkhitawatthana V, Tencomnao T. Rhinacanthus nasutus extracts prevent glutamate and amyloid-β neurotoxicity in HT-22 mouse hippocampal cells: possible active compounds include lupeol, stigmasterol and β-sitosterol. Int J Mol Sci 2012; 13:5074-5097.
47. Wang C-J, Hu C-P, Xu K-P, Yuan Q, Li F-S, Zou H, et al. Protective effect of selaginellin on glutamate-induced cytotoxicity and apoptosis in differentiated PC12 cells Naunyn Schmiedebergs Arch Pharmacol 2010; 381:73-81.
48. Salavati P, Ramezani M, Monsef-Esfahani HR, Hajiagha R, Parsa M, Tavajohi S, et al. Neuroprotective effect of total and sequential extract of Scrophularia striata Boiss. in rat cerebellar granule neurons following glutamate-induced neurotoxicity: an in-vitro study. Iran J Pharm Res 2013; 12:389-394.
49. Mohan M, Gangurde SK, Kadam V. Protective effect of Solanum torvum on monosodium glutamate-induced neurotoxicity in mice. Indian Nat Prod Resour 2018; 8:351-359.
50. Jang JY, Kim HN, Kim YR, Hong JW, Choi YW, Choi YH et al. Hexane extract from Uncaria sinensis exhibits anti-apoptotic properties against glutamate-induced neurotoxicity in primary cultured cortical neurons. Int J Mol Med 2012; 30:1465-1472.
51. Shimada Y, Goto H, Kogure T, Shibahara N, Sakakibara I, Sasaki H, et al. Protective effect of phenolic compounds isolated from the hooks and stems of Uncaria sinensis on glutamate-induced neuronal death. American J Chinese Med 2001; 29:173-180.
52. Kataria H, Wadhwa R, Kaul SC, Kaur G. Water extract from the leaves of Withania somnifera protect RA differentiated C6 and IMR-32 cells against glutamate-induced excitotoxicity. PLoS One 2012; 7:e37080.
53. Zhang Y, Wang W, Hao C, Mao X, Zhang L. Astaxanthin protects PC12 cells from glutamate-induced neurotoxicity through multiple signaling pathways. J Funct Foods 2015; 16:137-151.
54. Ahmed T, Abdollahi M, Daglia M, Nabavi SF, Nabavi SM. Berberine and neurodegeneration: A review of literature. Pharmacol Rep 2015; 67:970-979.
55. Imenshahidi M, Hosseinzadeh H. Berberis vulgaris and berberine: an update review. Phytother Res 2016; 30:1745-1764.
56. Sarma B, Pandey V, Mishra G, Singh U. Antifungal activity of berberine iodide, a constituent ofFumaria indica. Folia Microbiol 1999; 44:164-166.
57. Bhutada P, Mundhada Y, Bansod K, Dixit P, Umathe S, Mundhada D. Anticonvulsant activity of berberine, an isoquinoline alkaloid in mice. Epilepsy Behav 2010; 18:207-210.
58. Katiyar SK, Meeran SM, Katiyar N, Akhtar S. p53 cooperates berberine‐induced growth inhibition and apoptosis of non‐small cell human lung cancer cells in vitro and tumor xenograft growth in vivo. Mol Carcinog 2009; 48:24-37.
59. Hayashi K, Minoda K, Nagaoka Y, Hayashi T, Uesato S. Antiviral activity of berberine and related compounds against human cytomegalovirus. Bioorg Med Chem Lett 2007; 17:1562-1564.
60. Kuo C-L, Chi C-W, Liu T-Y. The anti-inflammatory potential of berberine in vitro and in vivo. Cancer letters 2004; 203:127-137.
61. Wang F, Zhao G, Cheng L, Zhou H-Y, Fu L-Y, Yao W-X. Effects of berberine on potassium currents in acutely isolated CA1 pyramidal neurons of rat hippocampus. Brain Res 2004; 999:91-97.
62. Punitha ISR, Shirwaikar A, Shirwaikar A. Antidiabetic activity of benzyl tetra isoquinoline alkaloid berberine in streptozotocin-nicotinamide induced type 2 diabetic rats. Diabetol Croat 2005; 34:117-128.
63.Pires ENS, Frozza RL, Hoppe JB, de Melo Menezes B, Salbego CG. Berberine was neuroprotective against an in vitro model of brain ischemia: survival and apoptosis pathways involved. Brain Res 2014; 1557:26-33.
64. Kulkarni S, Dhir A. Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders. Phytother Res 2010; 24:317-324.
65. Sadeghnia HR, Kolangikhah M, Asadpour E, Forouzanfar F, Hosseinzadeh H. Berberine protects against glutamate-induced oxidative stress and apoptosis in PC12 and N2a cells. Iran J Basic Med Sci 2017; 20:594.
66. Lin TY, Lin YW, Lu CW, Huang SK, Wang SJ. Berberine inhibits the release of glutamate in nerve terminals from rat cerebral cortex. PLoS One 2013; 8:e67215.
67. Liu X, Zhou J, Abid MDN, Yan H, Huang H, Wan L, et al. Berberine attenuates axonal transport impairment and axonopathy induced by calyculin a in N2a cells. PloS One 2014; 9:e93974.
68. Moneim AEA. Mercury-induced neurotoxicity and neuroprotective effects of berberine. Neural Regen Res 2015;10:881-882.
69. Yuan NN, Cai CZ, Wu MY, Su HX, Li M, Lu JH. Neuroprotective effects of berberine in animal models of Alzheimer’s disease: a systematic review of pre-clinical studies. BMC Complement Altern Med 2019; 19:109.
70. Campisi A, Acquaviva R, Mastrojeni S, Raciti G, Vanella A, De Pasquale R, et al. Effect of berberine and Berberis aetnensis C. Presl. alkaloid extract on glutamate‐evoked tissue transglutaminase up‐regulation in astroglial cell cultures. Phytother Res 2011; 25:816-820.
71. Song JH, Kang KS, Choi YK. Protective effect of casuarinin against glutamate-induced apoptosis in HT22 cells through inhibition of oxidative stress-mediated MAPK phosphorylation. Bioorg Med Chem Lett 2017;27:5109-5113.
72. Song JH, Shin MS, Hwang GS, Oh ST, Hwang JJ, Kang KS. Chebulinic acid attenuates glutamate-induced HT22 cell death by inhibiting oxidative stress, calcium influx and MAPKs phosphorylation. Bioorg Med Chem Lett 2018; 28:249-253.
73. Wijesekera R. Historical overview of the cinnamon industry. CRC Crit Rev Food Sci Nutr 1978; 10:1-30.
74. Singh G, Maurya S, Catalan CA. A comparison of chemical, antioxidant and antimicrobial studies of cinnamon leaf and bark volatile oils, oleoresins and their constituents. Food Chem Toxicol 2007; 45:1650-1661.
75. Chang S-T, Chen P-F, Chang S-C. Antibacterial activity of leaf essential oils and their constituents from Cinnamomum osmophloeum. J Ethnopharmacol 2001; 77:123-127.
76. Kim DH, Kim CH, Kim M-S, Kim JY, Jung KJ, Chung JH, et al. Suppression of age-related inflammatory NF-κB activation by cinnamaldehyde. Biogerontology 2007; 8:545-554.
77. Ka H, Park HJ, Jung HJ, Choi JW, Cho KS, Ha J, et al. Cinnamaldehyde induces apoptosis by ROS-mediated mitochondrial permeability transition in human promyelocytic leukemia HL-60 cells. Cancer Lett 2003; 196:143-152.
78. Mehraein F, Zamani M, Negahdar F, Shojaee A. Cinnamaldehyde attenuates dopaminergic neuronal loss in substantia nigra and induces midbrain catalase activity in a mouse model of Parkinson’s disease. J Basic Clin Pathophysiol 2018; 6:9-16.
79. Emamghoreishi M, Farrokhi MR, Amiri A, Keshavarz M. The neuroprotective mechanism of cinnamaldehyde against amyloid-β in neuronal SHSY5Y cell line: The role of N-methyl-D-aspartate, ryanodine, and adenosine receptors and glycogen synthase kinase-3β. Avicenna J phytomed 2019; 9:271.
80. Lv C, Yuan X, Zeng HW, Liu RH, Zhang WD. Protective effect of cinnamaldehyde against glutamate-induced oxidative stress and apoptosis in PC12 cells. Eur J Pharmacol 2017; 815:487-494.
81. Shehzad A, Islam SU, Lee YS. Curcumin and Inflammatory Brain Diseases. Curcumin for Neurological and Psychiatric Disorders: Elsevier; 2019. p. 437-458.
82. Sundar Dhilip Kumar S, Houreld NN, Abrahamse H. Therapeutic potential and recent advances of curcumin in the treatment of aging-associated diseases. Molecules 2018; 23:835.
83. Rahmani AH, Alsahli MA, Aly SM, Khan MA, Aldebasi YH. Role of curcumin in disease prevention and treatment. Adv Biomed Res 2018;7:38.
84. Lin TY, Lu CW, Wang C-C, Wang Y-C, Wang S-J. Curcumin inhibits glutamate release in nerve terminals from rat prefrontal cortex: possible relevance to its antidepressant mechanism. Prog Neuropsychopharmacol Biol Psychiatry 2011; 35:1785-1793.
85. Chen K, An Y, Tie L, Pan Y, Li X. Curcumin protects neurons from glutamate-induced excitotoxicity by membrane anchored AKAP79-PKA interaction network. Evid Based Complement Alternat Med 2015; 2015.
86. Khalil RM, Khedr NF. Curcumin protects against monosodium glutamate neurotoxicity and decreasing NMDA2B and mGluR5 expression in rat hippocampus. Neurosignals 2016; 24:81-87.
87. Wang R, Li Y-B, Li Y-H, Xu Y, Wu H-l, Li X-J. Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB. Brain Res 2008; 1210:84-91.
88. Chang C-H, Chen H-X, Yü G, Peng C-C, Peng RY. Curcumin-protected PC12 cells against glutamate-induced oxidative toxicity. Food Technol Biotechnol 2014; 52:468-478.
89. Suh HW, Kang S, Kwon KS. Curcumin attenuates glutamate-induced HT22 cell death by suppressing MAP kinase signaling. Mol Cell Biochem 2007; 298:187-194.
90. Li Y, Li J, Li S, Li Y, Wang X, Liu B, et al. Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK. Toxicol Appl Pharmacol 2015; 286:53-63.
91. Lou F, Ling Y, Tang Y, Wang Y. Isolation, purification and identification of ginkgo terpene lactones. Chin J Nat Med 2004; 2:11-15.
92. Vitolo O, Gong B, Cao Z, Ishii H, Jaracz S, Nakanishi K, et al. Protection against β-amyloid induced abnormal synaptic function and cell death by Ginkgolide J. Neurobiol Aging 2009; 30:257-265.
93. Ma S, Liu H, Jiao H, Wang L, Chen L, Liang J, et al. Neuroprotective effect of ginkgolide K on glutamate-induced cytotoxicity in PC 12 cells via inhibition of ROS generation and Ca 2+ influx. Neurotoxicology 2012; 33:59-69.
94. Mao XY, Zhou HH, Li X, Liu ZQ. Huperzine A alleviates oxidative glutamate toxicity in hippocampal HT22 cells via activating BDNF/TrkB-dependent PI3K/Akt/mTOR signaling pathway. Cell Mol Neurobiol 2016; 36:915-925.
95. Liu J, Jin DZ, Xiao L, Zhu XZ. Paeoniflorin attenuates chronic cerebral hypoperfusion-induced learning dysfunction and brain damage in rats. Brain Res 2006; 1089:162-170.
96. Yu HY, Liu MG, Liu DN, Shang GW, Wang Y, Qi C, et al. Antinociceptive effects of systemic paeoniflorin on bee venom-induced various ‘phenotypes’ of nociception and hypersensitivity. Pharmacol Biochem Behav 2007; 88:131-140.
97.Sun R, Wang K, Wu D, Li X, Ou Y. Protective effect of paeoniflorin against glutamate-induced neurotoxicity in PC12 cells via Bcl-2/Bax signal pathway. Folia Neuropathol 2012; 50:270-276.
98. Mao QQ, Zhong XM, Feng CR, Pan AJ, Li ZY, Huang Z. Protective effects of paeoniflorin against glutamate-induced neurotoxicity in PC12 cells via antioxidant mechanisms and Ca2+ antagonism. Cell Mol Neurobiol 2010; 30:1059-1066.
99. Chen A, Wang H, Zhang Y, Wang X, Yu L, Xu W, et al. Paeoniflorin exerts neuroprotective effects against glutamateinduced PC12 cellular cytotoxicity by inhibiting apoptosis. Int J Mol Med 2017; 40:825-833.
100. Han X, Pan J, Ren D, Cheng Y, Fan P, Lou H. Naringenin-7-O-glucoside protects against doxorubicin-induced toxicity in H9c2 cardiomyocytes by induction of endogenous antioxidant enzymes. Food Chemical Toxicol 2008; 46:3140-3146.
101. Xu XH, Ma CM, Han YZ, Li Y, Liu C, Duan ZH, et al. Protective effect of naringenin on glutamate-induced neurotoxicity in cultured hippocampal cells. Arch Biol Sci 2015; 67:639-646.
102. Bak D-H, Kim HD, Kim YO, Park CG, Han S-Y, Kim J-J. Neuroprotective effects of 20 (S)-protopanaxadiol against glutamate-induced mitochondrial dysfunction in PC12 cells. Int J Mol Med 2016; 37:378-386.
103. Wang X, Wei Y, Yuan S, Liu G, Lu Y, Zhang J, et al. Potential anticancer activity of tanshinone IIA against human breast cancer. Int J Cancer 2005; 116:799-807.
104. Xu S, Liu P. Tanshinone II-A: new perspectives for old remedies. Taylor & Francis; 2013.
105. Li H, Han W, Wang H, Ding F, Xiao L, Shi R, et al. Tanshinone IIA inhibits glutamate-induced oxidative toxicity through prevention of mitochondrial dysfunction and suppression of MAPK activation in SH-SY5Y human neuroblastoma cells. Oxid Med Cell Longev 2017; 2017.
106. Gali-Muhtasib H, Roessner A, Schneider-Stock R. Thymoquinone: a promising anti-cancer drug from natural sources. Int J Biochem Cell Biol 2006; 38:1249-1253.
107. Mansour MA, Nagi MN, El‐Khatib AS, Al‐Bekairi AM. Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT‐diaphorase in different tissues of mice: a possible mechanism of action. Cell Biochem Funct 2002; 20:143-151.
108. Woo CC, Kumar AP, Sethi G, Tan KHB. Thymoquinone: potential cure for inflammatory disorders and cancer. Biochem Pharmacol 2012; 83:443-451.
109. Khan A, Vaibhav K, Javed H, Khan MM, Tabassum R, Ahmed ME, et al. Attenuation of Aβ-induced neurotoxicity by thymoquinone via inhibition of mitochondrial dysfunction and oxidative stress. Mol Cell Biochem 2012; 369:55-65.
110. Genrikhs EE, Stelmashook EV, Popova OV, Kapay NA, Korshunova GA, Sumbatyan NV, et al. Mitochondria-targeted antioxidant SkQT1 decreases trauma-induced neurological deficit in rat and prevents amyloid-β-induced impairment of long-term potentiation in rat hippocampal slices. J Drug Target 2015; 23:347-352.
111. Alhebshi A, Gotoh M, Suzuki I. Thymoquinone protects cultured rat primary neurons against amyloid β-induced neurotoxicity. Biochem Biophys Res Commun 2013; 433:362-367.
112. Al Mamun A, Hashimoto M, Katakura M, Hossain S, Shido O. Neuroprotective effect of thymoquinone against glutamate-induced toxicity in SH-SY5Y cells. Current Topics in Nutraceuticals Research 2015; 13:143.
113. Sayeed MSB, Asaduzzaman M, Morshed H, Hossain MM, Kadir MF, Rahman MR. The effect of Nigella sativa Linn. seed on memory, attention and cognition in healthy human volunteers. J Ethnopharmacol 2013; 148:780-786.
114. Wen X, Huang A, Hu J, Zhong Z, Liu Y, Li Z, et al. Neuroprotective effect of astaxanthin against glutamate-induced cytotoxicity in HT22 cells: Involvement of the Akt/GSK-3β pathway. Neuroscience 2015; 303:558-568.
115. Lin TY, Lu CW, Wang SJ. Astaxanthin inhibits glutamate release in rat cerebral cortex nerve terminals via suppression of voltage-dependent Ca2+ entry and mitogen-activated protein kinase signaling pathway. J Agric Food Chem 2010; 58:8271-8278.
116. Lin X, Zhao Y, Li S. Astaxanthin attenuates glutamate-induced apoptosis via inhibition of calcium influx and endoplasmic reticulum stress. Eur J Pharmacol 2017; 806:43-51.
117. Kysenius K, Brunello CA, Huttunen HJ. Mitochondria and NMDA receptor-dependent toxicity of berberine sensitizes neurons to glutamate and rotenone injury. PloS One 2014; 9:e107129.
118. Biradar SP, Tamboli AS, Khandare RV, Pawar PK. Chebulinic acid and Boeravinone B act as anti-aging and anti-apoptosis phyto-molecules during oxidative stress. Mitochondrion 2019; 46:236-246.
119. Yokoyama T, Ohbuchi T, Saito T, Sudo Y, Fujihara H, Minami K, et al. Allyl isothiocyanates and cinnamaldehyde potentiate miniature excitatory postsynaptic inputs in the supraoptic nucleus in rats. Eur J Pharmacol 2011; 655:31-37.
120. Ma S, Liu H, Jiao H, Wang L, Chen L, Liang J, et al. Neuroprotective effect of ginkgolide K on glutamate-induced cytotoxicity in PC 12 cells via inhibition of ROS generation and Ca2+ influx. Neurotoxicology 2012; 33:59-69.
121. Zhou X, Wang H-Y, Wu B, Cheng C-Y, Xiao W, Wang Z-Z, et al. Ginkgolide K attenuates neuronal injury after ischemic stroke by inhibiting mitochondrial fission and GSK-3β-dependent increases in mitochondrial membrane permeability. Oncotarget 2017; 8:44682.
122. Ved HS, Koenig ML, Dave JR, Doctor BP. Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate. Neuroreport 1997; 8:963-967.
123. Chen A, Wang H, Zhang Y, Wang X, Yu L, Xu W, et al. Paeoniflorin exerts neuroprotective effects against glutamate‑induced PC12 cellular cytotoxicity by inhibiting apoptosis. Int J Mol Med 2017; 40:825-833.
124. Lu C, Dong L, Lv J, Wang Y, Fan B, Wang F, et al. 20 (S)-protopanaxadiol (PPD) alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of Egr-1, c-Fos and c-Jun in mice. Chem Biol Interact 2018; 279:64-72.
125. Lin TY, Lu CW, Huang SK, Wang S-J. Tanshinone IIA, a constituent of Danshen, inhibits the release of glutamate in rat cerebrocortical nerve terminals. J Ethnopharmacol 2013; 147:488-496.
126. Zhang M, Qian Y. Protection of Tanshinone II A on cellular damage induced by glutamate and β-amyloid protein. Chinese J Gerontol 2009; 29:2465-2468.
127. Fouad IA, Sharaf NM, Abdelghany RM, El Sayed NSED. Neuromodulatory effect of thymoquinone in attenuating glutamate-mediated neurotoxicity targeting the amyloidogenic and apoptotic pathways. Front Neurol 2018; 9:236.
)