Therapeutic Uses and Pharmacological Properties of Garlic, Shallot, and Their Biologically Active Compounds

Mikaili, Peyman; Maadirad, Surush; Moloudizargari, Milad; Aghajanshakeri, Shahin; Sarahroodi, Shadi

doi:10.22038/ijbms.2013.1865

Therapeutic Uses and Pharmacological Properties of Garlic, Shallot, and Their Biologically Active Compounds

Document Type : Review Article

Authors

¹ Department of Pharmacology, Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran

² Urmia University, Faculty of Veterinary Medicine, Urmia, Iran

³ Department of Physiology and Pharmacology, School of Medicine, Qom University of Medical Sciences, Qom, Iran

10.22038/ijbms.2013.1865

Abstract

Objective(s):
Garlic (Allium sativum L. family Liliaceae) is well known in Iran and its leaves, flowers, and cloves have been used in traditional medicine for a long time. Research in recent decades has shown widespread pharmacological effects of A. sativum and its organosulfur compounds especially Allicin. Studies carried out on the chemical composition of the plant show that the most important constituents of this plant are organosulfur compounds such as allicin, diallyl disulphide, S-allylcysteine, and diallyl trisulfide. Allicin represents one of the most studied among these naturally occurring compounds. In addition to A. sativum, these compounds are also present in A. hirtifolium (shallot) and have been used to treat various diseases. This article reviews the pharmacological effects and traditional uses of A. sativum, A. hirtifolium, and their active constituents to show whether or not they can be further used as potential natural sources for the development of novel drugs.

Materials and Methods:
For this purpose, the authors went through a vast number of sources and articles and all needed data was gathered. The findings were reviewed and classified on the basis of relevance to the topic and a summary of all effects were reported as tables.
Conclusion:
Garlic and shallots are safe and rich sources of biologically active compounds with low toxicity. Further studies are needed to confirm the safety and quality of the plants to be used by clinicians as therapeutic agents.

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