Wound dressings incorporating microRNAs: Innovative therapy for diabetic wound treatment

Document Type : Letter to the Editor

Authors

1 Department of Medical Laser, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran

2 Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran

Abstract

Diabetic wounds are the most critical complication in patients with diabetes, which often lead to hospitalization and limb amputations. Diabetic foot ulcers (DFU) is characterized by infections, prolonged inflammation, and a delayed wound healing process. Different types of medical procedures including surgical therapy, drug delivery, stem cell therapy, and wound dressings are used to manage DFU. Bioactive dressings such as hydrogels, nanofiber, and collagens are promising materials that can accelerate the healing process. The wound dressing materials can also be loaded with bioactive molecules like nucleic acids. MicroRNAs (miRNAs) are small non-coding RNA molecules that have recently emerged as regulators of impaired wound healing and could be a target for DFU treatment. miRNA therapeutics can be delivered to the wound region using different delivery systems such as exosomes and nanoparticles. These wound dressings have a high potential for treating diabetic wounds by topical delivery of certain miRNAs in a sustained release manner.

Keywords

References

1. Rodrigues M, Kosaric N, Bonham CA, Gurtner GC. Wound healing: A cellular perspective. Physiol Rev 2019; 99: 665-706.
2. Neghab HK, Soheilifar MH, Djavid GE. An in vitro model for investigation of vitamin A effects on wound healing. Int J Vitam Nutr Res 2021; 91:385-390.
3. Nourian Dehkordi A, Mirahmadi Babaheydari F, Chehelgerdi M, Raeisi Dehkordi S. Skin tissue engineering: Wound healing based on stem-cell-based therapeutic strategies. Stem Cell Res Ther 2019; 10:111-131.
4. Krzyszczyk P, Schloss R, Palmer A, Berthiaume F. The role of macrophages in acute and chronic wound healing and interventions to promote pro-wound healing phenotypes. Front Physiol 2018; 9:419-441.
5. Raziyeva K, Kim Y, Zharkinbekov Z, Kassymbek K, Jimi S, Saparov A. Immunology of acute and chronic wound healing. Biomolecules 2021; 11:700-725.
6. N Amirrah I, Mohd Razip Wee MF, Tabata Y, Bt Hj Idrus R, Nordin A, Fauzi MB. Antibacterial-integrated collagen wound dressing for diabetes-related foot ulcers: An evidence-based review of clinical studies. Polymers 2020; 12:2168-2185.
7. Alven S, Peter S, Mbese Z, Aderibigbe BA. Polymer-based wound dressing materials loaded with bioactive agents: Potential materials for the treatment of diabetic Wounds. Polymers 2022; 14:724-759.
8. Subramaniam T, Fauzi MB, Lokanathan Y, Law JX. The role of calcium in wound healing. Int J Mol Sci 2021; 22:6486-6500.
9. Soheilifar MH, Grusch M, Neghab HK, Amini R, Maadi H, Saidijam M, et al. Angioregulatory microRNAs in colorectal cancer. Cancers 2019; 12:71-91.
10. Petkovic M, Sørensen AE, Leal EC, Carvalho E, Dalgaard LT. Mechanistic actions of microRNAs in diabetic wound healing. Cells 2020; 9:2228-2260.
11. Goodarzi G, Maniati M, Qujeq D. The role of microRNAs in the healing of diabetic ulcers. Int Wound J 2019; 16:621-633.
12. Li X, Li D, Wang A, Chu T, Lohcharoenkal W, Zheng X, et al. MicroRNA-132 with therapeutic potential in chronic wounds. J Invest Dermatol 2017; 137:2630-2638.
13. Xie J, Wu W, Zheng L, Lin X, Tai Y, Wang Y, et al. Roles of microRNA-21 in skin wound healing: A comprehensive review. Front Pharmacol 2022; 13:828627-828637.
14. Shi J, Ma X, Su Y, Song Y, Tian Y, Yuan S, et al. MiR-31 mediates inflammatory signaling to promote re-epithelialization during skin wound healing. J Invest Dermatol 2018; 138:2253-2263.
15. Sener G, Hilton SA, Osmond MJ, Zgheib C, Newsom JP, Dewberry L, et al. Injectable, self-healable zwitterionic cryogels with sustained microRNA - cerium oxide nanoparticle release promote accelerated wound healing. Acta Biomater 2020; 101:262-272.
16. Ej M, Em M, N D, Ho M. A peptide/microRNA-31 nanomedicine within an electrospun biomaterial designed to regenerate wounds in vivo. Acta Biomater 2022; 138:285-300.
17. Tao S-C, Guo S-C, Li M, Ke Q-F, Guo Y-P, Zhang C-Q. Chitosan wound dressings incorporating exosomes derived from microrna-126-overexpressing synovium mesenchymal stem cells provide sustained release of exosomes and heal full-thickness skin defects in a diabetic rat model. Stem Cells Transl Med 2017; 6:736-747.
18. Kraskiewicz H, Hinc P, Krawczenko A, Bielawska-Pohl A, Paprocka M, Witkowska D, et al. HATMSC secreted factors in the hydrogel as a potential treatment for chronic wounds-in vitro study. Int J Mol Sci 2021; 22:12241-12259.
19. Chen X, Peng Y, Xue H, Liu G, Wang N, Shao Z. MiR-21 regulating PVT1/PTEN/IL-17 axis towards the treatment of infectious diabetic wound healing by modified GO-derived biomaterial in mouse models. J Nanobiotechnol 2022; 20:1-18.
Iranian Journal of Basic Medical Sciences
Volume 25, Issue 9
September 2022
Pages 1042-1044

Files

Share

How to cite

Statistics