1. Garre-Olmo J. Epidemiology of alzheimer’s disease and other dementias. Rev Neurol 2018;66:377-386.
2. Nichols E, Szoeke CEI, Vollset SE, Abbasi N, Abd-Allah F, Abdela J, et al. Global, regional, and national burden of Alzheimer’s disease and other dementias, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 2019;18:88-106.
3. Nelson PT, Braak H, Markesbery WR. Neuropathology and cognitive impairment in alzheimer disease: A complex but coherent relationship. J Neuropathol Exp Neurol 2009;68:1-14.
4. Williams BD, Pendleton N, Chandola T. Cognitively stimulating activities and risk of probable dementia or cognitive impairment in the English Longitudinal Study of Ageing. SSM Popul Health 2020;12:100656-100667.
5. Alanko V, Udeh-Momoh C, Kivipelto M, Sandebring-Matton A. Mechanisms underlying non-pharmacological dementia prevention strategies: A translational perspective. J Prev Alzheimer’s Dis 2022;9:3-11.
6. Herting MM, Chu X. Exercise, cognition, and the adolescent brain. Birth Defects Res 2017;109:1672-1679.
7. Taskin S, Celik T, Demiryurek S, Turedi S, Taskin A. Effects of different-intensity exercise and creatine supplementation on mitochondrial biogenesis and redox status in mice. Iran J Basic Med Sci 2022; 25:1009-1015.
8. van Praag H. Exercise and the brain: Something to chew on. Trends Neurosci 2009;32:283-290.
9. Liang KY, Mintun MA, Fagan AM, Goate AM, Bugg JM, Holtzman DM, et al. Exercise and Alzheimer’s disease biomarkers in cognitively normal older adults. Ann Neurol 2010; 68:311-318.
10. Biazus-Sehn LF, Schuch FB, Firth J, Stigger F de S. Effects of physical exercise on cognitive function of older adults with mild cognitive impairment: A systematic review and meta-analysis. Arch Gerontol Geriatr 2020;89:104048.
11. Serra FT, Cardoso F dos S, Petraconi N, dos Santos JCC, Araujo BHS, Arida RM, et al. Resistance exercise improves learning and memory and modulates hippocampal metabolomic profile in aged rats. Neurosci Lett 2022; 766:136322.
12. Ryan SM, Kelly ÁM. Exercise as a pro-cognitive, pro-neurogenic and anti-inflammatory intervention in transgenic mouse models of Alzheimer’s disease. Ageing Res Rev 2016;27:77-92.
13. Fancourt D, Steptoe A, Cadar D. Community engagement and dementia risk: Time-to-event analyses from a national cohort study. J Epidemiol Community Health 2020; 74:71-77.
14. Nousia A, Siokas V, Aretouli E, Messinis L, Aloizou AM, Martzoukou M, et al. Beneficial effect of multidomain cognitive training on the neuropsychological performance of patients with early-stage alzheimer’s disease. Neural Plast 2018;2018:2845176-2845184.
15. Baroncelli L, Braschi C, Spolidoro M, Begenisic T, Sale A, Maffei L. Nurturing brain plasticity: Impact of environmental enrichment. Cell Death Differ 2010;17:1092-103.
16. Hu Y, Xu P, Pigino G, Brady ST, Larson J, Lazarov O. Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer’s disease‐linked APPswe/PS1ΔE9 mice. FASEB J 2010; 24:1667-1681.
17. Beauquis J, Pavía P, Pomilio C, Vinuesa A, Podlutskaya N, Galvan V, et al. Environmental enrichment prevents astroglial pathological changes in the hippocampus of APP transgenic mice, model of Alzheimer’s disease. Exp Neurol 2013; 239:28-37.
18. Herring A, Ambrée O, Tomm M, Habermann H, Sachser N, Paulus W, et al. Environmental enrichment enhances cellular plasticity in transgenic mice with Alzheimer-like pathology. Exp Neurol 2009; 216:184-192.
19. Liew AKY, Teo, CH Soga T. The molecular effects of environmental enrichment on alzheimer’s disease. Mol Neurobiol 2022;59:7095-7118.
20. Petrosini L, De Bartolo P, Foti F, Gelfo F, Cutuli D, Leggio MG, et al. On whether the environmental enrichment may provide cognitive and brain reserves. Brain Res Rev 2009;61:221-239.
21. Arendash GW, Garcia MF, Costa DA, Cracchiolo JR, Wefes IM, Potter H. Environmental enrichment improves cognition in aged Alzheimer’s transgenic mice despite stable β-amyloid deposition. Neuroreport 2004;15:1751-1754.
22. Jankowsky JL, Xu G, Fromholt D, Gonzales V, Borchelt DR. Environmental enrichment exacerbates amyloid plaque formation in a transgenic mouse model of Alzheimer disease. J Neuropathol Exp Neurol 2003;62:1220-1227.
23. Mirochnic S, Wolf S, Staufenbiel M, Kempermann G. Age effects on the regulation of adult hippocampal neurogenesis by physical activity and environmental enrichment in the APP23 mouse model of Alzheimer disease. Hippocampus 2009;19:1008-1018.
24. Karssemeijer Ega , Aaronson JA, Bossers WJ , Smits T , Olde Rikkert MGM, Kessels RPC. Positive effects of combined cognitive and physical exercise training on cognitive function in older adults with mild cognitive impairment or dementia: A meta-analysis. Ageing Res Rev 2017;40:75-83.
25. Meng Q, Yin H, Wang S, Shang B, Meng X, Yan M, et al. The effect of combined cognitive intervention and physical exercise on cognitive function in older adults with mild cognitive impairment: a meta-analysis of randomized controlled trials. Aging Clin Exp Res 2022;34:261-276.
26. Kapgal V, Prem N, Hegde P, Laxmi TR, Kutty BM. Long term exposure to combination paradigm of environmental enrichment, physical exercise and diet reverses the spatial memory deficits and restores hippocampal neurogenesis in ventral subicular lesioned rats. Neurobiol Learn Mem 2016;130:61-70.
27. Fabel K, Wolf SA, Ehninger D, Babu H, Leal-Galicia P, Kempermann G. Additive effects of physical exercise and environmental enrichment on adult hippocampal neurogenesis in mice. Front Neurosci 2009;3:50-56.
28. Khodadadegan MA, Negah SS, Saheb M, Gholami J, Arabi MH, Hajali V. Combination effect of exercise and environmental enrichment on cognitive functions and hippocampal neurogenesis markers of rat. Neuroreport 2021;32:1234-1240.
29. Saadati H, Sheibani V, Esmaeili-Mahani S, Darvishzadeh-Mahani F, Mazhari S. Prior regular exercise reverses the decreased effects of sleep deprivation on brain-derived neurotrophic factor levels in the hippocampus of ovariectomized female rats. Regul Pept 2014;194-195:11-5.
30. Kim DY, Jung SY, Kim K, Kim CJ. Treadmill exercise ameliorates Alzheimer disease-associated memory loss through the Wnt signaling pathway in the streptozotocin-induced diabetic rats. J Exerc Rehabil 2016;12:276-83.
31. Abubakar MB, Sanusi KO, Ugusman A, Mohamed W, Kamal H, Ibrahim NH, et al. Alzheimer’s disease: An update and insights into pathophysiology. Front Aging Neurosci 2022; 14-29.
32. LaFerla FM, Green KN. Animal models of Alzheimer disease. Cold Spring Harb Perspect Med 2012; 2: 006320-006332.
33. Facchinetti R, Bronzuoli MR, and Scuderi C. An animal model of alzheimer disease based on the intrahippocampal injection of amyloid β-peptide (1–42). Methods Mol Biol 2018;1727:343-352.
34. Prado Lima MG, Schimidt HL, Garcia A, Daré LR, Carpes FP, Izquierdo I, et al. Environmental enrichment and exercise are better than social enrichment to reduce memory deficits in amyloid beta neurotoxicity. Proc Natl Acad Sci U S A 2018;115:E2403-E2409.
35. Dare LR, Garcia A, Soares CB, Lopes L, Neves BHS, Dias DV, et al. The reversal of memory deficits in an alzheimer’s disease model using physical and cognitive exercise. Front Behav Neurosci 2020;14:152-161.
36. Pardon MC, Sarmad S, Rattray I, Bates TE, Scullion GA, Marsden CA, et al. Repeated novel cage exposure-induced improvement of early Alzheimer’s-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels. Neurobiol Aging 2009;30:1099-1113.
37. Görtz N, Lewejohann L, Tomm M, Ambrée O, Keyvani K, Paulus W, et al. Effects of environmental enrichment on exploration, anxiety, and memory in female TgCRND8 Alzheimer mice. Behav Brain Res 2008;191:43-8.
38. Herring A, Lewejohann L, Panzer AL, Donath A, Kröll O, Sachser N, et al. Preventive and therapeutic types of environmental enrichment counteract beta amyloid pathology by different molecular mechanisms. Neurobiol Dis 2011;42:530-538.
39. McGurran H, Glenn JM, Madero EN, and Bott NT. Prevention and treatment of Alzheimer’s disease: Biological mechanisms of exercise. J Alzheimers Dis 2019;69:311-338.
40. Farì G, Lunetti P, Pignatelli G, Raele MV, Cera A, Mintrone G, et al. The effect of physical exercise on cognitive impairment in neurodegenerative disease: From pathophysiology to clinical and rehabilitative aspects. Int J Mol Sci 2021;22:1163211643.
41. Sattler C, Toro P, Schönknecht P, and Schröder J. Cognitive activity, education and socioeconomic status as preventive factors for mild cognitive impairment and Alzheimer’s disease. Psychiatry Res 2012; 196:90-95.
42. Arenaza-Urquijo EM, Wirth M, Chételat G. Cognitive reserve and lifestyle: Moving towards preclinical Alzheimer’s disease. Front Aging Neurosci 2015; 7:134-145.
43. Cardoso F dos S, França EF, Serra FT, Victorino AB, de Almeida AA, Fernandes J, et al. Aerobic exercise reduces hippocampal ERK and p38 activation and improves memory of middle-aged rats. Hippocampus 2017;27:899-905.
44. Hullinger R, O’Riordan K, Burger C. Environmental enrichment improves learning and memory and long-term potentiation in young adult rats through a mechanism requiring mGluR5 signaling and sustained activation of p70s6k. Neurobiol Learn Mem 2015;125:126-134.
45. Kim BK, Shin MS, Kim CJ, Baek SB, Ko YC, Kim YP. Treadmill exercise improves short-term memory by enhancing neurogenesis in amyloid beta-induced Alzheimer disease rats. J Exerc Rehabil 2014;10:2-8.
46. Dao AT, Zagaar MA, Levine AT, Salim S, Eriksen JL, Alkadhi KA. Treadmill exercise prevents learning and memory impairment in Alzheimer’s disease-like pathology. Curr Alzheimer Res 2013;10:507-515.
47. Jahangiri Z, Gholamnezhad Z, Hosseini M. Neuroprotective effects of exercise in rodent models of memory deficit and Alzheimer’s. Metab Brain Dis 2019 ;34:21-37.
48. Cho JY, Um HS, Kang EB, Cho IH, Kim CH, Cho JS, et al. The combination of exercise training and α-lipoic acid treatment has therapeutic effects on the pathogenic phenotypes of Alzheimer’s disease in NSE/APPsw-transgenic mice. Int J Mol Med 2010; 25:337-346.
49. Li W yi, Gao J yan, Lin SY, Pan S tao, Xiao B, Ma Y tao, et al. Effects of involuntary and voluntary exercise in combination with acousto-optic stimulation on adult neurogenesis in an Alzheimer’s mouse model. Mol Neurobiol 2022; 59:3254-3279.
50. Dong J, Zhou M, Wu X, Du M, Wang X. Memantine combined with environmental enrichment improves spatial memory and alleviates Alzheimer’s disease-like pathology in senescence-accelerated prone-8 (SAMP8) mice. J Biomed Res 2012; 26:439-447.
51. Koester-Hegmann C, Bengoetxea H, Kosenkov D, Thiersch M, Haider T, Gassmann M, et al. High-altitude cognitive impairment is prevented by enriched environment including exercise via VEGF signaling. Front Cell Neurosci 2019; 12:532-547.
52. Santoso DII, Yolanda S, Redjeki S, Andraini T, Ivanali K. Continuous environmental enrichment and aerobic exercise improves spatial memory: Focus on rat hippocampal BDNF and NGF. Comp Exerc Physiol 2020;16:121-128.
53. Aguspa Dita DA, Paramita N, Kodariah R, Kartinah NT. Environmental enrichment and aerobic exercise enhances spatial memory and synaptophysin expression in Rats. Indones Biomed J 2013;23:437-450.
54. Zhao X, Huang X, Cai Y, Cao T, Wan Q. The relative effectiveness of different combination modes for exercise and cognitive training on cognitive function in people with mild cognitive impairment or Alzheimer’s disease: A network meta-analysis. Aging Ment Health 2022;26:2328-2338.
55. Law LLF, Barnett F, Yau MK, Gray MA. Effects of combined cognitive and exercise interventions on cognition in older adults with and without cognitive impairment: A systematic review. Ageing Res Rev 2014;15:61-75.
56. Nocera JR, Mammino K, Kommula Y, Wharton W, Crosson B, McGregor KM. Effects of combined aerobic exercise and cognitive training on verbal fluency in older adults. Gerontol Geriatr Med 2020;6:2333721419896884-2333721419896894.
57. Koizumi H, Higginbotham H, Poon T, Tanaka T, Brinkman BC, Gleeson JG. Doublecortin maintains bipolar shape and nuclear translocation during migration in the adult forebrain. Nat Neurosci 2006;9:779-786.
58. Friocourt G, Koulakoff A, Chafey P, Boucher D, Fauchereau F, Chelly J, et al. Doublecortin functions at the extremities of growing neuronal processes. Cereb Cortex 2003;13:620-626.
59. Yu W, Lu B. Synapses and dendritic spines as pathogenic targets in Alzheimer’s disease. Neural Plast 2012;2012:247150-247157.
60. Baptista P, Andrade JP. Adult hippocampal neurogenesis: Regulation and possible functional and clinical correlates. Front Neuroanat 2018 ;12:44-66.