1. Sharma V, Gautam DNS, Radu AF, Behl T, Bungau SG, Vesa CM. Reviewing the traditional/modern uses, phytochemistry, essential oils/extracts and pharmacology of Embelia ribes burm. Antioxidants 2022; 11: 1359.
2. Harish GU, Danapur V, Jain R, Patell VM. Endangered medicinal plant Embelia ribes burm.f.- A review. Pharmacogn J 2012; 4: 6-19.
3. Basak UC, Mohapatra M. Quantitative reckoning of embelin from fruits of Embelia tsjeriam-cottam using water bath process as an alternate method of extraction. Indian J Pharm Biol Res 2015; 3: 15-23.
4. Carvalho NKG de, Mendes JW da S, Costa JGM da. Quinones: Biosynthesis, characterization of 13c spectroscopical data and pharmacological activities. Chem Biodivers 2023; 20: e202301365.
5. Kundap UP, Bhuvanendran S, Kumari Y, Othman I, Shaikh MF. Plant derived phytocompound, embelin in CNS disorders: A systematic review. Front Pharmacol 2017; 8: 229931.
6. Martín-Acosta P, Cuadrado I, González-Cofrade L, Pestano R, Hortelano S, de las Heras B, et al. Synthesis of quinoline and dihydroquinoline embelin derivatives as cardioprotective agents. J Nat Prod 2023;86: 317-329.
7. Prabhu KS, Achkar IW, Kuttikrishnan S, Akhtar S, Khan AQ, Siveen KS, et al. Embelin: A benzoquinone possesses therapeutic potential for the treatment of human cancer. Future Med Chem 2018;10:961-976.
8. Ko JH, Lee SG, Mo Yang W, Um JY, Sethi G, Mishra S, et al. The application of embelin for cancer prevention and therapy. Molecules. 2018; 23: 621.
9. Chen F, Zhang G, Hong Z, Lin Z, Lei M, Huang M, et al. Design, synthesis, and SAR of embelin analogues as the inhibitors of PAI-1 (plasminogen activator inhibitor-1). Bioorg Med Chem Lett 2014; 24: 2379-2382.
10. Modak R, Basha J, Bharathy N, Maity K, Mizar P, Bhat A V, et al. Probing p300/CBP associated factor (PCAF)-dependent pathways with a small molecule inhibitor. ACS Chem Biol 2013; 8: 1311-1323.
11. Basha NJ, Basavarajaiah SM, Baskaran S, Kumar P. A comprehensive insight on the biological potential of embelin and its derivatives. Nat Prod Res 2022; 36: 3054-3068.
12. Martín-Acosta P, Cuadrado I, González-Cofrade L, Pestano R, Hortelano S, de las Heras B, et al. Synthesis of quinoline and dihydroquinoline embelin derivatives as cardioprotective agents. J Nat Prod 2023; 86: 317-329.
13. Alam M, Ahad A, Abidin L, Aqil M, Mir S. Embelin-loaded oral niosomes ameliorate streptozotocin-induced diabetes in Wistar rats. Biomed Pharmacother 2018; 97:1514-1520.
14. Chen X, Gao M, Jian R, Hong WD, Tang X, Li Y, et al. Design, synthesis and α-glucosidase inhibition study of novel embelin derivatives. J Enzyme Inhib Med Chem 2020; 35: 565-573.
15. Kamble V, Attar U, Umdale S, Nimbalkar M, Ghane S, Gaikwad N. Phytochemical analysis, antioxidant activities and optimized extraction of embelin from different genotypes of Embelia ribes Burm f.: A woody medicinal climber from Western Ghats of India. Physiol Mol Biol Plants 2020; 26:1855-1865.
16. Kumaraswamy HM, Krishna V, Sharath R, Satyanarayan ND, Meghana P, Jain RSK, et al. Potential role of embelin in the prevention of Freund’s adjuvant induced inflammation and ROS. 3 Biotech 2022;12: 10-20.
17. Kundap UP, Bhuvanendran S, Kumari Y, Othman I, Shaikh MF. Plant derived phytocompound, embelin in CNS disorders: A systematic review. Front Pharmacol 2017; 8: 76-88.
18. Ramachandra VH, Sivanesan S, Koppal A, Anandakumar S, Howell MD, Sukumar E, et al. Embelin and levodopa combination therapy for improved Parkinson’s disease treatment. Transl Neurosci 2022;13: 145-162.
19. Nuthakki VK, Choudhary S, Reddy CN, Bhatt S, Jamwal A, Jotshi A, et al. Design, synthesis, and pharmacological evaluation of embelin-aryl/alkyl amine hybrids as orally bioavailable blood-brain barrier permeable multitargeted agents with therapeutic potential in alzheimer’s disease: discovery of SB-1448. ACS Chem Neurosci 2023; 14: 1193-1219.
20. Rupesh R, Mohankumar R, Sabarathinam S. Isolation and in-silico approach of Modified Embelin derivative from Embelia ribes fruits as anti‐Alzheimer agent. Nat Prod Res 2023;1-5.
21. Ramachandra VH, Sivanesan S, Koppal A, Anandakumar S, Howell MD, Sukumar E, et al. Embelin and levodopa combination therapy for improved Parkinson’s disease treatment. Transl Neurosci 2022;13: 145-162.
22. Kapahi H, Kumar A, Sandhu NK, Bansal P, Mishra N. Development and characterization of in situ gel of embelin for the management of Huntington’s disease. Pharmaspire 2020;12: 61-71.
23. Dhadde SB, Nagakannan P, Roopesh M, Anand Kumar SR, Thippeswamy BS, Veerapur VP, et al. Effect of embelin against 3-nitropropionic acid-induced Huntington’s disease in rats. Biomed Pharmacother 2016; 77: 52-58.
24. Xue Z, Ge Z, Zhang K, Sun R, Yang J, Han R, et al. Embelin suppresses dendritic cell functions and limits autoimmune encephalomyelitis through the TGF-β/β-catenin and STAT3 signaling pathways. Mol Neurobiol 2014; 49: 1087-1101.
25. Caruso F, Rossi M, Kaur S, GarciaVillar E, Molasky N. Antioxidant properties of embelin in cell culture. Electrochemistry and theoretical mechanism of scavenging. Potential scavenging of superoxide radical through the cell membrane. Antioxidants 2020; 9: 382-402.
26. Venkatachalam D. Antidepressant activity of embelin isolated from the methanol extract of fruits of Embelia ribes burm. J Pharmacogn Nat Prod 2023; 9: 5-8.
27. Wang B, Chen X, Zhou T, Wang X. Antidepressant-like effects of embelin and its possible mechanisms of action in chronic unpredictable stress-induced mice. Neurol Res 2018; 40: 666-676.
28. Chitra M, Sukumar E, Suja V, Shyamala Devi CS. Antitumour, anti-inflammatory and analgesic property of embelin, a plant product. Chemotherapy 1994; 40: 109-113.
29. Mahendran S, Badami S, Ravi S, Thippeswamy BS, Veerapur VP. Antioxidant, analgesic and anti-inflammatory properties of new ninhydrin adduct of embelin. Pharm Chem J 2011; 45: 547-551.
30. Mahendran S, Badami S, Ravi S, Thippeswamy BS, Veerapur VP. Synthesis and evaluation of analgesic and anti-inflammatory activities of most active free radical scavenging derivatives of embelin—a structure–activity relationship. Chem Pharm Bull (Tokyo) 2011; 59: 913-919.
31. Qin X, Meghana K, Sowjanya NL, Sushma KR, Krishna CG, Manasa J, et al. Embelin attenuates cisplatin-induced nephrotoxicity: Involving inhibition of oxidative stress and inflammation in addition with activation of Nrf-2/Ho-1 pathway. BioFactors 2019; 45: 471-478.
32. SreeHarsha N. Embelin impact on paraquat-induced lung injury through suppressing oxidative stress, inflammatory cascade, and MAPK/NF-κB signaling pathway. J Biochem Mol Toxicol 2020; 34: 22456.
33. Tessema EN, Alain S, Tanemossu F. Anthelmintic activity-guided fractionation and GC-MS analysis of extracts from Embelia schimperi fruits. Int J Appl Res Nat Prod 2018; 11: 11-16.
34. Anika, Arora R, Virendra SA, Chawla PA. Mechanistic study on the possible role of embelin in treating neurodegenerative disorders. CNS Neurol Disord Drug Targets 2023; 23: 55-66.
35. Kundap UP, Paudel YN, Kumari Y, Othman I, Shaikh MF. Embelin prevents seizure and associated cognitive impairments in a pentylenetetrazole-induced kindling zebrafish model. Front Pharmacol 2019;10: 315-329.
36. Afzal M, Gupta G, Kazmi I, Rahman M, Upadhyay G, Ahmad K, et al. Evaluation of anxiolytic activity of embelin isolated from Embelia ribes. Biomed Aging Pathol 2012; 2: 45-47.
37. Thippeswamy BS, Nagakannan P, Shivasharan BD, Mahendran S, Veerapur VP, Badami S. Protective effect of embelin from Embelia ribes burm. Against transient global ischemia-induced brain damage in rats. Neurotox Res 201; 20: 379-86.
38. Bhuvanendran S, Bakar SNS, Kumari Y, Othman I, Shaikh MF, Hassan Z. Embelin improves the spatial memory and hippocampal long-term potentiation in a rat model of chronic cerebral hypoperfusion. Sci Rep 2019; 9: 1-11.
39. Shrimali H, Mandal UK, Nivsarkar M, Shrivastava N. Fabrication and evaluation of a medicated hydrogel film with embelin from Embelia ribes for wound healing activity. Futur J Pharm Sci 2019; 5:1-10 .
40. Alavi M, Martinez F, Delgado D. Anticancer and antibacterial activities of embelin: Micro and nano aspects. Micro Nano Bio 2022; 1: 30-37.
41. Mahendran S, Hazirah B. Formulation and evaluation of antibacterial ointment containing embelin isolated from Embelia ribes. Int J Green Pharm 2018;12: 570-575.
42. Kiriyanthan RM, Radha A, Pandikumar P, Azhahianambi P, Madan N, Ignacimuthu S. Growth inhibitory effect of selected quinones from Indian medicinal plants against Theileria annulata. Exp Parasitol 2023; 254: 108622.
43. Radhakrishnan N, Gnanamani A. 2, 5-dihydroxy-3-undecyl-1, 4-benzoquinone (embelin)-a second solid gold of india- A review. Int J Pharm Pharm Sci 2014; 6: 23-30.
44. Kumar D, Vats N, Saroha K, Rana AC. Phytosomes as Emerging Nanotechnology for Herbal Drug Delivery. 2020; 5: 217–37.
45. Sandhiya V, Ubaidulla U. A review on herbal drug loaded into pharmaceutical carrier techniques and its evaluation process. Future J Pharm Sci 2020; 6: 1-16.
46. Ansari SH, Islam F, Sameem M. Influence of nanotechnology on herbal drugs: A Review. J Adv Pharm Technol Res 2012; 3: 142-146.
47. Mamillapalli V, Atmakuri AM, Khantamneni P. Nanoparticles for herbal extracts. Asian J Pharm 2016; 10: 54.
48. Jadhav NR, Powar T, Shinde S, Nadaf S. Herbal nanoparticles: A patent review. Asian J Pharm 2014 ;8: 58.
49. Li Z, Chen SJ, Yu XA, Li J, Gao XM, He J, et al. Pharmacokinetic and bioavailability studies of embelin after intravenous and oral administration to rats. Evid Based Complement Alternat Med 2019; 2019: 9682495.
50. Li F, Danquah M, Mahato RI. Synthesis and characterization of amphiphilic lipopolymers for micellar drug delivery. Biomacromolecules 2010; 11: 2610-2620.
51. Huang Y, Lu J, Gao X, Li J, Zhao W, Sun M, et al. PEG-derivatized embelin as a dual functional carrier for the delivery of paclitaxel. Bioconjug Chem 2012; 23: 1443-14451.
52. Danquah M. Embelin and Its derivatives: Design, synthesis, and potential delivery systems for cancer therapy. Pharmaceuticals 2022; 15: 1131-1143.
53. Singh B, Guru SK, Sharma R, Bharate SS, Khan IA, Bhushan S, et al. Synthesis and anti-proliferative activities of new derivatives of embelin. Bioorg Med Chem Lett 2014; 24: 4865-4870.
54. Kannaiyan R, Shanmugam MK, Sethi G. Molecular targets of celastrol derived from thunder of god vine: Potential role in the treatment of inflammatory disorders and cancer. Cancer Lett 2011; 303: 9-20.
55. Coutelle O, Hornig-Do HT, Witt A, Andree M, Schiffmann LM, Piekarek M, et al. Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing. EMBO Mol Med 2014; 6: 624-639.
56. Basha NJ, Basavarajaiah SM, Baskaran S, Kumar P. A comprehensive insight on the biological potential of embelin and its derivatives. Nat Prod Res 2022; 36: 3054-3068.
57. Nuthakki VK, Sharma A, Kumar A, Bharate SB. Identification of embelin, a 3-undecyl-1,4-benzoquinone from Embelia ribes as a multitargeted anti-Alzheimer agent. Drug Dev Res 2019; 80: 655-665.
58. Gupta G, Kazmi I, Afzal M, Upadhyay G, Singh R, Habtemariam S. Antidepressant-like activity of Embelin isolated from Embelia ribes. Phytopharmacology 2013; 2013: 87-95.
59. Gandhi GR, Stalin A, Balakrishna K, Ignacimuthu S, Paulraj MG, Vishal R. Insulin sensitization via partial agonism of PPARγ and glucose uptake through translocation and activation of GLUT4 in PI3K/p-Akt signaling pathway by embelin in type 2 diabetic rats. Biochim Biophys Acta 2013;1830: 2243-2255.
60. Gupta R, Sharma AK, Sharma MC, Gupta RS. Antioxidant activity and protection of pancreatic β-cells by embelin in streptozotocin-induced diabetes. J Diabetes 2012; 4: 248-256.
61. Bhandari U, Chaudhari HS, Bisnoi AN, Kumar V, Khanna G, Javed K. Anti-obesity effect of standardized ethanol extract of Embelia ribes in murine model of high fat diet-induced obesity. PharmaNutrition 2013; 1: 50-57.
62. Nazish I, Ansari SH, Arora P. Antiobesity actions of Embelia ribes. Pharmacogn J 2012; 4: 73-80.
63. Martín-Acosta P, Cuadrado I, González-Cofrade L, Pestano R, Hortelano S, de las Heras B, et al. Synthesis of quinoline and dihydroquinoline embelin derivatives as cardioprotective agents. J Nat Prod 2023; 86: 317-329.
64. Nurul S, Othman N, Lum PT, Sekar M, Mazlan NA, Zarith P, et al. Molecules of interest-embelin-A review. Res J Pharm Tech 2020; 13: 3485-3493.
65. Deshmukh PT, Gupta VB. Embelin accelerates cutaneous wound healing in diabetic rats. J Asian Nat Prod Res 2013; 15: 158-165.
66. Coutelle O, Hornig-Do HT, Witt A, Andree M, Schiffmann LM, Piekarek M, et al. Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing. EMBO Mol Med 2014; 6: 624-639.
67. Kumara Swamy HM, Krishna V, Shankarmurthy K, Abdul Rahiman B, Mankani KL, Mahadevan KM, et al. Wound healing activity of embelin isolated from the ethanol extract of leaves of Embelia ribes Burm. J Ethnopharmacol 2007; 109: 529-534.
68. Jagetia GC, Baliga MS. The evaluation of nitric oxide scavenging activity of certain Indian medicinal plants in vitro: A preliminary study. J Med Food 2004; 7: 343-348.
69. Caruso F, Rossi M, Kaur S, Garcia-Villar E, Molasky N, Belli S, et al. Antioxidant properties of embelin in cell culture. Electrochemistry and theoretical mechanism of scavenging. potential scavenging of superoxide radical through the membrane cell. Antioxidants 2020; 9: 382-403.
70. Qin X, Meghana K, Sowjanya NL, Sushma KR, Krishna CG, Manasa J, et al. Embelin attenuates cisplatin-induced nephrotoxicity: Involving inhibition of oxidative stress and inflammation in addition with activation of Nrf-2/Ho-1 pathway. BioFactors 2019; 45: 471-478.
71. Hossan MS, Fatima A, Rahmatullah M, Khoo TJ, Nissapatorn V, Galochkina A V., et al. Antiviral activity of Embelia ribes Burm. f. against influenza virus in vitro. Arch Virol 2018; 163: 2121-2131.
72. Caruso F, Rossi M, Pedersen JZ, Incerpi S. Computational studies reveal mechanism by which quinone derivatives can inhibit SARS-CoV-2. Study of embelin and two therapeutic compounds of interest, methyl prednisolone and dexamethasone. J Infect Public Health. 2020; 13: 1868-1877.
73. Debebe Y, Tefera M, Mekonnen W, Abebe D, Woldekidan S, Abebe A, et al. Evaluation of anthelmintic potential of the Ethiopian medicinal plant Embelia schimperi Vatke in vivo and in vitro against some intestinal parasites. BMC Complement Altern Med 2015; 15: 187-192.
74. Swarnkar CP, Singh D, Khan FA, Bhagwan PSK. Anthelmintic potential of Embelia ribes seeds against Haemonchus contortus of sheep. Indian J Anim Sci 2008; 2:167-170.
75. Bøgh HO, Andreassen J, Lemmich J. Anthelmintic usage of extracts of Embelia schimperi from Tanzania. J Ethnopharmacol 1996; 50: 35-42.
76. Sinha V, Singh A, Pal V, Maurya S. Anthelmintic efficacy of aqueous-alcoholic extracts formulations of Embelia ribes fruits and vernonia anthelmintica seeds against ovine gastrointestinal nematodes. Int J Livestock Res 2020; 10: 60-66.
77. Dhiman N, Awasthi R, Sharma B, Kharkwal H, Kulkarni GT. Lipid nanoparticles as carriers for bioactive delivery. Front Chem 2021; 9: 580118.
78. Haider M, Abdin SM, Kamal L, Orive G. Nanostructured lipid carriers for delivery of chemotherapeutics: A review. Pharmaceutics 2020;12: 288-313.
79. Barani M, Sangiovanni E, Angarano M, Rajizadeh MA, Mehrabani M, Piazza S, et al. Phytosomes as innovative delivery systems for phytochemicals: A comprehensive review of literature. Int J Nanomedicine 2021; 16: 6983-7022.
80. Ali A, Aqil M, Imam SS, Ahad A, Parveen A, Qadir A, et al. Formulation and evaluation of embelin loaded nanoliposomes: Optimization, in vitro and ex vivo evaluation. J Drug Deliv Sci Technol 2022; 72: 103414.
81. Sharma N, Bhandari S, Deshmukh R, Yadav AK, Mishra N. Development and characterization of embelin-loaded nanolipid carriers for brain targeting. Artif Cells Nanomed Biotechnol 2017; 45: 409-413.
82. Jain S, Jain N. PUB040 formulation and evaluation of Embelin loaded transfersome for effective treatment of skin cancer. J Thorac Oncol 2017; 12: S2378.
83. Badamaranahalli SS, Kopparam M, Bhagawati ST, Durg S. Embelin lipid nanospheres for enhanced treatment of ulcerative colitis–Preparation, characterization and in vivo evaluation. Eur J Pharm Sci 2015; 76: 73-82.
84. Cui P, Qu F, Sreeharsha N, Sharma S, Mishra A, Gubbiyappa SK. Antiarthritic effect of chitosan nanoparticle loaded with embelin against adjuvant-induced arthritis in Wistar rats. IUBMB Life 2020; 72: 1054-1064.
85. Ajay K, Nikhat KM, Jovita K, Amandeep S, Neeraj M, Mishra N. Ligand decorated Embelin loaded PLGA nanoparticles for management of alcohol induced hepatotoxicity. J Drug Deliv Ther 2020; 10: 72-80.
86. Khare T, Mahalunkar S, Shriram V, Gosavi S, Kumar V. Embelin-loaded chitosan gold nanoparticles interact synergistically with ciprofloxacin by inhibiting efflux pumps in multidrug-resistant Pseudomonas aeruginosa and Escherichia coli. Environ Res 2021; 199: 111321.
87. Jagtap RR, Garud A, Puranik SS, Rudrapal M, Ansari MA, Alomary MN, et al. Biofabrication of silver nanoparticles (AgNPs) using Embelin for effective therapeutic management of lung cancer. Front Nutr 2022; 9: 1-9.
88. Karpuz M, Gunay MS, Ozer AY. Liposomes and phytosomes for phytoconstituents. Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents. 2020; 525–53.
89. Yadav E, Alam J, Shiva, Arfi S, Khalid M, Pal P, et al. Fabrication of embelin incorporated phytosomes complex for assessing hepatoprotective potential against acetaminophen elicit hepatotoxicity in male wistar rats. Indo Am J Pharm Res 2023; 13: 726-738.
90. Alam MS, Ahad A, Abidin L, Aqil M, Mir SR, Mujeeb M. Embelin-loaded oral niosomes ameliorate streptozotocin-induced diabetes in Wistar rats. Biomed Pharmacother 2018; 97:1514-1520.
91. Opatha SAT, Titapiwatanakun V, Chutoprapat R. Transfersomes: A promising nanoencapsulation technique for transdermal drug delivery. Pharmaceutics 2020; 12: 1-23.
92. Wilson RJ, Li Y, Yang G, Zhao CX. Nanoemulsions for drug delivery. Particuology 2022; 64: 85-97.
93. Zhang L, Zhang L, Zhang M, Pang Y, Li Z, Zhao A, et al. Self-emulsifying drug delivery system and the applications in herbal drugs. Drug Deliv 2015; 22: 475-486.
94. Abaszadeh F, Ashoub MH, Amiri M. Nanoemulsions challenges and future prospects as a drug delivery system. Current Trends in Green Nano-emulsions 2023; 217-243.
95. Parmar K, Patel J, Sheth N. Formulation and optimization of Embelin nanosuspensions using central composite design for dissolution enhancement. J Drug Deliv Sci Technol 2015; 29: 1–7.
96. Parmar K, Patel J, Sheth N. Self nano-emulsifying drug delivery system for Embelin: Design, characterization and in-vitro studies. Asian J Pharm Sci 2015; 10: 396–404.
97. Mehnert W, Mader K. Solid lipid nanoparticles: Production, characterization and applications. Adv Drug Deliv Rev 2012; 47: 165-96.
98. Srivastava S, Sharma V, Bhushan B, Malviya R. Nanocarriers for protein and peptide delivery: Recent advances and progress. J Res Pharm 2021; 25: 99-116.
99. Dhiman N, Awasthi R, Sharma B, Kharkwal H, Kulkarni GT. Lipid nanoparticles as carriers for bioactive delivery. Front Chem 2021; 9: 580118.
100. Wang Q, Cheng H, Zhou K, Wang L, Dong S, Wang D, et al. Nanostructured lipid carriers as a delivery system of biochanin A. Drug Deliv 2013; 20: 331–337.
101. Bhatia T, Gupta G Das, Kurmi B Das, Singh D. Role of solid lipid nanoparticles for the delivery of lipophilic drugs and herbal medicines in the treatment of pulmonary hypertension. Pharm Nanotechnol 2022; 10: 342–353.
102. Ahmed HM, Nabavi S, Behzad S. Herbal drugs and natural products in the light of nanotechnology and nanomedicine for developing drug formulations. Mini Rev Med Chem 2020; 21: 302-313.
103. Lacatusu I, Iordache TA, Mihaila M, Mihaiescu DE, Pop AL, Badea N. Multifaced role of dual herbal principles loaded-lipid nanocarriers in providing high therapeutic efficacity. Pharmaceutics 2021; 13: 1511-1533.
104. Nemati S, Mohammad Rahimi H, Hesari Z, Sharifdini M, Jalilzadeh Aghdam N, Mirjalali H, et al. Formulation of Neem oil-loaded solid lipid nanoparticles and evaluation of its anti-Toxoplasma activity. BMC Complement Med Ther 2022; 22: 1-11.
105. Kumar A, Kaur V, Singh A, Mishra N. Development and characterization of paclitaxel and embelin loaded solid lipid nanoparticles for breast cancer. J Drug Deliv Ther 2020; 10: 60-68.
106. Zielinska A, Carreiró F, Oliveira AM, Neves A, Pires B, Nagasamy Venkatesh D, et al. Polymeric nanoparticles: Production, characterization, toxicology and ecotoxicology. Molecules 2020; 25: 1511-1533.
107. Shree D, Patra CN, Sahoo BM. Fabrication and applications of polymeric nanoparticles for herbal drug delivery and targeting. Curr Trad Med 2022 Aug 19; 9: 23-33.
108. Saini S, Nanda S, Dhiman A. Chitosan nanoparticles: An approbative system for the delivery of herbal bioactives. Nat Prod J 2020; 12: 3-16.
109. Maanvizhi S, Radhakrishnan N, Krishnan C, Gnanamani A. Pharmacological evaluation of embelin - chitosan nanoparticles as an antidiabetic agent. Indian J Pharmacol 2022; 54: 126-130.
110. Ghazali NF, Zarith P, Yusri S, Mazlan NA, Lum PT, Akmal A, et al. Synthesis, characterization, antioxidant and cytotoxic studies of embelin loaded N,O-CMC nanoparticles. Int J Res Pharm Sci 2020; 11: 1738–1747.
111. Chandrakala V, Aruna V, Angajala G. Review on metal nanoparticles as nanocarriers: current challenges and perspectives in drug delivery systems. Emergent Mater 2022; 5: 1593-1615.
112. Chopra H, Bibi S, Singh I, Hasan MM, Khan MS, Yousafi Q, et al. Green metallic nanoparticles: Biosynthesis to applications. Front Bioeng Biotechnol 2022; 10: 874742-874770.
113. Jain N, Jain P, Rajput D, Patil UK. Green synthesized plant-based silver nanoparticles: therapeutic prospective for anticancer and antiviral activity. Micro and Nano Syst Lett 2021; 9: 1-24.
114. Jagtap RR, Garud A, Puranik SS, Rudrapal M, Ansari MA, Alomary MN, et al. Biofabrication of silver nanoparticles (AgNPs) using Embelin for effective therapeutic management of lung cancer. Front Nutr 2022; 9: 960674.
115. Jagtap RR, Garud A, Warude B, Puranik SS. Embelin isolated from Embelia ribes derived silver nanoparticles and its application in breast cancer nanomedicine. Mater Today Proc 2023; 73: 403-411.
116. Ahmed U, Ong SK, Khan KM, Siddiqui R, Khan NA, Shaikh MF, et al. Effect of Embelin on inhibition of cell growth and induction of apoptosis in Acanthamoeba castellanii. Arch Microbiol 2023; 205: 1-18.
117. Rajalakshmi TU, Sheeba H, Doss A, Veerabahu R, Sivagnanam A, Alfarraj S, et al. Synthesis of silver nanoparticles from natural derived embelin compound and their uses in mercury degradation under solar light. Mater Res Express 2023; 10: 055502-055512.
118. Dhayalan M, Denison MIJ, Anitha Jegadeeshwari L, Krishnan K, Nagendra Gandhi N. In vitro antioxidant, antimicrobial, cytotoxic potential of gold and silver nanoparticles prepared using Embelia ribes. Nat Prod Res 2017; 31: 465-468.
119. Kalimuthu K, Cha B, Kim S, Park K. Eco-friendly synthesis and biomedical applications of gold nanoparticles: A review. Microchem J 2020; 152: 104296.
120. Hammami I, Alabdallah NM, jomaa A Al, kamoun M. Gold nanoparticles: Synthesis properties and applications. J King Saud Univ Sci 2021; 33: 101560-101570.
121. Khare T, Mahalunkar S, Shriram V, Gosavi S, Kumar V. Embelin-loaded chitosan gold nanoparticles interact synergistically with ciprofloxacin by inhibiting efflux pumps in multidrug-resistant Pseudomonas aeruginosa and Escherichia coli. Environ Res 2021; 199: 111321.
122. Sasidharan S, Poojari R, Bahadur D, and Srivastava R. Embelin-mediated green synthesis of quasi-spherical and star-shaped plasmonic nanostructures for antibacterial activity, photothermal therapy, and computed tomographic imaging. ACS Sustain Chem Eng 2018; 6: 10562-10577.
123. Mahakal M, Kutumbale A, Mehta D, Mehta BK. Green synthesis of ZnO nanoparticles from the methanolic extract of Embelia ribes and their characterization by uv-visible, FTIR, XRD and SEM analysis. Int J Pharm Biol Sci 2018; 8: 402-409.
124. You S, Zhang J, Yu L, Li Z, Zhang J, Zhao N, et al. Construction of SLC16A1/3 targeted gallic acid-iron-embelin nanoparticles for regulating glycolysis and redox pathways in cervical cancer. Mol Pharm 2023; 20: 4574-4586.
125. Quan Y. Preparation and in vitro anti-tumor activity of doxorubicin and embelin co-loaded liposomes decorated with transferrin. Basic Clin Med 2014; 34: 1548-1552.
126. Rashid M, Wani TU, Mishra N, Sofi HS, Sheikh FA. Development and characterization of drug-loaded self-solidnano-emulsified drug delivery system for treatment of diabetes. Mat Sci Res India 2018; 15: 01–11.
127. Ali MH, Alam O, Ali A, Ali MU, Parvez S, Aldosari E, et al. Donepezil and Embelin loaded nanostructured lipid carriers for direct brain delivery as an intervention for alzheimer’s disease: Formulation design, optimization and evaluation. J Clust Sci 2023;35: 1021-1044.
128. Arya JS, Joseph MM, Murali VP, Vidyalekshmi MS, Maiti KK. Targeted delivery polymeric nanosystem reinforced by synergism of Embilin and RPI-1 for therapeutics of pancreatic cancer. ACS Appl Nano Mater 2022; 5:18622-18636.
129. Xu Y, Liu D, Hu J, Ding P, Chen M. Hyaluronic acid-coated pH sensitive poly (β-amino ester) nanoparticles for co-delivery of embelin and TRAIL plasmid for triple negative breast cancer treatment. Int J Pharm 2020; 573: 118637-118646.
130. Lu J, Huang Y, Zhao W, Marquez RT, Meng X, Li J, et al. PEG-derivatized embelin as a nanomicellar carrier for delivery of paclitaxel to breast and prostate cancers. Biomaterials 2013; 34: 1591-1600.
131. Jain S. Nose to brain delivery of embelin with carbidopa nanoparticle for effective management of Parkisonism. Parkinsonism Relat Disord 2020; 79: e65.