1. Delaby C, Hirtz C, Lehmann S. Overview of the blood biomarkers in Alzheimer’s disease: Promises and challenges. Rev Neurol 2022; 179:161-172.
2. Association As. https://www.alz.org/alzheimers-dementia/facts-figures 2022 [cited 2022 14th November].
3. Association As. 2018 Alzheimer’s Disease Facts and Figures. Alzheimers Dement 2018; 14:367-429.
4. Fish PV, Steadman D, Bayle ED, Whiting P. New approaches for the treatment of Alzheimer’s disease. Bioorg Med Chem Lett 2019; 29:125-133.
5. Blennow K, Zetterberg H. Biomarkers for Alzheimer’s disease: Current status and prospects for the future. J Intern Med 2018; 284:643-663.
6. Francis PT. The interplay of neurotransmitters in Alzheimer’s disease. CNS Spectr 2005; 10: 6-9.
7. Pangalos MN, Schechter LE, Hurko O. Drug development for CNS disorders: Strategies for balancing risk and reducing attrition. Nat Rev Drug Discov 2007; 6: 521-532.
8. Paramanick D, Singh VD, Singh VK. Neuroprotective effect of phytoconstituents via nanotechnology for treatment of Alzheimer diseases. J Control Release 2022; 351: 638-655.
9. Ma Y, Liu S, Zhou Q, Li Z, Zhang Z, Yu B. Approved drugs and natural products at clinical stages for treating Alzheimer’s disease. Chin J Nat Med 2024; 22: 1-12.
10. Rygnestad T. Development of physostigmine from a poisonous plant to an antidote. One of the most important drugs in the development of modern medicine?. Tidsskr Nor Laegeforen 1992; 112:1300-1303.
11. Rehman MU, Wali AF, Ahmad A, Shakeel S, Rasool S, Ali R, et al. Neuroprotective strategies for neurological disorders by natural products: an update. Curr Neuropharmacol 2019; 17:247-267.
12. Chauhan NB. Effect of aged garlic extract on APP processing and tau phosphorylation in Alzheimer’s transgenic model Tg2576. J Ethnopharmacol 2006; 108:385-394.
13. Arredondo SB, Reyes DT, Herrera-Soto A, Mardones MD, Inestrosa NC, Varela-Nallar L. Andrographolide promotes hippocampal neurogenesis and spatial memory in the APPswe/PS1ΔE9 mouse model of Alzheimer’s disease. Sci Rep 2021; 11: 22904-22918.
14. Bhanukiran K, Singh R, Gajendra T, Ramakrishna K, Singh SK, Krishnamurthy S, et al. Vasicinone, a pyrroloquinazoline alkaloid from Adhatoda vasica Nees enhances memory and cognition by inhibiting cholinesterases in Alzheimer’s disease. Phytomedicine Plus 2023; 3: 100439-100454.
15. Meena J, Ojha R, Muruganandam A, Krishnamurthy S. Asparagus racemosus competitively inhibits in vitro the acetylcholine and monoamine metabolizing enzymes. Neuroscience letters 2011; 503:6-9.
16. Tayanloo-Beik A, Kiasalari Z, Roghani M. Paeonol alleviates brain glucose hypometabolism in streptozotocin murine model of sporadic Alzheimer’s disease using microPET imaging. J Basic Clin Pathophysiol 2022; 10:45-49.
17. Xia C-L, Tang G-H, Guo Y-Q, Xu Y-K, Huang Z-S, Yin S. Mulberry Diels-Alder-type adducts from Morus alba as multi-targeted agents for Alzheimer’s disease. Phytochemistry 2019; 157:82-91.
18. Yi S, Chen S, Xiang J, Tan J, Huang K, Zhang H, et al. Genistein exerts a cell-protective effect via Nrf2/HO-1//PI3K signaling in Ab25-35-induced Alzheimer’s disease models in vitro. Folia Histochemica et Cytobiologica 2021; 59:49-56.
19. Chalatsa I, Arvanitis DA, Koulakiotis NS, Giagini A, Skaltsounis AL, Papadopoulou-Daifoti Z, et al. The Crocus sativus compounds trans-crocin 4 and trans-crocetin modulate the amyloidogenic pathway and tau misprocessing in Alzheimer disease neuronal cell culture models. Front Neurosci 2019; 13: 249-263.
20. Rafieipour F, Hadipour E, Emami SA, Asili J, Tayarani-Najaran Z. Safranal protects against beta-amyloid peptide-induced cell toxicity in PC12 cells via MAPK and PI3 K pathways. Metab Brain Dis 2019; 34:165-172.
21. Choi W-Y, Lee W-K, Kim T-H, Ryu Y-K, Park A, Lee Y-J, et al. The effects of Spirulina maxima extract on memory improvement in those with mild cognitive impairment: A randomized, double-blind, placebo-controlled clinical Trial. Nutrients 2022; 14:3714-3729.
22. Ito N, Saito H, Seki S, Ueda F, Asada T. Effects of composite supplement containing astaxanthin and sesamin on cognitive functions in people with mild cognitive impairment: A randomized, double-blind, placebo-controlled trial. J Alzheimers Dis 2018; 62:1767-1775.
23. Lee W-J, Shin Y-W, Kim D-E, Kweon M-H, Kim M. Effect of desalted Salicornia europaea L. ethanol extract (PM-EE) on the subjects complaining memory dysfunction without dementia: A 12 week, randomized, double-blind, placebo-controlled clinical trial. Sci Rep 2020; 10:19914-19925.
24. Oyeleke MB, Owoyele BV. Saponins and flavonoids from Bacopa floribunda plant extract exhibit antioxidant and anti-inflammatory effects on amyloid beta 1-42-induced Alzheimer’s disease in BALB/c mice. J Ethnopharmacol 2022; 288:114997.
25. Kim MJ, Park SY, Kim Y, Jeon S, Cha MS, Kim YJ, et al. Beneficial effects of a combination of Curcuma longa L. and Citrus junos against beta-amyloid peptide-induced neurodegeneration in mice. J Med Food 2022; 25:12-23.
26. Afewerky HK, Li H, Zhang T, Li X, Mahaman YAR, Duan L, et al. Sodium–calcium exchanger isoform-3 targeted Withania somnifera (L.) Dunal therapeutic intervention ameliorates cognition in the 5xFAD mouse model of Alzheimer’s disease. Sci Rep 2022; 12:1537-1553.
27. Boonyarat C, Yenjai C, Monthakantirat O, Kaewamatawong R, Poonsawas P, Wangboonskul J, et al. Multifunctionality of Clausena harmandiana extract and its active constituents against Alzheimer’s Disease. Curr Issues Mol Biol 2022; 44:3681-3694.
28. Sahraei R, Aminyavari S, Hosseini M, Hassanzadeh-Taheri M, Foadoddini M, Saebipour M. The ameliorative impact of centella asiatica on the working memory deficit in streptozotocin-induced rat model of Alzheimer disease. Basic Clin Neurosci 2022; 13:25-34.
29. Anupama KP, Shilpa O, Antony A, Raghu SV, Gurushankara HP. Jatamansinol from Nardostachys jatamansi (D. Don) DC. Protects Aβ42-Induced neurotoxicity in Alzheimer’s disease drosophila model. NeuroToxicology 2022; 90:62-78.
30. Temviriyanukul P, Kittibunchakul S, Trisonthi P, Kunkeaw T, Inthachat W, Siriwan D, et al. Mangifera indica ‘Namdokmai’ prevents neuronal cells from amyloid peptide toxicity and inhibits BACE-1 activities in a Drosophila model of Alzheimer’s amyloidosis. Pharmaceuticals (Basel) 2022; 15:591-610.
31. Joshi R, Garabadu D, Teja GR, Krishnamurthy S. Silibinin ameliorates LPS-induced memory deficits in experimental animals. Neurobiol Learn Mem 2014; 116:117-131.
32. Rehman S, Ali Ashfaq U, Sufyan M, Shahid I, Ijaz B, Hussain M. The insight of in silico and in vitro evaluation of Beta vulgaris phytochemicals against Alzheimer’s disease targeting acetylcholinesterase. PLoS One 2022; 17:e0264074-0264092.
33. Hara Y, Fillit HM. The dawn of a new era of Alzheimer’s research and drug development. J Prev Alzheimers Dis 2022; 9:385-386.
34. Şener G, Karakadıoglu G, Ozbeyli D, Ede S, Yanardag R, Sacan O, et al. Petroselinum crispum extract ameliorates scopolamine-induced cognitive dysfunction: role on apoptosis, inflammation and oxidative stress. Food Sci Hum Wellness 2022; 11:1290-1298.
35. Hosseini R, Mirshekar MA, Sedaghat G, Clark CC, Jalali M. The effect of sub-chronic administration of brewed coffee on long-term potentiation in a rat model of Alzheimer’s disease. Shiraz E-Med J 2022; 23:e113268-113273.
36. Geng J, Liu W, Gao J, Jiang C, Fan T, Sun Y, et al. Andrographolide alleviates Parkinsonism in MPTP‐PD mice via targeting mitochondrial fission mediated by dynamin‐related protein 1. Br J Pharmacol 2019; 176:4574-4591.
37. Souza LC, Andrade MK, Azevedo EM, Ramos DC, Bail EL, Vital MA. Andrographolide attenuates short-term spatial and recognition memory impairment and neuroinflammation induced by a streptozotocin rat model of Alzheimer’s disease. Neurotox Res 2022; 40:1440-1454.
38. Hegazy E, Sabry A, Khalil WK. Neuroprotective effects of onion and garlic root extracts against Alzheimer’s disease in rats: Antimicrobial, histopathological, and molecular studies. BioTechnologia 2022; 103:153-167.
39. Srivastava P, Shanker K. Pluchea lanceolata (Rasana): Chemical and biological potential of Rasayana herb used in traditional system of medicine. Fitoterapia 2012; 83:1371-1385.
40. Asirvatham R, Daiay P, SALAM S. The beneficial effect of Pluchea lanceolata on aluminum chloride-induced Alzheimer’s disease in rats. J Cell Neurosci Oxid Stress 2022; 14:1045-1062.
41. Sethiya NK, Nahata A, Mishra SH, Dixit VK. An update on Shankhpushpi, a cognition-boosting Ayurvedic medicine. Zhong Xi Yi Jie He Xue Bao 2009; 7:1001-1022.
42. Mettupalayam Kaliyannan Sundaramoorthy P, Kilavan Packiam K. In vitro enzyme inhibitory and cytotoxic studies with Evolvulus alsinoides (Linn.) Linn. Leaf extract: A plant from Ayurveda recognized as Dasapushpam for the management of Alzheimer’s disease and diabetes mellitus. BMC Complement Med Ther 2020; 20:1-12.
43. Jiménez-Aliaga K, Bermejo-Bescós P, Benedí J, Martín-Aragón S. Quercetin and rutin exhibit antiamyloidogenic and fibril-disaggregating effects in vitro and potent antioxidant activity in APPswe cells. Life Sci 2011; 89: 939-945.
44. Carmona V, Martín-Aragón S, Goldberg J, Schubert D, Bermejo-Bescós P. Several targets involved in Alzheimer’s disease amyloidogenesis are affected by morin and isoquercitrin. Nutr Neurosci 2020; 23:575-590.
45. Geng CA, Ma YB, Zhang XM, Yao SY, Xue DQ, Zhang RP, et al. Mulberrofuran G and isomulberrofuran G from Morus alba L.: Anti-hepatitis B virus activity and mass spectrometric fragmentation. J Agric Food Chem 2012; 60:8197-8202.
46. Ganai AA, Farooqi H. Bioactivity of genistein: A review of in vitro and in vivo studies. Biomed Pharmacother 2015; 76:30-38.
47. Bagheri M, Roghani M, Joghataei M-T, Mohseni S. Genistein inhibits aggregation of exogenous amyloid-beta1-40 and alleviates astrogliosis in the hippocampus of rats. Brain Res 2012; 1429:145-154.
48. Soeda S, Ochiai T, Paopong L, Tanaka H, Shoyama Y, Shimeno H. Crocin suppresses tumor necrosis factor-α-induced cell death of neuronally differentiated PC-12 cells. Life Sci 2001; 69:2887-2898.
49. Papandreou MA, Kanakis CD, Polissiou MG, Efthimiopoulos S, Cordopatis P, Margarity M, et al. Inhibitory activity on amyloid-β aggregation and antioxidant properties of Crocus sativus stigmas extract and its crocin constituents. J Agric Food Chem 2006; 54:8762-8768.
50. Tiribuzi R, Crispoltoni L, Chiurchiù V, Casella A, Montecchiani C, Del Pino AM, et al. Trans-crocetin improves amyloid-β degradation in monocytes from Alzheimer’s disease patients. J Neurol Sci 2017; 372:408-412.
51. Shafiee M, Arekhi S, Omranzadeh A, Sahebkar A. Saffron in the treatment of depression, anxiety and other mental disorders: Current evidence and potential mechanisms of action. J Affect Disord 2018; 227:330-337.
52. Takahashi Y, Shindo S, Kanbayashi T, Takeshima M, Imanishi A, Mishima K. Examination of the influence of cedar fragrance on cognitive function and behavioral and psychological symptoms of dementia in Alzheimer type dementia. Neuropsychopharmacol Rep 2020; 40:10-15.
53. Miczke A, Szulinska M, Hansdorfer-Korzon R, Kregielska-Narozna M, Suliburska J, Walkowiak J, et al. Effects of spirulina consumption on body weight, blood pressure, and endothelial function in overweight hypertensive Caucasians: A double-blind, placebo-controlled, randomized trial. Eur Rev Med Pharmacol Sci 2016; 20:150-156.
54. Koh EJ, Seo YJ, Choi J, Lee HY, Kang DH, Kim KJ, et al. Spirulina maxima extract prevents neurotoxicity via promoting activation of BDNF/CREB signaling pathways in neuronal cells and mice. Molecules 2017; 22:1363-1372.
55. Guo H, Tian J, Wang X, Tian Z, Li X, Yang L, et al. Neuroprotection of sesamin against cerebral ischemia in-vivo and N-Methyl-D-Aspartate-induced apoptosis in-vitro. Biochem Pharmacol (Los Angel) 2015; 4:1-7.
56. Ambati RR, Siew Moi P, Ravi S, Aswathanarayana RG. Astaxanthin: Sources, extraction, stability, biological activities and its commercial applications—A review. Mar Drugs 2014; 12:128-152.
57. Mori J, Yokoyama H, Sawada T, Miyashita Y, Nagata K. Anti-oxidative properties of astaxanthin and related compounds. Mol Cryst Liq Cryst 2013; 580:52-57.
58. Katagiri M, Satoh A, Tsuji S, Shirasawa T. Effects of astaxanthin-rich Haematococcus pluvialis extract on cognitive function: a randomised, double-blind, placebo-controlled study. J Clin Biochem Nutr 2012; 51:102-107.
59. Wu H, Niu H, Shao A, Wu C, Dixon BJ, Zhang J, et al. Astaxanthin as a potential neuroprotective agent for neurological diseases. Mar Drugs 2015; 13:5750-5766.
60. Grimmig B, Kim S-H, Nash K, Bickford PC, Douglas Shytle R. Neuroprotective mechanisms of astaxanthin: A potential therapeutic role in preserving cognitive function in age and neurodegeneration. Geroscience 2017; 39:19-32.
61. Min AY, Doo CN, Son EJ, Sung NY, Lee KJ, Sok D-E, et al. N-palmitoyl serotonin alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of BDNF and p-CREB in mice. Chem Biol Interact 2015; 242:153-162.
62. Karthivashan G, Kweon MH, Park SY, Kim JS, Kim DH, Ganesan P, et al. Cognitive-enhancing and ameliorative effects of acanthoside B in a scopolamine-induced amnesic mouse model through regulation of oxidative/inflammatory/cholinergic systems and activation of the TrkB/CREB/BDNF pathway. Food Chem Toxicol 2019; 129:444-457.
63. Dong L, May BH, Feng M, Hyde AJ, Tan HY, Guo X, et al. Chinese herbal medicine for mild cognitive impairment: A systematic review and meta‐analysis of cognitive outcomes. Phytother Res 2016; 30:1592-1604.
64. Pineda A, Gomez F, Echeverry A. Comparison of the NINDS-AIREN and VASCOG criteria for the diagnosis of major vascular cognitive impairment in a memory clinic. Rev Neurol 2019; 69:235-241.
65. Liu Ny, Pei H, Liu Mx, Liu Lt, Fu Cg, Li H, et al. Efficacy and safety of guilingji capsules (龟龄集胶囊) for treating mild-to-moderate cognitive impairment: Study protocol for a randomized, double-blind, positive-controlled, multicenter and noninferiority trial. Chin J Integr Med 2020; 26:577-582.
66. Zhang H, Chen H, Pei H, Wang H, Ma L, Li H. The effect of guilingji capsules on vascular mild cognitive impairment: A randomized, double-blind, controlled trial. Evid Based Complement Alternat Med 2022; 2022:4778163-4778174.
67. Xing Sh, Zhu Cx, Zhang R, An L. Huperzine a in the treatment of Alzheimer’s disease and vascular dementia: A meta-analysis. Evid Based Complement Alternat Med 2014; 2014:363985-363994.
68. Wang R, Yan H, TANG Xc. Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine 1. Acta Pharmacol Sin 2006; 27:1-26.
69. Gul A, Bakht J, Mehmood F. Huperzine-A response to cognitive impairment and task switching deficits in patients with Alzheimer’s disease. J Chin Med Assoc 2019; 82:40-43.
70. Perry NSL, Menzies R, Hodgson F, Wedgewood P, Howes MR, Brooker HJ, et al. A randomised double-blind placebo-controlled pilot trial of a combined extract of sage, rosemary and melissa, traditional herbal medicines, on the enhancement of memory in normal healthy subjects, including influence of age. Phytomedicine 2018; 39:42-48.
71. Lewerenz J, Maher P. Chronic glutamate toxicity in neurodegenerative diseases-what is the evidence? Front Neurosci 2015; 9:469-488.
72. Angelova PR, Vinogradova D, Neganova ME, Serkova TP, Sokolov VV, Bachurin SO, et al. Pharmacological sequestration of mitochondrial calcium uptake protects neurons against glutamate excitotoxicity. Mol Neurobiol 2019; 56:2244-2255.
73. Choi WY, Kang DH, Lee HY. Enhancement of neuroprotective effects of spirulina maxima by a low-temperature extraction process with ultrasonic pretreatment. Biotechnol Bioproc E 2018; 23:415-423.
74. Rashedinia M, Lari P, Abnous K, Hosseinzadeh H. Protective effect of crocin on acrolein-induced tau phosphorylation in the rat brain. Acta Neurobiol Exp 2015; 75:208-219.
75. Moussa C, Hebron M, Huang X, Ahn J, Rissman RA, Aisen PS, et al. Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease. J Neuroinflammation 2017; 14:1-10.
76. Wyss-Coray T. Inflammation in Alzheimer disease: Driving force, bystander or beneficial response? Nat Med 2006; 12:1005-1015.
77. Asadi F, Jamshidi AH, Khodagholi F, Yans A, Azimi L, Faizi M, et al. Reversal effects of crocin on amyloid β-induced memory deficit: Modification of autophagy or apoptosis markers. Pharmacol Biochem Behav 2015; 139:47-58.
78. Jaliani HZ, Riazi GH, Ghaffari SM, Karima O, Rahmani A. The effect of the Crocus sativus L. carotenoid, crocin, on the polymerization of microtubules, in vitro. Iran J Basic Med Sci 2013; 16:101–107.
79. Karakani AM, Riazi G, Ghaffari SM, Ahmadian S, Mokhtari F, Firuzi MJ, et al. Inhibitory effect of corcin on aggregation of 1N/4R human tau protein in vitro. Iran J Basic Med Sci 2015; 18:485-492.
80. Koh EJ, Kim KJ, Song JH, Choi J, Lee HY, Kang DH, et al. Spirulina maxima extract ameliorates learning and memory impairments via inhibiting GSK-3β phosphorylation induced by intracerebroventricular injection of amyloid-β 1–42 in mice. Int J Mol Sci 2017; 18:2401-.
81. Jung SJ, Jung ES, Ha KC, Baek HI, Park YK, Han SK, et al. Efficacy and safety of sesame oil cake extract on memory function improvement: A 12-week, randomized, double-blind, placebo-controlled pilot study. Nutrients 2021; 13:2606-2621.
82. Hamdan AME, Alharthi FHJ, Alanazi AH, El-Emam SZ, Zaghlool SS, Metwally K, et al. Neuroprotective effects of phytochemicals against aluminum chloride-induced Alzheimer’s Disease through ApoE4/LRP1, Wnt3/β-Catenin/GSK3β, and TLR4/NLRP3 pathways with physical and mental activities in a rat model. Pharmaceuticals (Basel) 2022; 15:1008-1030.
83. Mokarrami S, Jahanshahi M, Elyasi L, Badelisarkala H, Khalili M. Naringin prevents the reduction of the number of neurons and the volume of CA1 in a Scopolamine-Induced animal model of Alzheimer’s disease (AD): A stereological study. Int J Neurosci 2024;134:364-371.
84. Kim DS, Zhang T, Park S. Protective effects of Forsythiae fructus and Cassiae semen water extract against memory deficits through the gut-microbiome-brain axis in an Alzheimer’s disease model. Pharm Biol 2022; 60:212-224.
85. Samanta T, Chandran KS, Medda N, Banerjee A, Mitra A, De SK. Black tea and its theaflavin derivatives firmly inhibit acetylcholinesterase activity, possible implications in cholinergic neurodegenerative or muscular disorder. 2022.
86. Suttisansanee U, Charoenkiatkul S, Jongruaysup B, Tabtimsri S, Siriwan D, Temviriyanukul P. Mulberry fruit cultivar ‘Chiang Mai’prevents beta-amyloid toxicity in PC12 neuronal cells and in a Drosophila model of Alzheimer’s disease. Molecules 2020; 25:1837-1850.
87. Bakhsh HT, Abdelhafez OH, Elmaidomy AH, Aly HF, Younis EA, Alzubaidi MA, et al. Anti-Alzheimer potential of Solanum lycopersicum seeds: in vitro, in vivo, metabolomic, and computational investigations. Beni-Suef Univ J Basic Appl Sci 2024; 13:1-19.
88. Kamli MR, Sharaf AAM, Sabir JS, Rather IA. Phytochemical Screening of Rosmarinus officinalis L. as a Potential Anticholinesterase and Antioxidant–Medicinal Plant for Cognitive Decline Disorders. Plants 2022; 11:514-528.
89. Ureña-Vacas I, González-Burgos E, De Vita S, Divakar PK, Bifulco G, Gómez-Serranillos MP. Phytochemical characterization and pharmacological properties of lichen extracts from cetrarioid clade by multivariate analysis and molecular docking. Evid Based Complement Alternat Med 2022; 2022: 5218248-5218263.
90. Lopa SS, Al-Amin M, Hasan M, Ahammed M, Islam KM, Alam A, et al. Phytochemical analysis and cholinesterase inhibitory and antioxidant activities of Enhydra fluctuans relevant in the management of Alzheimer’s disease. Int J Food Sci 2021; 2021:8862025-8862032.
91. Dhakal S, Ramsland PA, Adhikari B, Macreadie I. Trans-Chalcone plus baicalein synergistically reduce intracellular amyloid beta (Aβ42) and protect from Aβ42 induced oxidative damage in yeast models of Alzheimer’s disease. Int J Mol Sci 2021; 22:9456-9469.
92. Takim K, Yigin A, Koyuncu I, Kaya R, Gülçin İ. Anticancer, anticholinesterase and antidiabetic activities of tunceli garlic (Allium tuncelianum): Determining its phytochemical content by LC–MS/MS analysis. J Food Meas Charact 2021; 15:3323-3335.
93. Youssef AMM, Maaty DAM, Al-Saraireh YM. Qualitative chemical compounds analysis and in vitro estimation of antiproliferative, antidiabetic and anti-Alzheimer’s disease effects of Ononis natrix (L.) family Fabaceae. Pharmacia 2024; 71:1-11.
94. Homwuttiwong K, Buranrat B, Yannasithinon S, Noisa P, Mairuae N. Neuroprotective potential of Thunbergia laurifolia lindl leaf extracts against beta amyloid-induced neurotoxicity: An in vitro model of Alzheimer’s disease. Pharmacognosy Magazine 2024:09731296241226769.
95. Liu X, Dhana K, Furtado JD, Agarwal P, Aggarwal NT, Tangney C, et al. Higher circulating α-carotene was associated with better cognitive function: An evaluation among the MIND trial participants. J Nutr Sci 2021; 10:e64-72.
96. Stites SD, Turner RS, Gill J, Gurian A, Karlawish J, Grill JD. Research attitudes questionnaire scores predict Alzheimer’s disease clinical trial dropout. Clin Trials 2021; 18:237-244.
97. Noguchi Shinohara M, Ono K, Hamaguchi T, Nagai T, Kobayashi S, Komatsu J, et al. Safety and efficacy of Melissa officinalis extract containing rosmarinic acid in the prevention of Alzheimer’s disease progression. Sci Rep 2020; 10:18627-18636.
98. Yagishita Y, Fahey JW, Dinkova-Kostova AT, Kensler TW. Broccoli or sulforaphane: Is it the source or dose that matters? Molecules 2019; 24:3593-3630.
99. Salehi B, Mishra AP, Nigam M, Sener B, Kilic M, Sharifi-Rad M, et al. Resveratrol: A double-edged sword in health benefits. Biomedicines 2018; 6:91-111.
100. Drewnowski A, Rehm CD. Sources of caffeine in diets of US children and adults: Trends by beverage type and purchase location. Nutrients 2016; 8:154-166.
)