1. Ghasemzadeh Rahbardar M, Hosseinzadeh H. Effects of rosmarinic acid on nervous system disorders: an updated review. Naunyn Schmiedebergs Arch Pharmacol 2020; 393:1779-1795.
2. Saxena S, Caroni P. Selective neuronal vulnerability in neurodegenerative diseases: from stressor thresholds to degeneration. Neuron 2011; 71:35-48.
3. Rahbardar MG, Hosseinzadeh H. Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders. Iran J Basic Med Sci 2020; 23:1100.
4. Jalali J, Ghasemzadeh Rahbardar M. Ameliorative effects of Portulaca oleracea L. (purslane) and its active constituents on nervous system disorders: A review. Iran J Basic Med Sci 2023, 26: 2–12.
5. Tan B, Wang Y, Zhang X, Sun X. Recent Studies on Protective Effects of Walnuts against Neuroinflammation. Nutrients 2022; 14.
6. Mohebbati R, Khazdair M, Hedayati M. Neuroprotective effects of medicinal plants and their constituents on different induced neurotoxicity methods: A. J Rep Pharm Sci 2017; 6:34-50.
7. Boskabady MH, Vatanprast A, Parsee H, Ghasemzadeh M. Effect of aqueous-ethanolic extract from Rosa damascena on guinea pig isolated heart. Iran J Basic Med Sci 2011; 14:116-121.
8. Yahyazadeh R, Ghasemzadeh Rahbardar M, Razavi BM, Karimi G, Hosseinzadeh H. The effect of Elettaria cardamomum (cardamom) on the metabolic syndrome: Narrative review. Iran J Basic Med Sci 2021; 24:1462-1469.
9. Alavi MS, Fanoudi S, Ghasemzadeh Rahbardar M, Mehri S, Hosseinzadeh H. An updated review of protective effects of rosemary and its active constituents against natural and chemical toxicities. Phytother Res 2021; 35:1313-1328.
10. Hosseini M, Pkan P, Rakhshandeh H, Aghaie A, Sadeghnia HR, Rahbardar MG. The effect of hydro-alcoholic extract of citrus flower on pentylenetetrazole and maximal electroshock-induced seizures in mice. World Appl Sci J 2011; 15:1104-1109.
11. Fadishei M, Ghasemzadeh Rahbardar M, Imenshahidi M, Mohajeri A, Razavi BM, Hosseinzadeh H. Effects of Nigella sativa oil and thymoquinone against bisphenol A‐induced metabolic disorder in rats. Phytother Res 2021; 35:2005-2024.
12. Yahyazadeh R, Ghasemzadeh Rahbardar M, Razavi BM, Karimi G, Hosseinzadeh H. The effect of Elettaria cardamomum (cardamom) on the metabolic syndrome: Narrative review. Iran J Basic Med Sci 24: 1462–1469.
13. Jalali J, Ghasemzadeh Rahbardar M. Ameliorative effects of Portulaca oleracea L. (purslane) on the metabolic syndrome: A review. J Ethnopharmacol 2022; 299:115672.
14. Tandisepanah Z, Foroutanfar A, Aziminia A, Ghasemzadeh Rahbardar M, Razavi BM, Hosseinzadeh H. Protective effect of aqueous and ethanolic extracts of Lippia citriodora Kunth. on acrylamide-induced neurotoxicity. Avicenna J Phytomedicine 2022 ;12:281-294.
15. Ardakanian A, Rahbardar MG, Omidkhoda F, Razavi BM, Hosseinzadeh H. Effect of alpha-mangostin on olanzapine-induced metabolic disorders in rats. Iran J Basic Med Sci 2022; 25: 198-207.
16. Aradhya M, Velasco D, Ibrahimov Z, Toktoraliev B, Maghradze D, Musayev M, et al. Genetic and ecological insights into glacial refugia of walnut (Juglans regia L.). PloS one 2017; 12:e0185974.
17. Pollegioni P, Woeste K, Chiocchini F, Del Lungo S, Ciolfi M, Olimpieri I, et al. Rethinking the history of common walnut (Juglans regia L.) in Europe: Its origins and human interactions. PloS one 2017; 12:e0172541.
18. Khan NA, Bostan N, Ali N, Anjum MM, Iqbal A, Khan F, et al. Screening and evaluation of exotic and indigenous walnut genotype and varieties. Agric Res Tech 2017; 7:555709.
19. Taha NA, Al-wadaan MA. Utility and importance of walnut, Juglans regia Linn: A review. Afr J Microbiol Res 2011; 5:5796-5805.
20. Liu M, Yang S, Yang J, Lee Y, Kou J, Wang C. Neuroprotective and memory-enhancing effects of antioxidant peptide from walnut (Juglans regia L.) protein hydrolysates. Nat Prod Commun 2019; 14:1934578X19865838.
21. Ozcan MM. Some nutritional characteristics of fruit and oil of walnut (Juglans regia L.) growing in Turkey. Iran J Chem Chem Eng 2009; 26:57-62.
22. Sánchez-González C, Ciudad CJ, Noe V, Izquierdo-Pulido M. Health benefits of walnut polyphenols: An exploration beyond their lipid profile. Crit Rev Food Sci Nutr 2017; 57:3373-3383.
23. Cosmulescu SN, Baciu A, Achim G, Mihai B, Trandafir I. Mineral composition of fruits in different walnut (Juglans regia L.) cultivars. Not Bot Horti Agrobot Cluj Napoca 2009; 37:156-160.
24. Bhat AA, Shakeel A, Rafiq S, Farooq I, Malik AQ, Alghuthami ME, et al. Juglans regia Linn.: A natural repository of vital phytochemical and pharmacological compounds. Life (Basel) 2023; 13:380.
25. Richard D, Kefi K, Barbe U, Bausero P, Visioli F. Polyunsaturated fatty acids as antioxidants. Pharmacol Res 2008; 57:451-455.
26. Jahanbani R, Ghaffari SM, Salami M, Vahdati K, Sepehri H, Sarvestani NN, et al. Antioxidant and anticancer activities of walnut (Juglans regia L.) protein hydrolysates using different proteases. Plant Foods Hum Nutr 2016; 71:402-409.
27. Chen N, Yang H, Sun Y, Niu J, Liu S. Purification and identification of antioxidant peptides from walnut (Juglans regia L.) protein hydrolysates. Peptides 2012; 38:344-349.
28. Liu M, Du M, Zhang Y, Xu W, Wang C, Wang K, et al. Purification and identification of an ACE inhibitory peptide from walnut protein. J Agric Food Chem 2013; 61:4097-4100.
29. Ma S, Huang D, Zhai M, Yang L, Peng S, Chen C, et al. Isolation of a novel bio-peptide from walnut residual protein inducing apoptosis and autophagy on cancer cells. BMC Complement Altern Med 2015; 15:1-14.
30. Spaccarotella KJ, Kris-Etherton PM, Stone WL, Bagshaw DM, Fishell VK, West SG, et al. The effect of walnut intake on factors related to prostate and vascular health in older men. Nutr J 2008; 7:1-10.
31. Mouhajir F, Hudson J, Rejdali M, Towers G. Multiple antiviral activities of endemic medicinal plants used by Berber peoples of Morocco. Pharm Biol 2001; 39:364-374.
32.Yeşilada E. Biodiversity in Turkish folk medicine. Biodiversity: Springer; 2002. p. 119-135.
33. Rahimi R, Shams-Ardekani MR, Abdollahi M. A review of the efficacy of traditional Iranian medicine for inflammatory bowel disease. World J Gastroenterol 2010; 16:4504-4514.
34. Kaileh M, Berghe WV, Boone E, Essawi T, Haegeman G. Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity. J Ethnopharmacol 2007; 113:510-516.
35. McKay DL, Chen C-Y, Yeum K-J, Matthan NR, Lichtenstein AH, Blumberg JB. Chronic and acute effects of walnuts on antioxidant capacity and nutritional status in humans: a randomized, cross-over pilot study. Nutr J 2010; 9:1-10.
36. Papoutsi Z, Kassi E, Chinou I, Halabalaki M, Skaltsounis L, Moutsatsou P. Walnut extract (Juglans regia L.) and its component ellagic acid exhibit anti-inflammatory activity in human aorta endothelial cells and osteoblastic activity in the cell line KS483. Br J Nutr 2008; 99:715-722.
37. Mobashar A, Shabbir A, Shahzad M, Gobe G. Preclinical rodent models of arthritis and acute inflammation indicate immunomodulatory and anti-inflammatory properties of Juglans regia extracts. Evid-based Complement Altern Med 2022; 2022.
38. Samei M, Dowlatkhahi N, Boozari M, Hosseinzadeh H. Can daily consumption of enriched fatty acids diet be effective in improving metabolic syndrome? An attractive paradox for walnut kernel. Food Sci Nutr 2024; 12:2311-2333.
39. Hosseinzadeh H, Zarei H, Taghiabadi E. Antinociceptive, anti-inflammatory and acute toxicity effects of juglans regia L. Leaves in mice. Iran Red Crescent Med J 2011; 13:27-33.
40. Nakanishi M, Chen Y, Qendro V, Miyamoto S, Weinstock E, Weinstock GM, et al. Effects of walnut consumption on colon carcinogenesis and microbial community structure. Cancer Prev Res 2016; 9:692-703.
41. Hardman WE. Walnuts have potential for cancer prevention and treatment in mice. J Nutr 2014; 144:555S-560S.
42. Banel DK, Hu FB. Effects of walnut consumption on blood lipids and other cardiovascular risk factors: a meta-analysis and systematic review. Am J Clin Nutr 2009; 90:56-63.
43. Chauhan A, Chauhan V. Beneficial effects of walnuts on cognition and brain health. Nutrients 2020; 12.
44. Kris-Etherton PM. Walnuts decrease risk of cardiovascular disease: a summary of efficacy and biologic mechanisms. J Nutr 2014; 144:547S-554S.
45. Pribis P, Bailey RN, Russell AA, Kilsby MA, Hernandez M, Craig WJ, et al. Effects of walnut consumption on cognitive performance in young adults. Br J Nutr 2012; 107:1393-1401.
46. Poulose SM, Miller MG, Shukitt-Hale B. Role of walnuts in maintaining brain health with age. J Nutr 2014; 144:561S-566S.
47. Devidas SB, Rahmatkar SN, Singh R, Sendri N, Purohit R, Singh D, et al. Amelioration of cognitive deficit in zebrafish by an undescribed anthraquinone from Juglans regia L.: An in-silico, in-vitro and in-vivo approach. Eur J Pharmacol 2021; 906:174234.
48. Wong MYZ, Tan CS, Venketasubramanian N, Chen C, Ikram MK, Cheng C-Y, et al. Prevalence and risk factors for cognitive impairment and dementia in Indians: A multiethnic perspective from a Singaporean study. J Alzheimers Dis 2019; 71:341-351.
49. Cognato GdP, Bortolotto JW, Blazina AR, Christoff RR, Lara DR, Vianna MR, et al. Y-Maze memory task in zebrafish (Danio rerio): the role of glutamatergic and cholinergic systems on the acquisition and consolidation periods. Neurobiol Learn Mem 2012; 98:321-328.
50. Wang M, Amakye WK, Guo L, Gong C, Zhao Y, Yao M, et al. Walnut‐derived peptide PW5 ameliorates cognitive impairments and alters gut microbiota in APP/PS1 transgenic mice. Mol Nutr Food Res 2019; 63:1900326.
51. Esselun C, Dilberger B, Silaidos CV, Koch E, Schebb NH, Eckert GP. A walnut diet in combination with enriched environment improves cognitive function and affects lipid metabolites in brain and liver of aged NMRI mice. Neuromolecular Med 2021; 23:140-160.
52. Poulose SM, Bielinski DF, Shukitt-Hale B. Walnut diet reduces accumulation of polyubiquitinated proteins and inflammation in the brain of aged rats. J Nutr Biochem 2013; 24:912-919.
53. Muthaiyah B, Essa MM, Chauhan V, Chauhan A. Protective effects of walnut extract against amyloid beta peptide-induced cell death and oxidative stress in PC12 cells. Neurochem Res 2011; 36:2096-2103.
54. Esselun C, Dieter F, Sus N, Frank J, Eckert GP. Walnut oil reduces Aβ levels and increases neurite length in a cellular model of early Alzheimer disease. Nutrients 2022; 14:1694.
55. Li W, Zhao T, Zhang J, Wu C, Zhao M, Su G. Comparison of neuroprotective and cognition-enhancing properties of hydrolysates from soybean, walnut, and peanut protein. J Chem 2016; 2016.
56. Wang S, Su G, Zhang Q, Zhao T, Liu Y, Zheng L, et al. Walnut (Juglans regia) peptides reverse sleep deprivation-induced memory impairment in rat via alleviating oxidative stress. J Agric Food Chem 2018; 66:10617-10627.
57. Wang S, Zheng L, Zhao T, Zhang Q, Liu Y, Sun B, et al. Inhibitory effects of walnut (Juglans regia) peptides on neuroinflammation and oxidative stress in lipopolysaccharide-induced cognitive impairment mice. J Agric Food Chem 2020; 68:2381-2392.
58. Zhao F, Liu C, Fang L, Lu H, Wang J, Gao Y, et al. Walnut-derived peptide activates PINK1 via the NRF2/KEAP1/HO-1 pathway, promotes mitophagy, and alleviates learning and memory impairments in a mice model. J Agric Food Chem 2021; 69:2758-2772.
59. Haider S, Batool Z, Ahmad S, Siddiqui RA, Haleem DJ. Walnut supplementation reverses the scopolamine-induced memory impairment by restoration of cholinergic function via mitigating oxidative stress in rats: a potential therapeutic intervention for age related neurodegenerative disorders. Metab Brain Dis 2018; 33:39-51.
60. Pandareesh MD, Chauhan V, Chauhan A. Walnut supplementation in the diet reduces oxidative damage and improves antioxidant status in transgenic mouse model of Alzheimer’s disease. J Alzheimers Dis 2018; 64:1295-1305.
61. Khanna D, Parle M. Anticholinergic and hypocholesterolemic activity of Juglan regia improves cognitive functions in mice. Curr Psychopharmacol 2018; 7:173-179.
62. An L, Sun Y, Zhang W, Huang X, Xue R, Zhang Y, et al. Walnut diets up-regulate the decreased hippocampal neurogenesis and age-related cognitive dysfunction in d-galactose induced aged rats. Food Funct 2018; 9:4755-4762.
63. Rusu ME, Georgiu C, Pop A, Mocan A, Kiss B, Vostinaru O, et al. Antioxidant effects of walnut (Juglans regia L.) kernel and walnut septum extract in a D-galactose-induced aging model and in naturally aged rats. Antioxidants 2020; 9:424.
64. Kim JM, Lee U, Kang JY, Park SK, Shin EJ, Kim H-J, et al. Anti-amnesic effect of walnut via the regulation of BBB function and neuro-inflammation in Aβ1-42-induced mice. Antioxidants 2020; 9:976.
65. Liao J, Nai Y, Feng L, Chen Y, Li M, Xu H. Walnut oil prevents scopolamine-induced memory dysfunction in a mouse model. Molecules 2020; 25:1630.
66. Geng M, Zhao F, Lu H, Fang L, Wang J, Liu C, et al. Insights into the hippocampus proteome and phosphorylation modification alterations in C57BL/6 revealed the memory improvement mechanisms of a walnut-derived peptide. Food Res Int 2022:111311.
67. Sala-Vila A, Valls-Pedret C, Rajaram S, Coll-Padrós N, Cofán M, Serra-Mir M, et al. Effect of a 2-year diet intervention with walnuts on cognitive decline. The Walnuts And Healthy Aging (WAHA) study: a randomized controlled trial. Am J Clin Nutr 2020; 111:590-600.
68. Bishop NJ, Zuniga KE. Investigating walnut consumption and cognitive trajectories in a representative sample of older US adults. Public Health Nutr 2021; 24:1741-1752.
69. Yeh A-L, Chao C-L, Huang W-F, Lin H-C, Wang C-J. Walnut (Juglans regia L.) oligopeptide effects on enhancing memory, cognition and improving sleep quality in teenagers and elderly people in a randomized double-blind controlled trial. Nat Prod Commun 2022; 17:1934578X221089065.
70. Mohammadzadeh L, Rahbardar MG, Razavi BM, Hosseinzadeh H. Crocin protects malathion-induced parkinson-like disease by inhibiting apoptosis and α-synuclein accumulation in rats’ striatum. J Mol Neurosci 2021; 72:983-993.
71. Essa MM, Subash S, Dhanalakshmi C, Manivasagam T, Al-Adawi S, Guillemin GJ, et al. Dietary supplementation of walnut partially reverses 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine induced neurodegeneration in a mouse model of Parkinson’s disease. Neurochem Res 2015; 40:1283-1293.
72. Najafi N, Ghasemzadeh Rahbardar M, Hosseinzadeh H, Hayes AW, Karimi G. Chemical agents protective against rotenone-induced neurotoxicity. Environ Toxicol Chem 2022; 104:149-175.
73. Choi JG, Park G, Kim HG, Oh D-S, Kim H, Oh MS. In vitro and in vivo neuroprotective effects of walnut (Juglandis semen) in models of Parkinson’s disease. Int J Mol Sci 2016; 17:108.
74. Depression W. Other common mental disorders: global health estimates. Geneva: World Health Organization 2017; 24.
75.Rahbardar MG, Hosseinzadeh H. Mechanisms of action of herbal antidepressants. The Neuroscience of Depression: Elsevier; 2021. p. 503-518.
76. Rath B, Pradhan D. Antidepressant activity of Juglans regia L. fruit extract. Int J Toxicol Pharmacol Res 2009; 1:24-26.
77. Maggu A, Singh J, Gulsheen A, Sharma A. In vivo antianxiety and antidepressant activity of almonds (P. amygdalus) and walnuts (J. regia). Int J Food Sci Nutr 2019; 4:51-54.
78. Pribis P. Effects of walnut consumption on mood in young adults—a randomized controlled trial. Nutrients 2016; 8:668.
79. Ghasemzadeh MR, Amin B, Mehri S, Mirnajafi-Zadeh SJ, Hosseinzadeh H. Effect of alcoholic extract of aerial parts of Rosmarinus officinalis L. on pain, inflammation and apoptosis induced by chronic constriction injury (CCI) model of neuropathic pain in rats. J Ethnopharmacol 2016; 194:117-130.
80. Nakisa N, Ghasemzadeh Rahbardar M. Therapeutic Potential of Rosemary (Rosmarinus officinalis L.) on Sports Injuries: a Review of Patents. Res J pharmacogn 2022; 9:71-83.
81. Ghasemzadeh Rahbardar M, Razavi BM, Hosseinzadeh H. Investigating the ameliorative effect of alpha‐mangostin on development and existing pain in a rat model of neuropathic pain. Phytother Res 2020; 34:3211-3225.
82. Rahbardar MG, Amin B, Mehri S, Mirnajafi-Zadeh SJ, Hosseinzadeh H. Rosmarinic acid attenuates development and existing pain in a rat model of neuropathic pain: An evidence of anti-oxidative and anti-inflammatory effects. Phytomedicine 2018; 40:59-67.
83. Nasiry D, Ahmadvand H, Talebpour Amiri F, Akbari E. Protective effects of methanolic extract of Juglans regia L. leaf on streptozotocin-induced diabetic peripheral neuropathy in rats. BMC Complement Altern Med 2017; 17:1-11.
84. Raafat K. Phytochemical analysis of Juglans regia oil and kernel exploring their antinociceptive and anti-inflammatory potentials utilizing combined bio-guided GC-FID, GC-MS and HPLC analyses. Rev Bras Farmacogn 2018; 28:358-368.
85. Amel B, Cherif HS, Eswayah AA, Abdennour MA, Oliveira IV. Evaluation of the anti-inflammatory, antispasmodic and healing effects of walnut leaves Juglans regia L. aqueous extract. Arabian Journal of Medicinal and Aromatic Plants 2021; 7:123-140.
86. Thurman DJ, Begley CE, Carpio A, Helmers S, Hesdorffer DC, Mu J, et al. The primary prevention of epilepsy: A report of the prevention task force of the international league against epilepsy. Epilepsia 2018; 59:905-914.
87. Oyrer J, Maljevic S, Scheffer IE, Berkovic SF, Petrou S, Reid CA. Ion channels in genetic epilepsy: from genes and mechanisms to disease-targeted therapies. Pharmacol Rev 2018; 70:142-173.
88. Jahanbani R, Bahramnejad E, Rahimi N, Shafaroodi H, Sheibani N, Moosavi-Movahedi AA, et al. Anti-seizure effects of walnut peptides in mouse models of induced seizure: The involvement of GABA and nitric oxide pathways. Epilepsy Res 2021; 176:106727.
89. Bhati P, Jain J, Singh L, Vyas M, Niyaz A, Kaushik R. Ameliorative effect of sodium valporate in combination with Juglans regia fruit extract against pentylentetrazole induced convulsions in mice J Appl Pharm Sci 2018; 1:23-28.
90. Asadi-Shekaari M, Kalantaripour TP, Nejad FA, Namazian E, Eslami A. The anticonvulsant and neuroprotective effects of walnuts on the neurons of rat brain cortex. Avicenna J Med Biotechnol 2012; 4:155.
91. Harandi S, Abbasnejad M, Mirnajafi-Zadeh J, Esmaeilpour K, Masoumi Y, Asadi-Shekaari M, et al. Effect of walnut (Juglans regia L) consumption on anticonvulsant low-frequency stimulation in rats. J Vet Res 2013; 17:177-187.
92. Asadi-Shekaari M, Eslami A, Kalantaripour T, Joukar S. Potential mechanisms involved in the anticonvulsant effect of walnut extract on pentylenetetrazole-induced seizure. Med Princ Pract 2014; 23:538-542.
93. Chen H, Zhao M, Lin L, Wang J, Sun-Waterhouse D, Dong Y, et al. Identification of antioxidative peptides from defatted walnut meal hydrolysate with potential for improving learning and memory. Food Res Int 2015; 78:216-223.
94. Moon JH, Kim JM, Lee U, Kang JY, Kim MJ, Lee HL, et al. Walnut prevents cognitive impairment by regulating the synaptic and mitochondrial dysfunction via JNK signaling and apoptosis pathway in high-fat diet-induced C57BL/6 mice. Molecules 2022; 27:5316.
95. Asadi-Shekaari M, Karimi A, Shabani M, Sheibani V, Esmaeilpour K. Maternal feeding with walnuts (Juglans regia) improves learning and memory in their adult pups. Avicenna J Phytomedicine 2013; 3:341.
96. Shi D, Chen C, Zhao S, Ge F, Liu D, Hao S. Effects of walnut polyphenol on learning and memory functions in hypercholesterolemia mice. J Food Nutr Res 2014; 2:450-456.
97. Muthaiyah B, Essa MM, Lee M, Chauhan V, Kaur K, Chauhan A. Dietary supplementation of walnuts improves memory deficits and learning skills in transgenic mouse model of Alzheimer’s disease. J Alzheimers Dis 2014; 42:1397-1405.
98. Harandi S, Golchin L, Ansari M, Moradi A, Shabani M, Sheibani V. Antiamnesic effects of walnuts consumption on scopolamine-induced memory impairments in rats. Basic Clin Neurosci 2015; 6:91.
99. Li W, Zhao T, Zhang J, Xu J, Sun-Waterhouse D, Zhao M, et al. Effect of walnut protein hydrolysate on scopolamine-induced learning and memory deficits in mice. J Food Sci Technol 2017; 54:3102-3110.
100. Wang S, Su G, Zhang X, Song G, Zhang L, Zheng L, et al. Characterization and exploration of potential neuroprotective peptides in walnut (Juglans regia) protein hydrolysate against cholinergic system damage and oxidative stress in scopolamine-induced cognitive and memory impairment mice and zebrafish. J Agric Food Chem 2021; 69:2773-2783.