Therapeutic potential of casticin in alleviating ovarian torsion/detorsion-induced ovarian and lung injuries

Document Type : Original Article

Authors

1 Department of Physiology, Faculty of Medicine, Bandırma Onyedi Eylül University, Bandırma, Turkey

2 Department of Physiology, Faculty of Medicine, Atatürk University, Erzurum, Turkey

3 Department of Nutrition and Dietetics, Faculty of Health Science, Ağrı İbrahim Çeçen University, Ağrı, Turkey

4 Department of Internal Medicine, Faculty of Medicine, Bahçeşehir University, Istanbul, Turkey

5 Department of Obstetrics and Gynecology, Erzurum City Hospital, Erzurum, Turkey

6 Department of Physiology, Faculty of Medicine, Sakarya University, Sakarya, Turkey

7 Department of Medicine Education, Atatürk University, Erzurum, Turkey

8 Department of Pathology, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey

10.22038/ijbms.2025.85990.18572

Abstract

Objective(s): Ovarian torsion is a critical gynecological emergency caused by the twisting of the ovary around its supporting structures, resulting in compromised blood flow and potential ovarian damage. Ovarian torsion/detorsion (T/D) can lead to severe complications, including infertility, if not promptly addressed. This study aimed to investigate the therapeutic effects of casticin (CAST) on ovarian and lung tissue injuries induced by a bilateral ovarian T/D model in rats.
Materials and Methods: Experimental animals were randomly allocated into groups of sham, T/D, CAST 5 mg/kg, and CAST 10 mg/kg. Ovarian and lung tissues were subjected to biochemical, histopathological, and immunohistochemical analyses.
Results: In the T/D group, markers of oxidative stress and inflammation, including myeloperoxidase (MPO) activity, malondialdehyde (MDA), oxidative stress index (OSI), tumor necrosis factor-alpha (TNF-α), and 8-hydroxy-2’ deoxyguanosine (8-OHdG), were significantly elevated (P<0.05). Conversely, superoxide dismutase (SOD) activity and total antioxidant status (TAS) levels were notably decreased (P<0.05). CAST administration significantly attenuated tissue damage by reducing oxidative stress and inflammatory markers while enhancing antioxidant defense (P<0.05).
Conclusion: CAST demonstrated a therapeutic effect against ovarian and lung tissue damage induced by T/D, suggesting that it may serve as a potential therapeutic agent for treating ovarian T/D-related injuries. These findings underscore the potential of CAST in clinical settings, particularly as a novel intervention to mitigate complications associated with I/R injuries in gynecological emergencies.

Keywords

Main Subjects

References

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Iranian Journal of Basic Medical Sciences
Volume 28, Issue 8
August 2025
Pages 1057-1064

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