Beyond chemotherapy: Exploring tree turmeric root and nano-hydroxyapatite for neuroprotective applications

Articles in Press

Document Type : Original Article

Authors

1 Department of Rehabilitation Medicine, Ankang People’s Hospital, Ankang, 725000, China

2 Vinayaka Mission’s Medical College and Hospital, Vinayaka Mission’s Research Foundation (Deemed to be University), Karaikal, Puducherry, India, 609609

3 Department of Chemistry, Nandha Engineering College, Tamil Nadu- 638052, India

10.22038/ijbms.2025.84185.18205

Abstract

Objective(s): To investigate the physicochemical properties, in vitro efficacy, and in vivo therapeutic potential of novel tree turmeric root and nano-hydroxyapatite (TRE@NHA) composites in mitigating chemotherapy-induced peripheral neuropathy (CIPN).
Materials and Methods: TRE@NHA composites were synthesized and characterized using FTIR, XRD, TGA, and HRTEM. In vitro studies using PC12 cells assessed cytotoxicity, anti-inflammatory effects, and neuroprotective properties. An in vivo rat model of CIPN was established using paclitaxel (PTX). Behavioral assessments, histopathological analysis, and oxidative stress markers were evaluated in sciatic nerve tissues.
Results: TRE@NHA composites demonstrated successful integration of TRE into the NHA matrix. In vitro studies revealed significant anti-inflammatory and neuroprotective effects of TRE@NHA-2, particularly in suppressing cytokine production, enhancing cell viability, and mitigating oxidative stress. In vivo, TRE@NHA-2 effectively alleviated PTX-induced neuropathic pain, reduced neuronal damage, and exhibited potent antioxidant properties.
Conclusion: This study demonstrates the successful development and characterization of novel TRE@NHA composites. The findings strongly suggest that TRE@NHA-2 possesses promising therapeutic potential for mitigating CIPN due to its anti-inflammatory, antioxidant, and neuroprotective properties.

Keywords

Main Subjects

References

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Iranian Journal of Basic Medical Sciences

Articles in Press, Accepted Manuscript
Available Online from 09 July 2025

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