1. Gao D, Zhang Y, Bowers DT, Liu W, Ma M. Functional hydrogels for diabetic wound management. APL Bioeng 2021;5:031503.
2. Ong KL, Stafford LK, McLaughlin SA, Boyko EJ, Vollset SE, Smith AE, et al. Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: A systematic analysis for the Global Burden of Disease Study 2021. Lancet 2023;402:203-34.
3. Huang K, Mi B, Xiong Y, Fu Z, Zhou W, Liu W, et al. Angiogenesis during diabetic wound repair: from mechanism to therapy opportunity. Burns Trauma 2025;13:tkae052.
4. Kim K, Mahajan A, Patel K, Syed S, Acevedo-Jake AM, Kumar VA. Materials and cytokines in the healing of diabetic foot ulcers. Adv Ther 2021;4:2100075.
5. Stachura A, Khanna I, Krysiak P, Paskal W, Włodarski P. Wound healing impairment in type 2 diabetes model of leptin-deficient mice—a mechanistic systematic review. Int J Mol Sci 2022;23:8621.
6. Rodríguez-Rodríguez N, Martínez-Jiménez I, García-Ojalvo A, Mendoza-Mari Y, Guillén-Nieto G, Armstrong DG, et al. Wound chronicity, impaired immunity and infection in diabetic patients. MEDICC Rev 2022;24:44-58.
7. Seraphim PM, Leal EC, Moura J, Gonçalves P, Gonçalves JP, Carvalho E. Lack of lymphocytes impairs macrophage polarization and angiogenesis in diabetic wound healing. Life Sci 2020;254:117813.
8. Aitcheson SM, Frentiu FD, Hurn SE, Edwards K, Murray RZ. Skin wound healing: Normal macrophage function and macrophage dysfunction in diabetic wounds. Molecules 2021;26:4917.
9. Theocharidis G, Veves A. Autonomic nerve dysfunction and impaired diabetic wound healing: The role of neuropeptides. Auton Neurosci 2020;223:102610.
10. Yadav JP. Based on clinical research matrix metalloprotease (MMP) inhibitors to promote diabetic wound healing. Horm Metab Res 2023;55:752-757.
11. Bian X, Li B, Yang J, Ma K, Sun M, Zhang C, et al. Regenerative and protective effects of dMSC-sEVs on high-glucose-induced senescent fibroblasts by suppressing RAGE pathway and activating Smad pathway. Stem Cell Res Ther 2020;11:166.
12. Ariyanti AD, Zhang J, Marcelina O, Nugrahaningrum DA, Wang G, Kasim V, et al. Salidroside-pretreated mesenchymal stem cells enhance diabetic wound healing by promoting paracrine function and survival of mesenchymal stem cells under hyperglycemia. Stem Cells Transl Med 2019;8:404-414.
13. Knapp M, Tu X, Wu R. Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy. Acta Pharmacol Sin 2019;40:1-8.
14. An Y, Xu B-t, Wan S-r, Ma X-m, Long Y, Xu Y, et al. The role of oxidative stress in diabetes mellitus-induced vascular endothelial dysfunction. Cardiovasc Diabetol 2023;22:237.
15. Wang X, Li R, Zhao H. Enhancing angiogenesis: Innovative drug delivery systems to facilitate diabetic wound healing. Biomed Pharmacother 2024;170:116035.
16. Lv D, Cao X, Zhong L, Dong Y, Xu Z, Rong Y, et al. Targeting phenylpyruvate restrains excessive NLRP3 inflammasome activation and pathological inflammation in diabetic wound healing. Cell Rep Med 2023;4:101155.
17. Peña OA, Martin P. Cellular and molecular mechanisms of skin wound healing. Nat Rev Mol Cell Biol 2024;25:599-616.
18. Sharifiaghdam M, Shaabani E, Faridi-Majidi R, De Smedt SC, Braeckmans K, Fraire JC. Macrophages as a therapeutic target to promote diabetic wound healing. Mol Ther 2022;30:2891-2908.
19. Raziyeva K, Kim Y, Zharkinbekov Z, Kassymbek K, Jimi S, Saparov A. Immunology of acute and chronic wound healing. Biomolecules 2021;11:700.
20. Matoori S, Veves A, Mooney DJ. Advanced bandages for diabetic wound healing. Sci Transl Med 2021;13:eabe4839.
21. Hannoodee S, Nasuruddin DN. Acute inflammatory response. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026.
22. Stanimirovic J, Radovanovic J, Banjac K, Obradovic M, Essack M, Zafirovic S, et al. Role of C-reactive protein in diabetic inflammation. Mediators Inflamm 2022;2022:3706508.
23. Dunnill C, Patton T, Brennan J, Barrett J, Dryden M, Cooke J, et al. Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS-modulating technologies for augmentation of the healing process. Int Wound J 2017;14:89-96.
24. Cano Sanchez M, Lancel S, Boulanger E, Neviere R. Targeting oxidative stress and mitochondrial dysfunction in the treatment of impaired wound healing: a systematic review. Antioxidants (Basel) 2018;7:98.
25. Dworzański J, Strycharz-Dudziak M, Kliszczewska E, Kiełczykowska M, Dworzańska A, Drop B, et al. Glutathione peroxidase (GPx) and superoxide dismutase (SOD) activity in patients with diabetes mellitus type 2 infected with Epstein-Barr virus. PLoS One 2020;15:e0230374.
26. Baldini E, Testa E, Voellenkle C, De Domenico E, Cianfarani F, Martelli F, et al. Dysregulation of microRNA expression in diabetic skin. J Dermatol Sci 2020;98:186-194.
27. Kim JH, Yoon NY, Kim DH, Jung M, Jun M, Park HY, et al. Impaired permeability and antimicrobial barriers in type 2 diabetes skin are linked to increased serum levels of advanced glycation end-product. Exp Dermatol 2018;27:815-823.
28. David JA, Rifkin WJ, Rabbani PS, Ceradini DJ. The Nrf2/Keap1/ARE pathway and oxidative stress as a therapeutic target in type II diabetes mellitus. J Diabetes Res 2017;2017:4826724.
29. Garg P, Chandra M. Cutaneous manifestation of diabetes mellitus. J Adv Med Dent Scie Res 2021;9:100-105.
30. OuYang H, Tang Y, Yang F, Ren X, Yang J, Cao H, et al. Platelet-rich plasma for the treatment of diabetic foot ulcer: A systematic review. Front Endocrinol (Lausanne) 2023;14:1256081.
31. Ratter-Rieck JM, Maalmi H, Trenkamp S, Zaharia O-P, Rathmann W, Schloot NC, et al. Leukocyte counts and T-cell frequencies differ between novel subgroups of diabetes and are associated with metabolic parameters and biomarkers of inflammation. Diabetes 2021;70:2652-2662.
32. Boschetti G, Sgarabotto D, Meloni M, Bruseghin M, Whisstock C, Marin M, et al. Antimicrobial resistance patterns in diabetic foot infections, an epidemiological study in northeastern Italy. Antibiotics (Basel) 2021;10:1241.
33. Preet S, Kaur J, Raza K. Nisin loaded carbopol gel against Pseudomonas aeruginosa infected third-degree burns: A therapeutic intervention. Wound Repair Regen 2021;29:711-724.
34. Chen H, Wang L, Zeng X, Schwarz H, Nanda HS, Peng X, et al. Exosomes, a new star for targeted delivery. Front Cell Dev Biol 2021;9:751079.
35. Dilsiz N. Exosomes as new generation vehicles for drug delivery systems. J Drug Deliv Sci Technol 2024;95:105562.
36. Yao X, Wei W, Wang X, Chenglin L, Björklund M, Ouyang H. Stem cell derived exosomes: microRNA therapy for age-related musculoskeletal disorders. Biomaterials 2019;224:119492.
37. Liu W, Yu M, Xie D, Wang L, Ye C, Zhu Q, et al. Melatonin-stimulated MSC-derived exosomes improve diabetic wound healing through regulating macrophage M1 and M2 polarization by targeting the PTEN/AKT pathway. Stem Cell Res Ther 2020;11:259.
38. Joorabloo A, Liu T. Engineering exosome-based biomimetic nanovehicles for wound healing. J Control Release 2023;356:463-480.
39. Liu J, Yan Z, Yang F, Huang Y, Yu Y, Zhou L, et al. Exosomes derived from human umbilical cord mesenchymal stem cells accelerate cutaneous wound healing by enhancing angiogenesis through delivering angiopoietin-2. Stem Cell Rev Rep 2021;17:305-317.
40. Kong Z, Hong Y, Zhu J, Cheng X, Liu Y. Endothelial progenitor cells improve functional recovery in focal cerebral ischemia of rat by promoting angiogenesis via VEGF. J Clin Neurosci 2018;55:116-121.
41. Sun T, Yin L, Kuang H. miR-181a/b-5p regulates human umbilical vein endothelial cell angiogenesis by targeting PDGFRA. Cell Biochem Funct 2020;38:222-230.
42. Li L, Yu Z-Q, Qian L, Xu J-Y, Liu F, Zhao G-C, et al. Interleukin-19 and angiopoietin-2 can enhance angiogenesis of diabetic complications. J Diabetes Complications 2016;30:386-387.
43. Zhang Y, Zhang Y-y, Pan Z-w, Li Q-q, Sun L-h, Li X, et al. GDF11 promotes wound healing in diabetic mice via stimulating HIF-1α-VEGF/SDF-1α-mediated endothelial progenitor cell mobilization and neovascularization. Acta Pharmacol Sin 2023;44:999-1013.
44. Deng H, Li B, Shen Q, Zhang C, Kuang L, Chen R, et al. Mechanisms of diabetic foot ulceration: A review. J Diabetes 2023;15:299-312.
45. Wang P, Theocharidis G, Vlachos IS, Kounas K, Lobao A, Shu B, et al. Exosomes derived from epidermal stem cells improve diabetic wound healing. J Invest Dermatol 2022;142:2508-2517.e13.
46. Liang X, Zhang L, Wang S, Han Q, Zhao RC. Exosomes secreted by mesenchymal stem cells promote endothelial cell angiogenesis by transferring miR-125a. J Cell Sci 2016;129:2182-2189.
47. Patel S, Srivastava S, Singh MR, Singh D. Mechanistic insight into diabetic wounds: Pathogenesis, molecular targets and treatment strategies to pace wound healing. Biomed Pharmacother 2019;112:108615.
48. Shahzadi A, Sonmez H. Bioactives from clove oil for antibacterial wound dressings for the treatment and management of wounds in type 2 diabetes mellitus. In: Pandey KB, Suttajit M, Atukeren P, Editors. Natural Products and Their Bioactives in Antidiabetic Drug Discovery. Hoboken (NJ): Wiley; 2023; 195-210.
49. Li X, Xie X, Lian W, Shi R, Han S, Zhang H, et al. Exosomes from adipose-derived stem cells overexpressing Nrf2 accelerate cutaneous wound healing by promoting vascularization in a diabetic foot ulcer rat model. Exp Mol Med 2018;50:1-14.
50. Wang J, Xia J, Huang R, Hu Y, Fan J, Shu Q, et al. Mesenchymal stem cell-derived extracellular vesicles alter disease outcomes via endorsement of macrophage polarization. Stem Cell Res Ther 2020;11:424.
51. He X, Dong Z, Cao Y, Wang H, Liu S, Liao L, et al. MSC-derived exosome promotes M2 polarization and enhances cutaneous wound healing. Stem Cells Int 2019;2019:7132708.
52. Zhao B, Zhang X, Zhang Y, Lu Y, Zhang W, Lu S, et al. Human exosomes accelerate cutaneous wound healing by promoting collagen synthesis in a diabetic mouse model. Stem Cells Dev 2021;30:922-933.
53. Wang L, Cai Y, Zhang Q, Zhang Y. Pharmaceutical activation of Nrf2 accelerates diabetic wound healing by exosomes from bone marrow mesenchymal stem cells. Int J Stem Cells 2022;15:164-172.
54. Dalirfardouei R, Jamialahmadi K, Jafarian AH, Mahdipour E. Promising effects of exosomes isolated from menstrual blood-derived mesenchymal stem cell on wound-healing process in diabetic mouse model. J Tissue Eng Regen Med 2019;13:555-568.
55. Jiang T, Wang Z, Sun J. Human bone marrow mesenchymal stem cell-derived exosomes stimulate cutaneous wound healing mediates through TGF-β/Smad signaling pathway. Stem Cell Res Ther 2020;11:198.
56. Fang S, Xu C, Zhang Y, Xue C, Yang C, Bi H, et al. Umbilical cord-derived mesenchymal stem cell-derived exosomal microRNAs suppress myofibroblast differentiation by inhibiting the transforming growth factor-β/SMAD2 pathway during wound healing. Stem Cells Transl Med 2016;5:1425-1439.
57. Yao Z, Li J, Xiong H, Cui H, Ning J, Wang S, et al. MicroRNA engineered umbilical cord stem cell-derived exosomes direct tendon regeneration by mTOR signaling. J Nanobiotechnology 2021;19:169.
58. Si Z, Wang X, Sun C, Kang Y, Xu J, Wang X, et al. Adipose-derived stem cells: Sources, potency, and implications for regenerative therapies. Biomed Pharmacother 2019;114:108765.
59. Yuan X, Li L, Liu H, Luo J, Zhao Y, Pan C, et al. Strategies for improving adipose-derived stem cells for tissue regeneration. Burns Trauma 2022;10:tkac028.
60. Qiu H, Liu S, Wu K, Zhao R, Cao L, Wang H. Prospective application of exosomes derived from adipose-derived stem cells in skin wound healing: a review. J Cosmet Dermatol 2020;19:574-581.
61. Ma T, Fu B, Yang X, Xiao Y, Pan M. Adipose mesenchymal stem cell-derived exosomes promote cell proliferation, migration, and inhibit cell apoptosis via Wnt/β-catenin signaling in cutaneous wound healing. J Cell Biochem 2019;120:10847-10854.
62. Zhang W, Bai X, Zhao B, Li Y, Zhang Y, Li Z, et al. Cell-free therapy based on adipose tissue stem cell-derived exosomes promotes wound healing via the PI3K/Akt signaling pathway. Exp Cell Res 2018;370:333-342.
63. Khorasani HR, Sanchouli M, Mehrani J, Sabour D. Potential of bone-marrow-derived mesenchymal stem cells for maxillofacial and periodontal regeneration: A narrative review. Int J Dent 2021;2021:4759492.
64. Alexandru N, Andrei E, Safciuc F, Dragan E, Balahura AM, Badila E, et al. Intravenous administration of allogenic cell-derived microvesicles of healthy origins defends against atherosclerotic cardiovascular disease development by a direct action on endothelial progenitor cells. Cells 2020;9:423.
65. Rong X, Liu J, Yao X, Jiang T, Wang Y, Xie F. Human bone marrow mesenchymal stem cells-derived exosomes alleviate liver fibrosis through the Wnt/β-catenin pathway. Stem Cell Res Ther 2019;10:98.
66. Liao Z, Luo R, Li G, Song Y, Zhan S, Zhao K, et al. Exosomes from mesenchymal stem cells modulate endoplasmic reticulum stress to protect against nucleus pulposus cell death and ameliorate intervertebral disc degeneration in vivo. Theranostics 2019;9:4084.
67. Shen C, Tao C, Zhang A, Li X, Guo Y, Wei H, et al. Exosomal microRNA-93-3p secreted by bone marrow mesenchymal stem cells down-regulates apoptotic peptidase activating factor 1 to promote wound healing. Bioengineered 2022;13:27-37.
68. Műzes G, Sipos F. Mesenchymal stem cell-derived secretome: a potential therapeutic option for autoimmune and immune-mediated inflammatory diseases. Cells 2022;11:2300.
69. Caldara M, Marmiroli N. Antimicrobial properties of antidepressants and antipsychotics—possibilities and implications. Pharmaceuticals (Basel) 2021;14:915.
70. Kouhihabibidehkordi G, Ghanavatinejad F, Taheri K, Soleimannejad M, Lorigooini Z, Amini-Khoei H, et al. The protective effects of lavender officinalis extract against impairment of anti-oxidant–detoxification system induced by glucose deprivation through Nrf2 expression. Proc Natl Acad Sci India Sect B Biol Sci 2024;94:135-143.
71. Rabiei Z, Rafieian-Kopaei M, Heidarian E, Saghaei E, Mokhtari S. Effects of Zizyphus jujube extract on memory and learning impairment induced by bilateral electric lesions of the nucleus basalis of meynert in rat. Neurochem Res 2014;39:353-560.
72. Rabiei Z, Shirchi M, Rafieian-Kopaei M, Asgharzade S. Effects of Satureja Bachtiarica Essential Oil in Preventing Seizure in Pentylenetetrazol-Kindled Mice. Basic Clin Neurosci 2022;13:465.
73. Rabiei Z, Joodaki R, Setorki M. Effects of ethanolic extract of Artemisia persica on scopolamine-induced cognitive impairment and anxiety in rats. J Med Plants 2020;19:133-142.
74. Ti YL, Song F, Fang Z, Zhang P. Plants and phytochemicals inhibit scar formation: A systematic review. Ind Crops Prod 2022;185:115113.
75. Vitale S, Colanero S, Placidi M, Di Emidio G, Tatone C, Amicarelli F, et al. Phytochemistry and biological activity of medicinal plants in wound healing: an overview of current research. Molecules 2022;27:3566.
76. Scialò F, Fernández-Ayala DJ, Sanz A. Role of mitochondrial reverse electron transport in ROS signaling: potential roles in health and disease. Front Physiol 2017;8:428.
77. Comino-Sanz IM, López-Franco MD, Castro B, Pancorbo-Hidalgo PL. The role of anti-oxidants on wound healing: A review of the current evidence. J Clin Med 2021;10:3558.
78. Rajendran NK, Houreld NN, Abrahamse H. Photobiomodulation reduces oxidative stress in diabetic wounded fibroblast cells by inhibiting the FOXO1 signaling pathway. J Cell Commun Signal 2021;15:195-206.
79. Polaka S, Katare P, Pawar B, Vasdev N, Gupta T, Rajpoot K, et al. Emerging ROS-modulating technologies for augmentation of the wound healing process. ACS Omega 2022;7:30657-30672.
80. Karppinen S-M, Heljasvaara R, Gullberg D, Tasanen K, Pihlajaniemi T. Toward understanding scarless skin wound healing and pathological scarring. F1000Res 2019;8:F1000 Faculty Rev-787.
81. Singer AJ. Healing mechanisms in cutaneous wounds: tipping the balance. Tissue Eng Part B Rev 2022;28:1151-1167.
82. Hassanshahi A, Moradzad M, Ghalamkari S, Fadaei M, Cowin AJ, Hassanshahi M. Macrophage-mediated inflammation in skin wound healing. Cells 2022;11:2953.
83. Hu Z, Zhao K, Chen X, Zhou M, Chen Y, Ye X, et al. A berberine-loaded Bletilla striata polysaccharide hydrogel as a new medical dressing for diabetic wound healing. Int J Mol Sci 2023;24:16286.
84. Shahzadiand A, Sonmez H. Bioactives from clove oil for antibacterial wound dressings for the treatment and management of wounds in type 2 diabetes mellitus. In: Natural Products and their Bioactives in Antidiabetic Drug Discovery 2023. 195-210.
85. Vassiliou E, Awoleye O, Davis A, Mishra S. Anti-inflammatory and antimicrobial properties of thyme oil and its main constituents. Int J Mol Sci 2023;24:6936.
86. Eckmann C, Tulkens PM. Current and future options for treating complicated skin and soft tissue infections: focus on fluoroquinolones and long-acting lipoglycopeptide antibiotics. J Antimicrob Chemother 2021;76:iv9-iv22.
87. Ebbo A, Sani D, Suleiman M, Ahmad A, Hassan A. Assessment of anti-oxidant and wound healing activity of the crude methanolic extract of Diospyros mespiliformis Hochst. ex A. DC.(Ebenaceae) and its fractions in Wistar rats. S Afr J Bot 2022;150:305-312.
88. Agour A, Mssillou I, Es-Safi I, Conte R, Mechchate H, Slighoua M, et al. The anti-oxidant, analgesic, anti-inflammatory, and wound healing activities of Haplophyllum tuberculatum (Forsskal) A. Juss aqueous and ethanolic extract. Life (Basel) 2022;12:1553.
89. Espinosa-Espinosa L, Garduño-Siciliano L, Rodriguez-Canales M, Hernandez-Portilla LB, Canales-Martinez MM, Rodriguez-Monroy MA. The wound-healing effect of mango peel extract on incision wounds in a murine model. Molecules 2022;27:259.
90. Rocha MI, Gonçalves MJ, Cavaleiro C, Cruz MT, Pereira C, Moreira P, et al. Chemical characterization and bioactive potential of Artemisia campestris L. subsp. maritima (DC) Arcang. essential oil and hydrodistillation residual water. J Ethnopharmacol 2021;276:114146.
91. Li D, Zhang C, Gao Z, Xia N, Wu C, Liu C, et al. Curcumin-loaded macrophage-derived exosomes effectively improve wound healing. Mol Pharm 2023;20:4453-4467.
92. Zhang L, Luo Z, Chen H, Wu X, Zhao Y. Glycyrrhizic acid hydrogel microparticles encapsulated with mesenchymal stem cell exosomes for wound healing. Research (Wash D C) 2024;7:0496.
93. Xu N, Wang L, Guan J, Tang C, He N, Zhang W, et al. Wound healing effects of a Curcuma zedoaria polysaccharide with platelet-rich plasma exosomes assembled on chitosan/silk hydrogel sponge in a diabetic rat model. Int J Biol Macromol 2018;117:102-107.
94. Benalaya I, Alves G, Lopes J, Silva LR. A review of natural polysaccharides: sources, characteristics, properties, food, and pharmaceutical applications. Int J Mol Sci 2024;25:1322.
95. Gharge S, Hiremath SI, Kagawad P, Jivaje K, Palled MS, Suryawanshi SS. Curcuma zedoaria Rosc (Zingiberaceae): a review on its chemical, pharmacological and biological activities. Future J Pharm Sci 2021;7:166.
96. Herrmann IK, Wood MJA, Fuhrmann G. Extracellular vesicles as a next-generation drug delivery platform. Nat Nanotechnol 2021;16:748-759.
97. Castelli G, Logozzi M, Mizzoni D, Di Raimo R, Cerio A, Dolo V, et al. Ex vivo anti-leukemic effect of exosome-like grapefruit-derived nanovesicles from organic farming—the potential role of ascorbic acid. Int J Mol Sci 2023;24:15663.
98. Huang L, Cai H-A, Zhang M-S, Liao R-Y, Huang X, Hu F-D. Ginsenoside Rg1 promoted the wound healing in diabetic foot ulcers via miR-489-3p/Sirt1 axis. J Pharmacol Sci 2021;147:271-283.
99. Tan M, Liu Y, Xu Y, Yan G, Zhou N, Chen H, et al. Plant-derived exosomes as novel nanotherapeutics contrive glycolysis reprogramming-mediated angiogenesis for diabetic ulcer healing. Biomater Res 2024;28:0035.
100. Moroni L, Boland T, Burdick JA, De Maria C, Derby B, Forgacs G, et al. Biofabrication: a guide to technology and terminology. Trends Biotechnol 2018;36:384-400.
101. Jiang L, Dong J, Jiang M, Tan W, Zeng Y, Liu X, et al. 3D-printed multifunctional bilayer scaffold with sustained release of apoptotic extracellular vesicles and antibacterial coacervates for enhanced wound healing. Biomaterials 2025;318:123196.
102. Nosrati H, Khodaei M, Banitalebi-Dehkordi M, Alizadeh M, Asadpour S, Sharifi E, et al. Preparation and characterization of poly(ethylene oxide)/zinc oxide nanofibrous scaffold for chronic wound healing applications. Polim Med 2020;50:41-51. 
103. Murphy SV, De Coppi P, Atala A. Opportunities and challenges of translational 3D bioprinting. Nat Biomed Eng 2020;4:370-380.
104. Ali F, Kalva SN, Koc M. Advancements in 3D printing techniques for biomedical applications: a comprehensive review of materials consideration, post processing, applications, and challenges. Discov Mater 2024;4:53.
105. Zheng Y, Pan C, Xu P, Liu K. Hydrogel-mediated extracellular vesicles for enhanced wound healing: the latest progress, and their prospects for 3D bioprinting. J Nanobiotechnology 2024;22:57.
106. Palmara G, Frascella F, Roppolo I, Chiappone A, Chiadò A. Functional 3D printing: Approaches and bioapplications. Biosens Bioelectron 2021;175:112849.
107. Liu N, Zhang X, Guo Q, Wu T, Wang Y. 3D bioprinted scaffolds for tissue repair and regeneration. Front Mater 2022;9:925321.
108. Do AV, Khorsand B, Geary SM, Salem AK. 3D printing of scaffolds for tissue regeneration applications. Adv Healthc Mater 2015;4:1742-1762.
109. Chowdhury SR, Lokanathan Y, Xian LJ, Busra FM, Yazid MD, Sulaiman N, et al. 3D Printed Bioscaffolds for Developing Tissue-Engineered Constructs. In: Design and Manufacturing. London: IntechOpen; 2020.
110. Ma H, Li T, Huan Z, Zhang M, Yang Z, Wang J, et al. 3D printing of high-strength bioscaffolds for the synergistic treatment of bone cancer. NPG Asia Mater 2018;10:31-44.
111. Chen A, Tian H, Yang N, Zhang Z, Yang G-Y, Cui W, et al. Towards extracellular vesicle delivery systems for tissue regeneration: material design at the molecular level. Extracell Vesicles Circ Nucleic Acids 2022;3:323.
112. Amiri FT, Omraninava M, Shahzamani S, Khodashenas A, Daryakar A, Nasiry D. Bioactive and degradable collagen-based three-dimensional scaffold encapsulated with adipose mesenchymal stem cells-derived exosomes improved diabetic wound healing. Regen Ther 2025;28:606.
113. Jin W, Li Y, Yu M, Ren D, Han C, Guo S. Advances of exosomes in diabetic wound healing. Burns Trauma 2025;13:tkae078.
114. Hu Y, Wu B, Xiong Y, Tao R, Panayi AC, Chen L, et al. Cryogenic 3D printed hydrogel scaffolds loading exosomes accelerate diabetic wound healing. Chem Eng J 2021;426:130634.
115. Yang T, Dong Y, Wan J, Liu X, Liu Y, Huang J, et al. Sustained release of BMSC-EVs from 3D printing gel/HA/nHAP scaffolds for promoting bone regeneration in diabetic rats. Adv Healthc Mater 2023;12:2203131.
116. Ferroni L, Gardin C, D’Amora U, Calza L, Ronca A, Tremoli E, et al. Exosomes of mesenchymal stem cells delivered from methacrylated hyaluronic acid patch improve the regenerative properties of endothelial and dermal cells. Biomater Adv 2022;139:213000.
117. Kong X, Zhu D, Hu Y, Liu C, Zhang Y, Wu Y, et al. Melt electrowriting (MEW)-PCL composite Three-Dimensional exosome hydrogel scaffold for wound healing. Mater Des 2024;238:112717.
118. Abdollahi A, Aghayan HR, Mousivand Z, Motasadizadeh H, Maghsoudian S, Abdorashidi M, et al. Chitosan based extruded nanofibrous bioscaffold for local delivery of mesenchymal stem cells to improve diabetic wound healing. Stem Cell Res Ther 2024;15:262.
119. Wang Y, Zhang Y, Li T, Shen K, Wang KJ, Tian C, et al. Adipose mesenchymal stem cell derived exosomes promote keratinocytes and fibroblasts embedded in collagen/platelet-rich plasma scaffold and accelerate wound healing. Adv Mater 2023;35:2303642.
120. Sideek SA, El-Nassan HB, Fares AR, ElMeshad AN, Elkasabgy NA. Different curcumin-loaded delivery systems for wound healing applications: A comprehensive review. Pharmaceutics 2022;15:38.
121. Wang X, Zhang Y, Song A, Wang H, Wu Y, Chang W, et al. A printable hydrogel loaded with medicinal plant extract for promoting wound healing. Adv Healthc Mater 2024;13:2303017.
122. Gupta M, Sharma A, Beniwal CS, Tyagi P. Curcumin coated 3D biocomposite scaffolds based on chitosan and cellulose for diabetic wound healing. Heliyon 2022;8:e11345.
123. Naik K, Singh P, Yadav M, Srivastava SK, Tripathi S, Ranjan R, et al. 3D printable, injectable amyloid-based composite hydrogel of bovine serum albumin and aloe vera for rapid diabetic wound healing. J Mater Chem B 2023;11:8142-8158.
124. Ahmed J, Zhang Y, Maniruzzaman M. Fabrication of 3D-printed thyme and cinnamon essential oils in γ-cyclodextrin encapsulates/sodium alginate-methylcellulose antimicrobial films with a core-shell structure. Food Packag Shelf Life 2024;46:101406.
125. Hu Y, Xiong Y, Zhu Y, Zhou F, Liu X, Chen S, et al. Copper-epigallocatechin gallate enhances therapeutic effects of 3D-printed dermal scaffolds in mitigating diabetic wound scarring. ACS Appl Mater Interfaces 2023;15:38230-38246.
126. Ashtariyan A, Mollania H, Annabestani N, Mollania N, Malayjerdi F, Dolatabadi M, et al. Synergistic effect of Cydonia oblonga and its extracted silver nanoparticles for improving anti-oxidant and antibacterial activity of 3D printed alginate-based hydrogel as wound dressing. Int J Biol Macromol 2024;276:133989.
127. Patitucci F, Motta MF, Dattilo M, Malivindi R, Leonetti AE, Pezzi G, et al. 3D-printed alginate/pectin-based patches loaded with olive leaf extracts for wound healing applications: development, characterization and in vitro evaluation of biological properties. Pharmaceutics 2024;16:99.
128. Saatcioglu E, Koyun M, Ulag S, Sahin A, Yilmaz BK, Aksu B, et al. 3D printing of Osage orange extract/Chitosan scaffolds for soft tissue engineering. Food Hydrocoll Health 2021;1:100039.
129. Weng J, Chen Y, Zeng Y, Jin W, Ji Y, Zhang W, et al. A novel hydrogel loaded with plant exosomes and stem cell exosomes as a new strategy for treating diabetic wounds. Mater Today Bio 2025:101810.
130. Nadi A, Khodaei M, Javdani M, Mirzaei SA, Soleimannejad M, Tayebi L, et al. 3D printed bioscaffolds for developing tissue-engineered constructs. In: Design and manufacturing. Int J Biol Macromol 2022;219:1319–1336.
131. Wang X, Jia J, Niu M, Li W, Zhao Y. Living Chinese herbal scaffolds from microfluidic bioprinting for wound healing. Research (Wash D C) 2023;6:0138.
132. Yi J, Tang Q, Sun S, Xie H, Wang L, Yin X. Exosomes in diabetic wound healing: Mechanisms, Applications, and perspectives. Diabetes Metab Syndr Obes 2025:2955-2976.
133. Chen L, Liu J, He Y, Zeng C, Liao W, Luo C. A systematic review and meta-analysis to investigate the effectiveness of exosome for diabetic wounds. J Tissue Viability 2025:100917.
134. Guo L, Xiao D, Xing H, Yang G, Yang X. Engineered exosomes as a prospective therapy for diabetic foot ulcers. Burns Trauma 2024;12:tkae023.
135. Zhao H, Li Z, Wang Y, Zhou K, Li H, Bi S, et al. Bioengineered MSC-derived exosomes in skin wound repair and regeneration. Front Cell Dev Biol 2023;11:1029671.
136. Chen H, Li Q. Recent advances in scalable exosome production: Challenges and innovations. Chin J Plast Reconstr Surg 2025;7:149-163.
137. Lv Q, Deng J, Chen Y, Wang Y, Liu B, Liu J. Engineered human adipose stem-cell-derived exosomes loaded with miR-21-5p to promote diabetic cutaneous wound healing. Mol Pharm 2020;17:1723-1733.
138. Zhang L, Ouyang P, He G, Wang X, Song D, Yang Y, et al. Exosomes from microRNA-126 overexpressing mesenchymal stem cells promote angiogenesis by targeting the PIK3R2-mediated PI3K/Akt signalling pathway. J Cell Mol Med 2021;25:2148-2162.
139. Chowdhury S, Kumar A, Patel P, Kurmi BD, Jain S, Kumar B, et al. Stem cell-derived exosomes for diabetic wound healing: Mechanisms, nano-delivery systems, and translational perspectives. J Nanotheranostics 2026;7:1.
140. Allahham N, Colic I, Rayner ML, Gurnani P, Phillips JB, Rahim AA, et al. Advanced formulation approaches for emerging therapeutic technologies. Handb Exp Pharmacol 2024:284:343-365. 
141. Ahmadian R, Bahramsoltani R, Marques AM, Rahimi R, Farzaei MH. Medicinal plants as efficacious agents for diabetic foot ulcers: a systematic review of clinical studies. Wounds 2021;33:207-218.
142. Mahmood BA, Youssef HA, Mohamed BA, Radwan A, Elghouneimy MA, Mohamed NA, et al. Topical herbal products as adjuncts to standard care for the management of diabetic foot ulcers. Nat Prod J 2026;16:pages.
143. Zamanifard M, Nasiri M, Yarahmadi F, Zonoori S, Razani O, Salajegheh Z, et al. Healing of diabetic foot ulcer with topical and oral administrations of herbal products: A systematic review and meta-analysis of randomized controlled trials. Int Wound J 2024;21:e14760.
144. Talukdar N, Das K, Barman I. A review on ethanobotanical survey of medicinal plants available in North-East India against microbes involved in diabetic foot ulcer. J Diabetol 2021;12:128-133.
145. Herman A, Herman AP. Herbal products and their active constituents for diabetic wound healing—Preclinical and clinical studies: A systematic review. Pharmaceutics 2023;15:281.
146. Joulaei H, Tavakoli A, Foroozanfar Z, Afrashteh S, Amiri M. Complementary and alternative medicine use in diabetic foot ulcer patients at a shiraz diabetes clinic: A cross-sectional study. Shiraz E-Med J 2024;26:e145592.
147. Mariadoss AVA, Sivakumar AS, Lee C-H, Kim SJ. Diabetes mellitus and diabetic foot ulcer: Etiology, biochemical and molecular based treatment strategies via gene and nanotherapy. Biomed Pharmacother 2022;151:113134.
148. Kumar S, Dubey MV, Nishad V. 3D Printing in medicine: Technology overview and drug delivery applications. J Adv Future Res 2025;3:61-86.
149. Mao S, Man J, Wang J, Fu L, Yin C, Karimi-Maleh H. Research progress and challenges of bioprinting in wound dressing and healing: Bibliometrics-based analysis and perspectives. Int J Bioprint 2022;9:653.
150. Yuan X, Wang Z, Che L, Lv X, Xu J, Shan D, et al. Recent developments and challenges of 3D bioprinting technologies. Int J Bioprint 2024;10:1752.
151. Tavakoli E, Yarmand B, Soleimannejad M, Saeidifar M. Improvement of biomedical properties of PEO-treated titanium with flurbiprofen and exosome conjugation. Surf Interfaces 2024;49:104429.
152. Ferreira D, Moreira JN, Rodrigues LR. New advances in exosome-based targeted drug delivery systems. Crit Rev Oncol Hematol 2022;172:103628.
153. Zhang M, Hu S, Liu L, Dang P, Liu Y, Sun Z, et al. Engineered exosomes from different sources for cancer-targeted therapy. Signal Transduct Target Ther 2023;8:124.
154. He J, Ren W, Wang W, Han W, Jiang L, Zhang D, et al. Exosomal targeting and its potential clinical application. Drug Deliv Transl Res 2022;12:2385-402.
155. Choi H, Choi Y, Yim HY, Mirzaaghasi A, Yoo J-K, Choi C. Biodistribution of exosomes and engineering strategies for targeted delivery of therapeutic exosomes. Tissue Eng Regen Med 2021;18:499-511.
156. Chakraborty A, Roy A, Ravi S, Paul A. Exploiting the role of nanoparticles for use in hydrogel-based bioprinting applications: concept, design, and recent advances. Biomater Sci 2021;9:6337-6354.
157. Si H, Xing T, Ding Y, Zhang H, Yin R, Zhang W. 3D bioprinting of the sustained drug release wound dressing with double-crosslinked hyaluronic-acid-based hydrogels. Polymers (Basel) 2019;11:1584.
158. Nosrati H, Banitalebi-Dehkordi M, Khodaei M, Sharifi E, Asadpour S, Mansouri K, et al. Preparation and in vitro characterization of electrospun scaffolds composed of chitosan, gelatin and 58S bioactive glass nanoparticles for skin tissue engineering. J Shahrekord Univ Med Sci 2022;24:1-6.
159. Souza C, Jayme CC, Rezende N, Tedesco AC. Synergistic effect of photobiomodulation and phthalocyanine photosensitizer on fibroblast signaling responses in an in vitro three-dimensional microenvironment. J Photochem Photobiol B 2021;222:112256.
160. Ahrabi B, Tavirani MR, Khoramgah MS, Noroozian M, Darabi S, Khoshsirat S, et al. The effect of photobiomodulation therapy on the differentiation, proliferation, and migration of the mesenchymal stem cell: A review. J Lasers Med Sci 2019;10:S96.
161. Ataollahi S. A review on additive manufacturing of lattice structures in tissue engineering. Bioprinting 2023;35:e00304.
162. Amantino CF, do Amaral SR, Aires-Fernandes M, Oliani SM, Tedesco AC, Primo FL. Development of 3D skin equivalents for application in photodynamic biostimulation therapy assays using curcumin nanocapsules. Heliyon 2024;10:e32645.
163. Dayyoub T, Maksimkin AV, Filippova OV, Tcherdyntsev VV, Telyshev DV. Shape memory polymers as smart materials: A review. Polymers (Basel) 2022;14:3511.
164. Kumar AM, Kachhawa K. Biomedical applications of bioelectrochemical sensors. In: Multifaceted Bio-Sensing Technology. Amsterdam: Elsevier; 2023. p. 239-60.
165. Dong R, Guo B. Smart wound dressings for wound healing. Nano Today 2021;41:101290.
166. Sadraei A, Naghib SM. 4D printing of physical stimuli-responsive hydrogels for localized drug delivery and tissue engineering. Polym Rev 2025;65:104-168.
167. Naghib SM, Hosseini SN, Beigi A. 3D 4D printing of chitosan-based scaffolds for wound dressing applications. Carbohydr Polym Technol Appl 2024;8:100594.
168. Wu J, Chen L-H, Sun S-Y, Li Y, Ran X-W. Mesenchymal stem cell-derived exosomes: The dawn of diabetic wound healing. World J Diabetes 2022;13:1066.