Iranian Journal of Basic Medical Sciences

Iranian Journal of Basic Medical Sciences

Effects of anthocyanins on stem/progenitor cell activities: A comprehensive review

Articles in Press

Document Type : Review Article

Authors
Fateme Sabahati 1
Ricardo Ambrosio Fock 2
Mahmood Abedinzade 3
Azar Hosseini 1
Ahmad Ghorbani 1, 4
1 Pharmacological Research Center of Medicinal Plants, Basic Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran
2 Department of Clinical and Toxicologic Analysis, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil
3 Biomedicine Research Center, Trauma Institute, Guilan University of Medical Sciences, Rasht, Iran
4 Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
10.22038/ijbms.2026.95275.20550
Abstract
Anthocyanins are water-soluble pigments belonging to the flavonoid family vastly found in fruits, vegetables, and flowers. Their antioxidant and anti-inflammatory properties verify therapeutic potential against health conditions including cancer, diabetes, cardiovascular diseases, and neurodegenerative disorders. Recent studies have shown that anthocyanins influence stem/progenitor cell activities. Maintaining stem cell populations in tissues is essential for preserving their regenerative potential and physiological functions. In addition, in vitro stem cell proliferation provides sufficient cells for cell therapy. Evidence suggests that anthocyanins could maintain stem cell survival under stressful conditions such as hypoxia, radiation, and inflammation. Also, these compounds can influence the differentiation of various stem and progenitor cells (e.g., mesenchymal, hematopoietic, and neural stem cells) into adipocytes, osteoblasts, chondroblasts, neurons, etc. These effects may vary depending on the chemical structure of the anthocyanins, the anatomical depot of stem cells, and human age. This comprehensive review covers the molecular mechanisms by which anthocyanins impact stem cell survival, proliferation, differentiation, and function. In addition, the natural source, chemical structure, bioavailability, and safety of anthocyanins are discussed. Taken together, the findings discussed in this review highlight the potential of anthocyanins to preserve stem cells and optimize their therapeutic efficacy.
Keywords
Anthocyanins
Differentiation
Oxidative stress
Proliferation
Regenerative medicine
Stem cells
Subjects
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Iranian Journal of Basic Medical Sciences

Articles in Press, Accepted Manuscript
Available Online from 17 August 2026