1. Yang D, Xu Z, Huang D, Luo Q, Zhang C, Guo J, et al. Immunomodulatory multifunctional janus collagen-based membrane for advanced bone regeneration. Nat Commun 2025; 16:4264.
2. Zhang X, Jiang W, Xie C, Wu X, Ren Q, Wang F, et al. Msx1+ stem cells recruited by bioactive tissue engineering graft for bone regeneration. Nat Commun 2022; 13:5211.
3. Wang P, Shao W, Li Z, Wang B, Lv X, Huang Y, et al. Non-bone-derived exosomes: A new perspective on regulators of bone homeostasis. Cell Commun Signal 2024; 22:70.
4. Azaryan E, Karbasi S, Zarban A, Naseri M. Cell‐free therapy based on stem cell‐derived exosomes: A promising approach for wound healing. Wound Repair Regen 2022; 30:585–594.
5. Azaryan E, Karbasi S, Saharkhiz M, Hanafi-Bojd MY, Zarban A, Emadian Razavi F, et al. Effect of HM-Exos on the migration and inflammatory response of LPS-exposed dental pulp stem cells. BMC Oral Health 2023; 23:95.
6. Azaryan E, Zarban A, Alemzadeh E, Alemzadeh E, Rajabi-Moghaddam M, Zangooie A, et al. Anti-inflammatory and immunomodulatory effects of camel milk exosomes (CM-Exo) in rat models for burn wound healing. Iran J Basic Med Sci 2025; 28:1539–1547.
7. Shah M, Dukharan V, Broughton L, Stegura C, Schur N, Samman L, et al. Exosomes for aesthetic dermatology: A comprehensive literature review and update. J Cosmet Dermatol 2025; 24:e16766.
8. Li Y, Lyu P, Ze Y, Li P, Zeng X, Shi Y, Qiu B, Gong P, Yao Y. Exosomes derived from plasma: Promising immunomodulatory agents for promoting angiogenesis to treat radiation-induced vascular dysfunction. Peer J 2021;9:e11147.
9. Xiang X, Pathak JL, Wu W, Li J, Huang W, Wu Q, et al. Human serum‐derived exosomes modulate macrophage inflammation to promote VCAM1‐mediated angiogenesis and bone regeneration. J Cell Mol Med 2023; 27:1131–1143.
10. Meng F, Wang G, Zhou F, Li G, Wang M, Zhou Z, et al. Exosomes from young plasma alleviate osteoporosis through miR-217-5p-regulated osteogenesis of bone marrow mesenchymal stem cell. Compos B Eng 2024; 276:111358.
11. Zhan Q, Yi K, Cui X, Li X, Yang S, Wang Q, et al. Blood exosomes-based targeted delivery of cPLA2 siRNA and metformin to modulate glioblastoma energy metabolism for tailoring personalized therapy. Neuro Oncol 2022; 24:1871–1883.
12. Jung HH, Kim J-Y, Lim JE, Im Y-H. Cytokine profiling in serum-derived exosomes isolated by different methods. Sci Rep 2020; 10:14069.
13. Wang H, Chen R, Li X, Wang J, Chen T, Sun S, et al. Exosomes as precise regulators of the osteoimmune microenvironment: engineering strategies for bone regeneration. Biomater Res 2026; 30:0321.
14. Lin Y, Xie Y, He Y, Zhang M, Li J, He J. Exosomes in bone generation and repair: Focusing on bone microenvironmental crosstalk and engineering biomaterial designs. Int J Nanomedicine 2026; 21:1–31.
15. Daneshvar A, Nemati P, Azadi A, Amid R, Kadkhodazadeh M. M2 macrophage-derived exosomes for bone regeneration: A systematic review. Arch Oral Biol 2024; 166:106034.
16. Dayanandan AP, Bello AB, Arai Y, Lee SJ, Lee S-H. Therapeutic strategy for exosome-based bone regeneration to osteoporosis: challenges and potential solutions. J Adv Res 2025; 84:361–385.
17. Lötvall J, Hill AF, Hochberg F, Buzás EI, Di Vizio D, Gardiner C, et al. Minimal experimental requirements for definition of extracellular vesicles and their functions: A position statement from the International Society for Extracellular Vesicles. J Extracell Vesicles 2014; 3:26913.
18. Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): A position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles 2018; 7:1535750.
19. Johnstone R. Maturation of reticulocytes: Formation of exosomes as a mechanism for shedding membrane proteins. Biochem Cell Biol 1992; 70:179–190.
20. Pan B-T, Johnstone RM. Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor. Cell 1983; 33:967–978.
21. Pan B-T, Teng K, Wu C, Adam M, Johnstone RM. Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes. J Cell Biol 1985; 101:942–948.
22. Gao C, Wang B, Chen Q, Wang M, Fei X, Zhao N. Serum exosomes from diabetic kidney disease patients promote pyroptosis and oxidative stress through the miR-4449/HIC1 pathway. Nutr Diabetes 2021; 11:33.
23. Gangadaran P, Hong CM, Oh JM, Rajendran RL, Kalimuthu S, Son SH, et al. In vivo non-invasive imaging of radio-labeled exosome-mimetics derived from red blood cells in mice. Front Pharmacol 2018; 9:817.
24. Shi L, Song D, Meng C, Cheng Y, Wang B, Yang Z. Opportunities and challenges of engineered exosomes for diabetic wound healing. Giant (Oxf) 2024; 18:100251.
25. Lange M, Babczyk P, Tobiasch E. Exosomes: A new hope for angiogenesis-mediated bone regeneration. Int J Mol Sci 2024; 25:5204.
26. Kang J-Y, Park H, Kim H, Mun D, Park H, Yun N, et al. Human peripheral blood-derived exosomes for microRNA delivery. Int J Mol Med 2019; 43:2319–2328.
27. Masaoutis C, Theocharis S. The role of exosomes in bone remodeling: implications for bone physiology and disease. Dis Markers 2019; 2019:9417914.
28. Jiao Y, Liu Y, Du J, Xu J, Luo Z, Liu Y, et al. Advances in the study of extracellular vesicles for bone regeneration. Int J Mol Sci 2024; 25:3480.
29. Liu X, Yu W, Huang C, Wang Z, Qian Y, Chen X, et al. Exosomes in bone health and disease: cellular crosstalk, systemic signaling, and AI-driven advances in regenerative therapy. Stem Cell Res Ther 2026; 17:265.
30. Li R, Li D, Wang H, Chen K, Wang S, Xu J, et al. Exosomes from adipose-derived stem cells regulate M1/M2 macrophage phenotypic polarization to promote bone healing via miR-451a/MIF. Stem Cell Res Ther 2022; 13:149.
31. Lin Z, Xiong Y, Meng W, Hu Y, Chen L, Chen L, et al. Exosomal PD-L1 induces osteogenic differentiation and promotes fracture healing by acting as an immunosuppressant. Bioact Mater 2022; 13:300–311.
32. Takeuchi R, Katagiri W, Endo S, Kobayashi T. Exosomes from conditioned media of bone marrow-derived mesenchymal stem cells promote bone regeneration by enhancing angiogenesis. PLoS One 2019; 14:e0225472.
33. Palviainen M, Saraswat M, Varga Z, Kitka D, Neuvonen M, Puhka M, et al. Extracellular vesicles from human plasma and serum are carriers of extravesicular cargo—Implications for biomarker discovery. PLoS One 2020; 15:e0236439.
34. Mehdipour Chari K, Enderami SE, Mansour RN, Hasanzadeh E, Amini Mahabadi J, Abazari M, et al. Applications of blood plasma derivatives for cutaneous wound healing: A mini-review of clinical studies. Regen Ther 2024; 27:251–258.
35. Li Y, Lyu P, Ze Y, Li P, Zeng X, Shi Y, et al. Exosomes derived from plasma: Promising immunomodulatory agents for promoting angiogenesis to treat radiation-induced vascular dysfunction. PeerJ 2021; 9:e11147.
36. Vallejos PA, Gonda A, Yu J, Sullivan BG, Ostowari A, Kwong ML, et al. Plasma exosome gene signature differentiates colon cancer from healthy controls. Ann Surg Oncol 2023; 30:3833–3844.
37. Cai H, Pang Y, Wang Q, Qin W, Wei C, Li Y, et al. Proteomic profiling of circulating plasma exosomes reveals novel biomarkers of Alzheimer’s disease. Alzheimers Res Ther 2022; 14:181.
38. Abdel-Haq H. Blood exosomes as a tool for monitoring treatment efficacy and progression of neurodegenerative diseases. Neural Regen Res 2019; 14:72–74.
39. Tavasolian F, Lively S, Pastrello C, Tang M, Lim M, Pacheco A, et al. Proteomic and genomic profiling of plasma exosomes from patients with ankylosing spondylitis. Ann Rheum Dis 2023; 82:1429–1443.
40. Shuai Z-Q, Wang Z-X, Ren J-L, Yang X-K, Xu B. Differential expressions and potential clinical values of lncRNAs in the plasma exosomes of rheumatoid arthritis. Int Immunopharmacol 2024; 128:111511.
41. Shin H, Kang Y, Choi KW, Kim S, Ham B-J, Choi Y. Artificial intelligence-based major depressive disorder (MDD) diagnosis using Raman spectroscopic features of plasma exosomes. Anal Chem 2023; 95:6410–6416.
42. Wang Y, Gao C, Gao T, Zhao L, Zhu S, Guo L. Plasma exosomes from depression ameliorate inflammation-induced depressive-like behaviors via sigma-1 receptor delivery. Brain Behav Immun 2021; 94:225–234.
43. Zhang X, Takeuchi T, Takeda A, Mochizuki H, Nagai Y. Comparison of serum and plasma as a source of blood extracellular vesicles: Increased levels of platelet-derived particles in serum extracellular vesicle fractions alter content profiles from plasma extracellular vesicle fractions. PLoS One 2022; 17:e0270634.
44. Zhang B, Pei Z, He W, Feng W, Hao T, Sun M, et al. 3D-printed porous zinc scaffold combined with bioactive serum exosomes promotes bone defect repair in rabbit radius. Aging (Albany NY) 2024; 16:9625.
45. Xun J, Li C, Liu M, Mei Y, Zhou Q, Wu B, et al. Serum exosomes from young rats improve the reduced osteogenic differentiation of BMSCs in aged rats with osteoporosis after fatigue loading in vivo. Stem Cell Res Ther 2021; 12:1–16.
46. Liang S-N, Xia M-H, Wu L-F, He P, Lu X, Deng F-Y, et al. Plasma exosomal miR-181a-5p is linked to osteoporosis by mediating endothelial-osteoblast crosstalk and regulating bone remodeling. Biochem Biophys Res Commun 2026; 814:153661.
47. Xia M-H, Lu Y-H, Wu L-f, Deng F-Y, Lei S-f. Plasma exosomal miR-106b-5p is associated with osteoporosis by targeting SMAD5, BMP2, and MAPK1 genes. In Vivo (Brooklyn) 2026; 40:1530–1544.
48. Kajitani K, Ohtani T, Higuchi R, Chimura M, Sera F, Tsai C-HD, et al. An on-chip deformability checker demonstrates that the severity of iron deficiency is associated with increased deformability of red blood cells. Sci Rep 2025; 15:19994.
49. Díaz-Varela M, de Menezes-Neto A, Perez-Zsolt D, Gámez-Valero A, Seguí-Barber J, Izquierdo-Useros N, et al. Proteomics study of human cord blood reticulocyte-derived exosomes. Sci Rep 2018; 8:14046.
50. D’Alessandro A, Zolla L. Proteomic analysis of red blood cells and the potential for the clinic: what have we learned so far? Expert Rev Proteomics 2017; 14:243–252.
51. Kong Y, Tian X, He R, Li C, Xu H, Tian L, et al. The accumulation of exosome-associated microRNA-1246 and microRNA-150-3p in human red blood cell suspensions. J Transl Med 2021; 19:225.
52. Huang H, Zhu J, Fan L, Lin Q, Fu D, Wei B, et al. MicroRNA profiling of exosomes derived from red blood cell units: Implications in transfusion‐related immunomodulation. Biomed Res Int 2019; 2019:2045915.
53. Shao Y, Jiang Y, Yang K, Zhu Y, Liu Y, Zhang P, et al. Apoptotic vesicles derived from human red blood cells promote bone regeneration via carbonic anhydrase 1. Cell Prolif 2024; 57:e13547.
54. Thangaraju K, Neerukonda SN, Katneni U, Buehler PW. Extracellular vesicles from red blood cells and their evolving roles in health, coagulopathy and therapy. Int J Mol Sci 2020; 22:153.
55. Chang M, Hsiao J-K, Yao M, Chien L-Y, Hsu S-C, Ko B-S, et al. Homologous RBC-derived vesicles as ultrasmall carriers of iron oxide for magneticresonance imaging of stem cells. Nanotechnology 2010; 21:235103.
56. Xu L, Xu X, Liang Y, Wen C, Ouyang K, Huang J, et al. Osteoclast-targeted delivery of anti-miRNA oligonucleotides by red blood cell extracellular vesicles. J Control Release 2023; 358:259–272.
57. Phan TK, Ozkocak DC, Poon IKH. Unleashing the therapeutic potential of apoptotic bodies. Biochem Soc Trans 2020; 48:2079–2088.
58. Zhang X, Tang J, Kou X, Huang W, Zhu Y, Jiang Y, et al. Proteomic analysis of MSC‐derived apoptotic vesicles identifies Fas inheritance to ameliorate haemophilia a via activating platelet functions. J Extracell Vesicles 2022; 11:e12240.
59. Levoux J, Prola A, Lafuste P, Gervais M, Chevallier N, Koumaiha Z, et al. Platelets facilitate the wound-healing capability of mesenchymal stem cells by mitochondrial transfer and metabolic reprogramming. Cell Metab 2021; 33:283–299.
60. Chen X, Xu Y, Chen Q, Zhang H, Zeng Y, Geng Y, et al. The phosphatase PTEN links platelets with immune regulatory functions of mouse T follicular helper cells. Nat Commun 2022; 13:2762.
61. Sánchez M, Mercader Ruiz J, Marijuán Pinel D, Sánchez P, Fiz N, Guadilla J, et al. Increasing the concentration of plasma molecules improves the biological activity of platelet-rich plasma for tissue regeneration. Sci Rep 2025; 15:4523.
62. Erfanian S, Mostafaei F, Ajalloueian F, Baharvand H, Rajabi S, Ashtiani MK. Controlled delivery of PRP from decellularized extracellular matrix enhances skeletal muscle regeneration. Sci Rep 2025; 15:12719.
63. Li L, Zhao C, Zhang R, Wei W, Liu B, Dong J, et al. Beclin 1 of megakaryocytic lineage cells is locally dispensable for platelet hemostasis but functions distally in bone homeostasis. Bone Res 2025; 13:32.
64. Ogino Y, Ayukawa Y, Kukita T, Atsuta I, Koyano K. Platelet‐rich plasma suppresses osteoclastogenesis by promoting the secretion of osteoprotegerin. J Periodontal Res 2009; 44:217–224.
65. Gianakos A, Zambrana L, Savage-Elliott I, Lane JM, Kennedy JG. Platelet-rich plasma in the animal long-bone model: an analysis of basic science evidence. Orthopedics 2015; 38:e1079–e1090.
66. Fernandes G, Wang C, Yuan X, Liu Z, Dziak R, Yang S. Combination of controlled release platelet‐rich plasma alginate beads and bone morphogenetic protein‐2 genetically modified mesenchymal stem cells for bone regeneration. J Periodontol 2016; 87:470–480.
67. Saumell-Esnaola M, Delgado D, García del Caño G, Beitia M, Sallés J, González-Burguera I, et al. Isolation of platelet-derived exosomes from human platelet-rich plasma: Biochemical and morphological characterization. Int J Mol Sci 2022; 23:2861.
68. Guo S-C, Tao S-C, Yin W-J, Qi X, Yuan T, Zhang C-Q. Exosomes derived from platelet-rich plasma promote the re-epithelization of chronic cutaneous wounds via activation of YAP in a diabetic rat model. Theranostics 2017; 7:81–96.
69. Liu X, Wang L, Ma C, Wang G, Zhang Y, Sun S. Exosomes derived from platelet-rich plasma present a novel potential in alleviating knee osteoarthritis by promoting proliferation and inhibiting apoptosis of chondrocyte via Wnt/β-catenin signaling pathway. J Orthop Surg Res 2019; 14:470.
70. Zhang X, Yang L, Wang Y, Ban Z, Ma X, Zhang Q, et al. Potential of platelet-rich plasma-derived exosomes for bone-defect repair: In vitro and in vivo study. Hum Cell 2025; 38:117.
71. Mo C, Liu Z, Lin Y, Bu NEBYA, Ku DX, Li S, et al. Effects of exosomes derived from platelet-rich plasma on osteogenic differentiation of dental pulp stem cells. Cell Mol Biol 2024; 70:227–234.
72. Li M, Shi L, Chen X, Yi D, Ding Y, Chen J, et al. In-situ gelation of fibrin gel encapsulating platelet-rich plasma-derived exosomes promotes rotator cuff healing. Commun Biol 2024; 7:205.
73. Tao SC, Yuan T, Rui BY, Zhu ZZ, Guo SC, Zhang CQ. Exosomes derived from human platelet-rich plasma prevent apoptosis induced by glucocorticoid-associated endoplasmic reticulum stress in rat osteonecrosis of the femoral head via the Akt/Bad/Bcl-2 signal pathway. Theranostics 2017; 7:733–750.
74. Tang Q, Lim T, Wei X-J, Wang Q-Y, Xu J-C, Shen L-Y, et al. A free-standing multilayer film as a novel delivery carrier of platelet lysates for potential wound-dressing applications. Biomaterials 2020; 255:120138.
75. Zheng G, Ma H-W, Xiang G-H, He G-L, Cai H-C, Dai Z-H, et al. Bone-targeting delivery of platelet lysate exosomes ameliorates glucocorticoid-induced osteoporosis by enhancing bone-vessel coupling. J Nanobiotechnology 2022; 20:220.
76. Torreggiani E, Perut F, Roncuzzi L, Zini N, Baglìo SR, Baldini N. Exosomes: Novel effectors of human platelet lysate activity. Eur Cell Mater 2014; 28:10.22203.
77. Xiong Y, Mi B-B, Lin Z, Hu Y-Q, Yu L, Zha K-K, et al. The role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: From mechanism to therapeutic opportunity. Mil Med Res 2022; 9:65.
78. Yari D, Movaffagh J, Ebrahimzadeh MH, Saberi A, Qujeq D, Moradi A. Biomimetic ECM-based hybrid scaffold for cartilage tissue engineering applications. J Polym Environ 2024; 32:3973–3991.
79. Elieh-Ali-Komi D, Shafaghat F, Alipoor SD, Kazemi T, Atiakshin D, Pyatilova P, et al. Immunomodulatory significance of mast cell exosomes (MC-EXOs) in immune response coordination. Clin Rev Allergy Immunol 2025; 68:20.
80. Xie X, Pi M, Zhang H, Zhou L, Liu M, Zhu W, et al. Neutrophil-derived exosomes promote sepsis-related multiple organ dysfunction through the induction of neutrophil extracellular trap formation. Int Immunopharmacol 2025; 159:114892.
81. Mazzeo C, Cañas JA, Zafra MP, Marco AR, Fernández-Nieto M, Sanz V, et al. Exosome secretion by eosinophils: A possible role in asthma pathogenesis. J Allergy Clin Immunol 2015; 135:1603–1613.
82. Chen J, Chen S, Shen K, Wang S, Liu X, Lun J, et al. Basophilic exosomes promote SLE development via exacerbating B cell activation through the lncRNA ENST00000537616/miR-330-5p/KRAS axis. J Adv Res 2025; 81:593–611.
83. Guan X, Li C, Wang X, Yang L, Lu Y, Guo Z. Engineered M2 macrophage-derived exosomes: Mechanisms and therapeutic potential in inflammation regulation and regenerative medicine. Acta Biomater 2025; 203:38–58.
84. Rao Q, Ma G, Li M, Wu H, Zhang Y, Zhang C, et al. Targeted delivery of triptolide by dendritic cell‐derived exosomes for colitis and rheumatoid arthritis therapy in murine models. Br J Pharmacol 2023; 180:330–346.
85. Luo H, Zhou Y, Zhang J, Zhang Y, Long S, Lin X, et al. NK cell-derived exosomes enhance the anti-tumor effects against ovarian cancer by delivering cisplatin and reactivating NK cell functions. Front Immunol 2023; 13:1087689.
86. Zhang H, Xie Y, Li W, Chibbar R, Xiong S, Xiang J. CD4+ T cell-released exosomes inhibit CD8+ cytotoxic T-lymphocyte responses and antitumor immunity. Cell Mol Immunol 2011; 8:23–30.
87. Admyre C, Bohle B, Johansson SM, Focke-Tejkl M, Valenta R, Scheynius A, et al. B cell–derived exosomes can present allergen peptides and activate allergen-specific T cells to proliferate and produce TH2-like cytokines. J Allergy Clin Immunol 2007; 120:1418–1424.
88. Silva AM, Almeida MI, Teixeira JH, Maia AF, Calin GA, Barbosa MA, et al. Dendritic cell-derived extracellular vesicles mediate mesenchymal stem/stromal cell recruitment. Sci Rep 2017; 7:1667.
89. Murayama M, Chow SK, Lee ML, Young B, Ergul YS, Shinohara I, et al. The interactions of macrophages, lymphocytes, and mesenchymal stem cells during bone regeneration. Bone Joint Res 2024; 13:462–473.
90. Silva AM, Oliveira MI, Sette L, Almeida CR, Oliveira MJ, Barbosa MA, et al. Resveratrol as a natural anti-tumor necrosis factor-α molecule: Implications to dendritic cells and their crosstalk with mesenchymal stromal cells. PLoS One 2014; 9:e91406.
91. Almeida CR, Vasconcelos DP, Gonçalves RM, Barbosa MA. Enhanced mesenchymal stromal cell recruitment via natural killer cells by incorporation of inflammatory signals in biomaterials. J R Soc Interface 2012; 9:261–271.
92. Ekström K, Omar O, Graneli C, Wang X, Vazirisani F, Thomsen P. Monocyte exosomes stimulate the osteogenic gene expression of mesenchymal stem cells. PLoS One 2013; 8:e75227.
93. Wu AC, Raggatt LJ, Alexander KA, Pettit AR. Unraveling macrophage contributions to bone repair. Bonekey Rep 2013; 2:373.
94. Vi L, Baht GS, Whetstone H, Ng A, Wei Q, Poon R, et al. Macrophages promote osteoblastic differentiation in vivo: Implications in fracture repair and bone homeostasis. J Bone Miner Res 2014; 30:1090–1102.
95. Löffler J, Sass FA, Filter S, Rose A, Ellinghaus A, Duda GN, et al. Compromised bone healing in aged rats is associated with impaired M2 macrophage function. Front Immunol 2019; 10:2443.
96. Kim H, Wang SY, Kwak G, Yang Y, Kwon IC, Kim SH. Exosome-guided phenotypic switch of M1 to M2 macrophages for cutaneous wound healing. Adv Sci 2019; 6:1900513.
97. Jin S, Wen J, Zhang Y, Mou P, Luo Z, Cai Y, et al. M2 macrophage-derived exosome-functionalized topological scaffolds regulate the foreign body response and the coupling of angio/osteoclasto/osteogenesis. Acta Biomater 2024; 177:91–106.
98. Xie H, Cui Z, Wang L, Xia Z, Hu Y, Xian L, et al. PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis. Nat Med 2014; 20:1270–1278.
99. Wang Y, Lin Q, Zhang H, Wang S, Cui J, Hu Y, et al. M2 macrophage-derived exosomes promote diabetic fracture healing by acting as an immunomodulator. Bioact Mater 2023; 28:273–283.
100. Liu Y, Yang R, Liu X, Zhou Y, Qu C, Kikuiri T, et al. Hydrogen sulfide maintains mesenchymal stem cell function and bone homeostasis via regulation of Ca2+ channel sulfhydration. Cell stem cell 2014; 15:66–78.
101. Yang R, Liu Y, Yu T, Liu D, Shi S, Zhou Y, et al. Hydrogen sulfide maintains dental pulp stem cell function via TRPV1-mediated calcium influx. Cell Death Discov 2018; 4:69.
102. Zhou Y-k, Han C-s, Zhu Z-l, Chen P, Wang Y-m, Lin S, et al. M2 exosomes modified by hydrogen sulfide promoted bone regeneration by moesin mediated endocytosis. Bioact Mater 2024; 31:192–205.
103. Qiao W, Xie H, Fang J, Shen J, Li W, Shen D, et al. Sequential activation of heterogeneous macrophage phenotypes is essential for biomaterials-induced bone regeneration. Biomaterials 2021; 276:121038.
104. Chen Z, Klein T, Murray RZ, Crawford R, Chang J, Wu C, et al. Osteoimmunomodulation for the development of advanced bone biomaterials. Mater Today 2016; 19:304–321.
105. Sun Y, Zhang B, Zhai D, Wu C. Three-dimensional printing of bioceramic-induced macrophage exosomes: Immunomodulation and osteogenesis/angiogenesis. NPG Asia Mater 2021; 13:72.
106. Chen F, Li X, Xiao Y, Zhu X, Chen X, Zhang X. Calcium phosphate ceramic-induced osteoimmunomodulation: Submicron-surface-treated macrophage-derived exosomes driving osteogenesis. Mater Des 2024; 241:112903.
107. Ho C-C, Hsu T-T, Lin Y-H, Kuo T-Y, Chen C-Y, Hu S-H, et al. 3D-printed dictamni-calcium silicate scaffolds modulate the osteoimmune microenvironment and enhance macrophage-derived exosomal miR-21 signaling in vascularized bone regeneration. J Nanobiotechnology 2026; 24:596.
108. Wei F, Li M, Crawford R, Zhou Y, Xiao Y. Exosome-integrated titanium oxide nanotubes for targeted bone regeneration. Acta Biomater 2019; 86:480–492.
109. Wang Z, Zhao F, Zhao Y, Bai L, Hang R. Simultaneously enhanced osteogenesis and angiogenesis via macrophage-derived exosomes upon stimulation with titania nanotubes. Biomater Adv 2022; 134:112708.
110. Liu G, Cao R, Liu Q, Li H, Yan P, Wang K, et al. M2 macrophages-derived exosomes for osteonecrosis of femoral head treatment: Modulating neutrophil extracellular traps formation and endothelial phenotype transition. Bone Res 2025; 13:42.
111. Qian Y, Chu G, Zhang L, Wu Z, Wang Q, Guo JJ, et al. M2 macrophage-derived exosomal miR-26b-5p regulates macrophage polarization and chondrocyte hypertrophy by targeting TLR3 and COL10A1 to alleviate osteoarthritis. J Nanobiotechnology 2024; 22:72.
112. Bin-Bin Z, Da-Wa ZX, Chao L, Lan-Tao Z, Tao W, Chuan L, et al. M2 macrophagy-derived exosomal miRNA-26a-5p induces osteogenic differentiation of bone mesenchymal stem cells. J Orthop Surg Res 2022; 17:137.
113. Li S, Hu C, Li J, Liu L, Jing W, Tang W, et al. Effect of miR-26a-5p on the Wnt/Ca2+ pathway and osteogenic differentiation of mouse adipose-derived mesenchymal stem cells. Calcif Tissue Int 2016; 99:174–186.
114. Zhang K, Geng Y, Wang S, Huo L. MicroRNA-26a-5p targets Wnt5a to regulate osteogenic differentiation of human periodontal ligament stem cell from inflammatory microenvironment. Zhonghua Kou Qiang Yi Xue Za Zhi 2019; 54:662–669.
115. Wang D, Liu Y, Diao S, Shan L, Zhou J. Long non-coding RNAs within macrophage-derived exosomes promote BMSC osteogenesis in a bone fracture rat model. Int J Nanomedicine 2023; 18:1063–1083.
116. Shou J, Li S, Shi W, Zhang S, Zeng Z, Guo Z, et al. 3WJ RNA nanoparticles-aptamer functionalized exosomes from M2 macrophages target BMSCs to promote the healing of bone fractures. Stem Cells Transl Med 2023; 12:758–774.
117. Hozain S, Cottrell J. CDllb+ targeted depletion of macrophages negatively affects bone fracture healing. Bone 2020; 138:115479.
118. Luo X, Meng C, Zhang Y, Du Q, Hou C, Qiang H, et al. MicroRNA-21a-5p-modified macrophage exosomes as natural nanocarriers promote bone regeneration by targeting GATA2. Regen Biomater 2023; 10:rbad075.
119. Liu K, Luo X, Lv Z-Y, Zhang Y-J, Meng Z, Li J, et al. Macrophage-derived exosomes promote bone mesenchymal stem cells towards osteoblastic fate through microRNA-21a-5p. Front Bioeng Biotechnol 2022; 9:801432.
120. Chen R, Ai L, Zhang J, Jiang D. Dendritic cell-derived exosomes promote tendon healing and regulate macrophage polarization in preventing tendinopathy. Int J Nanomedicine 2024; 19:11701–11718.
121. Cao Z, Wu Y, Yu L, Zou L, Yang L, Lin S, et al. Exosomal miR-335 derived from mature dendritic cells enhanced mesenchymal stem cell-mediated bone regeneration of bone defects in athymic rats. Mol Med 2021; 27:20.
122. Elashiry M, Elashiry MM, Elsayed R, Rajendran M, Auersvald C, Zeitoun R, et al. Dendritic cell derived exosomes loaded with immunoregulatory cargo reprogram local immune responses and inhibit degenerative bone disease in vivo. J Extracell Vesicles 2020; 9:1795362.
123. Zheng M, Chen H, Liu Z, Wang Z, Jiang T, He Y. Ionizing radiation-mediated dendritic cell maturation exacerbates inflammatory response of bone marrow mesenchymal stem cells and impairs osteogenesis in radiation-induced jaw injury. Stem Cell Res Ther 2025; 16:388.
124. Chen Y, Wang Y, Tang R, Yang J, Dou C, Dong Y, et al. Dendritic cells-derived interferon-λ1 ameliorated inflammatory bone destruction through inhibiting osteoclastogenesis. Cell Death Discovery 2020; 11:414.
125. Alnaeeli M, Teng Y-T. Dendritic cells: A new player in osteoimmunology. Curr Mol Med 2009; 9:893–910.
126. Zhang L, Ke J, Wang Y, Yang S, Miron RJ, Zhang Y. An in vitro investigation of the marked impact of dendritic cell interactions with bone grafts. J Biomed Mater Res A 2017; 105:1703–1711.
127. Zhao Z, Zhao Q, Chen H, Chen F, Wang F, Tang H, et al. Role of dendritic cells in MYD88-mediated immune recognition and osteoinduction initiated by the implantation of biomaterials. Int J Oral Sci 2023; 15:31.
128. Chen L, Zhang J, Huang Y, Zhang X, Zhang G, Kong S, et al. Drug delivery systems based on dendritic-cell-derived exosomes. Pharmaceutics 2025; 17:326.
129. Wang L, Zhang G, Gao Y, Dai T, Yu J, Liu Y, et al. Extracellular vesicles derived from neutrophils accelerate bone regeneration by promoting osteogenic differentiation of BMSCs. ACS Biomater Sci Eng 2024; 10:3868–3882.
130. Herath TD, Saigo L, Schaller B, Larbi A, Teoh SH, Kirkpatrick CJ, et al. In vivo efficacy of neutrophil-mediated bone regeneration using a rabbit calvarial defect model. Int J Mol Sci 2021; 22:13016.
131. Herath TD, Larbi A, Teoh SH, Kirkpatrick CJ, Goh BT. Neutrophil‐mediated enhancement of angiogenesis and osteogenesis in a novel triple cell co‐culture model with endothelial cells and osteoblasts. J Tissue Eng Regen Med 2018; 12:e1221–e1236.
132. Jiang T, Tang XY, Su H, Chen JY, Qin YQ, Qin YC, et al. Neutrophils are involved in early bone formation during midpalatal expansion. Oral Dis 2024; 30:4483–4494.
133. Yang L, Shi F, Cao F, Wang L, She J, He B, et al. Neutrophils in tissue injury and repair: Molecular mechanisms and therapeutic targets. MedComm (2020) 2025; 6:e70184.
134. Cai B, Lin D, Li Y, Wang L, Xie J, Dai T, et al. N2‐polarized neutrophils guide bone mesenchymal stem cell recruitment and initiate bone regeneration: A missing piece of the bone regeneration puzzle. Adv Sci 2021; 8:2100584.
135. Wang L, Yang L, Tian L, Guo B, Dai T, Lv Q, et al. Exosome-capturing scaffold promotes endogenous bone regeneration through neutrophil-derived exosomes by enhancing fast vascularization. Biomaterials 2025; 319:123215.
136. Welsh JA, Goberdhan DC, O’Driscoll L, Buzas EI, Blenkiron C, Bussolati B, et al. Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. Brain Behav Immun 2024; 13:e12404.
137. Yin L, Huang H, Zhu J, Lin P. 3D-printed PCL/nHA/SA/COL loaded with M2 macrophage-derived exosomes alleviates the senescence of bone marrow mesenchymal stem cells. Int Immunopharmacol 2026; 185:116950.