Oxytocin alleviates cisplatin-induced renal damage in rats

Document Type : Original Article

Authors

1 Gaziosmanpasa University Faculty of Medicine, Department of Physiology, Tokat Turkey

2 Izmir Dr Behcet Uz Pediatric Medicine and Surgery Training and Research Hospital, Pediatric Endocrinology Clinic, Izmir, Turkey

3 Ege University School of Medicine, Department of Histology and Embryology, Izmir, Turkey

4 Ege University School of Medicine, Department of Gynecology and Obstetrics, Izmir, Turkey

5 Gaziosmanpasa University Faculty of Medicine, Department of Neurology, Tokat, Turkey

6 Ege University Faculty of Medicine, Department of Physiology, Izmir, Turkey

Abstract

Objective(s):The purpose of the present study was to investigate the protective effect of oxytocin on cisplatin (CP)-induced renal damage in rats.
Materials and Methods: Fourteen adult Sprague Dawley rats, weighing 200 to 210, were administered by cisplatin (CP, 2 mg/kg/day) twice a week for five weeks. Then, they were randomly divided into two groups and treated with either saline (1 ml/kg/day) or OT                       (200 µg/kg/day) for five weeks. Seven rats served as control group. At the end of the treatment period, animals were sacrificed and their kidneys were assessed histologically. In addition,            C-reactive protein (CRP), TGF-β and Akt expression were evaluated immunohistochemically.
Results:Both tubules and glomeruli were found to be severely damaged with marked medullary tubulo-interstitial inflammation due to chronic cisplatin exposure, particularly in the saline-treated group (Group 1) compared to control group. Oxytocin treatment spared renal tissue significantly by suppressing CRP and TGF-β, and enhancing Akt expression.
Conclusion: We conclude that renal damage due to cisplatin toxicity was prevented to a great extent by the anti-inflammatory effect of oxytocin.   

Keywords

References

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Iranian Journal of Basic Medical Sciences
Volume 17, Issue 10 - Serial Number 10
October 2014
Pages 747-752

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