Hypoglycemic and hypolipidemic activities of Salvia hydrangea in streptozotocin-induced diabetes in rats

Authors

1 Department of Biology, Damghan Branch, Islamic Azad University, Semnan, Iran

2 Department of Biology, Payame Noor University, Iran

3 Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran

Abstract

Objective(s): This study was to investigate the potential anti-diabetic effects of alcoholic extract of Salvia hydrangea in rats.
Materials and Methods:Thirty five male Wistar rats were divided into five groups namely non-diabetic control, diabetic control, and three experimental diabetic that received either Salvia hydrangea extract for 21 days at the doses of 100 and 200 or glibenclamide at the dose of 10 mg/kg through gavage feeding. To induce diabetes, streptozotocin was injected intraperitoneally.
Results:Insulin and HDL levels in the group receiving the high dose of the extract showed significant increase, whereas the amount of cholesterol in rats that received glibenclamide and the extract showed a significant decrease as compared to the diabetic control group (P<0.05). The blood glucose levels showed significant reduction in all experimental groups (P<0.05).
Conclusion: Consumption of the extract of the aerial parts of S. hydrangea which reduces blood fat and increases insulin may have beneficial effects on the symptoms of diabetes and hyperlipidemia.
 

Keywords

References

1. Mansouri E, Khorsandi L, Abedi HA. Antioxidant effects of proanthocyanidin from grape seed on hepatic tissue injury in diabetic rats. Iran J Basic Med Sci 2014; 17:460-464.
2. Patel DK, Prasad SK, Kumar R, Hemalatha S. An overview on anti diabetic medicinal plants having insulin mimetic property. Asian Pac J Trop Biomed 2012; 2:320-330.
3. Ponnusamy S, Ravindran R, Zinjarde S, Bhargava S, Kumar AR. Evaluation of traditional Indian antidiabetic medicinal plants for human pancreatic amylase inhibitory effect in vitro. Evid Based Complement Alternat Med 2011; 2011:515647.
4. Nickavar B, Kamalinejad M and Izadpanah H. In vitro free radical scavenging activity of five Salvia species. Pak J Pharm Sci 2007; 20:291-294.
5. Perry NS, Bollen C, Perry EK and Ballard C. Salvia for dementia therapy: review of pharmacological activity and pilot tolerability clinical trial. Pharmacol Biochem Behav 2003; 75:651-659.
6. Nickavar B, Abolhasani L, Izadpanah H. α-Amylase inhibitory activities of six Salvia species Iranian. J Pharm Res 2008; 7:297-303.
7. MoridiFarimani M, Bahadori MB, Taheri S, Ebrahimi SN, Zimmermann S, et al. Triterpenoids with rare carbon skeletons from Salvia hydrangea: antiprotozoal activity and absolute configurations. J Nat Prod 2011; 74:2200-2225.
8. Zare T, Mokhtari M, Mohammadi J. The effect of hydroalcoholic extracts of Prangos ferulacea on blood factors of kidney and liver functions in diabetic male wistar rats. J Fasa Univ Med Sci 2012; 2:174-180.
9. Sonbolia A, Babakhanib B, Mehrabian A. Antimicro-bial activity of six constituents of essential oil from Salvia. Naturforsch 2006; 61:160-164.
10. Ashraf H, Heidari R, Nejati V, Ilkhanipoo M. Preventive effect of Berberis Integerrima on the serum levels of glucose and lipids in streptozotocin induced diabetes in rats. J Fasa Univ Med Sci 2012; 2:148-155. (In Persian).
11. Pihlajamaki J, Gylling H, Miettinen TA, Laakso M. Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men. J Lipid Res 2004; 45:507-512.
12. Sharma A, Sharma AK, Chand T, Khardiya M, Yadav KC. Antidiabetic and antihyperlipidemic activity of Cucurbita maxima duchense seeds on streptozotocin induced diabetic rats. J Pharmacogn Phytochem 2013; 1:108-116.
13. Nickavar B, Abolhasani L, Izadpanah H.α-Amylase inhibitory activities of six Salviaspecies. Iran J Pharm Res 2008; 7:297-303.
14. Asadi S, Ahmadiani A, Esmaeili MA, Sonboli A, Ansari N, Khodagholi F. In vitro antioxidant activities and an investigation of neuroprotection by six Salvia species from Iran: a comparative study. Food Chem Toxicol 2010; 48:1341-1349.
15. Lim SS, Jung YJ, Hyun SK, Lee YS, Choi JS. Rat lens aldose reductase inhibitory constituents of Nelumbo-nuciferastamens. Phytother Res 2006; 20:825-30.
16. Jorge AP, Horst H, de Sousa E, Pizzolatti MG, Silva FR. Insulino mimetic effects of Kaempferitrin on glycaemia and on 14Cglucoseuptake in rat soleus muscle. Chem Biol Interact 2004; 149:89-96.
17. Shahabinezhad M, Rahmani MR, Khaksari Hadad M, Sepehri GH, Mahmoodi M, Karimghasemi E. The effect of licorice root extract on blood sugar level in streptozotocin induced diabetic rats. J Rafsanjan Univ Med Sci 2008; 6:237-244 (In Persian).
18. Ji W, Gong BQ. Hypolipidemic activity and mechanism of purified herbal extract of Salvia miltiorrhiza in hyperlipidemic rats. J Ethnopharmacol 2008; 119:291–298.

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