Molecular and genetic aspects of odontogenic tumors: a review

Document Type : Review Article

Authors

1 Department of Oral Pathology, Chandra Dental College, Barabanki, India

2 Department of Oral Pathology, King George Medical College, Lucknow, India

3 Department of Oral Pathology, Saraswati Dental College and Hospital, Lucknow, India

4 Department of Oral Surgery, Taibah University College of Dentistry, Al Madinah Al Munawwarah Saudi Arabia

5 Department of Restorative Dentistry, Taibah University College of Dentistry, Al Madinah Al Munawwarah, Saudi Arabia

Abstract

Odontogenic tumors contain a heterogeneous collection of lesions that are categorized from hamartomas to benign and malignant neoplasms of inconstant aggressiveness. Odontogenic tumors are usually extraordinary with assessed frequency of short of 0.5 cases/100,000 population for every year. The lesions such as odontogenic tumors are inferred from the components of the tooth-structuring contraption. They are discovered solely inside the maxillary and mandibular bones. This audit speaks to experiences and cooperation of the molecular and genetic variations connected to the development and movement of odontogenic tumors which incorporate oncogenes, tumor-silencer genes, APC gene, retinoblastoma genes, DNA repair genes, onco-viruses, development components, telomerase, cell cycle controllers, apoptosis-related elements, and regulators/controllers of tooth development. The reasonable and better understanding of the molecular components may prompt new ideas for their detection and administrating a better prognosis of odontogenic tumors.

Keywords

References

1. Rajendran R. Shafer's textbook of oral pathology. India: Elsevier; 2009.
2. Regezi JA, Sciubba JJ, Jordan RC. Oral pathology: clinical pathologic correlations. Elsevier Health Sciences; 2012.
3. Kumar V, Abbas AK, Fausto N, Aster JC. Robbins and Cotran Pathologic Basis of Disease, Professional Edition: Expert Consult-Online. Elsevier Health Sciences; 2009.
4. Reichart P, Philipsen H, Sonner S. Ameloblastoma: biological profile of 3677 cases. Eur J Cancer Part B: Oral Oncol 1995; 31:86-99.
5. Nakamura N, Mitsuyasu T, Higuchi Y, Sandra F, Ohishi M. Growth characteristics of ameloblastoma involving the inferior alveolar nerve: a clinical and histopathologic study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001; 91:557-562.
6. Becelli R, Carboni A, Cerulli G, Perugini M, Iannetti G. Mandibular ameloblastoma: analysis of surgical treatment carried out in 60 patients between 1977 and 1998. J Craniofac Surg 2002; 13:395-400.
7. Stevens A, Lowe J. Pathology. New York: Mosbay; 2000.
8. Kumamoto H. Molecular pathology of odontogenic tumors. J Oral Pathol Med 2006; 35:65-74.
9. Gazal G, Fareed WM, Zafar MS, Al-Samadani KH. Pain and anxiety management for pediatric dental procedures using various combinations of sedative drugs: A review. Saudi Pharm J 2014; Published ahead of print.
10. Cawson RA. Cawson's Essentials of Oral Pathology and Oral Medicine. 7th ed. Edinburgh: Churchill Livingstone; 2002.
11. Klein CA. Selection and adaptation during metastatic cancer progression. Nature 2013; 501:365-372.
12. Beerenwinkel N, Antal T, Dingli D, Traulsen A, Kinzler KW, Velculescu VE, et al. Genetic progression and the waiting time to cancer. PLoS Comput Biol 2007; 3:e225.
13. Michor F, Iwasa Y, Nowak MA. Dynamics of cancer progression. Nat Rev Cancer 2004; 4:197-205.
14. Kumamoto H, Ooya K. Expression of tumor necrosis factor α, TNF‐related apoptosis‐inducing ligand, and their associated molecules in ameloblastomas. J Oral Pathol Med 2005; 34:287-294.
15. Bishop JM. Molecular themes in oncogenesis. Cell 1991; 64:235-248.
16. Kumamoto H, Takahashi N, Ooya K. K‐Ras gene status and expression of Ras/mitogen‐activated protein kinase (MAPK) signaling molecules in ameloblastomas. J Oral Pathol Med 2004; 33:360-367.
17. Kumamoto H, Ooya K. Detection of mitochondria‐mediated apoptosis signaling molecules in ameloblastomas. J Oral Pathol Med 2005; 34:565-572.
18. Kumamoto H, Izutsu T, Ohki K, Takahashi N, Ooya K. p53 gene status and expression of p53, MDM2, and p14ARF proteins in ameloblastomas. J Oral Pathol Med 2004; 33:292-299.
19. Kumamoto H, Ohki K, Ooya K. Expression of p63 and p73 in ameloblastomas. J Oral Pathol Med 2005; 34:220-226.
20. Kumamoto H, Kimi K, Ooya K. Immunohistochemical analysis of apoptosis‐related factors (Fas, Fas ligand, caspase‐3 and single‐stranded DNA) in ameloblastomas. J Oral Pathol Med 2001; 30:596-602.
21. Wunder JS, Czitrom AA, Kandel R, Andrulis IL. Analysis of alterations in the retinoblastoma gene and tumor grade in bone and soft-tissue sarcomas. J Natl Cancer Inst 1991; 83:194-200.
22. Benedict WF, Murphree AL, Banerjee A, Spina CA, Sparkes MC, Sparkes RS. Patient with 13 chromosome deletion: evidence that the retinoblastoma gene is a recessive cancer gene. Science 1983; 219:973-975.
23. Castrilli G, Piantelli M, Artese L, Perfetti G, Rubini C, Fioroni M, et al. Expression of hMSH2 and hMLH1 proteins of the human DNA mismatch repair system in ameloblastoma. J oral path & med 2001; 30:305-308.
24. Mork J, Lie AK, Glattre E, Clark S, Hallmans G, Jellum E, et al. Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck. N Engl J Med 2001; 344:1125-1131.
25. Kreimer AR, Clifford GM, Boyle P, Franceschi S. Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiol Biomarkers Prev 2005; 14:467-475.
26. Sand L, Jalouli J, Larsson P, Magnusson B, Hirsch J. Presence of human papilloma viruses in intraosseous ameloblastoma. J Oral Maxillofac Surg 2000; 58:1129-1134.
27. Eberhart CG, Argani P. Wnt signaling in human development: beta-catenin nuclear translocation in fetal lung, kidney, placenta, capillaries, adrenal, and cartilage. Pediatri Dev Pathol 2001; 4:351-357.
28. Kumamoto H, Ooya K. Expression of bone morphogenetic proteins and their associated molecules in ameloblastomas and adenomatoid odontogenic tumors. Oral Dis 2006; 12:163-170.
29. So F, Daley TD, Jackson L, Wysocki GP. Immunohistochemical localization of fibroblast growth factors FGF‐1 and FGF‐2, and receptors FGFR2 and FGFR3 in the epithelium of human odontogenic cysts and tumors. J Oral Pathol Med 2001; 30:428-433.
30. Kumamoto H, Kinouchi Y, Ooya K. Telomerase activity and telomerase reverse transcriptase (TERT) expression in ameloblastomas. J Oral Pathol Med 2001; 30:231-236.
31. Allsopp RC, Weissman IL. Replicative senescence of hematopoietic stem cells during serial transplantation: does telomere shortening play a role? Oncogene 2002; 21:3270-3273.
32. Kumamoto H, Ooya K. Immunohistochemical detection of β‐catenin and adenomatous polyposis coli in ameloblastomas. J Oral Pathol Med 2005; 34:401-406.
33. Yamamoto K, Yoneda K, Yamamoto T, Ueta E, Osaki T. An immunohistochemical study of odontogenic mixed tumours. Eur J Cancer Part B: Oral Oncol 1995; 31:122-128.
34. Sekine J, Kitamura A, Ueno K, Sano K, Inokuchi T, Takahashi H, et al. Cell kinetics in mandibular ameloblastic fibro-odontoma evaluated by bromodeoxyuridine and proliferating cell nuclear antigen immunohistochemistry: case report. Br J Oral Maxillofac Surg 1996; 34:450-453.
35. Kumamoto H, Ooya K. Immunohistochemical and ultrastructural investigation of apoptotic cell death in granular cell ameloblastoma. J Oral Pathol Med 2001; 30:245-250.
36. Zafar MS, Ahmed N. Nano-mechanical evaluation of dental hard tissues using indentation technique. W App Sci J  2013; 28:1393-1399.
37. Kumamoto H. Detection of apoptosis‐related factors and apoptotic cells in ameloblastomas: analysis by immunohistochemistry and an in situ DNA nick end‐labelling method. J Oral Pathol Med 1997; 26:419-425.
38. Mitsuyasu T, Harada H, Higuchi Y, Kimura K, Nakamura N, Katsuki T, et al. Immunohistochemical demonstration of bcl‐2 protein in ameloblastoma. J Oral Pathol Med 1997; 26:345-358.
39. Kumamoto H, Ohki K, Ooya K. Expression of Sonic hedgehog (SHH) signaling molecules in ameloblastomas. J Oral Pathol Med 2004; 33:185-190.
40. Sauk JJ, Nikitakis NG, Scheper MA. Are we on the brink of nonsurgical treatment for ameloblastoma? Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 110:68-78.

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