Molecular and genetic aspects of odontogenic tumors: a review

Document Type : Review Article


1 Department of Oral Pathology, Chandra Dental College, Barabanki, India

2 Department of Oral Pathology, King George Medical College, Lucknow, India

3 Department of Oral Pathology, Saraswati Dental College and Hospital, Lucknow, India

4 Department of Oral Surgery, Taibah University College of Dentistry, Al Madinah Al Munawwarah Saudi Arabia

5 Department of Restorative Dentistry, Taibah University College of Dentistry, Al Madinah Al Munawwarah, Saudi Arabia


Odontogenic tumors contain a heterogeneous collection of lesions that are categorized from hamartomas to benign and malignant neoplasms of inconstant aggressiveness. Odontogenic tumors are usually extraordinary with assessed frequency of short of 0.5 cases/100,000 population for every year. The lesions such as odontogenic tumors are inferred from the components of the tooth-structuring contraption. They are discovered solely inside the maxillary and mandibular bones. This audit speaks to experiences and cooperation of the molecular and genetic variations connected to the development and movement of odontogenic tumors which incorporate oncogenes, tumor-silencer genes, APC gene, retinoblastoma genes, DNA repair genes, onco-viruses, development components, telomerase, cell cycle controllers, apoptosis-related elements, and regulators/controllers of tooth development. The reasonable and better understanding of the molecular components may prompt new ideas for their detection and administrating a better prognosis of odontogenic tumors.


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