Preventive and Therapeutic Vaccines against Human Papillomaviruses Associated Cervical Cancers

Document Type : Review Article


1 Women’s Health Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran

2 Microbiology and Virology Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran


Cervical cancer is, globally known to be, one of the most common cancers among women especially in
developing countries. More than 90% of cervical cancers are associated with high-risk human
papillomaviruses (HPVs) particularly HPV types 16 and 18. Two major strategies have been developed for
prevention and treatment of cervical cancer and other HPV-associated malignancies; the first one is based on
HPV virus-like particles (VLPs) containing HPV structural proteins. VLP based vaccines can induce
genotype specific virus neutralizing antibodies for preventing HPV infections. The other strategy is based on
HPV early genes especially E6 and E7 for eliminating the established HPV infections; therefore they are
classified as HPV therapeutic vaccines. This article reviews the preventive and therapeutic vaccines against
HPV infections and cervical cancer.


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