Investigation of Toxic Metals in the Tobacco of Different Iranian Cigarette Brands and Related Health Issues

Document Type : Original Article

Authors

1 Department of Environmental Science, Agriculture Faculty, Birjand University, Birjand, Iran

2 Department of Environmental Science, Natural Resources Faculty, Behbahan University, Behbahan, Iran

Abstract

Objective(s)
The primary objective of this study was to determine whether local and imported cigarette brands used in Iran, have elevated levels of metals or not. The produced data of cigarette brands are compared both with each other and with the existing brands in different countries.
Materials and Methods
In present study, nineteen various cigarettes brands were randomly purchased from the commercially available cigarettes in Iranian market (Birjand city) including local Iranian branded and imported cigarettes. All samples were analyzed for heavy metals, viz. Cd, ,Cu ,Co Ni, Zn and Pb by graphite furnace atomic absorption spectrophotometer after microwave-assisted wet digestion method with nitric and perchloric acids.
Results
The observed average metals concentrations for cadmium in all cigarette brands was 2.71 and ranging 1.76 to 3.20, copper 9.7 (5.18-17.6), cobalt 4.42 with range of 2.57-6.49, nickel 17.93 (10.0-30), zinc 27.02  (18.1-42.2) and value for lead was 2.07 with range of 1.05 to 3.10 (µg/g dry weight) and mean metals content per cigarette was also measured. The produced data of imported and local cigarette brands are discussed and compared together and with studies from elsewhere.
Conclusion
The investigation may confirm that the level of metal contents in Iranian cigarettes is similar to the other parts of the world. However, the concentration of these metals was slightly higher in comparison with other investigation.

Keywords

References

1. Harun CFTC, Ölcucu A. Determination of iron, copper, cadmium and zinc in some cigarette brands in Turkey. Int J Sci Technol 2007; 2:29-32.
2. Menden EE, Elia Victor J, Michael Leslie W, Petering Harold G. Distribution of cadmium and nickel of tobacco during cigarette smoking. Environ Sci Tec 1972; 6:830.
3. Gál G, Hursthouse A, Tatner P, Stewart F, Welton R. Cobalt and secondary poisoning in the terrestrial food chain: Data review and research gaps to support risk assessment. Environ Int 2008; 34:821–838.
4. Gault N, Sandre C,  Poncy  JL,  Moulin C,  Lefaix  JL,  Bresson C. Cobalt toxicity: Chemical and radiological combined effects on HaCaT keratinocyte cell line. Toxicol In Vitro 2010; 24:92–98.
5. Tripathi P, Srivastava S. Mechanism to combat cobalt toxicity in cobalt resistant mutants of Aspergillus nidulans. Indian J Microbiol 2007; 47:336–344.
6. Olayinka OK, Oyedeji  OA,  Oyeyiola OA. Removal of chromium and nickel ions from aqueous solution by adsorption on modified coconut husk. Afr J Environ Sci Technol 2009; 3:286-293.
7. Shakya PR. Nickel adsorption by wild type and nickel resistant isolate of Chlorella sp. Pak J  Anal Environ Chem  2007;  8:86–90.
8. Santon  A, Albergoni V, Sturniolo GC, Irato P. Evaluation of MT expression and detection of apoptotic cells in LEC rate kidneys. Biochim Biophys Acta  2004; 1688:223-231.
9. Ajab H, Yasmeen S, Yaqub A, Ajab Z, Junaid M., Siddique M., et al. Evaluation of trace metals in tobacco of local and imported cigarette brandfs used in Pakistan by spectrophotometer through microwave digestion. J Toxicol Sci  2008; 33:415-420.
10. Petrucelli GA, Poppi RJ, Mincato RL, Pereira-Filho ER.TS-FF-AAS and multivariate calibration: a proposition for sewage sludge slurry sample analyses. Talanta  2007; 71:620-626.
11. Andrade FP, Nascentes Clésia C,Costa Letícia M.Cadmium and lead cloud point preconcentration and determination in tobacco samples by thermospray flame furnace atomic absorption spectrometry. J Braz Chem Soc  2009; 20:1460-1466.
12. Regassa G. Investigation of metals in Ethiopian tobacco leaves and processed tobacco. Master thesis, Addis Ababa University, Ethiopia, 2007.
13. Harrison RH, Laxen DPH. Human exposure to lead and its effect in lead pollution, causes and control. Chapman and Hall, New York.:1984.p.133-158.
14. World Health Organization. Environmental Health Criteria: 3, Lead’, Geneva: 1977.
15. World Health Organization (WHO), ‘Lead-environmental Aspects’, WHO Environmental Health Criteria Series No. 85, Geneva:1989.
16. Kazi TG, Jalbani N, Arain MB, Jamali MK, Afridi HI,  Sarfraz RA, Shah AQ. Toxic metals distribution in different components of Pakistani and imported cigarettes by electrothermal atomic absorption spectrometer. J Hazardous Materials 2009; 16:302–307.
17. Sanchez FG, Diaz AN, Arbfiizar A, Mikrochim. Determination of cadmium in tobacco smoke and zinc in tap water by solvent extraction flame atomic absorption. Spectrom Acta 1995; 118:265-272.
18. Borges DLG, Veiga MAMS, Frescura VLA, Welz B, Curtis AJ. Cloud-point extraction for the determination of Cd, Pb, and Pd in blood by electrothermal atomic absorption spectrometry, using Ir or Ru as permanent modifier. J Anal At Spectrom 2003; 18:501-507.
19. Verma S, Yadav Singh I. Trace metal concentration in different Indian tobacco products and related health implications. Food Chem Toxicol 2010; doi: 10.1016/j.fct.2010.05.062.
20. Geiss O, Kotzias D. Tobacco, cigarettes and cigarette smoke an overview, Institute for Health and Consumer Protection, European Commission 2007.
21. Elinder CG, Kjellstrom T, Lind B, Linnman I, Piscator M, Sundstedt K. Cadmium exposure from smoking cigarettes; variations with time and country where purchased. Environ Res 1983; 32: 220-227.
22. Galażyn-Sidorczuk M, Brzóska MM, Moniuszko-Jakoniuk J. Estimation of Polish cigarettes contamination with cadmium and lead, and exposure to these metals via smoking. Environ Monit Assess 2008; 137:481–493.
23. Watanabe T, Kasahara M, Nakatsuka H, Ikeda M. Cadmium and lead contents of cigarettes produced in various areas of the world. Sci Total Environ 1987; 66:29–37.
24. Massadeh AM, Alali Feras Q, Jaradat Qasem M. Determination of cadmium and lead in different cigarette brands in Jordan. Environ Monitor  Assess 2005; 104:163–170.
25. Saldivar L, Luna M, Reyes E, Soto R, Fortoul TI. Cadmium determination in Mexican-produced tobacco. Environ Res 1991; 55:91-96.
26. Ebisike K, Ayejuyo OO, Sonibare JA, Ogunkunle OA, Ojumu TV. Pollution impact of cigarette consumption on indoor air quality in Nigeria. J Appl Sci 2004; 4:623-629.
27. Barlas H, Ubay G, Soyhan B, Bayat C. Heavy metal concentrations of cigarettes in Turkey. Fresenius Environ Bul  2001; 10: 80-83.
28. Yang G, Li Z, Shi H, Wang J. Study on the determination of heavy metal ions in tobacco additives by microwave digestion and HPLC with PAD detection. J Anal Chem 2005; 60:480-485.
29. Schneider G, Krivan V. Multi elemental analysis of tobacco and smokcondensate by instrumental neutron activation analysis and atomic absorption spectrometry. Int J Environ Anal Chem 1993; 53:87-100.
30. Pappas RS, Polzin GM., Watson CH, Ashley DL. Cadmium, lead, and thallium in smoke particulate from counterfeit cigarettes compared to authentic US brands. Food Chem Toxicol 2007;  45:202–209.
31. Nnorom IC, Osibanjo O, Oji-Nnorom CG.Cadmium determination in cigarettes available in Nigeria. African J Biol  2005; 4:1128-1132.
32. Feldmann C. Perchloric acid procedure for wet-ashing organics for the determination 11 of mercury (and other metals). Anal Chem 1974; 46:1606-1609.
33. Jung MC, Thornton I, Chon HT. Arsenic, cadmium, copper, lead and zinc concentrations in cigarettes produced in Korea and the United Kingdom. Environ Technol 1998; 19:237–241.
34. Stephens WE, Calder A, Newton J. Source and health implications of high toxic metal concentrations in illicit Tobacco products. Environ Sci Technol 2005; 39:479-488.
35. Galas W, Kita A. Determination of ten elements in the spice samples using an inductively coupled plasma-atomic emission spectroscopy. Chem Anal (Warsaw) 1997; 42:403–409.
36. Shaikh AN, Khandekar RN, Anand SJS, Mishra UC. Determination of some toxic trace elements in Indian tobacco and its smoke. J Radioanal Nucl Chem 1992; 163:349–353.
37. Engida AM. Levels of trace metals in cigarettes commonly sold in Ethiopia. Master thesis, Addis Ababa university, Ethiopia: 2007.
38. Dermelj M, Ravnik V, Byrne AR, Vakselj  A. Trace heavy metals in various Yugoslav tobaccos. Mikrochim Acta 1978; 1:261-270.
39. Mussalo-Rauhamaa H, Salmela SS, Leppäen A, Pyysalo H. Cigarettes as a source of some trace and heavy metals and pesticides in man. Arch Environ Health 1986; 41:49–55.
40. Shaikh AN, Negi BS, Sadasivan S. Characterization of Indian cigarette tobacco and its smoke aerosol by nuclear and allied techniques. J Radioanal Nucl Chem 2002; 253:231-234.
41. FAO/WHO. Expert Committee on Food Additives . 1998. Available at:http://www.inchem.org/
42. Sugita M, Takashi Izuno T, Tatemichi M, Otahara Y. Cadmium absorption from smoking cigarettes: calculation using recent findings from Japan. Environ Health  Prev Med  2001; 6:154–159.
43. Müller G. Scwermetallgehalt (Cd, Zn, Pb, Cu, Cr) im Tabak häutig in der BR Deutschland gerauchter Zigartten. Chem Ztg 1979; 103:17-21.
44. Gairola CG, Wagner GJ. Cadmium accumulation in the lung, liver and kidney of Mice and Rats chronically exposed to cigarette smoke. J Appl Toxicol 1991; 11:355-358.
45. Pappas RS, Polzin GM, Zhang L, Watson CH, Paschal DC, Ashley DL. Cadmium, lead, and thallium in mainstream tobacco smoke particulate. Food Chem Toxicol 2006; 44:714–723.
46. Janardhana RN, Kofod M, Isenbeck-Schröter M, Müaller G. Heavy metal content of Indian cigarettes. Toxicol Environ Chem 1999; 72:215-219.
Iranian Journal of Basic Medical Sciences
Volume 15, Issue 1 - Serial Number 1
January 2012
Pages 636-644

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